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Patrick Collison on what changes when biology becomes programmable: "We, humanity, have never cured a complex disease." "Most cardiovascular disease, most cancers, most autoimmune disease, most neurodegenerative disease... For none of them can we really say that we've cured it, that we understand the causal pathways in meaningful detail."... show more

a16z

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119,898 views • 4 months ago •via X (Twitter)

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Patrick Collison says humanity has never cured a complex disease. Not cancer. Not Alzheimer’s. Not Type 1 diabetes. His Arc Institute is trying something new: Simulate biology with AI. Test interventions before touching the body. Build a virtual cell. Test hypotheses in code. If it works, biology becomes computable.

Patrick Collison says humanity has never cured a complex disease. Not cancer. Not Alzheimer’s. Not Type 1 diabetes. His Arc Institute is trying something new: Simulate biology with AI. Test interventions before touching the body. Build a virtual cell. Test hypotheses in code. If it works, biology becomes computable.

vitrupo

1,095,973 views • 1 year ago

The hundreds of millions of people with autoimmune disease may get more clarity in this 80-second video than they’ve gotten from years of doctor visits. Gary Brecka flipped the narrative and asked: “What if God didn’t make a mistake?” “What if the immune system is actually acting properly,” and it’s attacking the body for a reason, but you just have to figure it out? He argues that, in most cases, you can trace the root cause of autoimmune disease back to four broad categories: • mold and mycotoxins • heavy metals • viruses • and parasites. According to Brecka, if you systematically eliminate those four drivers, you’ll discover that your autoimmune disease begins to resolve because the immune system no longer has a reason to attack. Like Brecka, A Midwestern Doctor has spent years uncovering what’s really driving autoimmune disease. If you or someone you love is suffering, don’t skip this 5-minute read. It goes deeper into what Brecka just laid out. 🧵

The hundreds of millions of people with autoimmune disease may get more clarity in this 80-second video than they’ve gotten from years of doctor visits. Gary Brecka flipped the narrative and asked: “What if God didn’t make a mistake?” “What if the immune system is actually acting properly,” and it’s attacking the body for a reason, but you just have to figure it out? He argues that, in most cases, you can trace the root cause of autoimmune disease back to four broad categories: • mold and mycotoxins • heavy metals • viruses • and parasites. According to Brecka, if you systematically eliminate those four drivers, you’ll discover that your autoimmune disease begins to resolve because the immune system no longer has a reason to attack. Like Brecka, A Midwestern Doctor has spent years uncovering what’s really driving autoimmune disease. If you or someone you love is suffering, don’t skip this 5-minute read. It goes deeper into what Brecka just laid out. 🧵

The Vigilant Fox 🦊

534,618 views • 4 months ago

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Jan Jekielek

170,003 views • 4 months ago

After relapsing on the only drug in development for my rare disease, my doctors told me ‘We’ve tried everything, there’s nothing more that we can do.’ To make things worse, I didn’t have a billion dollars and 10 years to develop a new drug from scratch. My only hope was to find a drug that was already FDA-approved that I could repurpose for my disease. It’s been over 9.5 years that I’ve been in remission and we have been able to identify and advance numerous treatments for diseases they weren’t initially intended for. Now through Every Cure we are utilizing artificial intelligence to maximize the potential of all existing drugs to treat every disease they possibly can. What rare disease would you like to find a repurposed drug to treat? #MedTwitter

After relapsing on the only drug in development for my rare disease, my doctors told me ‘We’ve tried everything, there’s nothing more that we can do.’ To make things worse, I didn’t have a billion dollars and 10 years to develop a new drug from scratch. My only hope was to find a drug that was already FDA-approved that I could repurpose for my disease. It’s been over 9.5 years that I’ve been in remission and we have been able to identify and advance numerous treatments for diseases they weren’t initially intended for. Now through Every Cure we are utilizing artificial intelligence to maximize the potential of all existing drugs to treat every disease they possibly can. What rare disease would you like to find a repurposed drug to treat? #MedTwitter

David Fajgenbaum, MD

138,664 views • 2 years ago

Here’s a sneak peek from episode # 252 of The Drive with Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick). In this clip, Rhonda explains why exercise is one of the most powerful tools we have to prevent chronic disease. This episode will be released on Monday (5/1).

Here’s a sneak peek from episode # 252 of The Drive with Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick). In this clip, Rhonda explains why exercise is one of the most powerful tools we have to prevent chronic disease. This episode will be released on Monday (5/1).

Peter Attia

155,237 views • 3 years ago

Tell that to the people cured of Parkinson’s disease with vitamin B1.

Tell that to the people cured of Parkinson’s disease with vitamin B1.

J͎Λ͎Y͎

106,697 views • 7 months ago

Chanhyuk: Company doesn’t matter, but it’s about the people you work with. “There’s also something like this. Even though we say we created a “company,” we just used that word because it’s easier for people to understand. But in the end, it’s not really about the company, it’s about the people. Like, who you work with. And what kind of experiences you share with them, that’s what really matters the most. So with these people, whether we go, volunteering or travel somewhere, we always move together as one group. Because if not and later on, when I write and release a song, if we hadn’t shared those experiences, I’d have to explain everything. Like, “I went somewhere and had this kind of experience…” But since we’ve all lived it together, I can just say, “Hey, I wrote this kind of song this time,” and they’ll be like, “Oh, yeah, I get it. I know exactly what that is.” It just makes everything so much faster, right?”

Chanhyuk: Company doesn’t matter, but it’s about the people you work with. “There’s also something like this. Even though we say we created a “company,” we just used that word because it’s easier for people to understand. But in the end, it’s not really about the company, it’s about the people. Like, who you work with. And what kind of experiences you share with them, that’s what really matters the most. So with these people, whether we go, volunteering or travel somewhere, we always move together as one group. Because if not and later on, when I write and release a song, if we hadn’t shared those experiences, I’d have to explain everything. Like, “I went somewhere and had this kind of experience…” But since we’ve all lived it together, I can just say, “Hey, I wrote this kind of song this time,” and they’ll be like, “Oh, yeah, I get it. I know exactly what that is.” It just makes everything so much faster, right?”

akmerch ⚔️

194,013 views • 2 months ago

Marc Andreessen says in the future, we may not have programming languages or even user interfaces: "I kind of think that in 10 years, I'm not sure there will even be a salient concept of a programming language in the way that we understand it today." "If you project forward, you have to think forward to a world in which it's just—I'm going to tell the thing what I need, and it's going to do it in whatever way is most optimal." Marc Andreessen 🇺🇸 with Latent.Space

Marc Andreessen says in the future, we may not have programming languages or even user interfaces: "I kind of think that in 10 years, I'm not sure there will even be a salient concept of a programming language in the way that we understand it today." "If you project forward, you have to think forward to a world in which it's just—I'm going to tell the thing what I need, and it's going to do it in whatever way is most optimal." Marc Andreessen 🇺🇸 with Latent.Space

a16z

65,549 views • 2 months ago

Cursor CEO Michael Truell: Programming in the future might not mean programming with an AI helper, but in a new language entirely. "There is a future version of the world where the way you interact with AI is a little bit less like it's a human helper that you're delegating work to... and instead, it's a little bit more of an advance in compiler or interpreter technology." "It can lead you to a world where programming languages actually change. They can start to be a little bit more about what you want and a little bit less about how you do it." "There is a world where direct manipulation of the UI starts to play a little bit more into it." Michael Truell with Patrick Collison

Cursor CEO Michael Truell: Programming in the future might not mean programming with an AI helper, but in a new language entirely. "There is a future version of the world where the way you interact with AI is a little bit less like it's a human helper that you're delegating work to... and instead, it's a little bit more of an advance in compiler or interpreter technology." "It can lead you to a world where programming languages actually change. They can start to be a little bit more about what you want and a little bit less about how you do it." "There is a world where direct manipulation of the UI starts to play a little bit more into it." Michael Truell with Patrick Collison

a16z

92,483 views • 4 months ago

Studies have shown that when a woman starts estrogen (or estrogen + progesterone) within 10 years of the onset of menopause, there is a ~25-50% reduction in fatal heart attacks and cardiovascular disease. That's enormously significant, given that heart disease is the leading cause of death in women.

Studies have shown that when a woman starts estrogen (or estrogen + progesterone) within 10 years of the onset of menopause, there is a ~25-50% reduction in fatal heart attacks and cardiovascular disease. That's enormously significant, given that heart disease is the leading cause of death in women.

Dr. Marty Makary

317,422 views • 11 months ago

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

OzSingleCell Omics

19,797 views • 3 years ago

NEW - Zuckerberg and his wife expand their existing Biohub initiative with AI-powered biology to cure or prevent disease, "The next decade is going to be really exciting, and we think that some of humanity's biggest dreams are finally coming within reach."

NEW - Zuckerberg and his wife expand their existing Biohub initiative with AI-powered biology to cure or prevent disease, "The next decade is going to be really exciting, and we think that some of humanity's biggest dreams are finally coming within reach."

Disclose.tv

179,586 views • 7 months ago

Platner: I think that if we are going to have a politics that is going to be representative of regular people, if we are going to have a politics that's going to allow us to move past the polarization and frankly, the division that we find ourselves in, we really need to understand that people are capable of changing. We need to we need to keep hope alive, that people that we may disagree with today, that we can find common ground with. Like if you listen to what I've been saying on the campaign trail across the state, that's what I'm trying to talk about. It is important to me that we realize that most of us, most Americans, have far more in common than we think we do, and we need to give each other grace, and we need to give each other space to grow and to evolve. Because if we can't do that, then I'm not really sure what the purpose of any of this is.

Platner: I think that if we are going to have a politics that is going to be representative of regular people, if we are going to have a politics that's going to allow us to move past the polarization and frankly, the division that we find ourselves in, we really need to understand that people are capable of changing. We need to we need to keep hope alive, that people that we may disagree with today, that we can find common ground with. Like if you listen to what I've been saying on the campaign trail across the state, that's what I'm trying to talk about. It is important to me that we realize that most of us, most Americans, have far more in common than we think we do, and we need to give each other grace, and we need to give each other space to grow and to evolve. Because if we can't do that, then I'm not really sure what the purpose of any of this is.

Acyn

147,957 views • 8 months ago

Herasight advisor and genetics professor Alex Strudwick Young says that in the future, we may be able to create gametes from non-gamete adult cells and stack that with gene editing to remove disease-causing variants: "In vitro gametogenesis is a technology to create gametes — so sperm and eggs, eggs is what would be more useful generally — from adult cells that are not gamete cells." "That could potentially create thousands of embryos." "Then there's also gene editing. You can use CRISPR or a technology like that to go into an embryo and edit particular base pairs, remove some disease-causing variant, or maybe more controversially enhance some ability." "My idea for the future of this space could be that you have a stack, where you have in vitro gametogenesis that creates thousands of embryos. Then you can get the genome data, do the predictions of the disease risks and traits from that, select a few promising embryos, and then do some edits in them."

Herasight advisor and genetics professor Alex Strudwick Young says that in the future, we may be able to create gametes from non-gamete adult cells and stack that with gene editing to remove disease-causing variants: "In vitro gametogenesis is a technology to create gametes — so sperm and eggs, eggs is what would be more useful generally — from adult cells that are not gamete cells." "That could potentially create thousands of embryos." "Then there's also gene editing. You can use CRISPR or a technology like that to go into an embryo and edit particular base pairs, remove some disease-causing variant, or maybe more controversially enhance some ability." "My idea for the future of this space could be that you have a stack, where you have in vitro gametogenesis that creates thousands of embryos. Then you can get the genome data, do the predictions of the disease risks and traits from that, select a few promising embryos, and then do some edits in them."

TBPN

21,617 views • 2 months ago

RFK Jr. says HHS is working to find a cure for Alpha Gal. The tick disease that can make you allergic to red meat for life. “One bite from a lone star tick, and you could have a lifetime allergy to red meat.” “50% of the population of Martha’s Vineyard now has alpha gal.” “We’re also working on medicines that can prevent Alpha Gal and have the promise of actually curing it.” “One of those medicines is almost ready.” “We’re fast tracking it.” “We’re doing the studies over the next two years to see if we can actually reverse this devastating disease.”

RFK Jr. says HHS is working to find a cure for Alpha Gal. The tick disease that can make you allergic to red meat for life. “One bite from a lone star tick, and you could have a lifetime allergy to red meat.” “50% of the population of Martha’s Vineyard now has alpha gal.” “We’re also working on medicines that can prevent Alpha Gal and have the promise of actually curing it.” “One of those medicines is almost ready.” “We’re fast tracking it.” “We’re doing the studies over the next two years to see if we can actually reverse this devastating disease.”

End Tribalism in Politics

1,286,565 views • 1 month ago

#WorldMNDAwarenessDay We have to change the story of MND. Today is about shining a light on all the people and families affected by Motor Neurone Disease. It is currently untreatable, and considered a terminal illness, the stats will tell you that over half of people die within 2 years of diagnosis. This disease strips you of absolutely everything, and rewrites your story for you in the worst imaginable way. We have to find a way to treat it, and improve the lives of everyone stories it’s ruined.

#WorldMNDAwarenessDay We have to change the story of MND. Today is about shining a light on all the people and families affected by Motor Neurone Disease. It is currently untreatable, and considered a terminal illness, the stats will tell you that over half of people die within 2 years of diagnosis. This disease strips you of absolutely everything, and rewrites your story for you in the worst imaginable way. We have to find a way to treat it, and improve the lives of everyone stories it’s ruined.

Ed Slater

77,565 views • 2 years ago

Michael Truell says we're still early in automating software: "It's really easy at an executive level to underestimate just how far away we are from the limit of automating software." "I think that there's a really, really long way to go. There's a really long, messy middle." "We are in a market that's had an iPod moment, and it's going to have an iPhone moment and another iPhone moment. And I think that there have been a couple of those so far. I think that there are definitely more in the future." Michael Truell with martin_casado

Michael Truell says we're still early in automating software: "It's really easy at an executive level to underestimate just how far away we are from the limit of automating software." "I think that there's a really, really long way to go. There's a really long, messy middle." "We are in a market that's had an iPod moment, and it's going to have an iPhone moment and another iPhone moment. And I think that there have been a couple of those so far. I think that there are definitely more in the future." Michael Truell with martin_casado

a16z

55,613 views • 15 days ago