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🚨 Postdoc position in my lab Calico is live! I'm looking for someone deeply curious about the aging brain🧠⌛️, who wants to build novel scientific projects from scratch and carry them to publication and, ideally, into their own lab🥼🧪. No neuroscience background needed.

Oliver Hahn

2,064 subscribers

32,228 次观看 • 5 个月前 •via X (Twitter)

教育科学技术

Anya Rossi• Live Now

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My friends, I would like to report a true breakthrough in my life and career - the nomination of our 31st developmental candidate that is very special. Novel Mechanism, Novel Target, Novel Oral Brain-penetrant Multi-parameter Optimized Molecule for... Pain. The target is undisclosed and carries the first letter of my family name - Target Z. This is also our AI Eureka! Moment - the combination of Luck, AI, and curious human experts. I will post the press release and my blog story behind this drug separately but for this special moment, I recorded the video for you. My goal is to solve aging. But if in the process we solve pain - this life was also worth living. The beauty of Target Z is that it is also implicated in aging (and no, it is not our brain-penetrant NLRP3).

My friends, I would like to report a true breakthrough in my life and career - the nomination of our 31st developmental candidate that is very special. Novel Mechanism, Novel Target, Novel Oral Brain-penetrant Multi-parameter Optimized Molecule for... Pain. The target is undisclosed and carries the first letter of my family name - Target Z. This is also our AI Eureka! Moment - the combination of Luck, AI, and curious human experts. I will post the press release and my blog story behind this drug separately but for this special moment, I recorded the video for you. My goal is to solve aging. But if in the process we solve pain - this life was also worth living. The beauty of Target Z is that it is also implicated in aging (and no, it is not our brain-penetrant NLRP3).

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TRADE SCHOOLS ARE WHERE THE MONEY WILL BE IN THE FUTURE. Did you know plumbers and electricians who go on to own their own businesses make more than lawyers and doctors? The DOD is looking for 600,000 electricians and welders right now, and they don't exist. These are needed just to maintain the military equipment - not to build new equipment.

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🚨 RAND PAUL AFTER EXPLOSIVE COVID HEARING: “There was a scientific consensus at the CIA that the virus came out of the lab.” Following today’s Senate hearing, Senator Rand Paul alleged that Dr. Anthony intervened in 2021 and pressured CIA leadership to reverse internal conclusions pointing toward a Wuhan lab leak. “After Anthony Fauci came in, he influenced their higher-ups to overturn the idea that it came from the lab.” Paul says the investigation is FAR from over: “There’s more news to come.” Meanwhile, whistleblower attorney Carol Thompson warned there is ongoing “obstruction” inside intelligence agencies and admitted her client fears retaliation for testifying publicly.

🚨 RAND PAUL AFTER EXPLOSIVE COVID HEARING: “There was a scientific consensus at the CIA that the virus came out of the lab.” Following today’s Senate hearing, Senator Rand Paul alleged that Dr. Anthony intervened in 2021 and pressured CIA leadership to reverse internal conclusions pointing toward a Wuhan lab leak. “After Anthony Fauci came in, he influenced their higher-ups to overturn the idea that it came from the lab.” Paul says the investigation is FAR from over: “There’s more news to come.” Meanwhile, whistleblower attorney Carol Thompson warned there is ongoing “obstruction” inside intelligence agencies and admitted her client fears retaliation for testifying publicly.

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🚨 BREAKING: Democrat Pima County AZ Sheriff Chris Nanos is facing calls to RESIGN because he's STONEWALLING the FBI from key Nancy Guthrie evidence This is insane. "The FBI wanted to send DNA and a glove found inside the house to their lab at Quantico Virginia for testing. The sheriff here, the Pima County Sheriff, insisted instead on sending it to a private lab that is based in Florida!" "Now obviously you would think that there is nowhere better in the country, never even in the world, than the FBI's lab in Quantico for that kind of testing." "The Guthrie family hoping tonight that the infighting stops and finding Nancy Guthrie really gets underway here, because that is what the Guthrie family wants to hear. Not the people are fighting about who has jurisdiction, but what they're doing to find Nancy Guthrie."

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For anyone who wants to build a startup or get into Y Combinator, this video is a no-bullshit guide packed with some of the best insights you’ll hear. 📽️- Sameer Sadana speaks straight up about how to "build from what you have" and shares key lessons from his journey, From college experiments to getting into YC.

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Automating the lab bench is the best thing we can do for AI in biology. Most experiments are still run by hand. Every biologist's handiwork is unique and every lab is a little different. So, biology faces widespread reproducibility issues. But, AI will demand more reproducible data than we can produce, and generate more ideas than we can test. Experiments must be communicated and executed in a standardized way to generate reproducible data. So, Tetsuwan is building a lab where users specify experiments in an exact syntax. These experiments are executed by an automated platform to generate transparent, reproducible output. The user never needs physical access to a lab. This is a biology lab you can use like a computer. Our platform, built and tested with pilot labs over the past two years, lets users configure automated workflows rapidly & precisely. Later this year, we will bring our first services online, focusing on functional screens for protein design. Alex and I met at Caltech, where she was one year my senior. We're building this company because we were little kids who wanted to be biologists that grew up into adults who resented the lab bench. We want biology to be about asking questions, not the painful and frustrating manual process of asking them. For those looking to receive updates on our pilot services, looking for a meaningful job, or just to learn more about our work, see the links in the comments!

Automating the lab bench is the best thing we can do for AI in biology. Most experiments are still run by hand. Every biologist's handiwork is unique and every lab is a little different. So, biology faces widespread reproducibility issues. But, AI will demand more reproducible data than we can produce, and generate more ideas than we can test. Experiments must be communicated and executed in a standardized way to generate reproducible data. So, Tetsuwan is building a lab where users specify experiments in an exact syntax. These experiments are executed by an automated platform to generate transparent, reproducible output. The user never needs physical access to a lab. This is a biology lab you can use like a computer. Our platform, built and tested with pilot labs over the past two years, lets users configure automated workflows rapidly & precisely. Later this year, we will bring our first services online, focusing on functional screens for protein design. Alex and I met at Caltech, where she was one year my senior. We're building this company because we were little kids who wanted to be biologists that grew up into adults who resented the lab bench. We want biology to be about asking questions, not the painful and frustrating manual process of asking them. For those looking to receive updates on our pilot services, looking for a meaningful job, or just to learn more about our work, see the links in the comments!

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This “black” woman says she “wants out of the UK” because she feels “undervalued, overworked, and overlooked.” What about our own people who are second class citizens in their own country, having to pay for people like them to come here and moan about how shit it is? Always the race baiting victims

This “black” woman says she “wants out of the UK” because she feels “undervalued, overworked, and overlooked.” What about our own people who are second class citizens in their own country, having to pay for people like them to come here and moan about how shit it is? Always the race baiting victims

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Lady in blue, "And homes. Let's be honest. Most of the time we're talking about flats" "We're not talking about houses where people can grow into" "I see families in these tiny little flats who feel so happy they own their own home but they haven't got room to enjoy their home" "Are we actually going to build houses for people to live in and enjoy. Are they going to be affordable?"

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Sensitive content

Hi, this is my part of my story attached. I’m looking for donations to move abroad for my own safety and to be able to finally live with my son who lives abroad to stop social services taking him. They took my daughter when I spoke out about being a victim of Pakistani grooming gangs who raped me from 12yrs old. So I had my son abroad to stop them taking him also and for his own protection away from the rape gangs who also got me pregnant at 13 with my eldest son. I have to pay for everything for my 4yr old son, like school, food, clothing and medical bills. This is my story I constantly have to move because I'm found, I’ve had to move 15/16 times in 7/8yrs because I’m constantly found by the men who raped me from 12yrs old. If you’re in a position to help support me and my son we would be very grateful. Thank you 💗 please retweet

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Asked about the differences between her and Adriano Espaillat, Darializa Avila Chevalier, winner of the Democratic primary for New York’s 13th Congressional District, told NY1’s Errol Louis (@errollouis.bsky.social) that she is a working-class candidate that wants to build a government responsive to the people. She said she wants to make sure people know "their representative isn’t someone who just goes away to Washington and shuts the door behind them, but props the door open and leaves it open for them."

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The Deputy Chairman of the Russian Security Council Dmitry Medvedev: There's absolutely no need for mobilization [in Russia]. This is a lie made up by the enemy, who itself is suffering from a manpower shortage; there's simply no one left to fight, and they're rounding up their own citizens like pigs, beating them, and throwing them into buses.

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🚨 THEY'RE MAKING LAB-GROWN CHOCOLATE BY GENETICALLY MODIFYING THE WORLD'S COCOA TREES — AND PEOPLE ARE LOSING IT Lab grown chocolate is coming to shelves in 2027. Oreo, Cadbury, and Toblerone are already funding it because a lab is cheaper than a farm. But what Mars is doing is on another level. Mars is using CRISPR to gene edit cocoa trees in the real world, not just in a tank. Cocoa is a cross-pollinating perennial that releases pollen for 25–40 years. Once a gene edited tree flowers, the edited pollen spreads through insects and wind into the regional gene pool. In Ghana and Côte d’Ivoire (where ~2/3 of the world’s cocoa is grown), small farmers routinely plant seedlings from their own trees. This means edited genes could escape into nature and contaminate the entire global cocoa supply. They’re not just making chocolate in a lab. They’re playing God with the entire crop. How the hell did Mars get the right to permanently alter the genetics of the world's cocoa forever without asking any of us?

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If someone is in the United States preaching about destroying the American system and they aren't from the United States, they should deported as soon as possible. Why would our country host and provide opportunities for someone who wants to destroy it? Thats like inviting cancer into your body and nurturing it.

If someone is in the United States preaching about destroying the American system and they aren't from the United States, they should deported as soon as possible. Why would our country host and provide opportunities for someone who wants to destroy it? Thats like inviting cancer into your body and nurturing it.

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