📃 NEW PUBLICATION | Using #ArtificialIntelligence to reveal the secrets of #HepC Virus entry Kamilla Toon , #MichaelOliver & colleagues use #alphafold to uncover a potentially novel fusion mechanism in the Hepaci-, Pegi- and Pestiviruses Read here:

The membrane fusion mechanism for many enveloped viruses is unknown. Using machine learning tools such as AlphaFold, rather than traditional experimental approaches, allows rapid and accurate prediction of protein structures.

The authors discovered that the E1 protein has a conserved and novel structure, suggesting a common and previously unknown fusion mechanism. This work will guide further experiments to understand this mechanism and may also help vaccine design for viruses such as #HepC.

'Structures of the Hepaci-, Pegi- and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism' has been published in @PLOSBiology . 💰 Thank you to our funders - @wellcometrust @UKRI_News @royalsociety

Congratulations to the authors! 🎉 @GroveLab , #MichaelOliver @KamillaToon , @cb99_lewis , @sdevlinbio , @Paleovirologist #CVRHep @CVRGoesViral

@KamillaToon any tutorials on this?