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Prime editing has continuously improved since David R. Liu's lab introduced it in 2019. 3 new studies from his lab advance prime editing systems, addressing key bottlenecks by increasing the efficiency and improving its potency when delivered into the body.

Broad Institute

100,569 subscribers

23,414 Aufrufe • vor 3 Monaten •via X (Twitter)

Anya Rossi• Live Now

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3 Kommentare

Profilbild von Om Prakash

Om Prakashvor 3 Monaten

@davidrliu Prime editing is one of the best discovery in biology!

Profilbild von GreenDoc Gwen

GreenDoc Gwenvor 3 Monaten

@davidrliu Solid advances on pegRNA motifs and LNP packaging. Curious whether the AI-designed RT variants hold up across different tissue targets, or if liver tropism is doing most of the heavy lifting.

Profilbild von Jason傑森 🇭🇰 | 🛠️

Jason傑森 🇭🇰 | 🛠️vor 3 Monaten

@davidrliu 居然又進步了

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IMO the most important scientific event this week was the publication of David R. Liu’s new Nature article 🧵👇in which he presented a new and promising Gene Editing modality named PERT - Prime Editing-mediated Readthrough of premature termination codons. This new modality - which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons, could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! Here is an excellent lecture by Prof. David Liu - one of the most important scientists and innovators of our lifetime and the person who invented both Base editing and Prime editing - the 2 top leading modalities of Gene Editing, in which he throughly explains this huge scientific breakthrough. $PRME $BEAM

IMO the most important scientific event this week was the publication of David R. Liu’s new Nature article 🧵👇in which he presented a new and promising Gene Editing modality named PERT - Prime Editing-mediated Readthrough of premature termination codons. This new modality - which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons, could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! Here is an excellent lecture by Prof. David Liu - one of the most important scientists and innovators of our lifetime and the person who invented both Base editing and Prime editing - the 2 top leading modalities of Gene Editing, in which he throughly explains this huge scientific breakthrough. $PRME $BEAM

Yair Einhorn

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I would strongly advise every American leader and policymaker to listen carefully to David R. Liu - the most important scientist and innovator of our lifetime and the person who invented both Base editing & Prime editing - the 2 top leading modalities of Gene editing, when he describes in 60 Minutes the grave danger which the American BioTech ecosystem is facing due to insufficient federal funding. America is already losing its technological and innovative edge! $BEAM $PRME

I would strongly advise every American leader and policymaker to listen carefully to David R. Liu - the most important scientist and innovator of our lifetime and the person who invented both Base editing & Prime editing - the 2 top leading modalities of Gene editing, when he describes in 60 Minutes the grave danger which the American BioTech ecosystem is facing due to insufficient federal funding. America is already losing its technological and innovative edge! $BEAM $PRME

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It is amazing to see the remarkable advancement that has been already achieved in the Gene Editing field - specifically in Base Editing $BEAM and Prime Editing $PRME 🧵👇. It seems that the words of Prof David R. Liu - the inventor of both of these groundbreaking modalities, about their huge potential to change the lives and to cure some of the hardest medical conditions have never been more true. This is a huge step forward which provides hope to so many patients and their families. Godspeed!

It is amazing to see the remarkable advancement that has been already achieved in the Gene Editing field - specifically in Base Editing $BEAM and Prime Editing $PRME 🧵👇. It seems that the words of Prof David R. Liu - the inventor of both of these groundbreaking modalities, about their huge potential to change the lives and to cure some of the hardest medical conditions have never been more true. This is a huge step forward which provides hope to so many patients and their families. Godspeed!

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862,408 Aufrufe • vor 1 Jahr

Mr. Ajay Banga, President, World Bank Group (WBG) calls on Prime Minister Muhammad Shehbaz Sharif Pakistan acknowledges the World Bank Group’s valuable support which has been instrumental in advancing Pakistan's economic development and reforms. Prime Minister Mr. Ajay Banga, President, World Bank Group (WBG) calls on Prime Minister Muhammad Shehbaz Sharif in Islamabad today. Prime Minister welcomed Mr. Ajay Banga at his first official visit as President of the World Bank Group. The Prime Minister appreciated the World Bank Group for its long-standing partnership with Pakistan and its commitment to supporting the development priorities of the country especially through the 10-year World Bank Group Country Partnership Framework (CPF). The Premier also appreciated Mr.Banga's leadership in transforming the World Bank Group into more impactful development partner. Prime Minister stated that Government of Pakistan is vigorously working on economic reform agenda with multi-pronged comprehensive structural home grown program aimed at sustainable economic stability. The Prime Minister appreciated the support of the World Bank Group in resilient infrastructure, agribusiness, digital development, energy, human capital, fiscal reforms, and increasing productive private investment for job creation and growth. Prime Minister and Mr.Banga reiterated the need to fast-track implementation and ensure strong oversight to deliver impact at speed and scale on CPF-aligned priorities. These measures would duly assist Prime Minister’s initiative to address and resolve Implementation Bottlenecks in development projects. The Prime Minister expressed the government’s commitment to structural reforms that would unlock job-rich growth and further strengthen investors' confidence. Mr. Ajay Banga expressed his gratitude to the Prime Minister for his reception and hospitality in Pakistan. Mr. Ajay Banga commended Government of Pakistan’s ongoing reform efforts and reaffirmed his commitment to deepening cooperation through a One World Bank Group approach. He added that greater leverage of private resources, in addition to strong coordination with development partners, is necessary to meet the ambition of the government’s reform agenda.

Mr. Ajay Banga, President, World Bank Group (WBG) calls on Prime Minister Muhammad Shehbaz Sharif Pakistan acknowledges the World Bank Group’s valuable support which has been instrumental in advancing Pakistan's economic development and reforms. Prime Minister Mr. Ajay Banga, President, World Bank Group (WBG) calls on Prime Minister Muhammad Shehbaz Sharif in Islamabad today. Prime Minister welcomed Mr. Ajay Banga at his first official visit as President of the World Bank Group. The Prime Minister appreciated the World Bank Group for its long-standing partnership with Pakistan and its commitment to supporting the development priorities of the country especially through the 10-year World Bank Group Country Partnership Framework (CPF). The Premier also appreciated Mr.Banga's leadership in transforming the World Bank Group into more impactful development partner. Prime Minister stated that Government of Pakistan is vigorously working on economic reform agenda with multi-pronged comprehensive structural home grown program aimed at sustainable economic stability. The Prime Minister appreciated the support of the World Bank Group in resilient infrastructure, agribusiness, digital development, energy, human capital, fiscal reforms, and increasing productive private investment for job creation and growth. Prime Minister and Mr.Banga reiterated the need to fast-track implementation and ensure strong oversight to deliver impact at speed and scale on CPF-aligned priorities. These measures would duly assist Prime Minister’s initiative to address and resolve Implementation Bottlenecks in development projects. The Prime Minister expressed the government’s commitment to structural reforms that would unlock job-rich growth and further strengthen investors' confidence. Mr. Ajay Banga expressed his gratitude to the Prime Minister for his reception and hospitality in Pakistan. Mr. Ajay Banga commended Government of Pakistan’s ongoing reform efforts and reaffirmed his commitment to deepening cooperation through a One World Bank Group approach. He added that greater leverage of private resources, in addition to strong coordination with development partners, is necessary to meet the ambition of the government’s reform agenda.

Badar Shahbaz 🇵🇰

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