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ribosomes translating mRNA containing a frameshift mutation:

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Darrion Nguyen

45,072 subscribers

12,738 次观看 • 1 年前 •via X (Twitter)

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This video shows a subset of ribosomes inside a cancer cell actively translating mRNA molecules. Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.
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This video shows a subset of ribosomes inside a cancer cell actively translating mRNA molecules. Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.

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A team led by Ulrich Hartl found out that the protein GCN1 helps to secure the "accident site" after two #ribosomes collided and calls other complexes to degrade the defective #mRNA Cell ❕ press release ❕ full article
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This is beautiful. Making one protein, from one mRNA, takes minutes. This method images single mRNAs as they are translated by ribosomes. And can do it for >1 hour. Translation is start-stop; not continuous. (mRNAs = red; translation sites = green).
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This is beautiful. Making one protein, from one mRNA, takes minutes. This method images single mRNAs as they are translated by ribosomes. And can do it for >1 hour. Translation is start-stop; not continuous. (mRNAs = red; translation sites = green).

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