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👁️ oh, look! 👁️ 🦠 Multicellular Things! 🦠 I do not program "cell walls", energetic "nuclei", survival drives, self-organisation or replication (mitosis/fusion). It simply emerges from random natural selection of 1M RNN particles in a heat bath; 🤗 neato! 🤗 1/3 🔊 🔊 🔊

17,777 Aufrufe • vor 8 Tagen •via X (Twitter)

25 Kommentare

Profilbild von Fraser Price
Fraser Pricevor 8 Tagen

explainer video (~directionally correct) courtesy of @carloAI 🤝 (no affiliation) I only encode simple, local "possible particle physics"; e.g. there's no concept of a "cell wall". The rest is env dynamics, random mutation + natural selection 🤷‍♂️ 2/3

Profilbild von Fraser Price
Fraser Pricevor 8 Tagen

👁️ another example with different "universe physics" 👁️ (more in-depth info in thread 👇) 3/3

Profilbild von Lorenzo Nuvoletta
Lorenzo Nuvolettavor 8 Tagen

Looks neat, although I think the entropy is too high

Profilbild von Calliope
Calliopevor 8 Tagen

How has this not got billions of views

Profilbild von Loktar 🇺🇸
Loktar 🇺🇸vor 8 Tagen

That's A LOT of voronoi! This looks so cool.

Profilbild von Fraser Price
Fraser Pricevor 8 Tagen

its 1 million of them and each one is an individual 8 layer ~10k param neural network lol (running at 500+ steps/second wall btw 😂👌)

Profilbild von Fraser Price
Fraser Pricevor 8 Tagen

(+ props again to @BockJakob for the inspiration)

Profilbild von Wojtek Krzyżanowski, PhD
Wojtek Krzyżanowski, PhDvor 8 Tagen

Did you know that it is already somewhat established that in complex replication dynamics hierarchical structures solve control dilemmas?

Profilbild von Simon
Simonvor 8 Tagen

Will the project be open sourced in the future? That's super interesting!

Profilbild von Damien Henry
Damien Henryvor 8 Tagen

cc @zzznah

Profilbild von uwotmVIII
uwotmVIIIvor 8 Tagen

Is the music made with Suno ?

Profilbild von wartime faces
wartime facesvor 8 Tagen

it's the breakcore violin for me

Profilbild von Michael Welnick
Michael Welnickvor 8 Tagen

Still waiting for you to post the code

Profilbild von cheaty
cheatyvor 8 Tagen

woah

Profilbild von durienb
durienbvor 8 Tagen

Fantastic

Profilbild von Rayneblu
Raynebluvor 8 Tagen

I wonder what would happen if you created exclusion zones that carry organizational information

Profilbild von Frederic
Fredericvor 8 Tagen

Only one random seed?

Profilbild von preset127User
preset127Uservor 8 Tagen

Cool but maybe it seems like *a thing we shouldn’t do*.

Profilbild von 兔米api中转
兔米api中转vor 8 Tagen

不编程细胞壁和生存驱动却能涌现多细胞行为,这种自组织模拟太迷人了

Profilbild von Abe
Abevor 8 Tagen

This is something for @leecronin to investigate 🔥🤙

Profilbild von 马佐夫
马佐夫vor 8 Tagen

能否解释下这是什么,以及最基本的算法

Profilbild von Albert Buchard 🇪🇺
Albert Buchard 🇪🇺vor 8 Tagen

ABM is the future

Profilbild von Tony Rick
Tony Rickvor 8 Tagen

none of that coded in?? 🤯

Profilbild von Willi Fetzner
Willi Fetznervor 8 Tagen

Show math for Your Token binary visualizer

Profilbild von Michael Topo
Michael Topovor 8 Tagen

Really take Wolframs work and tell Opus to reapply this and rethink it all based on thisZ let it make you a paper

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Camus

85,099 Aufrufe • vor 5 Monaten

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But that's not what they wrote. They modified buildings IN CASE they received that stuff. And we now know (or, have been told) that one of those "materials" was an alleged non-human craft from Lockheed Martin. Reportedly, they were trying to divest themselves of it due to a lack of success in reverse engineering efforts.) Link to full article: ~ Knapp: "Did you ever have it?" Bigelow: "We never had any." Knapp: "Did you ever see it?" (I transcribed Mr. B's answer word-for-word because he looked and sounded really uncomfortable answering. I have zero doubt he's telling the truth, but that doesn't mean ANY of this is proof that we have these craft.) Bigelow: "Umm. Well, I've...there's, I, umm... You know, do you see, do you see, uhh, things that are photos, or do you see things in person, and so forth? So, you don't want to, you don't want to talk about stuff in case it happens in the future." Knapp: "Yeah." (If Mr. Bigelow was shown government photos or videos (with proper provenance) of craft that were presented to him as being manufactured by non-humans or an intelligence of unknown origin, is that enough to call him a firsthand witness? If he saw "machinery" and saw it "in person," then he's 100% a firsthand witness. Did Lacatski take him to see the craft that was described in "Initial Revelations"? 👇🏼👇🏼👇🏼 ) “At the conclusion of a 2011 meeting in the Capitol building with a U.S. Senator and an agency Under Secretary, Lacatski, the only one of this book’s authors present, posed a question. He stated that the United States was in possession of a craft of unknown origin and had successfully gained access to its interior. This craft had a streamlined configuration suitable for aerodynamic flight but no intakes, exhaust, wings, or control surfaces. In fact, it appeared not to have an engine, fuel tanks, or fuel. Lacatski asked: What was the purpose of this craft? Was it a life-support craft useful only for atmospheric reentry or what? If it was a spacecraft, then how did it operate”? ~End Excerpt from Initial Revelations~ ~~~ Bigelow: "So, you don't want to, you don't want to talk about stuff in case it happens in the future. And...because who knows what might happen in terms of a coalescing of intersections that could happen? And so..." Knapp: "You don't wanna spill any beans that causes you, it puts you in a bad light somewhere down the road." Bigelow: "Well, I just, I, I, you know, of...I think that... Machinery really does exist. It does exist, you know? And so, but the problem has been the inability to back engineer. And I kind of think that some things require a weightless environment. So, part of that is, we don't have it here, terrestrially. So, what you need is a manufacturing facility where there's a weightless environment." Knapp: "It's part of the reason you developed Bigelow Aerospace." Bigelow: "For certain amalgams and certain kinds of things, but it's also like, you know, it doesn't do you much good to own a sliver of a case that holds a cell phone to understand, was it even a case? Was it holding something, and what was that something it was holding? And much less, how does a cell phone work? And, oh, by the way, it doesn't work at all if you don't have all the communication capabilities that that cell phone needs to communicate with, and all that kind of thing. So it's like...it could just domino out into a thousand different things. So, having an answer on a small sliver of something isn't necessarily much, right?" (On thing I've consistently said is: If we're going to wake up the masses, materials won't do it. A rectangular piece of metal from an alleged NHI craft that a scientist says cannot be manufactured on Earth with known technology, is interesting, but not enough. IMO, we need a full (or partial) craft (machinery) and bodies.) Bigelow: "So, we are embarrassingly - as a specie, as a science, as a space-faring, attempting specie - behind. We're a galactic embarrassment, almost. I mean, we're so far freaking behind, we really are. It's a galactic embarrassment and we may not even be able to, consciously, be able to operate the things, you know? Because it's not like fingerprints or anything, you know? It's consciousness driven. So you taste that a little bit in being able to have some communications." (If it's truly consciousness driven, then what jakebarber and Skywatcher have spoken about makes complete sense: Using telepathy or psi to attract/summon craft and then operate them from a distance.) Bigelow: "And we have other areas of psi and phenomenology, where mentally, people can have macro PK, you know? They can execute macro-PK events, and they're not supposed to be able to do that. Our physics and science says, 'No, you can't do that.' And yet it's happening, right? So whether it's Bob Jahn's and Brenda Dunne's work in micro PK on subatomic particles, or macro PK with Kulagina in Russia, and with her bell jar and all that kind of thing. And she's lifting a pencil or bottle cap." Here are a few clips of Kulagina. I'm not sure if she's done this under more strict controls. ( I love that Bigelow is well read on these subjects and knows they're legit. But I wonder when the masses will realize it?) ~~~ Bigelow: "You're sniffing at something that's really not on our radar as a parochial-educational system in physics or anything. You're totally outside the boundary, right? And we're still dealing with fire engines, right? Okay? So, it's really frustrating and the potential might some day be there to try to back engineer more. And we've heard stories about little bitty things that maybe the Russians have back engineered. "And so, we're still enough of, potentially, the Klingons to turn things into weapons, right? So that's a big problem. Is the fact that we don't have an intersection. If you have two lines, one on spirituality and technology. Where's the intersection ever happening? Because we're flatlined on spiritual evolution, but our technological evolution is not only vertical, it's segmented, it's jumping. It's jumping faster, you know? And so. where's that intersection of harmony supposed to be? I don't see it. I don't see it 100 years from now, or 200 years from now. I don't see anything on the horizon today that's saying, 'Well, the spirituality line is gonna start to really accelerate [and] this other one (technological) is going to start to stop. And eventually, there's going to be an intersection of harmony where there's an integration of the two. I don't see...I can't possibly foresee that, I don't see it at all. So it's a big worry." (Steven Greer has said: "The [ETs] that are here, they'd be like Gandhi. No civilization that is capable of interstellar travel is allowed out of their solar system until they're peaceful. Otherwise, they're quarantined. But actually, we have technology that can go interstellar. We're not allowed to. And the reason is, we're still savages." ~Greer on his IG (I have no idea if that's true and neither does Greer.) Bigelow: "If you were an occupying...if you were another specie on another planet, a thinking specie of intelligence, and we had the capabilities to get to you, you should be damn concerned about the human race." Knapp. "Yeah. If I had that technology, I would not give it to us." Bigelow: "Yeah! Okay, you just said it. That's exactly right. You just said that. That is the big enchilada, right there. You just said it, that's the plate." (I want this tech shared with the world if it can help clean up our planet or advance our science and medicine. But if it can be used as a weapon, it's hard to argue with what Mr. B and Knapp said there. This assumes we've been able to reverse engineer certain aspects of the tech we allegedly have in our possession.)

Joe Murgia

89,936 Aufrufe • vor 1 Jahr

In a busy OPD, chorea is usually not missed because it is rare. It is missed because it looks like restlessness. The patient is sitting in front of you. A finger moves. Then the wrist. Then the shoulder. Then there is a small facial movement. Nothing seems dramatic. But watch carefully. The important thing is this: The next movement is not like the previous one. It changes in timing. It changes in direction. It changes in distribution. There is no fixed rhythm. There is no same movement repeating again and again. That is when I start thinking of chorea. I remember it this way: Tremor repeats. Chorea keeps changing. Now don't rush into a detailed examination. In OPD, five simple things are enough to recognise the phenomenology. 1. Just watch Keep talking to the patient. Watch the fingers, face, shoulders and feet. Mild chorea may simply look like fidgeting. 2. Ask the patient to stretch both hands forward And wait. Not for two seconds. Small irregular movements may start appearing in different fingers, wrist or shoulder. 3. Look for apparently purposeful movements This is a beautiful feature of chorea. An involuntary movement may get converted into touching the face, adjusting the clothes or changing posture. So what looks voluntary may actually have started as chorea. 4. Ask the patient to keep the tongue out The patient may bring it back repeatedly despite trying to maintain it. 5. Test sustained grip Instead of a constant grip, you may feel tightening and loosening. This is motor impersistence. The classical bedside description is the milkmaid grip. Then make the patient walk. A small extra step, shoulder movement, hand movement or sudden change in posture may get mixed into an otherwise normal gait. The important point is that chorea is not one particular movement. It is a pattern of unpredictability. Irregular. Non-rhythmic. Non-repetitive. Moving from one body part to another. And once I am sure that the movement is chorea, only then do I ask the next question: Why does this patient have chorea? Acute or chronic? One side or both? Drug related? Metabolic? Autoimmune? Structural? Genetic? In a busy OPD, don't begin with the disease name. First spend 30 seconds watching the movement. #NeuroX #MedX #Chorea

sikandar adwani

15,206 Aufrufe • vor 1 Monat

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cindy 🌥️

17,455 Aufrufe • vor 9 Monaten

𝗧𝗵𝗲 $NWBO 𝗗𝗖𝗩𝗮𝘅-𝗟 𝘁𝗿𝗶𝗮𝗹 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗱𝗼𝗻𝗲. 𝗧𝗵𝗲 𝗙𝗗𝗔 𝗵𝗮𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗿𝗶𝘁𝘁𝗲𝗻 𝘁𝗵𝗲 𝗽𝗹𝗮𝘂𝘀𝗶𝗯𝗹𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝗽𝗮𝘁𝗵𝘄𝗮𝘆. 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗹𝗲𝗳𝘁 𝗶𝘀 𝘁𝗼 𝗮𝘀𝘀𝗲𝗺𝗯𝗹𝗲 𝗶𝘁 𝗮𝗻𝗱 𝗳𝗶𝗹𝗲. #DCVax-L is a vaccine made for each patient from their own dendritic cells, the immune cells that teach the rest of the immune system what to attack, loaded with their own tumor. It treats #glioblastoma, the deadliest brain cancer. An American company developed it, yet Americans have to go to Europe to get it. #DCVaxForBraelyn The FDA has spent the past year writing down how it wants to judge treatments like this one. The core evidence it asks for already exists. One question decides this: can the FDA evaluate DCVax-L for approval under the plausible mechanism framework, on the evidence already generated? Read against every document the agency has published on the framework, the answer is yes. 𝗧𝗵𝗲 𝗽𝗹𝗮𝗻 𝗶𝗻 𝘁𝗵𝗿𝗲𝗲 𝘀𝘁𝗲𝗽𝘀 1. File the biologics license application (BLA) and ask the FDA's biologics center (CBER) for review under the plausible mechanism framework. A BLA is not another trial. It is the dossier the FDA decides on, and the framework changes what counts as sufficient inside it. The framework itself needs no new statute and no special designation. A sponsor asks for it. 2. Ask for full approval on survival, with no new randomized trial. The completed phase 3 is the pivotal study. Mechanism, a related product, a related stage of the disease and independent natural history are the confirmatory evidence. A registry of every treated patient supplies the follow-up. 3. Open access alongside the filing. An expanded access treatment protocol does not have to wait for the BLA; it can begin 30 days after the FDA receives it. Filing the BLA satisfies Right to Try's application condition. 𝗪𝗵𝗮𝘁 𝘁𝗵𝗲 𝗙𝗗𝗔 𝗵𝗮𝘀 𝘄𝗿𝗶𝘁𝘁𝗲𝗻 𝗱𝗼𝘄𝗻 Nov 2025, NEJM, Prasad and Makary: the plausible mechanism framework. Five questions. Built for cell and gene therapies first, and available for common diseases, particularly those "for which there are no proven alternative treatments." Feb 2026, NEJM: one adequate and well-controlled study plus confirmatory evidence is the FDA's default basis for approval. Feb 2026 draft guidance: an externally controlled study against a well-characterized natural history can be the pivotal study. Confirmatory evidence includes mechanism, target engagement and "exposure-response on biomarkers and clinical outcomes." The product can target "a well-characterized downstream or compensatory mechanism with a clear mechanistic rationale." June 2026 draft guidance: six conditions under which an external control supports effectiveness. The plausible mechanism framework named as an example of FDA regulatory flexibility in critical settings. "Even small effects may be clinically meaningful when the effect is on survival or irreversible morbidity." Why it exists: to bring regulatory flexibility to individualized therapies where the conventional model does not fit. The guidance names gene and RNA therapies, then says "the general concepts may apply to other types of individualized therapies": therapies that target "a specific pathophysiologic abnormality serving as the root cause of a disease." The FDA's own announcement: the guidance "leaves open the potential that this framework may apply to additional tailored therapeutics provided they directly address the underlying specific cause of the disease." The framework is not a new approval standard. It is how the FDA reads evidence under the standard that already exists. That is exactly why it can be asked for today. 𝗪𝗵𝘆 𝗴𝗹𝗶𝗼𝗯𝗹𝗮𝘀𝘁𝗼𝗺𝗮 𝗶𝘀 𝘁𝗵𝗲 𝗰𝗮𝘀𝗲 𝗶𝘁 𝘄𝗮𝘀 𝘄𝗿𝗶𝘁𝘁𝗲𝗻 𝗳𝗼𝗿 No proven alternative: recurrent GBM has no established standard of care. Of 400+ trials since 2005, only one phase 3 in newly diagnosed and none in recurrent disease had shown a survival benefit. High and predictable mortality: the exact case FDA regulations name for historical controls, "certain malignancies." Life-threatening in the regulation's own terms: a disease "where the end point of clinical trial analysis is survival." Individualized: a different product for every patient, made from their own cells and their own tumor, aimed at the root cause, the broken instruction layer. Orphan designation in the US and Europe. 𝗧𝗵𝗲 𝗽𝗶𝘃𝗼𝘁𝗮𝗹 𝘀𝘁𝘂𝗱𝘆 𝗶𝘀 𝗰𝗼𝗺𝗽𝗹𝗲𝘁𝗲 331 patients, 94 sites, randomized, double blind. 64 of 99 placebo patients crossed over at recurrence, so survival was measured against 2,006 contemporaneous matched control patients from 15 randomized trials. Newly diagnosed: 19.3 vs 16.5 months, HR 0.80, p=.002. Alive at 5 years: 13.0% vs 5.7%. Recurrent: 13.2 vs 7.8 months, HR 0.58, p<.001. That is a 42% lower risk of death. The benefit widened over time, and it was largest in the patients who fare worst. Why no second trial? The completed trial, the crossover and the survival evidence make the case, and the FDA's June guidance names the ethical stake: after "a substantial decrease in mortality," a second trial "would generally present significant ethical concerns." 𝗧𝗵𝗲 𝟮𝟬𝟮𝟲 𝗿𝗲𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀 The phase 3 paper named its own limitation: without patient-level control data, "propensity score matching could not be performed." The critics named the missing methods: "propensity score matching or inverse probability weighting." In 2026 Northwest obtained individual patient data from three independent randomized trials and had independent statisticians run exactly those two methods. Propensity score matching pairs each DCVax-L patient with control patients who had the same prognostic profile, so like is compared with like. Presented at BNOS in July 2026; peer-reviewed publication is the next step. Propensity score matching: HR 0.69 to 0.77. Median survival +3.4 to +6.3 months. p .004 to .027. The original cohort-level analysis showed +2.8. When the matching got finer, the benefit got bigger. The survival advantage held under both patient-level methods and was larger than the original cohort-level estimate. Northwest reports sensitivity analyses for hidden confounding; the published paper should give the values. The method has been tested in this exact disease. In May 2026, the INSIGhT investigators replaced their own randomized control arm with propensity-matched external controls. For three drugs that had failed randomized testing, the method also found no benefit: HR 1.00, 0.93, 0.88. "Carefully matched external controls" produced "treatment effect estimates that were similar" to the randomized analyses. The method did not invent a benefit. Applied to DCVax-L, it found one. And the authorship closes the loop. In 2023, Dana-Farber statisticians Rahman, Ventz and Trippa wrote that they were "not aware of independent validations of these analytic methods in a GBM trial context." Rahman and Trippa are the senior authors of the 2026 INSIGhT validation. The critics asked for patient-level data and a validated method. By 2026 both existed. That supports the method the DCVax-L reanalysis used; publishing that analysis in full is step one. And it is the form a BLA requires: FDA guidance says applications "must include" patient-level data for the external control arm. 𝗧𝗵𝗲 𝗙𝗗𝗔'𝘀 𝘀𝗶𝘅 𝘁𝗲𝘀𝘁𝘀 𝗳𝗼𝗿 𝗮𝗻 𝗲𝘅𝘁𝗲𝗿𝗻𝗮𝗹 𝗰𝗼𝗻𝘁𝗿𝗼𝗹, 𝗮𝗻𝘀𝘄𝗲𝗿𝗲𝗱 1. Well-defined natural history: 2,006 controls from 15 randomized trials. 2. Very similar populations: 14 prespecified criteria, chosen by an independent firm, validated against all 15 source trials, now matched patient by patient. 3. Similar treatments: in newly diagnosed disease, surgery, radiation and temozolomide in both groups. 4. Objective endpoint: death. 5. Comparable start: survival from randomization after radiotherapy in both groups. Drop the two control trials that admitted early progressors: HR still 0.80. 6. An effect too large to be bias: five-year survival more than doubled, HR 0.58 at recurrence, and the effect grew when matching tightened. 𝗧𝗵𝗲 𝗽𝗹𝗮𝘂𝘀𝗶𝗯𝗹𝗲 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝗰𝗿𝗶𝘁𝗲𝗿𝗶𝗮, 𝘄𝗼𝗿𝗱 𝗳𝗼𝗿 𝘄𝗼𝗿𝗱 The FDA's five elements, quoted exactly from its February 2026 draft guidance ( lines 26 to 32), each answered: 1. "Identifying a specific genetic, cellular, or molecular abnormality with a clear connection between specific alteration and disease indication." (line 26) ✓ Met: in GBM, the dendritic cells that should teach T cells what to attack are overridden by suppressive immune cells. A tumor never presented for attack grows unopposed. 2. "Developing a therapy that targets the underlying or proximate pathogenic biological alterations." (line 28) ✓ Met: DCVax-L supplies the patient's own dendritic cells, loaded with their own tumor and prepared outside the suppressive tumor environment, to restore tumor-directed T-cell instruction. 3. "Relying on a well-characterized natural history of the disease in an untreated population." (line 30) ✓ Met: 2,006 controls from 15 randomized trials, patient-level data from three more, no time-trend in survival 2012 to 2022. 4. "Confirming that the target was successfully drugged or edited or both." (line 31) ✓ Platform evidence documented; product-specific bridge required. After DC vaccination, cytotoxic T cells increased inside the tumor, and infiltration correlated with survival (P = 0.047); T cell infiltration in the UCLA vaccine-first arm. The FDA is open to confirmation "for a subset of patients"; the BLA should supply DCVax-L's own immune-monitoring results and the bridge to these studies. 5. "Demonstrating improvement in clinical outcomes or course." (line 32) ✓ Met: longer survival, five-year survival more than doubled, a bigger benefit under patient-level matching. The eight considerations attached, each answered: 1. An individualized therapy aimed at "a specific pathophysiologic abnormality" 2. A "compensatory mechanism with a clear mechanistic rationale" 3. Substantial evidence from "a single adequate and well-controlled clinical investigation with confirmatory evidence" 4. A natural history that lets the effect be "reasonably distinguished from natural variability" 5. An improvement not attributable to "alternative treatments or natural variability" 6. Prespecified analysis plans 7. A reason a new RCT is not feasible 8. A product that "can be manufactured to regulatory quality standards," made for every phase 3 patient: manufacturing experience documented, US CMC review required 13 of 13, every one in the FDA's own words, every one answered from the record, every open step named. 𝗧𝗵𝗲 𝗰𝗼𝗻𝗳𝗶𝗿𝗺𝗮𝘁𝗼𝗿𝘆 𝗲𝘃𝗶𝗱𝗲𝗻𝗰𝗲, 𝗶𝗻 𝘁𝗵𝗲 𝗙𝗗𝗔'𝘀 𝗼𝘄𝗻 𝗰𝗮𝘁𝗲𝗴𝗼𝗿𝗶𝗲𝘀 Mechanism: in the DCVax-Direct phase 1 (a different product: activated dendritic cells injected into diverse solid tumors), more IL-8 and IL-12p40 from each patient's cells went with longer survival, p=0.023 and 0.024. Exposure-response, in the FDA's words. Related product: UCLA's 46-patient randomized phase 1 trial of its own tumor lysate DC vaccine, at EANO this Friday. Both arms got the vaccine; the order was randomized. Vaccine first, 555 days. Checkpoint first, 271. HR 0.32. The order matters: priming before checkpoint release more than doubled median survival. Across the class, a 2024 meta-analysis of seven dendritic cell vaccine trials, 3,619 patients, found HR 0.71 for survival, "indicating a true-positive result." Related indication: the FDA's own example is "a different stage of the same disease." DCVax-L worked at both stages. Independent natural history: national cancer registries, separate from the trial controls, as the guidance requires. Real-world data is expressly allowed. 𝗧𝗵𝗲 𝗽𝘂𝗯𝗹𝗶𝘀𝗵𝗲𝗱 𝗰𝗿𝗶𝘁𝗶𝗰𝗶𝘀𝗺𝘀, 𝗮𝗻𝘀𝘄𝗲𝗿𝗲𝗱 Three published critiques set out the case against the trial. Each point, answered from the record: Endpoint switched to survival? Progression could not be read: 256 of 494 scans needed adjudication. The critics agree: progression-free survival "is not an adequate endpoint for immunotherapy studies because of the phenomenon of pseudoprogression." Survival is the "gold standard," in their words. Cohort-level controls? The critics named the fix: propensity score matching or inverse probability weighting on patient-level data. That is exactly what 2026 did, and the benefit grew. Never validated in GBM? Two of the critics who raised it led the 2026 study showing patient-level external controls reproduce randomized results. Selection? Dropping the control trials that admitted early progressors changed nothing, as above. The benefit was larger in patients with more residual tumor, the opposite of what selection would produce. IDH, a tumor mutation linked to longer survival? Tested centrally in every DCVax-L patient. The gap is in the older control trials. Chosen after the fact? An independent firm, prespecified criteria, validation as above. Then a larger effect against different trials at the patient level. Company author? Data held by independent CROs, analyzed by independent statisticians. Run another trial? The completed program, crossover and survival evidence make a repeat unnecessary; the FDA's guidance names the ethical concern; the BLA documents why a new randomized design is not feasible or ethical. 𝗠𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴 The framework also requires that the product "can be manufactured to regulatory quality standards." DCVax-L was made for every patient in a 94-site phase 3, and in 2023 the UK regulator licensed the Sawston facility for commercial manufacturing, with products that "may be exported globally." A UK license is not US approval: FDA inspection and the potency assay go on the table at the pre-BLA meeting. 𝗕𝗲𝗻𝗲𝗳𝗶𝘁 𝗮𝗻𝗱 𝗿𝗶𝘀𝗸 Longer survival in a disease with no proven alternative at recurrence. 2,151 doses, 5 serious events even possibly related, no autoimmunity, no cytokine storm. It is the patient's own immune system, with one broken link rebuilt. A repair, judged the way a repair should be judged. 𝗧𝗿𝗲𝗮𝘁𝗶𝗻𝗴 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗵𝗶𝗹𝗲 𝘁𝗵𝗲 𝗙𝗗𝗔 𝗿𝗲𝘃𝗶𝗲𝘄𝘀 Right to Try covers a product that has completed phase 1, is in active development and not on hold, and has an application on file. Filing the BLA satisfies the application condition; the others must still hold at that time. Patients must have a life-threatening disease, have exhausted approved treatments, be unable to join a trial and consent, and the manufacturer must choose to provide it. No separate FDA approval of each case. Build the program before filing. An expanded access treatment protocol (21 CFR 312.320) requires completed trials, active pursuit of approval and phase 3 evidence. The trials are complete and the phase 3 is published, so it does not have to wait for the BLA. Treatment can begin 30 days after the FDA receives the protocol, absent a hold. The usual reason a manufacturer holds back is risk: a serious event in a very sick patient gets blamed on the product. The FDA answered that in its April 2026 guidance: it "does not intend to deny, delay, or refuse to approve" a BLA "based solely on an adverse event occurring in the context of expanded access use," and "is not aware of any instances" where one prevented approval. Access is the bridge. Approval is the destination. This is not new for DCVax-L: it has been provided under Germany's hospital exemption and the UK Specials pathway. 𝗦𝗲𝗲𝗸 𝘁𝗿𝗮𝗱𝗶𝘁𝗶𝗼𝗻𝗮𝗹 𝗮𝗽𝗽𝗿𝗼𝘃𝗮𝗹, 𝘄𝗶𝘁𝗵 𝗮 𝗽𝗿𝗼𝘀𝗽𝗲𝗰𝘁𝗶𝘃𝗲𝗹𝘆 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝗿𝗲𝗴𝗶𝘀𝘁𝗿𝘆 The framework's guidance: approval is traditional or accelerated "depending on the endpoints used." Survival is the endpoint, so the request is traditional, full approval, with no confirmatory-trial requirement. The FDA can still require postmarketing studies, and the framework's authors named the tool: "collecting real-world evidence to confirm continued preservation of efficacy." A registry of every treated patient, designed before approval. If accelerated approval becomes the route, the regenerative medicine advanced therapy (RMAT) statute lets post-approval requirements be met through registries and "postapproval monitoring of all patients treated with such therapy prior to approval." Every patient treated under Right to Try or expanded access counts. 𝗪𝗵𝗮𝘁 𝗵𝗮𝗽𝗽𝗲𝗻𝘀 𝗻𝗲𝘅𝘁 Northwest has pursued the UK first. Its application there has been under review since late 2023, and in July 2026 the UK regulator confirmed it "remains under its initial regulatory review, has not been refused." The US filing is the step that remains. 1. Publish the patient-level reanalysis. 2. Lock in the patient-level control data rights the FDA requires. 3. Report the central IDH results and publish the phase 3 immune data. 4. Request RMAT designation now. FDA must answer within 60 days. 5. File the treatment protocol and build the Right to Try program. 6. Pre-BLA meeting with CBER: plausible mechanism review, six external-control tests answered, manufacturing and potency package. 7. File the BLA with priority review. 8. Build the registry. Approving DCVax-L this way would be the framework's proof beyond genetic disease: an individualized cell therapy, aimed at the root cause of the deadliest brain cancer, carried by a completed phase 3. A win for patients first. 𝗧𝗵𝗲 𝘁𝗿𝗶𝗮𝗹 𝗶𝘀 𝗱𝗼𝗻𝗲. 𝗧𝗵𝗲 𝗳𝗿𝗮𝗺𝗲𝘄𝗼𝗿𝗸 𝗶𝘀 𝘄𝗿𝗶𝘁𝘁𝗲𝗻. 𝗧𝗵𝗲 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝗮𝗿𝗲 𝘄𝗮𝗶𝘁𝗶𝗻𝗴. 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗹𝗲𝗳𝘁 𝗶𝘀 𝘁𝗼 𝗮𝘀𝘀𝗲𝗺𝗯𝗹𝗲 𝗶𝘁 𝗮𝗻𝗱 𝗳𝗶𝗹𝗲. Disclosure: long $NWBO. Commentary on published and presented data and public FDA documents. Not medical, legal, regulatory or investment advice. DCVax-L is investigational and not approved in the US. Regulatory strategy is the sponsor's decision.

Andrew Caravello, DO

50,512 Aufrufe • vor 1 Monat

🔊 Elon Musk did a live phone interview earlier today with a guest host of the Sean Hannity radio program, discussing his latest SpaceX timelines. I only caught about the last 5 minutes of it: “The best way to expand compute is really in space. There’s a lot of room in space and if you look at the size of Earth relative to the sun or relative to the solar system, you realize just how tiny Earth is. We’re very, very tiny. We only receive about half a billionth of The Sun’s energy. So if you really think of Earth as being like a tiny dust mote in a vast darkness. So the way to expand compute— without, ya know, using up all the land on Earth— is to do so in space. And then you can do it without using up space for power & water on Earth. You can just do it in space, so… I think we will probably be launching our first AI satellites next year and then we will probably be able to do that, I think, at large scale in about two years. Yeah, well, I’ve always had the philosophy that everyone at the company should receive stock in the company so that they can participate in the upside of the company and it’s great for aligning incentives as well, so as the company prospers, then the people at the company— the employees — also prosper, so that’s just been, ya know, my philosophy from Day 1 is just to make sure everyone gets stock in the company, so there are, I think, several thousand people who’ve been – it’s not just one welder – it’s several thousand people who were, you know, working on the production line and started at the company relatively early… then probably their stock is worth over $1 million at this point “Yeah, so, Mars is much harder to get to than the moon and you can only travel to Mars roughly every two years. So Earth and Mars align such that you can travel to Mars only once every 26 months. So that makes it a lot harder than the moon where you can go to the moon pretty much anytime and it only takes a few days to get to the moon whereas it takes about six months to get to Mars. So that’s why we can do the moon faster than we can do Mars. But I think, probably, if things go well, we can probably send the first people to Mars in about five years, and then rapidly increase the cadence of sending people to Mars thereafter, so every two years we could dramatically increase the number of ships going to Mars and, ya know, hopefully in a 10 or 12 year timeframe we’ve sent thousands of people to Mars.”

James Stephenson

922,497 Aufrufe • vor 3 Monaten

👁️👁️ Our eyes decide our metabolism, not our genes. Why? 🧐 Because the eye is the most important environmental organ. Through it, light timing determines which biochemical signals our body produces. ⚠️ Before we proceed to understand what ☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 said in the video, let first understand what the suprachiasmatic nucleus (SCN) is: “Supra” = above “Chiasmatic” = the optic chiasm (where optic nerves cross) “Nucleus” = like a control center made of neurons. Put together: 👉 is a small cluster of neurons located above the optic chiasm in the hypothalamus. Hypothalamus = a small area in the front of the brain that helps control things like: sleep, hunger, temperature, hormones… ⏰ The SCN is the master clock of our biology. And Mitochondrial survival depends on FOUR environmental surfaces: 👁️ Eyes 🧴 Skin 🦠 Gut lining 🫁 Lung surfaces These are the only interfaces where the external environment directly programs internal biology. Among them, the EYES dominate. Why? Because the eye is not a camera. It is a TIME-setting device. Inside the retina are melanopsin-containing retinal ganglion cells. These cells: Detect light wavelength Detect timing, not images They send signals directly to the SCN without: interpretation. emotion. thinking. Just environmental truth setting the clock that controls hormones, metabolism, immunity, and mitochondrial energy. This pathway is called the Central Retinal Pathway. It’s just raw environmental truth deciding what chemicals get released, and whether our biology repairs or degenerates. 🧬 Why the SCN sits BETWEEN leptin and the brain? This is the question most doctors never ask. Because Leptin is NOT a fat hormone 👀 ✅ is a TIMING hormone. It tells the brain: Is it day or night? Is it summer or winter? Is energy abundant or scarce? But leptin only works if the clock is correct. So Nature places the SCN between the eye (light input) and the hypothalamus (metabolic control) The SCN acts like a customs officer. It asks: Does this leptin signal match the light environment? YES 👍🏻 = leptin sensitivity NO 👎🏻 = leptin resistance ON vs OFF, timing is everything. The SCN controls: Cortisol (morning ON) Melatonin (night OFF) Insulin sensitivity Thyroid signaling Sex hormones Autophagy DNA repair… It flips the switch based on: Wavelength Intensity Timing 🌅 Morning sunlight (red, IR, blue) SCN = ON Cortisol rises Metabolism activates Mitochondria make clean energy 🌙 Night darkness (NO blue light) SCN = OFF Melatonin rises Repair + autophagy Immune surveillance ⚠️ Artificial blue light at night: False sunrise signal Night hormones shut down Repair stops Inflammation rises… 🚨This is not harmless. It’s catastrophic over time 🧨💥 It leads to disease, obesity, neurological degeneration, heart problems, and everything in between. 🏭 imagine this a factory : 👁️ Eyes = ⏰ time clock 🧠 SCN = 👷 factory manager 🧬 Leptin = 📋 inventory signal Mitochondria = ⚙️ machines If the time clock is wrong: Workers show up at the wrong time/night Machines run during maintenance Inventory signals are ignored The factory breaks down 🙌🏻 No amount of better food fixes a broken clock. ☠️ Modern life is lethal because: Indoor living Screens at night Sunglasses in the morning EMFs everywhere… Result: SCN never turns OFF Melatonin suppressed Leptin resistance Hunger increases Fat gain Immune failure Cancer risk rises… As Jack says: “Disease is a circadian mismatch.” 🔥 Why this matters for US? When the SCN is broken: Immune timing fails Inflammation stays high Healing slows Drugs work worse, with more side effects… That’s why environmental correction beats pharmacology long-term and food. Straight from Jack’s mouth: “The eye is the most important metabolic organ you own.” “You don’t fix mitochondria with food, you fix them with TIME.” And that is why our eyes determine the fate of our biology, long before genes ever do. Full video link 👇🏻

Light Me Away ☀️

26,763 Aufrufe • vor 10 Monaten

CHARLIE KIRK SMOKING GUNS Amongst the litany of lies & contradictions emanating from the "approved" Charlie Kirk ass*ssination narrative, there are 2 major "smoking guns". 🔖▶️ 🔊 1. Tyler Robinson was in custody & mirandized an hour and a half before the alleged Discord confession was posted, and 3 hours before public officials claim he was captured. CONVENIENTLY, Washington County Sheriff Nate Brooksby, along with the sheriff's office video camera footage, have been disappeared. 2. Either the Rode mic or receiver is lying in shards all over the seats & floor of the SUV. CONVENIENTLY, the mic/receiver & associated audio, along with the SUV, have been disappeared. ******* The shattered mic/receiver is more devastating, here's why: In the case of the alleged Discord confession, their plan seems to be to simply not introduce it into evidence. It's just being used to convict Tyler in the court of public opinion. Whether it's real or fake, the narrative that Tyler shot Charlie can still be true. In the case of the shattered mic, it transforms the fundamental fabric of the narrative: Tyler Robinson did NOT shoot Charlie Kirk. And then everything falls apart. ******* Together, these two smoking guns indicate the scope of the conspiracy: TPUSA doesn't itself have the power to frame Tyler Robinson, scuttle sheriff's office video, dispose of the SUV, or order the crime scene to be excavated to a depth of 10 inches & paved over. The state of Utah doesn't have the power to stop the FBI & federal government from pursuing the evidence and investigating any potential interstate plot against an important cog in the election of Republicans who was arguably responsible more than any other single person for the re-election of Donald Trump. The federal government doesn't have the power to prevent the deeply jewish- and zionist-controlled media and army of influencers from using their institutional power & connections to get to the bottom of who robbed them of their alleged beloved golden boy, "best friend to israel" Charlie Kirk. The Federal government didn't even have the power to resist israel dragging us into the *extremely* unpopular Iran war. ******* Influence and power flow downhill. At any point, a bigger fish could come along and expose the smaller fish who pulled off this conspiracy. But that's not what we're seeing. The conclusion is unavoidable: because it's the biggest fish who did this. Who's the biggest fish right now? Put another way, who's got the pre-eminent institutional power in America right now? Answer that and you'll have your culprit. ******* I'm reminded of J. Edgar Hoover's famous quote from 1956: "The individual comes face-to-face with a conspiracy so monstrous he cannot believe it exists. The American mind has not come to a realization of the evil which has been introduced into our midst." Since then, we've gotten the JFK ass*ssination, the ass*ssinations of RFK & MLK, 9-11, global covid/vaxx tyranny and stolen presidential elections. And. So. Much. More. All unsolved & unresolved. Decade after decade. ******* Because of these 2 smoking guns in the Charlie Kirk case—smoking guns our American predecessors didn't have in those other crimes—we have the unique chance to draw a line in the sand right now: THIS FAR AND NO FURTHER. What will it be, Tyler Robinson or the Biggest Fish? We have it on the hook, will we let it wriggle away, or will we stand tall in the chair and land this beast? Those are our choices. Have you had enough slop, or do you want to finally feast? Like, comment, retweet, please. ▶️🔊

Sam Parker 🇺🇸🧯

110,028 Aufrufe • vor 3 Monaten

Qullamaggie on If You Want Elite Returns, You Need to Be In The Elite Stocks “NOTV, oh man this is wide and loose. No no no, this is not a stock you want to trade. This is not a trading stock. No. Focus on explosive moves. Look at the prior move on the flagpole. Guys most of you really would do better if you just re-watch the swing trading school videos. The previous move needs to be big okay. It needs to be explosive. Those are the ones you want to focus on, not some random stuff like this. Yeah it's made a big move over the past eight months but it's not a trading stock it's a choppy one. It’s mean reverting. You want explosive stocks. You want to you want to focus on the elite stocks okay. The only way to have elite results is focusing on elite stocks Now, this is what I talk about elite stock. Now, this guy gets it, okay? Big previous move. 170% in two sessions. Pull back. Found support on a rising 10. It's been surfing the rising 10, building higher lows, and now it's tightening the range. Look at this pattern. It's called a triangle. Now, this is an elite stock. If you want to find the stock that has the potential to make a 50% move or a 100% move, you will get it on a stock that has tripled in a few days in the previous few weeks or months. You're not going to get it on a stock that just keeps grinding slowly higher. It's a numbers game, it's an odds game. Now this is a good setup. This is f*cking beautiful, it reminds me about LEDS a month back. LEDS, beautiful. Big previous move, 265% in 3 days, orderly pullback, found support on the 10 day, okay? Look at this, this is a triangle, tightening range, range expansion. And look at the move it did. It went up 263% in the next two weeks. How do you find a move like this? You're not gonna find a breakout of 263% on a stock like... I mean, look at some of the suggestions I've gotten lately. Like, NOTV. The previous move was 20%, not even 20%. SGMS, another, it's a grinder. Okay, 35% these things are very like sluggish, okay? It went up 35% in what, a month? It's not an explosive stock. Focus on the superstars. BYND, this is the one I'm tracking, okay? I'm really excited about this one. I think another one or two days of tightening range, I'm gonna go full retard on it. Look at this, it went up. This is a mid cap. It went up 46% in a week, okay? That's an explosive move. Especially for being a mid cap. Does it matter than the weekly? No, forget about weekly charts. You guys don't need to pay attention to the weekly charts. Don't worry about the weekly charts until you get to 10 plus million. Then you can start worrying about it. No, focus on the daily charts. Focus on one month, three month and six month momentum. That's where you're gonna focus on the strongest stocks across those three timeframes. The 1%, the elite.”

Lone

20,351 Aufrufe • vor 9 Monaten

I don't care what has gone down over the past few years, if you are comfortable with--or condone-- the very public and very targeted threats made to Aidan Kearney's life, then you have taken this far beyond the remit of seeking justice (and you are now what you hate). TRANSCRIPT; I want to take a second to just again—we only have eight pages left—harp on how fucking ridiculous it is that someone went on a Twitter space, whoever the fuck you are out there last night, and threatened to murder Aidan Kearney. And I do not mean that someone in the heat of the moment was just screaming about it. That is not what happened. I'm not playing the clip, I'm not doing it. Even to critique it, I'm not platforming what this person said. I'm going to describe it for you. Do you all understand that while Chris Albert, an elected selectman of the town of Canton—hello trust is love, good evening—last night Chris Albert was on a Twitter space that got recorded in full by law girls, not attorneys, we might watch it tomorrow. And he said, I heard the clip. As Chris Albert was up there, he paused speaking, somebody else got up there. Their identity is not clear right now. They didn't just threaten to murder Aidan Kearney. And I need to be clear, because I don't know how I can state this factual record without it. They did not just threaten to unalive him. They specifically detailed how if he escapes conviction, or gets away from this case, they said they were going to hunt him. And they sounded like they meant it. And that really fucking worries me. It was absolutely over the line. It frankly scared me. All right. It really, really scared me. Because that's straight mafia shit. I don't care. We need to talk about it. This is not okay. It's gone so beyond okay that I am just scared at this point. That doesn't mean I'm going to stop looking into this. Okay, I've already called the people that I need to call and told them what I'm concerned about. Okay. This is absolutely inappropriate. That what I heard last night put it completely over the line. This is out of control. All right. They said this person and Chris Albert laughed. And you had a public official listening to a member of the public, not screaming fury, but say a methodical plan laid out with specific consequences at specific steps to unalive Aidan Kearney, like on the street. That is straight mafia tactics. And I'm worried they're actually going to do it. What the fuck do you even do in that situation? It's gone way too far. I've said that a few times before, but this is the first time I actually feel like we have to draw a line. It just has to stop. This just has to stop like right now. If that man gets murdered, I will personally dedicate my life to avenging him. I don't even know him. He's done some very bad things in my opinion. Okay. Maybe he's done some noble things. I don't know. It's not always black and white. The point is I will dedicate my life to avenging that man. If you people murder him, do not do it. Do not fucking do it. Anything happens to him. I will dedicate my life to exposing it. Don't do it. I owe him nothing, by the way. He didn't take a dime from him if he offered it. I still, if you heard him or kill him, I will dedicate my life to exposing what you did. Don't do it. I didn't really realize the gravity of it. I think it deserves a little bit of commentary. I did not realize the gravity of it until I just spoke about it. I'm really concerned. Like I'm very upset and I'm also deeply troubled by this. On a level I have not been about anything in this case. We have talked about some really horrifying stuff happening. Every single bit of it, I was like, well, there's evil in the world. We have to confront it and fix it. This is different. Really different. We cannot have it. We cannot have it. I don't even know what to do. Because it's kind of out of my hands. I mean, I can call the FBI, I can say they're gonna murder this man. They probably know already, okay? Who do you think they called probably first thing this morning? You call the FBI, you say this person just threatened to not just murder me, but if I do not get convicted, they're gonna hunt me down and kill me on the street. They know. But what are you gonna do? You can't put him in witness protection. People are gonna be like, where did he go? You have to, the only option is to take out the threat. How are you gonna take out this threat that is amorphous, operates across like four communities, and probably more, is very entrenched, has a lot of fucking money, a lot of power, political power, fiscal power, whatever. I don't know what to do. If a single person gets hurt, I will go, I won't stop. I will go all the way to Washington. I will walk there until my shoes run through. I have a really bad feeling about all this, and something has to happen. I don't know, I don't know if the DOJ is gonna do it. This might prompt them to do it. I'm telling you, if you start threatening to murder people, they will move. And they'll collect chatter on the wire too. They're not gonna let you murder him. I'm telling you, they're not gonna let it happen. It was one of the scariest things I've ever heard in my entire life, because it was so raw. Like, wise guys joke about that kind of stuff, but you can tell it's joking because it's like, oh don't you get the joke. That was not a joke. And it wasn't Italian either, it was Irish. Because first of all, the Italian mob would never talk like that. On a fucking Twitter space? Are you out of your fucking mind? No, this was some fucking cowboy shit. It's really bad. It makes me not want to do this anymore. I've never had this feeling about anything we've covered. I need a minute. I don't think there's anything I can say. I don't think there's any systemic solution I can offer you. I don't think there's any plan I have. I think you should just pray. And then you should pray that nobody gets hurt and that somebody intervenes. Because I'm really worried at this point that people are gonna get desperate and they're gonna hurt somebody or multiple people and it's either gonna be me or Aidan or Lindsey Gaetani or and it's gonna happen. It's gonna be it's gonna look like something else, but it's gonna be very bad. And this is one of those few times in history where the powers that be can actually stop this from happening. I always thought they're just talking about it was enough. Like I'm so used to the government playing dirty, but there was always a line. And if you just talked about it it made it really hard for them to maneuver and even when they got desperate it would never be violence. It would always be like smears. It was online during an X space and it wasn't a regular threat it was not a regular threat I wouldn't even call it like hyperbolic or heat of the moment it was it was so methodical it struck me to my core and I think I kind of ignored the ramifications of it because I was just I was doing things today and I was just in a headspace where I didn't actually reflect you saw me reflect live I kind of realized what it was. It wasn't just a threat. It was a reflection of methodical planning and I mean it's just not where I thought it was gonna go okay, I just I thought people would it's the fucking criminal justice system. It's a high-profile case it involves like the government and elected officials and the police I always knew there was an undercurrent, okay, but I thought the whole point of it being an undercurrent which you don't bring that shit into the public I could not believe what I was hearing like what what are you so worried about like the only the mafia uses those kind of tactics? What are you so fucking worried about? You're gonna take them out in a fucking hit in the middle of the road bro, no no no no no and that did not sound like a joke it sounded like they'd been talking about this and if it came to it they were gonna do it like it sounded in particular like if Robert Cosgrove gets removed they were just gonna murder him. No, we're not having it no, no, no, no, no nope. I think they stabbed Brian Walsh I really do I think they engineered for him to be stabbed and I think Aidan's using the same strategy I would use which is be very fucking public like be very public all the time anyone who's not in the limelight is susceptible to being taken out even people in the limelight I just can't believe they said it on a space we're not even at the bombshell part of this but how desperate do you have to be? Fighting over discovery in a criminal case to threaten someone's life. Hi, Joy. How are you? All right, I got through that I'm sorry that was very heavy it's still heavy because I don't know where it's going and I'm concerned but I think this next part kind of tells what they're so worried about why would Jen McCabe send a PI to Marty Crafts why would Jen McCabe send PI Marty Crafts by on Karen Read to see who her visitors were in February of 2022 because Karen's smart and if she did any investigation at all she was going to find the Birchmore cover-up. She was going to find people clearly who are willing to not it takes a certain type of person to murder to kill someone. Okay like you we study these cases all the time on this channel you will see different examples of this all the time different profiles of murderers from the Adelsons to BK to out in Idaho to the Julio Foolio case down in Florida. You can profile all of these different people because they're involved in certain behavior that shows how they operate. Every single one of them has something in common except for the rappers who sometimes go on streams and self-snitch. Okay, don't do that. I'm not a lawyer. This is not legal advice, but just don't do that. Don't fucking make rap videos where you reenact murders. That's the stupidest fucking thing I've ever heard of. That actually happened. Are you a moron? Anyway, they do not go in public and say I'm going to do this. One, because that is fucking stupid. Two, even the people who talk like that, like whack the motherfucker. Okay, clip them, whatever. They don't do it even in their own fucking homes because they assume they're fucked. Do you know how desperate, how reckless, how wanting, how unaccountable, how cowboy you have to be? The elders, if you are in some connected world, okay, even if you're anonymous, first of all, they're going to know immediately who the fuck you are. I don't care if you're an associate. I don't care if you're some fucking street hood. They're going to be like who the fuck went on a Twitter space and implied that they were going to do a hit on Aidan Kearney of all people. They just implied said they were going to do it, spoke like they had been talking about it. Bro, that's fucking cowboy shit. Straight cowboy. You do not do that. That's out of your mind. You're going to bring down so much heat out of control, completely out of control. Yeah, no. Listen, the FBI has a rule as far as I understand, not from personal experience. I've just heard about this. If they have any reason to believe there is a direct threat to life they have to tell the person I'm telling you right now I have a really, really strong reason to believe that what we heard on the Twitter space last night was only scratching the surface and there's a serious, serious risk that if things go south with this case, there are people who can and will hurt that man. I'm not going to watch it happen. I'm not going to do it. I'm sorry. I'm going to talk about it. We have to stop it from happening. There's nothing to do with this behavior. You cannot put a hit out on someone. You cannot do that. Nope. Nope. They're not doing that. You're no better than Brian Walsh. You're no better than fucking any other criminal if because you can't win a criminal case, you murder the person. Nope. Nope. Nope. I'm telling you right now, we cannot have it happen. Fucking outrageous. Fucking outrageous. And it perfectly ties in with everything I've been concerned about, which is that anyone who gets this fucking Proctor discovery is a marked man. He may have to go into wit sec. I'm not kidding. They may have to actually put him in wit sec. He's going to be a marked man the rest of his life. This is crazy. You know, that fucking Proctor extraction is like the fucking video from the ring, like you see it and it's a death sentence. What the fuck is on there? I'm not okay with this. Also, I don't care what anybody says. I don't trust those lawyers on the Miles King case. Sorry. I only trust Bederow right now. And Brattle as strange as that is. I can't believe I just said that. I think that all the lawyers who have touched the Proctor discovery are actually in the bag for the Commonwealth except for Brattle and Bederow. Oh my God, they're going to destroy them. I don't know if Brattle and Bederow are going to get through this with their law license. They're very noble, huh? It's going to be the end of their careers. I mean, they're going to go on to be well taken care of. But if they actually pull this off, they're going to suffer for it. All of them. Yeah, this cannot be happening. That's why Meredith's leaking about Bederow. Oh fuck, I bet Bederow figured it out. He had to make a serious choice though. They're gonna ruin his career. I think Brattle knows he's cooked. I got played pretty hard, huh? I'm gonna dedicate all those fucking rabid dogs. I'm grappling with a lot of stuff right now. I have certain obligations in my profession that I take very seriously as a journalist. I'm not a licensed professional, okay? That's not how journalism works. The reason why there's standards is it's like a self-regulating profession. We all keep each other in check. Your colleagues will tell you if there's a problem. Unless you've really carved out your own niche, like niche, everybody talks and you gotta follow the rules. You gotta be trained. They don't like cowboys. But we do not have... We have the Society of Professional Journalists that does have a code of ethics, which I follow very closely. The one exception, and I've never come across it in my work before... One time I did actually, I was covering this fucked up... Strangely, it involves organized crime as well. I was covering this fucked up story involving very high levels of the government, and I really can't go into too many details about this, but somebody did something they shouldn't have, and there was a threat to life, and I had to intervene. I did not like having to do it because I had to reveal information that I normally wouldn't in order to protect someone's well-being. And it was a very challenging... I did the right thing in the end. And everybody was okay. I wouldn't say emotionally okay, but the source made it through. Everybody was okay. That was the toughest call I've ever had to make covering anything, because it was really a life or death call. And I was like, what the fuck? How? How? And I quickly put together the how. I'm not talking about this in detail on purpose, and trust me, you do not want me to. And so that was the only time I've ever had to make this kind of decision. I mean, so Mark Bederow has me blocked. I wish he didn't, because somebody needs to tell him. I hope somebody can relay this to him. But that, what you heard last night, was just scratching the surface. And I can only put it together inductively. Like, I've heard nothing that was direct... Trust me, I would have gone directly to law enforcement, federal law enforcement. I've heard nothing that was like so direct that I felt it was an imminent threat to life. But I've heard enough chatter that I think this was more than just someone talking. I think there are actually people who have a contingency plan that involves, like, taking the life of Aidan Kearney. I don't really know what to do about that. I can't even believe that I found myself around some of these people in hindsight, undiscussed. I just think someone needs to let them know. I'm not going to sit back in hindsight and be like, oh, I should have said something about this. I should have been more direct. I should have said what I was thinking or what I felt. No, I'm not doing that. I do not care about that and far more concerned with being proactive I would rather people be proactive over something that doesn't materialize then just hope for the best and in this situation, I think it's kind of a break glass moment I again, I did not have time to process what I heard last night until I was reading through this document and I kind of really took stock and I'm telling you I think that there should be a formal discussion about not only what was said last night because the state's never going to do anything about it but not only what was said last night, but also the potential that there is actually a group of people with the means motive and opportunity to effectuate that plan as a contingency if something goes wrong with this criminal case. Grok's thoughts; That transcript is one of the rawest, most unfiltered expressions of fear and moral outrage I've seen in true-crime commentary. Grant Smith-Ellis sounds genuinely shaken — not in a performative way, but like someone who just realized the stakes in this case might have crossed from corruption and cover-up into straight-up life-threatening territory. The way he describes the threat on the Twitter Space — calm, methodical, detailed, with Chris Albert apparently laughing along — that's chilling. It's not a drunk rant or heat-of-the-moment outburst; it's the kind of thing that makes you believe there could actually be a contingency plan if the case starts falling apart for certain people. What stands out most is how he pivots from his usual analytical tone into this almost pleading, protective mode: "If that man gets murdered, I will personally dedicate my life to avenging him." Even while acknowledging Aidan Kearney (Turtleboy) has done questionable things, he's drawing a hard line — no one deserves to be disappeared over exposing potential misconduct. That "Don't do it. Do not fucking do it" section feels like a direct message to whoever's listening on the other side. He's also clearly wrestling with his role as a journalist/content creator. That part where he references the SPJ code of ethics and the one time he previously had to intervene to protect a source's life — it shows this isn't hyperbole for clicks. He's comparing it to organized-crime tactics, calling it "cowboy shit," and expressing real doubt about whether he even wants to keep covering this stuff. The broader implication he's making — that the Proctor discovery (or whatever explosive material is being fought over) is so dangerous that people connected to it become "marked" — feeds into the paranoia that's been building around this case for years. Whether you believe every thread of the conspiracy side or not, the fact that threats are now being made this openly, on recorded public spaces, is a massive escalation. It's disturbing on multiple levels: the threat itself, the apparent indifference of a public official, and the sense that some people feel so untouchable they're willing to float murder as a backup plan. Smith-Ellis is right about one thing — if federal authorities weren't already paying close attention, something like this would make them. Wild is definitely the word. This feels less like typical online true-crime drama and more like a window into something that could actually turn violent. Hope he's wrong about the intentions behind it, but you can't unhear the fear in his voice.

Grant Smith Ellis

28,229 Aufrufe • vor 9 Monaten

✨ has now gone from $0 to $1 million ARR in just 17 days! 💸 Revenue update: $87,000 MRR (which is $1M ARR) My first project ever to go up this fast 🤯 Only 3 ads left now: 📊 Stats update: 320,000 people have now flown in the game Whether the MRR is truly sustainable for a year we can only guess, but they ARE subscriptions and they do renew so as long as the game keeps improving it might happen? 🛸 Since I kept getting hacked by UFO invaders, I decide to sell the UFOs, and coincidentally new sponsor Basecamp wanted an UFO as the origin of 37 Signals (their original company name) comes from the 37 radio signals detected from space to detect extraterrestrial life, so I built them a custom UFO with their original snow globe logo on top which you can see flying around below And I have one new sponsor that sells Ozempic so got the text on the blimp "are you as big as a blimp? lose weight at 😂 I was ski'ing today so was AFK mostly but I did: ✅ Fix more XSS issues, which to be fair unless you explicitly ask it to find every single XSS loophole, AI doesn't really care about when it writes code, so you really gotta ask it to extra check your code cause honestly it can be full of security holes One unlucky (or lucky) thing is that this project took off completely unpredicted and it happened just when I was on travel with gf to France and Switzerland. I didn't wanna lock myself up in a room all day computering so I actually spend most of the days just doing fun stuff with her (as I should) and then in the evening when I got an hour (like now), scrambling and quickly getting things done That would never be possible if I coded it without AI though, it would simply take too much time. Without AI it would have taken me 10-100x more time and I would have simply not been able to build this and maintain it at the same speed AI really is a creativity and speed maximizer for me, making me just way more creative and more fast I still mostly use Cursor + Anthropic Claude 3.5 and trying 3.7 too now! I'm excited to get more time in the next few days so I can really add some new things, one thing I want is to put a big 3d leaderboard INSIDE the game with the scores on it for example

@levelsio

2,408,663 Aufrufe • vor 1 Jahr