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Neural population dynamics in mouse motor cortex during voluntary gait modification. Neuropixels 2.0 is really a game-changer for resolving single-trial dynamics in a freely-moving prep. Check out Eric Kirk’s poster at SfN for more details …

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Britton Sauerbrei

3,451 subscribers

19,802 просмотров • 2 лет назад •via X (Twitter)

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Комментарии: 8

Фото профиля Jianing Yu
Jianing Yu2 лет назад

Cool demo! Why does the contral-trail type drive MC eariler than the contral-lead type in PC1/2? I thought the mouse lifts contral paw first in the later contral-lead type?

Фото профиля Britton Sauerbrei
Britton Sauerbrei2 лет назад

Great question! The data in both conditions are aligned to swing onset for the contralateral limb. While there are certainly neurons (like this one) that fire during cFL swing over the obstacle, the dominant signal in PC 1-2 is synchronized with swing in the *leading* limb.

Фото профиля Dan Butler
Dan Butler2 лет назад

Looks interesting - is there a link to read more?

Фото профиля Britton Sauerbrei
Britton Sauerbrei2 лет назад

Thanks! Not yet, but stay tuned …

Фото профиля GG🌱
GG🌱2 лет назад

wow, it looks cool! I will let my team to visit the Eric Kirk's poster!

Фото профиля Mackenzie Mathis, PhD
Mackenzie Mathis, PhD2 лет назад

DLC still? Beautiful work 🥳

Фото профиля Britton Sauerbrei
Britton Sauerbrei2 лет назад

Thanks, Mackenzie! Yep - DLC + Anipose are the backbone of our tracking pipeline, and they work beautifully!

Фото профиля Dr Rob Leigh
Dr Rob Leigh2 лет назад

@JohnRHutchinson @CathalMcCrory1

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