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Neural population dynamics in mouse motor cortex during voluntary gait modification. Neuropixels 2.0 is really a game-changer for resolving single-trial dynamics in a freely-moving prep. Check out Eric Kirk’s poster at SfN for more details …

Britton Sauerbrei

3,451 subscribers

19,802 次观看 • 2 年前 •via X (Twitter)

健康养生科学技术

Anya Rossi• Live Now

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8 条评论

Jianing Yu 的头像

Jianing Yu2 年前

Cool demo! Why does the contral-trail type drive MC eariler than the contral-lead type in PC1/2? I thought the mouse lifts contral paw first in the later contral-lead type?

Britton Sauerbrei 的头像

Britton Sauerbrei2 年前

Great question! The data in both conditions are aligned to swing onset for the contralateral limb. While there are certainly neurons (like this one) that fire during cFL swing over the obstacle, the dominant signal in PC 1-2 is synchronized with swing in the *leading* limb.

Dan Butler 的头像

Dan Butler2 年前

Looks interesting - is there a link to read more?

Britton Sauerbrei 的头像

Britton Sauerbrei2 年前

Thanks! Not yet, but stay tuned …

GG🌱 的头像

GG🌱2 年前

wow, it looks cool! I will let my team to visit the Eric Kirk's poster!

Mackenzie Mathis, PhD 的头像

Mackenzie Mathis, PhD2 年前

DLC still? Beautiful work 🥳

Britton Sauerbrei 的头像

Britton Sauerbrei2 年前

Thanks, Mackenzie! Yep - DLC + Anipose are the backbone of our tracking pipeline, and they work beautifully!

Dr Rob Leigh 的头像

Dr Rob Leigh2 年前

@JohnRHutchinson @CathalMcCrory1

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