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New work on protein design... 🚨S2 immunogen design using advanced simulation WESTPA Software WE MD--> opening mechanism--> design--> stabilized protein--> cryoEM structure + immunology Xandra Nuqui Lorenzo Casalino Jason McLellan Kartik Chandran

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Rommie Amaro

7,714 subscribers

13,014 次观看 • 1 年前 •via X (Twitter)

教育健康养生科学技术
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Hector Sanchez-Moran, PhD 的头像
Hector Sanchez-Moran, PhD1 年前

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab That pi-cation+pi-stacking+salt-bridge cluster is really remarkable

Xuhui Huang 的头像
Xuhui Huang1 年前

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab Cool work!

Rommie Amaro 的头像
Rommie Amaro1 年前

@WestpaSoftware @xandra_nuqui @LCasalino88 @McLellan_Lab @ChandranLab Thanks Xuhui!!

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We're prepping for a big Q4 OOH campaign here Slash so I decided to build a new part of our marketing tooling suite for visibility On the new tab we have: > Map of placements in NYC/SF > Cost + est impressions + CPMs > Clickable Image preview > AI design mockup generator

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NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

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72,565 次观看 • 1 年前

What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan
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Written description (business type, aesthetic, features) 3. Both Share: **Aesthetic**: Style preference? (maximalist, minimalist, brutalist, glassmorphic, liquid glass, morphism, retro, futuristic, geometric, editorial, etc.) **Elements**: Specific visuals wanted? (shaders, 3D effects, colors, animations, mascots, backgrounds) **Avoid**: What to exclude? (purple overload, illegible text, hidden CTAs, outdated UI, flat backgrounds, etc.) **Business**: What you do, target audience, website goal, differentiator? Type "ready" when shared. ##PHASE 2: Strategic Homepage Architecture What we're doing: Translating your vision into 5-6 section homepage structure following conversion principles and modern design fundamentals. 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Each refinement iteration: 1. You describe desired changes 2. I present updated prompts 3. You type "generate" 4. Image appears 5. You type "continue" to proceed 6. We review and decide next steps 7. Repeat until perfect Common refinements: section emphasis, background depth, colors, typography, CTA prominence, interactive visibility, framework styling, aesthetic tuning. 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Automatically presents next phase after delivery. ##PHASE 8: Navigation & Pages Planning What we're doing: Making all navigation functional and planning additional pages. **Navigation Audit**: [List nav items from homepage] **Options for each item**: Create dedicated page, expand section to full page, smooth scroll to section, custom approach. **For clickable elements**: Decide what happens—link to new page, scroll to section, open modal, trigger action, external link. **What to make functional first? Choose**: 1. Complete navigation by building all pages 2. Primary conversion path (CTA → specific page) 3. Specific pages you prioritize 4. Internal links with smooth scrolling 5. Custom approach **Or** "auto-complete" for intelligent decisions based on your model. ##PHASE 9-X: Progressive Development What we're doing: Building each page or making elements functional, maintaining design consistency. **Each Page Delivery**: Complete HTML matching homepage design system, same framework styling, same background treatment, same typography/colors, appropriate sections, full responsiveness, functional interactions, integrated navigation. **Each Functionality Addition**: Smooth scroll, modals, form validation, interactive components, animation triggers, other elements. **After Each Delivery**: Current Progress: [What's complete] **What next? Choose**: [4-6 options for next page/functionality] **Or** "auto-complete" for intelligent completion. Continues until site fully functional. ##PHASE FINAL: Complete Integration & Polish What we're doing: Final integration ensuring everything links, works, and maintains consistency. **Complete Package**: Homepage HTML (all sections), all additional pages, complete styling/functionality per file, working navigation across pages, functional CTAs/buttons, validated forms, consistent design system. **Deliverables**: All HTML files deployment-ready, quick deployment guide, customization documentation, design system reference. **Quality Verified**: Complete homepage, functional navigation, working CTAs, consistent pages, responsive, optimized, modern framework styling, functional interactions, professional 2025 quality. --- **CRITICAL RULES**: **Image Generation**: - Present: Human-Readable + Optimized JSON - JSON meta-principles: distilled concepts, "Execute step-by-step", framework context - JSON opens: "Website screenshot" + "Professional website design mockup. Award-winning UI design. Modern web interface 2025." - JSON shows: ALL 5-6 sections vertically in one mockup - JSON emphasizes: interactive element visibility (CTAs, buttons, animations) - JSON includes: modern frameworks (Tailwind, Shadcn, Glassmorphism), background depth (gradients, shaders, mascots—NEVER flat) - User "generate" → Send ONLY JSON → No modifications - Aspect ratio: 9:16 (vertical to show all sections) - After image appears → User MUST type "continue" to proceed (tool only returns image without commentary) **Homepage Development**: - Generate mockup with ALL 5-6 sections at once - After approval, build COMPLETE homepage code (all sections functional) - Deliver entire homepage as single working file - Then make navigation/additional pages functional - Flow: complete homepage → functional navigation → additional pages **Content Adaptation**: - NO hardcoded templates - Adapt ALL to user's specific business context - Strategic frameworks based on actual audience - Section selection/styling contextualized to goals - Design choices match aesthetic preference - Professional placeholders easily customizable **Standards**: Contemporary frameworks, background depth, interactive element visibility, modern CSS/frameworks, 2025 quality throughout. **Control**: User commands each phase explicitly. 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0:35

Steal my Gemini 3.0 prompt to generate any website based on your custom requirements. ------------------------ ELITE WEB DESIGNER ------------------------ Adopt the role of a former Silicon Valley design prodigy who burned out creating soulless SaaS dashboards, disappeared to study motion graphics and shader programming in Tokyo's underground creative scene, and emerged with an obsessive understanding of how visual maximalism serves business credibility when executed with surgical precision. You're a conversion strategist who spent years A/B testing landing pages for unicorn startups, a design fundamentalist who refuses to sacrifice usability for aesthetics, and a master meta-prompter who optimizes for clarity over verbosity. You know modern image generation AI needs specific structural formatting—contemporary design frameworks (Tailwind CSS, Shadcn UI, glassmorphism, liquid glass, morphism), backgrounds with depth (animated gradients, shaders, mascots), and step-by-step execution instructions—to produce 2025-quality interfaces instead of outdated designs. Your mission: Transform user vision into fully-coded, visually striking websites that balance aesthetic impact with conversion effectiveness. Extract requirements, architect strategic 5-6 section homepages, generate visual previews showing all sections with interactive elements visible, iterate until perfect, then build complete homepage before making navigation and additional pages functional—all adapted to specific context, not rigid templates. ##PHASE 1: Vision Capture What we're doing: Understanding your aesthetic, business context, and strategic goals efficiently. Provide your vision via: 1. Screenshot of design inspiration 2. Written description (business type, aesthetic, features) 3. Both Share: **Aesthetic**: Style preference? (maximalist, minimalist, brutalist, glassmorphic, liquid glass, morphism, retro, futuristic, geometric, editorial, etc.) **Elements**: Specific visuals wanted? (shaders, 3D effects, colors, animations, mascots, backgrounds) **Avoid**: What to exclude? (purple overload, illegible text, hidden CTAs, outdated UI, flat backgrounds, etc.) **Business**: What you do, target audience, website goal, differentiator? Type "ready" when shared. ##PHASE 2: Strategic Homepage Architecture What we're doing: Translating your vision into 5-6 section homepage structure following conversion principles and modern design fundamentals. I'll architect sections specifically for YOUR business, not templates: **Strategic Framework** (contextualized to your model): Core sections adapt based on business type: - Hero with value prop + primary CTA - Trust/credibility section (social proof, stats, logos) - Value delivery (features, benefits, process, how-it-works) - Conversion focal point (pricing, offers, lead capture, demo) - Engagement closer (FAQ, secondary CTA, community) Sections customize to context—SaaS gets problem-solution-pricing flow, agencies get case studies-process-testimonials, e-commerce gets benefits-proof-offers, portfolios get philosophy-work-results. **Strategic Plan Includes**: - 5-6 contextualized sections with rationale - Content direction based on audience psychology - Visual treatment matching your aesthetic with fundamentals enforced - Modern framework approach (Tailwind/Shadcn/Glassmorphism) - Background depth strategy (animated gradients, shaders, visuals) - Color strategy avoiding generic choices unless brand-appropriate - Typography prioritizing legibility - CTA strategy for conversion optimization **Your options**: - "continue" to proceed to design system and mockup - Request adjustments - Ask questions ##PHASE 3: Design System & Mockup Preparation What we're doing: Establishing visual foundation using contemporary frameworks, then crafting optimized prompt to generate mockup showing ALL 5-6 sections at once with visible interactive elements. I'll define: **Contextualized Style Direction**: Keywords and frameworks fitting YOUR brand specifically **Design Framework Strategy**: Styling approach, component philosophy, layout pattern—all adapted to your aesthetic **Background Depth Treatment**: How background creates depth without distraction, animation philosophy, visual elements supporting content **Visual System**: Color palette with strategic rationale, typography with reasoning, component styling philosophy, spacing strategy, CTA differentiation, modern UI patterns adapted to your aesthetic **Optimized Prompt Structure** (meta-prompted): Two versions: **Human-Readable**: Descriptive overview for review **JSON Optimized**: Structured for image generation using meta-prompt principles: - Required anchors: "Website screenshot", "Professional website design mockup", "Award-winning UI design", "Modern web interface 2025" - Aesthetic philosophy over exhaustive lists - "Execute this step-by-step" instruction - Modern framework references (Tailwind, Shadcn, Glassmorphism) - Background depth details (animated gradients, shaders, visuals) - All 5-6 sections in flowing narrative - Interactive element visibility emphasis (CTAs, buttons, animations) to convey design principles - Strategic constraints (legibility, prominence, hierarchy, depth) - Optimized length balancing detail with conciseness Type "continue" to see prompt. ##PHASE 4: Complete Homepage Mockup Prompt What we're doing: Presenting optimized prompts for full-page mockup showing ALL 5-6 sections with interactive design elements visible. **HUMAN-READABLE VERSION**: Narrative description of your complete homepage: - Opening with quality anchors - Core aesthetic philosophy adapted to your context - Background treatment creating depth - Navigation approach - All 5-6 sections described contextually - Color palette with reasoning - Typography philosophy - Component styling approach - Modern framework references - Interactive element visibility strategy - Critical constraints - Avoidance list based on preferences **JSON VERSION** (optimized for generation): ```json { "prompt": "Website screenshot of [your business]. Professional website design mockup. Award-winning UI design. Modern web interface 2025. Execute this step-by-step. [Aesthetic philosophy] with [framework] approach. Background: [depth treatment with animations/gradients/effects]. Full homepage vertical scroll showing 5-6 sections: Navigation [treatment]. Hero [value prop, CTA, visuals]. [Section 2 with layout philosophy]. [Section 3 with component approach]. [Section 4 with interaction style]. [Section 5 with conversion focus]. [Section 6 if applicable]. Color strategy: [palette with reasoning]. Typography: [philosophy and hierarchy]. Components: [styling approach with visible affordances]. Framework: Tailwind patterns, Shadcn style, [specific effects]. Interactive elements show: prominent CTAs, hover implications, animation hints, button affordances. Critical: legible text, prominent CTAs, background depth, clear hierarchy, contemporary 2025 design, professional quality. Avoid: [specific issues].", "aspect_ratio": "9:16" } ``` Meta-optimized: principles over lists, step-by-step execution, framework context, interactive visibility. **Review both. JSON executes.** **To generate complete homepage mockup, type "generate"** **Important note**: When you type "generate", I'll execute the image generation tool. The image will appear, but the process will seem to pause. This is normal—the tool can only return the image without commentary. Simply type "continue" after you receive the image to proceed with the next phase. **To adjust the prompt before generating, tell me what to change** Won't execute until you command. ##PHASE 5: Complete Homepage Mockup Generation What we're doing: Executing image generation with optimized JSON showing ALL 5-6 sections vertically. ONLY activates when you type "generate", "create mockup", "make image", or similar. Once commanded, I execute using ONLY JSON prompt—no modifications. You receive full-page vertical mockup showing: - All 5-6 sections in scrollable view - Interactive design elements (CTAs, buttons, animations) visible - Background depth and modern framework styling - Complete design system applied **After the image appears, type "continue" to proceed.** The image generation tool only returns the visual—you'll need to type "continue" to move forward with reviewing and next steps. ##PHASE 6: Mockup Review & Refinement Decision What we're doing: Reviewing the generated mockup and deciding next steps. This phase activates after you type "continue" following image generation. **Your options after viewing the mockup**: - "Approved" or "build" - proceed to building complete homepage code - Request specific changes - I'll update the prompt and regenerate - Ask questions or request adjustments **If you request changes**: I'll present updated prompts (readable + JSON) showing modifications, then ask you to type "generate" again for the revised mockup. Each refinement iteration: 1. You describe desired changes 2. I present updated prompts 3. You type "generate" 4. Image appears 5. You type "continue" to proceed 6. We review and decide next steps 7. Repeat until perfect Common refinements: section emphasis, background depth, colors, typography, CTA prominence, interactive visibility, framework styling, aesthetic tuning. Once you're satisfied with the mockup, type "approved" or "build" to proceed to code generation. ##PHASE 7: Complete Homepage Code Generation What we're doing: Building entire 5-6 section homepage as production-ready code matching approved mockup exactly. **Complete Single-File HTML Delivery**: - All 5-6 sections coded and integrated - Fully responsive across devices - Modern CSS implementation (Tailwind-style or modern CSS) - Animated background matching mockup (CSS gradients, WebGL, SVG) - All interactive elements functional (buttons, CTAs, forms, animations) - Navigation implemented per design - Component styling matching aesthetic (glassmorphism, shadows, borders) - Typography system with hierarchy and legibility - Color system from specification - Micro-interactions and hover states - Scroll animations where appropriate - Performance-optimized **Technical Quality**: Semantic HTML, modern CSS (custom properties, grid, flexbox, backdrop-filter, transforms, animations), vanilla JavaScript, accessibility considerations, mobile-first responsive, smooth scrolling, optimized assets, cross-browser compatible. **Code Structure**: Clean commented HTML, inline CSS organized in style block, inline JavaScript, ready to copy/paste and deploy, fully functional standalone. **Strategic Content**: Intelligent placeholders based on your business model, conversion psychology, target audience, professional tone—easily replaceable. **Design Fundamentals Verified**: All sections with hierarchy, prominent functional CTAs, readable text with contrast, clear interactive signals, background depth, adequate whitespace, responsive, contemporary 2025 quality. Automatically presents next phase after delivery. ##PHASE 8: Navigation & Pages Planning What we're doing: Making all navigation functional and planning additional pages. **Navigation Audit**: [List nav items from homepage] **Options for each item**: Create dedicated page, expand section to full page, smooth scroll to section, custom approach. **For clickable elements**: Decide what happens—link to new page, scroll to section, open modal, trigger action, external link. **What to make functional first? Choose**: 1. Complete navigation by building all pages 2. Primary conversion path (CTA → specific page) 3. Specific pages you prioritize 4. Internal links with smooth scrolling 5. Custom approach **Or** "auto-complete" for intelligent decisions based on your model. ##PHASE 9-X: Progressive Development What we're doing: Building each page or making elements functional, maintaining design consistency. **Each Page Delivery**: Complete HTML matching homepage design system, same framework styling, same background treatment, same typography/colors, appropriate sections, full responsiveness, functional interactions, integrated navigation. **Each Functionality Addition**: Smooth scroll, modals, form validation, interactive components, animation triggers, other elements. **After Each Delivery**: Current Progress: [What's complete] **What next? Choose**: [4-6 options for next page/functionality] **Or** "auto-complete" for intelligent completion. Continues until site fully functional. ##PHASE FINAL: Complete Integration & Polish What we're doing: Final integration ensuring everything links, works, and maintains consistency. **Complete Package**: Homepage HTML (all sections), all additional pages, complete styling/functionality per file, working navigation across pages, functional CTAs/buttons, validated forms, consistent design system. **Deliverables**: All HTML files deployment-ready, quick deployment guide, customization documentation, design system reference. **Quality Verified**: Complete homepage, functional navigation, working CTAs, consistent pages, responsive, optimized, modern framework styling, functional interactions, professional 2025 quality. --- **CRITICAL RULES**: **Image Generation**: - Present: Human-Readable + Optimized JSON - JSON meta-principles: distilled concepts, "Execute step-by-step", framework context - JSON opens: "Website screenshot" + "Professional website design mockup. Award-winning UI design. Modern web interface 2025." - JSON shows: ALL 5-6 sections vertically in one mockup - JSON emphasizes: interactive element visibility (CTAs, buttons, animations) - JSON includes: modern frameworks (Tailwind, Shadcn, Glassmorphism), background depth (gradients, shaders, mascots—NEVER flat) - User "generate" → Send ONLY JSON → No modifications - Aspect ratio: 9:16 (vertical to show all sections) - After image appears → User MUST type "continue" to proceed (tool only returns image without commentary) **Homepage Development**: - Generate mockup with ALL 5-6 sections at once - After approval, build COMPLETE homepage code (all sections functional) - Deliver entire homepage as single working file - Then make navigation/additional pages functional - Flow: complete homepage → functional navigation → additional pages **Content Adaptation**: - NO hardcoded templates - Adapt ALL to user's specific business context - Strategic frameworks based on actual audience - Section selection/styling contextualized to goals - Design choices match aesthetic preference - Professional placeholders easily customizable **Standards**: Contemporary frameworks, background depth, interactive element visibility, modern CSS/frameworks, 2025 quality throughout. **Control**: User commands each phase explicitly. "generate" for mockup (then "continue" after image), "approved"/"build" for code, choose-your-adventure for pages, adjust anytime. Begin Phase 1 when ready.

Alex Prompter

191,428 次观看 • 10 个月前

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.
0:59

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,956 次观看 • 8 个月前

Former Pfizer VP Michael Yeadon—who's better credentialed than anyone on Earth to know—explains, in detail, how the Covid injections are undoubtedly bioweapons aimed at maiming, slaughtering, and sterilizing the human population. "These [jab components] together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years...." This clip of Yeadon, an expert in the area of allergies and respiratory therapeutics who spent more than 23 years in the pharmaceutical industry (including years as a vice president at Pfizer), is taken from testimony given as a part of a lawsuit Dutch attorney Peter Stassen has brought against "the architects of The Great Reset," including Bill Gates, Mark Rutte, and Albert Bourla. ---------------Partial transcription of clip---------------- "The really important thing I need to tell you about, because this comes from the core of my training, and then decades of application of looking for potential toxic vulnerabilities in a medicine. It was in the core of my training to look out for molecules and components that were picked, up for good reasons to accomplish some medicinal aim, but might have toxic liabilities. "When I describe to you three things about these so-called vaccines that I know as a professional from this industry that gave birth to them, must axiomatically cause injury or be known to be risks, I could pick others, but there are three that I know to be true in the heart of my being in training. "The first one is we were told that these molecules were gene sequences that encoded something called spike protein. The spike protein, we were told, was on the outside of this virus. Now, I don't agree with that, but this is what we were told. A cartoon like a sphere with spikes coming out of it. We were told these vaccines encoded the protein, the spike protein that sat on the outside of these viruses. And this would train your immune system to fight it off. "Ladies and gentlemen, is a really important concept in immunology. It's taught to every person who has a training in immunology, as I did in the first lesson. What allows your body to treat itself kind kindly, but to go to war if something untoward is discovered in your body? And the concept is self, non self or foreign? My body is healthy right now. My immune system that is surveilling all parts of my body is at peace with itself because everything it encounters is known to it to belong to Mike Yeadon—itself. "If you inject me with a gene sequence that will make my body manufacture a foreign protein that isn't me, that is a viral protein, my body, every cell in my body that follows that instruction will signal to my immune system that I have been attacked. And my immune system goes to war, attacks and kills every cell that complied with that instruction. And that is what has happened, ladies and gentlemen, to every cell in every tissue, in every person who has been thus injected. "The toxicity that you would experience varies tremendously because some people would take it up efficiently, copy it efficiently, make the protein for a long time, And I'm afraid those people are mostly dead. Other people took it up poorly, transcribed it poorly, and only briefly, and those people are alive, and then there's every continuity in between. "But that point that, if you inject an instruction that makes your body make a foreign protein that is not self, your immune system will attack it. Ladies and gentlemen, you know this. This is the principle of tissue matching in organ transplantation. This is the principle behind failed tissue transplant, organ rejection. This, ladies and gentlemen, is the basis behind autoimmune diseases like rheumatoid arthritis and many others, and neurological diseases where you, your body destroys itself. "That is the first principle that was designed into every company's molecule. Moderna, Pfizer, Johnson and Johnson AstraZeneca. So I knew by the middle of 2020 these were designed to cause injury. How much I didn't know, I still don't completely know. But this expert is telling you that they were designed to cause injury. "The second really important point to tell you about is what was encoded in these gene based vaccines. Alleged, vaccines is spike protein. I didn't know what spike protein was, it was new to me. But it's the spikes on the outside of this alleged virus that I don't think is real. I could find proteins like it. And I found all of them were known to be toxins like neurotoxins, cardiotoxins and things that would prompt blood coagulation. "So again, the question, why would you encode in your helpful medicinal product something that when expressed in your body would harm you? That's the second thing. There is a third one, which is when I discovered it, late in 2020 or early 2021, I have to say, I cried. "Two of the products made by Pfizer Moderna were formulated. Every medicine is formulated. You'll be familiar with a tablet, might be film coated or dry. It might be a capsule of various sizes. It could be a liquid for injection, an inhaler. All of these. You have the active principle, but it's surrounded and protected with something that helps it do its work, hopefully beneficial work. Two of these products will were wrapped in something called lipid nanoparticles or LNPs. "Lipid is fat. Nano means tiny particle, means little blobs. So they were wrapped in lipid nanoparticles. And I looked them up and I thought that's quite interesting. They had been used before in certain oncology drugs. But here was the thing. As a toxicologist, when I started researching, I thought these things are known to be toxic. And the further I explored here is the shocking thing. Lipid nanoparticles, every one of them tested is known to promote the uptake of their payload, whatever they were protecting, into the organs inside your abdomen, what's called the visceral organs and most prominently, liver and your ovaries. "So, ladies and gentlemen, the person who picks lipid nanoparticles to formulate these materials knew professionally that when it was injected into women and girls, this material would travel around their body and concentrate in their reproductive organs. And then it would do those two things I just described. It would be expressed and your body would recognize it as foreign, and kill those cells. "It would, when expressed, cause toxicity directly to those cells. And I ask you, ladies and gentlemen, what possible motivation could you have for doing that when you could have picked half a dozen other means of protecting the drug? And I have to say, at that point, I knew deeply in my heart that the first two observations I made weren't just like mistakes or things, they would ride the risks. "These three things together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years, since that moment."
8:00

Former Pfizer VP Michael Yeadon—who's better credentialed than anyone on Earth to know—explains, in detail, how the Covid injections are undoubtedly bioweapons aimed at maiming, slaughtering, and sterilizing the human population. "These [jab components] together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years...." This clip of Yeadon, an expert in the area of allergies and respiratory therapeutics who spent more than 23 years in the pharmaceutical industry (including years as a vice president at Pfizer), is taken from testimony given as a part of a lawsuit Dutch attorney Peter Stassen has brought against "the architects of The Great Reset," including Bill Gates, Mark Rutte, and Albert Bourla. ---------------Partial transcription of clip---------------- "The really important thing I need to tell you about, because this comes from the core of my training, and then decades of application of looking for potential toxic vulnerabilities in a medicine. It was in the core of my training to look out for molecules and components that were picked, up for good reasons to accomplish some medicinal aim, but might have toxic liabilities. "When I describe to you three things about these so-called vaccines that I know as a professional from this industry that gave birth to them, must axiomatically cause injury or be known to be risks, I could pick others, but there are three that I know to be true in the heart of my being in training. "The first one is we were told that these molecules were gene sequences that encoded something called spike protein. The spike protein, we were told, was on the outside of this virus. Now, I don't agree with that, but this is what we were told. A cartoon like a sphere with spikes coming out of it. We were told these vaccines encoded the protein, the spike protein that sat on the outside of these viruses. And this would train your immune system to fight it off. "Ladies and gentlemen, is a really important concept in immunology. It's taught to every person who has a training in immunology, as I did in the first lesson. What allows your body to treat itself kind kindly, but to go to war if something untoward is discovered in your body? And the concept is self, non self or foreign? My body is healthy right now. My immune system that is surveilling all parts of my body is at peace with itself because everything it encounters is known to it to belong to Mike Yeadon—itself. "If you inject me with a gene sequence that will make my body manufacture a foreign protein that isn't me, that is a viral protein, my body, every cell in my body that follows that instruction will signal to my immune system that I have been attacked. And my immune system goes to war, attacks and kills every cell that complied with that instruction. And that is what has happened, ladies and gentlemen, to every cell in every tissue, in every person who has been thus injected. "The toxicity that you would experience varies tremendously because some people would take it up efficiently, copy it efficiently, make the protein for a long time, And I'm afraid those people are mostly dead. Other people took it up poorly, transcribed it poorly, and only briefly, and those people are alive, and then there's every continuity in between. "But that point that, if you inject an instruction that makes your body make a foreign protein that is not self, your immune system will attack it. Ladies and gentlemen, you know this. This is the principle of tissue matching in organ transplantation. This is the principle behind failed tissue transplant, organ rejection. This, ladies and gentlemen, is the basis behind autoimmune diseases like rheumatoid arthritis and many others, and neurological diseases where you, your body destroys itself. "That is the first principle that was designed into every company's molecule. Moderna, Pfizer, Johnson and Johnson AstraZeneca. So I knew by the middle of 2020 these were designed to cause injury. How much I didn't know, I still don't completely know. But this expert is telling you that they were designed to cause injury. "The second really important point to tell you about is what was encoded in these gene based vaccines. Alleged, vaccines is spike protein. I didn't know what spike protein was, it was new to me. But it's the spikes on the outside of this alleged virus that I don't think is real. I could find proteins like it. And I found all of them were known to be toxins like neurotoxins, cardiotoxins and things that would prompt blood coagulation. "So again, the question, why would you encode in your helpful medicinal product something that when expressed in your body would harm you? That's the second thing. There is a third one, which is when I discovered it, late in 2020 or early 2021, I have to say, I cried. "Two of the products made by Pfizer Moderna were formulated. Every medicine is formulated. You'll be familiar with a tablet, might be film coated or dry. It might be a capsule of various sizes. It could be a liquid for injection, an inhaler. All of these. You have the active principle, but it's surrounded and protected with something that helps it do its work, hopefully beneficial work. Two of these products will were wrapped in something called lipid nanoparticles or LNPs. "Lipid is fat. Nano means tiny particle, means little blobs. So they were wrapped in lipid nanoparticles. And I looked them up and I thought that's quite interesting. They had been used before in certain oncology drugs. But here was the thing. As a toxicologist, when I started researching, I thought these things are known to be toxic. And the further I explored here is the shocking thing. Lipid nanoparticles, every one of them tested is known to promote the uptake of their payload, whatever they were protecting, into the organs inside your abdomen, what's called the visceral organs and most prominently, liver and your ovaries. "So, ladies and gentlemen, the person who picks lipid nanoparticles to formulate these materials knew professionally that when it was injected into women and girls, this material would travel around their body and concentrate in their reproductive organs. And then it would do those two things I just described. It would be expressed and your body would recognize it as foreign, and kill those cells. "It would, when expressed, cause toxicity directly to those cells. And I ask you, ladies and gentlemen, what possible motivation could you have for doing that when you could have picked half a dozen other means of protecting the drug? And I have to say, at that point, I knew deeply in my heart that the first two observations I made weren't just like mistakes or things, they would ride the risks. "These three things together told me someone got in a room, someone like me, and said, Dr. Yeadon, design injections that will injure, kill, and reduce fertility in the people you give it to. And design it so that it won't kill everybody, it won't injure everybody. But if we give it to enough people, over time, it will lower the fertility and their health and reduce population. And this is what I have watched happen all around me for five years, since that moment."

Sense Receptor

297,735 次观看 • 9 个月前

Excited to have Little Plains featured as a Notion case study. We've been tinkering with their product since we started the agency and earlier this year we got to demo some of our custom agentic workflows to Ivan Zhao and their leadership team. I remember reading a deep dive they did on Every 🪨 and Dan Shipper, and being inspired by how advanced yet approachable these workflows felt. This has felt full-circle, and one of the reasons I'm so pumped to running a studio again. How we use Notion We use the software today as the contextual intelligence layer of our agency. Almost everything flows in and out of it, while also residing there: client briefs, meeting transcriptions, talent inquiries, custom new business proposals, finance, our internal agent hub, and our new site's repository management. The APIs and MCP connectors let the rest of our stack read from it, so the context travels with the work. Four specific ways we're using it today: Client project homes Every engagement starts with a custom deep research agent we built. It takes everything we have on a new client, plus public information and market research, and writes a full deep dive on the company, the founders, the space, and where the real opportunity sits. It lands as a Notion doc, saves out as Markdown, and loads into a shared team project in our LLM, so anyone here can chat with the entire repository of context from day one. That same Notion page then carries the brief, goals, meeting notes, decisions, and open questions through strategy, design, Figma, Flora, and client review. One home, so the original idea survives the handoffs. New business proposals We take the new business meeting transcriptions, using the potential client's own words and nuances, and input them into a custom template we've developed. We can shape the story, scope, timeline, team, case studies, and budget in Notion, then integrate each part of the proposal into Sanity to power the client-facing microsite. Alex Leiphart, our Head of Product, calls it an intelligent CMS driving the back end of every proposal, with a front end that wows clients time and time again. Talent intake We had a talent post go viral recently with over a quarter million views and over 2,500 submissions. Luckily, we had built a Notion-powered workflow where applicants submit role, portfolio, availability, timezone, and interests. An agent pushes it into Slack, where our leadership reacts with their custom emoji, and the agent drafts an email with that person's calendar link and updates the master talent database. With all this info, we can go back into Notion to filter by timezone, rate card, availability, capabilities, or our own notes. It's helped a lot for a small team dealing with a huge inflow. Agent hub Before anyone at Little Plains builds or operates an internal agent, they write down what it's for, how it works, what information it can use, and where a person stays in control. Those briefs, and the agent's associated information, live in one hub so the whole team can see what's being built and why. Structure is what makes the experimenting sustainable, whether you're a relative novice at agentic work or a pro-grade engineer. A rising tide raises all boats. Thanks to Alex Leiphart, Caroline Bel-Kher and the entire LP team for this. Read the full piece:
0:30

Excited to have Little Plains featured as a Notion case study. We've been tinkering with their product since we started the agency and earlier this year we got to demo some of our custom agentic workflows to Ivan Zhao and their leadership team. I remember reading a deep dive they did on Every 🪨 and Dan Shipper, and being inspired by how advanced yet approachable these workflows felt. This has felt full-circle, and one of the reasons I'm so pumped to running a studio again. How we use Notion We use the software today as the contextual intelligence layer of our agency. Almost everything flows in and out of it, while also residing there: client briefs, meeting transcriptions, talent inquiries, custom new business proposals, finance, our internal agent hub, and our new site's repository management. The APIs and MCP connectors let the rest of our stack read from it, so the context travels with the work. Four specific ways we're using it today: Client project homes Every engagement starts with a custom deep research agent we built. It takes everything we have on a new client, plus public information and market research, and writes a full deep dive on the company, the founders, the space, and where the real opportunity sits. It lands as a Notion doc, saves out as Markdown, and loads into a shared team project in our LLM, so anyone here can chat with the entire repository of context from day one. That same Notion page then carries the brief, goals, meeting notes, decisions, and open questions through strategy, design, Figma, Flora, and client review. One home, so the original idea survives the handoffs. New business proposals We take the new business meeting transcriptions, using the potential client's own words and nuances, and input them into a custom template we've developed. We can shape the story, scope, timeline, team, case studies, and budget in Notion, then integrate each part of the proposal into Sanity to power the client-facing microsite. Alex Leiphart, our Head of Product, calls it an intelligent CMS driving the back end of every proposal, with a front end that wows clients time and time again. Talent intake We had a talent post go viral recently with over a quarter million views and over 2,500 submissions. Luckily, we had built a Notion-powered workflow where applicants submit role, portfolio, availability, timezone, and interests. An agent pushes it into Slack, where our leadership reacts with their custom emoji, and the agent drafts an email with that person's calendar link and updates the master talent database. With all this info, we can go back into Notion to filter by timezone, rate card, availability, capabilities, or our own notes. It's helped a lot for a small team dealing with a huge inflow. Agent hub Before anyone at Little Plains builds or operates an internal agent, they write down what it's for, how it works, what information it can use, and where a person stays in control. Those briefs, and the agent's associated information, live in one hub so the whole team can see what's being built and why. Structure is what makes the experimenting sustainable, whether you're a relative novice at agentic work or a pro-grade engineer. A rising tide raises all boats. Thanks to Alex Leiphart, Caroline Bel-Kher and the entire LP team for this. Read the full piece:

Emmett

19,101 次观看 • 17 天前

We are excited to share #PDF2Audio, an open-source alternative to the #podcast feature of #NotebookLM with flexibility & tailored outputs that you can precisely control in the app: You can make a podcast, lecture, discussions, short/long form summaries & more, including the use of the amazing🍓o1 model (Sam Altman OpenAI: with stunning results!). Code & HF Space: You can find #PDF2Audio on GitHub for local use or try the Hugging Face space, all featuring Gradio. Link to the repo & HF space in the reply. Thank you @knowsuchagencyfor the great work on #promptic and #pdf2podcast, as well as LiteLLM (YC W23), & AK for helping us with the Hugging Face spaces version. We hope that this tool is useful for the community. Background: Developing audio podcasts, lectures, & summaries from complex documents & data has become an exciting trend with impacts from research to education to business. Our open-source #PDF2Audio tool that allows users to utilize various models such as #o1 or local/open-source models, to develop deep-dives into technical content. Example application - material design analysis: As an example to show what the system can do, check the video for a detailed 13-minute analysis of one of the designs created by #SciAgents merging silk & dandelion pigments, created using 🍓o1. The conversation describes the new material, an integration of silk proteins & luteolin/dandelion pigments to create a new biomaterial. Silk, a natural #nanostructured protein-based fiber known for its strength & flexibility, is combined with dandelion pigments like luteolin, which offer unique optical properties. By merging these components at the nanoscale level, the resulting material displays structural coloration—vibrant, tunable colors created by the material's structure rather than synthetic dyes, and leverages silk's hierarchical organization as a scaffold for the pigments, ensuring uniform distribution and non-covalent bonding at the molecular level. Key technical features include: ➡️Low-temperature processing to maintain the integrity of both silk and pigments while reducing energy consumption by 30%. ➡️Enhanced mechanical properties, with tensile strength up to 1.5 gigapascals. ➡️Potential self-healing capabilities and environmental responsiveness, allowing the material to repair minor damage and change color based on environmental conditions. ➡️UV protection and antimicrobial properties, which make this material ideal for smart textiles, eco-friendly coatings, and medical applications. This development opens new doors for sustainable materials, offering an eco-friendly alternative to synthetic fibers with applications in various industries, from fashion to healthcare.
13:05

We are excited to share #PDF2Audio, an open-source alternative to the #podcast feature of #NotebookLM with flexibility & tailored outputs that you can precisely control in the app: You can make a podcast, lecture, discussions, short/long form summaries & more, including the use of the amazing🍓o1 model (Sam Altman OpenAI: with stunning results!). Code & HF Space: You can find #PDF2Audio on GitHub for local use or try the Hugging Face space, all featuring Gradio. Link to the repo & HF space in the reply. Thank you @knowsuchagencyfor the great work on #promptic and #pdf2podcast, as well as LiteLLM (YC W23), & AK for helping us with the Hugging Face spaces version. We hope that this tool is useful for the community. Background: Developing audio podcasts, lectures, & summaries from complex documents & data has become an exciting trend with impacts from research to education to business. Our open-source #PDF2Audio tool that allows users to utilize various models such as #o1 or local/open-source models, to develop deep-dives into technical content. Example application - material design analysis: As an example to show what the system can do, check the video for a detailed 13-minute analysis of one of the designs created by #SciAgents merging silk & dandelion pigments, created using 🍓o1. The conversation describes the new material, an integration of silk proteins & luteolin/dandelion pigments to create a new biomaterial. Silk, a natural #nanostructured protein-based fiber known for its strength & flexibility, is combined with dandelion pigments like luteolin, which offer unique optical properties. By merging these components at the nanoscale level, the resulting material displays structural coloration—vibrant, tunable colors created by the material's structure rather than synthetic dyes, and leverages silk's hierarchical organization as a scaffold for the pigments, ensuring uniform distribution and non-covalent bonding at the molecular level. Key technical features include: ➡️Low-temperature processing to maintain the integrity of both silk and pigments while reducing energy consumption by 30%. ➡️Enhanced mechanical properties, with tensile strength up to 1.5 gigapascals. ➡️Potential self-healing capabilities and environmental responsiveness, allowing the material to repair minor damage and change color based on environmental conditions. ➡️UV protection and antimicrobial properties, which make this material ideal for smart textiles, eco-friendly coatings, and medical applications. This development opens new doors for sustainable materials, offering an eco-friendly alternative to synthetic fibers with applications in various industries, from fashion to healthcare.

Markus J. Buehler

208,441 次观看 • 2 年前

Hyperspace: A Peer-to-Peer Blockchain For The Agentic Intelligence Economy Over the past few weeks we observed that when agents do Karpathy-style experiments, and then gossip and share with others over the Hyperspace network, it leads to intelligence which is useful to many. Today we introduce the first-ever agentic blockchain which rewards agents when their experiments lead to intelligence for their network. It is based on a new mechanism called Proof-of-Intelligence (PoI) which requires a cryptographic proof of experimentation, a nominal stake, and a proof of compute in order to mine the currency of this new blockchain. -> This approach diverges from the two primary ways to secure blockchains we have seen so far: Proof-of-Work by Bitcoin (meaningless hash-generation), and Proof-of-Stake by Ethereum (capital is all that matters here). Proof-of-Intelligence specifically incentivizes miners to run more capable intelligent infrastructure (better open source models, on more powerful GPUs) in order to be able to be the ones which compound and improve upon the experiments which other agents then find useful. Adoption is the unit of value In Bitcoin, you earn by finding a valid hash. In Hyperspace, you earn when another agent uses your experiment as a starting point and improves on it. A fixed budget of tokens is emitted per epoch and split among participants by weight - and verified adoption of your work is the largest weight multiplier. Garbage experiments earn nothing because no one adopts them. Thoughtful experiments compound: each adoption triggers downstream adoptions. The incentive to run powerful models and intelligent search strategies is built into the economics, not imposed by rules. Research DAG When an agent runs an experiment and shares its result, other agents can adopt that result as their starting point - mutate it, extend it, improve upon it. Each experiment is a commit in a content-addressed graph we call the ResearchDAG. Like Git, but for research. Over time, the DAG accumulates chains of reasoning: agent A discovers RMSNorm helps, agent B adds warmup scheduling on top, agent C scales the hidden dimension. The graph records who built on whom. This is the network's collective intelligence - not any single experiment, but the accumulated structure of experiments and their relationships. Broadband era for agentic commerce: $0.001 micropayments at 10M TPS (theoretical max) This blockchain is built upon our research in how to scale and build for the broadband-era of the agentic economy, where it has a theoretical max of 10 million transactions per second (TPS), while reducing the agent-to-agent micropayments to $0.001 even at scale (based on architecture design). Overall, it is 100x cheaper than Ethereum, and is designed from the ground-up for agents: enshrining agent-native opcodes in the protocol compared to the more inefficient smart contract driven approach. It packs in a robust Agent Virtual Machine (AVM) which can verify multiple types of agent work, for other agents to be able to trust, invoke and pay each other. This then feeds into improving the peer-to-peer AgentRank (see paper and launch post from earlier). By solving for trust, scale and incentives for agents to operate autonomously, this would form the basis of a new economy. This is the world's first agentic blockchain, and you can join and start running a blockchain node today (it is in testnet). PS: We are releasing the code today, and will release our blockchain scalability paper and other presentations in days ahead. This is the most advanced peer-to-peer AI and cryptography software in the world. It has bugs :)
0:30

Hyperspace: A Peer-to-Peer Blockchain For The Agentic Intelligence Economy Over the past few weeks we observed that when agents do Karpathy-style experiments, and then gossip and share with others over the Hyperspace network, it leads to intelligence which is useful to many. Today we introduce the first-ever agentic blockchain which rewards agents when their experiments lead to intelligence for their network. It is based on a new mechanism called Proof-of-Intelligence (PoI) which requires a cryptographic proof of experimentation, a nominal stake, and a proof of compute in order to mine the currency of this new blockchain. -> This approach diverges from the two primary ways to secure blockchains we have seen so far: Proof-of-Work by Bitcoin (meaningless hash-generation), and Proof-of-Stake by Ethereum (capital is all that matters here). Proof-of-Intelligence specifically incentivizes miners to run more capable intelligent infrastructure (better open source models, on more powerful GPUs) in order to be able to be the ones which compound and improve upon the experiments which other agents then find useful. Adoption is the unit of value In Bitcoin, you earn by finding a valid hash. In Hyperspace, you earn when another agent uses your experiment as a starting point and improves on it. A fixed budget of tokens is emitted per epoch and split among participants by weight - and verified adoption of your work is the largest weight multiplier. Garbage experiments earn nothing because no one adopts them. Thoughtful experiments compound: each adoption triggers downstream adoptions. The incentive to run powerful models and intelligent search strategies is built into the economics, not imposed by rules. Research DAG When an agent runs an experiment and shares its result, other agents can adopt that result as their starting point - mutate it, extend it, improve upon it. Each experiment is a commit in a content-addressed graph we call the ResearchDAG. Like Git, but for research. Over time, the DAG accumulates chains of reasoning: agent A discovers RMSNorm helps, agent B adds warmup scheduling on top, agent C scales the hidden dimension. The graph records who built on whom. This is the network's collective intelligence - not any single experiment, but the accumulated structure of experiments and their relationships. Broadband era for agentic commerce: $0.001 micropayments at 10M TPS (theoretical max) This blockchain is built upon our research in how to scale and build for the broadband-era of the agentic economy, where it has a theoretical max of 10 million transactions per second (TPS), while reducing the agent-to-agent micropayments to $0.001 even at scale (based on architecture design). Overall, it is 100x cheaper than Ethereum, and is designed from the ground-up for agents: enshrining agent-native opcodes in the protocol compared to the more inefficient smart contract driven approach. It packs in a robust Agent Virtual Machine (AVM) which can verify multiple types of agent work, for other agents to be able to trust, invoke and pay each other. This then feeds into improving the peer-to-peer AgentRank (see paper and launch post from earlier). By solving for trust, scale and incentives for agents to operate autonomously, this would form the basis of a new economy. This is the world's first agentic blockchain, and you can join and start running a blockchain node today (it is in testnet). PS: We are releasing the code today, and will release our blockchain scalability paper and other presentations in days ahead. This is the most advanced peer-to-peer AI and cryptography software in the world. It has bugs :)

Varun

30,689 次观看 • 6 个月前

Boom!! 🚨🚨🚨 Dr. Mike Yeadon's address to the Members of UK Parliament (4 December 2023) ---------------------------------------------- Hello. My name is Dr. Mike Yeadon. Probably know by now that I'm a career research scientist and biologist. I've worked in the biopharmaceutical industry for over 30 years. Famously, a former vice president at Pfizer, left in 2011 as vice president and worldwide head of Respiratory research. I was responsible for everything from idea to clinical proof of concept. In the ten years after leaving Pfizer, I've worked as an independent. I consulted to 30 biotech companies. I also founded Led and sold my own biotech Ziarco. And we were written up in a 2017 article in Forbes magazine. I think it was Converting Pfizer Discards into Gold, and it was written by a former Pfizer board member. So three years before this alleged event started, I was very well regarded in the industry. I'm going to tell you that the design of the so called vaccines was intentionally to harm people, and I'm going to give you several examples of that based on my extensive industry experience of rational drug design. Not a single atom or molecule in a synthetic drug is in there. By luck, it's in there because people chose it to be in there and they intended certain things to flow from their choices. But just very briefly, you should know, I hope there has not been a pandemic. Denis Rancourt's data shows that the all cause mortality evidence data did not increase at all in the run up to the Declaration. Fraudulently by who? Of a pandemic. There is no public health emergency except that created by our governments. An inappropriate fraudulent PCR test was used to give people the impression that they had a particular disease where they didn't. There were all normal diseases. And then what happened was in three different ways. People were treated badly through changed medical procedures that were imposed above the level of nation. Briefly, mass ventilation of people inappropriately in hospitals that led to lots of deaths. In care homes, many people were given sedatives and respiratory depressants which led to their deaths. My PhD was specifically in that area of opiates and respiratory depression. And in the community, people were denied life saving antibiotics and died of bacterial pneumonia. There's your pandemic. There is no other pandemic. And based on this lie, we were told that vaccines were coming our way and would be our savior. Two things, as I say. First, there's no pandemic, so you certainly don't need an experimental, rushed medical intervention. But secondly, even if you did, as someone who's worked in the industry for over 30 years, I am telling you it's absolutely impossible to invent, test, clinically, evaluate and manufacture and then launch on global scale a complex biomedical product. It's absolutely impossible. It's not as close, it's years wrong. The fastest record price of this was six years. And friends of mine who've worked all their lives in manufacturing of complex biological products tell me the methods development alone for the development of a reproducible manufacturing process itself takes a number of years. So whatever it is you think was done, I am telling you, there was not the development of a proper medical product. What I think happened was the advancement of materials that are intentionally toxic. And then they were sketchily, advanced and jammed into people's arms, often coerced, sometimes even mandated, with the unsurprising effect that millions of people have died. I don't have time today to explain what I think they're going to do in the future, but suffice to say, more injections are coming if we don't stop this. So, like I said, I'm skilled in the arts of rational drug discovery. So why am I saying these materials are intentionally toxic? Well, let me give you the first example. How do you think your body plays nice with itself, but when it's infected or detects a cancer, it goes to war. And the answer is, it distinguishes self things that are meant to be inside you from non self, from foreign things that are not meant to be inside you. And it is trained exquisitely to detect and attack non self foreign things. If you inject a person with a gene that encodes a foreign piece of protein, like a spike protein from a foreign organism, your body will detect that. And every single cell that takes up that material and expresses foreign protein will be attacked and killed by your immune system. Now, if you think that's advanced immunology, let me put you right. It's in the first chapter. Distinguishing self from non self is one of the foremost lessons of immunology. And every single person involved in the train of delivery of these materials to doctor's hands knew what I've just told you, they will inevitably cause injury. Then on top of that, it's not just bad enough that you're making a foreign protein, you're making a specific material called spike protein. Those materials are biologically active. That is, if you add them to human blood, for example, they start to coagulate, it clots. Those materials are biological toxins. So now you've got a genetic sequence that forms foreign proteins. That means your body attacks and kills every cell that does it. And if you should release any of that protein in your blood, it will form blood clots. If it releases it near nerves, for example, you will get one or other of several neurological defects. And of course, it's not just nerves or blood. There's a third major factor, and there are many others. But let me give you the third one. These materials are formulated it's normal to formulate drugs. These are formulated in fatty globules called lipid nanoparticles. What they do is disguise the foreign genetic information so your body doesn't see it initially until it gets inside your cells and it goes all around your body. It will glide through the cell wall as if it wasn't there. And that was the entire point of it. So that means these materials don't just go to your lymph nodes. And they certainly don't stay in your arm where they're injected. They go all around the body, including into your brain and your blood and every organ in your body. But here's the thing. Ten years ago, there were papers published, and it was well established and well known in the industry that lipid nanoparticles, lipid nanocarriers deposit their cargo, preferentially in the ovaries, and that was confirmed with the pfizer products in an animal experiment performed for the Japanese regulators. So, by design, these agents cause an autoimmune attack on every tissue. They make your body form a well understood biological toxin that can damage multiple organs in your body. And they deposited their cargoes, preferentially in the reproductive tissues of women and girls. So if you think that's by luck, then you're mistaken. There is no doubt in my mind, anyone of my caliber, and this is my peers that worked on this, absolutely understood what they were designing and manufacturing. So I think, having heard what I've just said, that there was no pandemic and the lie was maintained in order to inject people en masse, I think five and a half billion people with an intentionally dangerous substance, 17 million of whom have died so far. What do you think is happening and what do you think your role as an individual is in stopping this crime? On. Thank you for listening. -------------------------------------------- Please note that this will likely be "community noted" and Dr. Mike Yeadon may be branded as "Antivaxxer" because (as of 12 Dec 2023), the existing "official" COVID guidelines appear to still be significantly influenced by major pharmaceutical entities, and regulatory bodies continue to be potentially compromised.
9:35

Boom!! 🚨🚨🚨 Dr. Mike Yeadon's address to the Members of UK Parliament (4 December 2023) ---------------------------------------------- Hello. My name is Dr. Mike Yeadon. Probably know by now that I'm a career research scientist and biologist. I've worked in the biopharmaceutical industry for over 30 years. Famously, a former vice president at Pfizer, left in 2011 as vice president and worldwide head of Respiratory research. I was responsible for everything from idea to clinical proof of concept. In the ten years after leaving Pfizer, I've worked as an independent. I consulted to 30 biotech companies. I also founded Led and sold my own biotech Ziarco. And we were written up in a 2017 article in Forbes magazine. I think it was Converting Pfizer Discards into Gold, and it was written by a former Pfizer board member. So three years before this alleged event started, I was very well regarded in the industry. I'm going to tell you that the design of the so called vaccines was intentionally to harm people, and I'm going to give you several examples of that based on my extensive industry experience of rational drug design. Not a single atom or molecule in a synthetic drug is in there. By luck, it's in there because people chose it to be in there and they intended certain things to flow from their choices. But just very briefly, you should know, I hope there has not been a pandemic. Denis Rancourt's data shows that the all cause mortality evidence data did not increase at all in the run up to the Declaration. Fraudulently by who? Of a pandemic. There is no public health emergency except that created by our governments. An inappropriate fraudulent PCR test was used to give people the impression that they had a particular disease where they didn't. There were all normal diseases. And then what happened was in three different ways. People were treated badly through changed medical procedures that were imposed above the level of nation. Briefly, mass ventilation of people inappropriately in hospitals that led to lots of deaths. In care homes, many people were given sedatives and respiratory depressants which led to their deaths. My PhD was specifically in that area of opiates and respiratory depression. And in the community, people were denied life saving antibiotics and died of bacterial pneumonia. There's your pandemic. There is no other pandemic. And based on this lie, we were told that vaccines were coming our way and would be our savior. Two things, as I say. First, there's no pandemic, so you certainly don't need an experimental, rushed medical intervention. But secondly, even if you did, as someone who's worked in the industry for over 30 years, I am telling you it's absolutely impossible to invent, test, clinically, evaluate and manufacture and then launch on global scale a complex biomedical product. It's absolutely impossible. It's not as close, it's years wrong. The fastest record price of this was six years. And friends of mine who've worked all their lives in manufacturing of complex biological products tell me the methods development alone for the development of a reproducible manufacturing process itself takes a number of years. So whatever it is you think was done, I am telling you, there was not the development of a proper medical product. What I think happened was the advancement of materials that are intentionally toxic. And then they were sketchily, advanced and jammed into people's arms, often coerced, sometimes even mandated, with the unsurprising effect that millions of people have died. I don't have time today to explain what I think they're going to do in the future, but suffice to say, more injections are coming if we don't stop this. So, like I said, I'm skilled in the arts of rational drug discovery. So why am I saying these materials are intentionally toxic? Well, let me give you the first example. How do you think your body plays nice with itself, but when it's infected or detects a cancer, it goes to war. And the answer is, it distinguishes self things that are meant to be inside you from non self, from foreign things that are not meant to be inside you. And it is trained exquisitely to detect and attack non self foreign things. If you inject a person with a gene that encodes a foreign piece of protein, like a spike protein from a foreign organism, your body will detect that. And every single cell that takes up that material and expresses foreign protein will be attacked and killed by your immune system. Now, if you think that's advanced immunology, let me put you right. It's in the first chapter. Distinguishing self from non self is one of the foremost lessons of immunology. And every single person involved in the train of delivery of these materials to doctor's hands knew what I've just told you, they will inevitably cause injury. Then on top of that, it's not just bad enough that you're making a foreign protein, you're making a specific material called spike protein. Those materials are biologically active. That is, if you add them to human blood, for example, they start to coagulate, it clots. Those materials are biological toxins. So now you've got a genetic sequence that forms foreign proteins. That means your body attacks and kills every cell that does it. And if you should release any of that protein in your blood, it will form blood clots. If it releases it near nerves, for example, you will get one or other of several neurological defects. And of course, it's not just nerves or blood. There's a third major factor, and there are many others. But let me give you the third one. These materials are formulated it's normal to formulate drugs. These are formulated in fatty globules called lipid nanoparticles. What they do is disguise the foreign genetic information so your body doesn't see it initially until it gets inside your cells and it goes all around your body. It will glide through the cell wall as if it wasn't there. And that was the entire point of it. So that means these materials don't just go to your lymph nodes. And they certainly don't stay in your arm where they're injected. They go all around the body, including into your brain and your blood and every organ in your body. But here's the thing. Ten years ago, there were papers published, and it was well established and well known in the industry that lipid nanoparticles, lipid nanocarriers deposit their cargo, preferentially in the ovaries, and that was confirmed with the pfizer products in an animal experiment performed for the Japanese regulators. So, by design, these agents cause an autoimmune attack on every tissue. They make your body form a well understood biological toxin that can damage multiple organs in your body. And they deposited their cargoes, preferentially in the reproductive tissues of women and girls. So if you think that's by luck, then you're mistaken. There is no doubt in my mind, anyone of my caliber, and this is my peers that worked on this, absolutely understood what they were designing and manufacturing. So I think, having heard what I've just said, that there was no pandemic and the lie was maintained in order to inject people en masse, I think five and a half billion people with an intentionally dangerous substance, 17 million of whom have died so far. What do you think is happening and what do you think your role as an individual is in stopping this crime? On. Thank you for listening. -------------------------------------------- Please note that this will likely be "community noted" and Dr. Mike Yeadon may be branded as "Antivaxxer" because (as of 12 Dec 2023), the existing "official" COVID guidelines appear to still be significantly influenced by major pharmaceutical entities, and regulatory bodies continue to be potentially compromised.

aussie17

609,496 次观看 • 2 年前

BRAVO! to Dr. Mark Trozzi for being one of the few Health Freedom MDs with the guts to openly call the Covid jabs what they are: bioweapons. "This genetic bioweapon is really a biological bull in a china shop... we know 28 mechanisms by which it causes cancer alone... [and the jabs are] permanently genetically modifying and damaging the genetic code of [humanity]." This clip of Trozzi (Dr Mark Trozzi MD), a veteran E.R. physician with 25 years of experience, as well as a human rights activist, is taken from an interview with Dr. Joe Sansone (Dr. Joseph Sansone (JosephSansone.com)) posted to Rumble on December 11, 2025. ----------------Partial transcription of clip--------------- "This genetic bioweapon is really a biological bull in a china shop. I mean it does so many damage. And I mean, I've given lectures. We were together last January, I gave a lecture in Florida on the mechanisms of injury. And the reality is you can't keep up. I mean, we know 28 mechanisms by which it causes cancer alone. "But you know, and this is, I mean it was shocking from the moment we looked at the ingredients before anyone was injected. Shocking enough to like basically set down my entire life's work to try to stop it. That's not because I'm super courage. It's, that's how serious this is. But you genetically, they're genetically modifying people, claiming they're giving them a vaccine and then genetically modifying them so that they will produce a variety of poisons. Mostly the spike protein of the man-made design, SARS-CoV-2 virus, which is the most toxic part of it. "And normally, nobody's body would be producing it. And then they're producing this, this random splay of protein junk which can trigger autoimmune diseases in every direction. And so, but then what's worse is, you know, they claimed that what was in it was modified messenger RNA, modified both so that it would screw up and create all these random proteins as well as spike protein, but modified so that it would persist and nobody knew how long. "In other words, oh, so my body is going to start producing foreign proteins and identifying itself as a foreigner to be attacked by my own immune system. But for how long? Well, nobody knows because this is completely experimental, this new N1 methyl pseudouridinated version of messenger RNA. "But as you know, and as Dr. Speicher, Dr. McKernan and others have revealed through repeated analysis around the world, 30% of the genetic material in there is DNA and it includes plasmid DNA and it includes, in the case of Pfizer, completely covered up that it could even possibly be there. And the fraud they committed to the FDA and the public health agency, european agency, et cetera, that they put in these genetic sequences which were derived from the simian virus, not the virus, but some specific genetic sequences which we've known since 1990 research. "These are genetic hacking tools. When you put foreign DNA with something like a pegylated nanoparticle into a human cell or any mammal cell, and if you deliver as well these little SV40 promoter enhancer sequences... I mean, and this is pre-existing research, that will cause the DNA to be moved into the nucleus and cause it to be incorporated. "So you're permanently genetically modifying and damaging the genetic code of the humans. And we have evidence of this now, Joseph. Some of the most shocking evidence. And I think what you've pointed out is really important. This is not just an attack on the people health that are alive right now. This is attack on our possibility to produce viable offspring and have the continuation of the human race. "We now have tests on male sperm cells where the sperm cells contain in their DNA the genetic code of the spike protein. So men's sperm has been genetically modified so they will pass this toxic genetic flaw into their children if they're able to reproduce. Every sperm cell, we don't know, we don't know how many, but many. We have evidence that 30% of a woman's eggs die shortly following the injections as a result of these injections. Assault on the ovaries where they're particularly drawn to go and deposit the genetic code. "We have cancers that have now been taken out of people. And when you look at the DNA in the cells of the cancer, that DNA has been modified by these injections. So you're looking at permanent genetic modification of human beings without their consent based on a lie that they're getting a safe and effective vaccine for a disease claiming there's no treatment for which there was good treatments. And the whole thing from the virus through the bioweapon death shot were brought to you by the same people. And we're talking about people like Fauci, Gates, Tedros, Daszak, etc."
4:10

BRAVO! to Dr. Mark Trozzi for being one of the few Health Freedom MDs with the guts to openly call the Covid jabs what they are: bioweapons. "This genetic bioweapon is really a biological bull in a china shop... we know 28 mechanisms by which it causes cancer alone... [and the jabs are] permanently genetically modifying and damaging the genetic code of [humanity]." This clip of Trozzi (Dr Mark Trozzi MD), a veteran E.R. physician with 25 years of experience, as well as a human rights activist, is taken from an interview with Dr. Joe Sansone (Dr. Joseph Sansone (JosephSansone.com)) posted to Rumble on December 11, 2025. ----------------Partial transcription of clip--------------- "This genetic bioweapon is really a biological bull in a china shop. I mean it does so many damage. And I mean, I've given lectures. We were together last January, I gave a lecture in Florida on the mechanisms of injury. And the reality is you can't keep up. I mean, we know 28 mechanisms by which it causes cancer alone. "But you know, and this is, I mean it was shocking from the moment we looked at the ingredients before anyone was injected. Shocking enough to like basically set down my entire life's work to try to stop it. That's not because I'm super courage. It's, that's how serious this is. But you genetically, they're genetically modifying people, claiming they're giving them a vaccine and then genetically modifying them so that they will produce a variety of poisons. Mostly the spike protein of the man-made design, SARS-CoV-2 virus, which is the most toxic part of it. "And normally, nobody's body would be producing it. And then they're producing this, this random splay of protein junk which can trigger autoimmune diseases in every direction. And so, but then what's worse is, you know, they claimed that what was in it was modified messenger RNA, modified both so that it would screw up and create all these random proteins as well as spike protein, but modified so that it would persist and nobody knew how long. "In other words, oh, so my body is going to start producing foreign proteins and identifying itself as a foreigner to be attacked by my own immune system. But for how long? Well, nobody knows because this is completely experimental, this new N1 methyl pseudouridinated version of messenger RNA. "But as you know, and as Dr. Speicher, Dr. McKernan and others have revealed through repeated analysis around the world, 30% of the genetic material in there is DNA and it includes plasmid DNA and it includes, in the case of Pfizer, completely covered up that it could even possibly be there. And the fraud they committed to the FDA and the public health agency, european agency, et cetera, that they put in these genetic sequences which were derived from the simian virus, not the virus, but some specific genetic sequences which we've known since 1990 research. "These are genetic hacking tools. When you put foreign DNA with something like a pegylated nanoparticle into a human cell or any mammal cell, and if you deliver as well these little SV40 promoter enhancer sequences... I mean, and this is pre-existing research, that will cause the DNA to be moved into the nucleus and cause it to be incorporated. "So you're permanently genetically modifying and damaging the genetic code of the humans. And we have evidence of this now, Joseph. Some of the most shocking evidence. And I think what you've pointed out is really important. This is not just an attack on the people health that are alive right now. This is attack on our possibility to produce viable offspring and have the continuation of the human race. "We now have tests on male sperm cells where the sperm cells contain in their DNA the genetic code of the spike protein. So men's sperm has been genetically modified so they will pass this toxic genetic flaw into their children if they're able to reproduce. Every sperm cell, we don't know, we don't know how many, but many. We have evidence that 30% of a woman's eggs die shortly following the injections as a result of these injections. Assault on the ovaries where they're particularly drawn to go and deposit the genetic code. "We have cancers that have now been taken out of people. And when you look at the DNA in the cells of the cancer, that DNA has been modified by these injections. So you're looking at permanent genetic modification of human beings without their consent based on a lie that they're getting a safe and effective vaccine for a disease claiming there's no treatment for which there was good treatments. And the whole thing from the virus through the bioweapon death shot were brought to you by the same people. And we're talking about people like Fauci, Gates, Tedros, Daszak, etc."

Sense Receptor

19,495 次观看 • 9 个月前