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New preprint from our group, led by Lissa Ventura Antunes, explores structural changes in arterioles with cerebral amyloid angiopathy. Lissa is a master of quantitative 3D microscopy. In this clip, healthy tissue is first, then two cases with CAA. @VUMCneurology Vanderbilt University Medical Center

Matthew Schrag

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11,966 次观看 • 2 年前 •via X (Twitter)

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Matthew Schrag 的头像

Matthew Schrag2 年前

The healthy lacy network of vessels in the brain is profoundly disrupted in CAA and the penetrating arterioles become thickened, stiff and distorted. As rings of beta-amyloid form on the vessels (blue), vascular smooth muscle dies (red).

Matthew Schrag 的头像

Matthew Schrag2 年前

As the vessels deteriorate, the lumen expands and the organized rings of beta-amyloid start to fracture into sharply contoured "shards." @VUCellImaging

Matthew Schrag 的头像

Matthew Schrag2 年前

At the point of rupture, vessels are often severely distended and the amyloid "rings" are completely shattered into fragments. (Amyloid is stained red in these clips.)

Matthew Schrag 的头像

Matthew Schrag2 年前

We explore a potential role for the extracellular matrix modifying enzyme LOX in CAA, showing it correlates with degenerative phenotypes. LOX (in pink) could mediate the increased vascular stiffness and structural distortion we observed in CAA by crosslinking ECM proteins.

Matthew Schrag 的头像

Matthew Schrag2 年前

Shoutout to @anackenoff who did some of the foundational technical work for this project, to @LippmannLabVU for a major contribution and imaging expertise from Jose Maldonado/Neurovisualization lab. Preliminary draft at the link and we welcome feedback.

Steven Mathern 的头像

Steven Mathern2 年前

@MicrobiomDigest @AntunesLissa @VUMCneurology @VUMCDiscoveries @DaniBeckman @RolandBakerIII ?

Danielle Beckman 的头像

Danielle Beckman2 年前

@AntunesLissa @VUMCneurology @VUMCDiscoveries Such beautiful work. Congrats to the team! Now I have to try the same staining in my aged monkeys, the CAA pathology looks similar!

Abdul Moiz 的头像

Abdul Moiz2 年前

@AntunesLissa @VUMCneurology @VUMCDiscoveries Great Work. This is revolutionary. Personally, I love reading about degenerate organic diseases of the brain and I seriously love this.

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