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Our latest work on structures of translation initiation complexes trapped by natural product inhibitors kasugamycin, edeine and GE81112 is out in the Biorxiv…

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WilsonLab

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13,068 görüntüleme • 1 yıl önce •via X (Twitter)

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WilsonLab1 yıl önce

Great collaboration with Milon group @pmilonma at @UPCedu spearheaded by talented PhD student in the lab @HaarisAhsan with help from @MartinoMorici and @anisancas and special thanks to @CssbHamburg for amazing cryoEM data!!

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At higher resolution, we reveal binding sites for edeine and GE81112 on the 30S that differ from previous studies…

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WilsonLab1 yıl önce

While kasugmycin and edeine trap early pre-initiation complexes (PIC), we observe that GE81112 stabilizes a late PIC with closed head, accommodated initiator-tRNA but prior to IF3 release.

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Collectively we show how three distinct compounds can bind within the E-site of the 30S to inhibit different stages of translation initiation

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Tremendous efforts! Congrats to such an amazing team!

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Thanks Victor!

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Ahmad Jomaa1 yıl önce

Great work, @WilsonLab2 , and team!

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WilsonLab1 yıl önce

Thanks Ahmad!!

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