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SSRIS can cause permanent sexual dysfunction and Doctors underestimate the severity and likelihood of side effects

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Evidence suggests that SSRIs, a class of antidepressants, can cause PERMANENT damage to sexual function, says leading sexual medicine physician Dr. Irwin Goldstein San Diego Sexual Med. "It's an awful condition. It persists, causes frustration, embarrassment, humiliation," Dr. Goldstein says. Yet most patients aren't aware of this risk when they first get on SSRIs. PSSD Network | Post-SSRI Sexual Dysfunction Inner Compass Initiative
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Evidence suggests that SSRIs, a class of antidepressants, can cause PERMANENT damage to sexual function, says leading sexual medicine physician Dr. Irwin Goldstein San Diego Sexual Med. "It's an awful condition. It persists, causes frustration, embarrassment, humiliation," Dr. Goldstein says. Yet most patients aren't aware of this risk when they first get on SSRIs. PSSD Network | Post-SSRI Sexual Dysfunction Inner Compass Initiative

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"There's a huge population of SSRI-eunuchs, many of whom kill themselves out of despair caused by SSRIs, and yet, for some reason, nobody knows this is happening" Tucker Carlson reacts with shock at the lack of awareness of Post-SSRI Sexual Dysfunction (PSSD) among doctors.
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“I have no sensation in my genitals. My clitoris is completely numb.” Lauren Friedman, 23, shared her devastating experience with PSSD (Post-SSRI Sexual Dysfunction) — permanent loss of libido, sensation, and ability to orgasm after taking antidepressants. Chris Williamson and Isabel Brown reacted with shock, noting how little mainstream coverage this issue receives. Sexual side effects from SSRIs affect 50-70% of users. For a subset of people, these effects (including genital numbness and anorgasmia) persist long after discontinuation, a condition known as Post-SSRI Sexual Dysfunction (PSSD). The exact prevalence is unknown, but patient reports and emerging research suggest it may be under-recognized. People deserve full informed consent about potential long-term risks before starting these medications. What do you think, should PSSD get more public and medical attention?
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“I have no sensation in my genitals. My clitoris is completely numb.” Lauren Friedman, 23, shared her devastating experience with PSSD (Post-SSRI Sexual Dysfunction) — permanent loss of libido, sensation, and ability to orgasm after taking antidepressants. Chris Williamson and Isabel Brown reacted with shock, noting how little mainstream coverage this issue receives. Sexual side effects from SSRIs affect 50-70% of users. For a subset of people, these effects (including genital numbness and anorgasmia) persist long after discontinuation, a condition known as Post-SSRI Sexual Dysfunction (PSSD). The exact prevalence is unknown, but patient reports and emerging research suggest it may be under-recognized. People deserve full informed consent about potential long-term risks before starting these medications. What do you think, should PSSD get more public and medical attention?

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‼️The antidepressant sexual dysfunction rate is 59%. The average starting age is getting younger. And the side effects can outlast the prescription permanently. A study on antidepressant use found that 59.1% of patients experience sexual dysfunction, and the European Medicines Agency updated the official product information for SSRIs and SNRIs in 2019 to acknowledge that these symptoms have continued in some patients even after stopping the drug entirely. The damage can be permanent. This is the medication being prescribed to seven-year-olds. A parent giving an SSRI to a child that young may rationalize that sexual side effects are not relevant yet. What that parent may not understand is that most children who start on these medications never come off them. The decision made at age seven follows that child into adulthood, and a 59% rate of sexual dysfunction is not a risk they are choosing for themselves. It is a risk being chosen for them before they are old enough to have any say in the matter. When adverse event rates in vaccine trials hit 5%, alarm bells go off. When one in two patients reports sexual dysfunction from a drug being prescribed to primary school children, it barely makes the news.
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‼️The antidepressant sexual dysfunction rate is 59%. The average starting age is getting younger. And the side effects can outlast the prescription permanently. A study on antidepressant use found that 59.1% of patients experience sexual dysfunction, and the European Medicines Agency updated the official product information for SSRIs and SNRIs in 2019 to acknowledge that these symptoms have continued in some patients even after stopping the drug entirely. The damage can be permanent. This is the medication being prescribed to seven-year-olds. A parent giving an SSRI to a child that young may rationalize that sexual side effects are not relevant yet. What that parent may not understand is that most children who start on these medications never come off them. The decision made at age seven follows that child into adulthood, and a 59% rate of sexual dysfunction is not a risk they are choosing for themselves. It is a risk being chosen for them before they are old enough to have any say in the matter. When adverse event rates in vaccine trials hit 5%, alarm bells go off. When one in two patients reports sexual dysfunction from a drug being prescribed to primary school children, it barely makes the news.

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A study of over a thousand patients found that 59% of people on antidepressants experience sexual dysfunction. Doctors are prescribing these drugs to seven-year-olds. A peer-reviewed study of over 1,000 outpatients found that 59.1% of patients on antidepressants experienced sexual dysfunction when all antidepressants were considered together. Men came in at 62.4%, women at 56.9%, with women reporting higher severity. Those are the numbers attached to a class of drugs now being prescribed to children as young as seven. The European Medicines Agency took that seriously enough in 2019 that it updated the official product labeling for SSRIs and SNRIs after petitioners, researchers, and people harmed by these drugs forced their hand. The new language states that these drugs may cause symptoms of sexual dysfunction, and that there have been reports of long-lasting sexual dysfunction where the symptoms continued even after the drug was discontinued. A parent putting a seven-year-old on an SSRI may be thinking their child is not sexually active yet, so the risk feels abstract. What that framing misses is that most children put on these medications do not come off them. They carry the drug into adulthood, into relationships, and into marriage, along with a 50 to 60 percent likelihood of sexual dysfunction that the label now acknowledges may not resolve even after they stop taking it. 👇
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A study of over a thousand patients found that 59% of people on antidepressants experience sexual dysfunction. Doctors are prescribing these drugs to seven-year-olds. A peer-reviewed study of over 1,000 outpatients found that 59.1% of patients on antidepressants experienced sexual dysfunction when all antidepressants were considered together. Men came in at 62.4%, women at 56.9%, with women reporting higher severity. Those are the numbers attached to a class of drugs now being prescribed to children as young as seven. The European Medicines Agency took that seriously enough in 2019 that it updated the official product labeling for SSRIs and SNRIs after petitioners, researchers, and people harmed by these drugs forced their hand. The new language states that these drugs may cause symptoms of sexual dysfunction, and that there have been reports of long-lasting sexual dysfunction where the symptoms continued even after the drug was discontinued. A parent putting a seven-year-old on an SSRI may be thinking their child is not sexually active yet, so the risk feels abstract. What that framing misses is that most children put on these medications do not come off them. They carry the drug into adulthood, into relationships, and into marriage, along with a 50 to 60 percent likelihood of sexual dysfunction that the label now acknowledges may not resolve even after they stop taking it. 👇

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My entire SSRI series in one video. What doctors never tell you about SSRI withdrawal. Chris Masterjohn, PhD, Founder and Scientific Director of explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis. On the other hand, 20-50% of people who go off experience SSRI discontinuation syndrome. This can involve irritability, anxiety, mood problems, crying, dread, suicidal ideation, insomnia, nightmares, excessive dreaming, lethargy, fatigue, headache, tremor, sweating, anorexia, flu-like symptoms, nausea, vomiting, diarrhea, pain, numbness, tingling, feeling like something is crawling on the skin, electric shocks running through the brain or body, rushing noises, visual traces (seeing something persist when it is no longer there, or seeing moving objects leaving illusory streaks of light behind them, etc), dizziness, light-headedness, "brain zaps," vertigo, confusion, difficulty concentrating, amnesia, genital hypersensitivity, and premature ejaculation. A closely related problem is post-SSRI sexual dysfunction (PSSD), which can cause total inability to feel the penis for males or for females the genitals and nipples, loss of sexual pleasure, weak orgasms, decreased libido, erectile dysfunction, and premature ejaculation. PSSD is often associated with general anhedonia, apathy, and poor mood. In this video, I maintain that the reason there are no good solutions to these problems is because we have completely misunderstood the role of serotonin and SSRIs. Serotonin's role is to help mitochondria adapt to changing demands for oxygen-based energy production. SSRIs enhance some of the mechanisms, and interfere with others. They enter the cell and stimulate independent mechanisms of mitochondrial stress adaptation, but in doing so they turn a cyclical and rhythmic pathway into a constantly stimulated one, creating mitochondrial dependence and making mitochondria vulnerable to new-onset dysfunction upon withdrawal. Once they make it to the mitochondria itself, the SSRIs act as mitochondrial toxins. Scientific references for everything can be found in the series on my web site. 0:30 SSRI Side Effects 1:00 SSRI Discontinuation Syndrome and PSSD 11:33 The Problem With Primary Care Doctors and Psychiatrists 14:56 The Reason We Don’t Have Good Solutions Is Because We Don’t Understand the Problem 16:22 Prozac Is a Performance-Enhancing Drug 18:40 Depression and Altitude 19:36 The Truth About Serotonin 25:10 How Serotonin Helps Us Breathe 30:05 Hypoxia Explains Why Serotonin Is So Abundant In the Gut 33:55 Serotonin, Melatonin, and the Mitochondria 35:50 Serotonin and Light 39:25 Intermittent Hypobaric Hypoxia Training 42:56 SSRIs Are Whole-Body, Primarily Non-Brain, Non-Neuronal, Mitochondrial Drugs 44:00 SSRIs and Birth Defects 46:37 SSRIs Deplete Serotonin 48:50 SSRIs Distort the Sigma-1 Receptor From a Cyclical to a Constant Activation 51:10 Different SSRIs Promote Different Ratios of Mitophagy and Mitochondrial Biogenesis 54:00 Going Off SSRIs Causes New-Onset Mitochondrial Dysfunction 58:30 Slow and Parabolic Tapers 1:02:10 What to Do About SSRI Withdrawal Mitochondrial Dysfunction Do You Have Hidden Mitochondrial Dysfunction? Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it here at Mitome™
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My entire SSRI series in one video. What doctors never tell you about SSRI withdrawal. Chris Masterjohn, PhD, Founder and Scientific Director of explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become the first-line treatment of depression. These can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis. On the other hand, 20-50% of people who go off experience SSRI discontinuation syndrome. This can involve irritability, anxiety, mood problems, crying, dread, suicidal ideation, insomnia, nightmares, excessive dreaming, lethargy, fatigue, headache, tremor, sweating, anorexia, flu-like symptoms, nausea, vomiting, diarrhea, pain, numbness, tingling, feeling like something is crawling on the skin, electric shocks running through the brain or body, rushing noises, visual traces (seeing something persist when it is no longer there, or seeing moving objects leaving illusory streaks of light behind them, etc), dizziness, light-headedness, "brain zaps," vertigo, confusion, difficulty concentrating, amnesia, genital hypersensitivity, and premature ejaculation. A closely related problem is post-SSRI sexual dysfunction (PSSD), which can cause total inability to feel the penis for males or for females the genitals and nipples, loss of sexual pleasure, weak orgasms, decreased libido, erectile dysfunction, and premature ejaculation. PSSD is often associated with general anhedonia, apathy, and poor mood. In this video, I maintain that the reason there are no good solutions to these problems is because we have completely misunderstood the role of serotonin and SSRIs. Serotonin's role is to help mitochondria adapt to changing demands for oxygen-based energy production. SSRIs enhance some of the mechanisms, and interfere with others. They enter the cell and stimulate independent mechanisms of mitochondrial stress adaptation, but in doing so they turn a cyclical and rhythmic pathway into a constantly stimulated one, creating mitochondrial dependence and making mitochondria vulnerable to new-onset dysfunction upon withdrawal. Once they make it to the mitochondria itself, the SSRIs act as mitochondrial toxins. Scientific references for everything can be found in the series on my web site. 0:30 SSRI Side Effects 1:00 SSRI Discontinuation Syndrome and PSSD 11:33 The Problem With Primary Care Doctors and Psychiatrists 14:56 The Reason We Don’t Have Good Solutions Is Because We Don’t Understand the Problem 16:22 Prozac Is a Performance-Enhancing Drug 18:40 Depression and Altitude 19:36 The Truth About Serotonin 25:10 How Serotonin Helps Us Breathe 30:05 Hypoxia Explains Why Serotonin Is So Abundant In the Gut 33:55 Serotonin, Melatonin, and the Mitochondria 35:50 Serotonin and Light 39:25 Intermittent Hypobaric Hypoxia Training 42:56 SSRIs Are Whole-Body, Primarily Non-Brain, Non-Neuronal, Mitochondrial Drugs 44:00 SSRIs and Birth Defects 46:37 SSRIs Deplete Serotonin 48:50 SSRIs Distort the Sigma-1 Receptor From a Cyclical to a Constant Activation 51:10 Different SSRIs Promote Different Ratios of Mitophagy and Mitochondrial Biogenesis 54:00 Going Off SSRIs Causes New-Onset Mitochondrial Dysfunction 58:30 Slow and Parabolic Tapers 1:02:10 What to Do About SSRI Withdrawal Mitochondrial Dysfunction Do You Have Hidden Mitochondrial Dysfunction? Mitochondrial dysfunction is one of the earliest signs of aging and chronic disease—and most people don’t know they have it. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it here at Mitome™

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🚨Many people prescribed SSRI antidepressants don’t realize that they can cause irreversible damage to sexual function, says leading sexual medicine clinician Dr. Irwin Goldstein San Diego Sexual Med. “SSRIs, selective serotonin reuptake inhibitors, are one of the most widely prescribed medications in the United States…The problem is they are recognized to raise serotonin—that's their mechanism—but serotonin is an inhibitor of sexual function. While using the medication, it's widely appreciated that individuals will suffer sexual health concerns. But…when they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function. And that's not what we're seeing in our sexual health clinic here. The name of the condition is post-SSRI sexual dysfunction, or PSSD, and it's an awful condition. It persists, causes frustration, embarrassment, humiliation. It causes erectile dysfunction in young men, libido problems, genital sensation changes, orgasmic dysfunction.”
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🚨Many people prescribed SSRI antidepressants don’t realize that they can cause irreversible damage to sexual function, says leading sexual medicine clinician Dr. Irwin Goldstein San Diego Sexual Med. “SSRIs, selective serotonin reuptake inhibitors, are one of the most widely prescribed medications in the United States…The problem is they are recognized to raise serotonin—that's their mechanism—but serotonin is an inhibitor of sexual function. While using the medication, it's widely appreciated that individuals will suffer sexual health concerns. But…when they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function. And that's not what we're seeing in our sexual health clinic here. The name of the condition is post-SSRI sexual dysfunction, or PSSD, and it's an awful condition. It persists, causes frustration, embarrassment, humiliation. It causes erectile dysfunction in young men, libido problems, genital sensation changes, orgasmic dysfunction.”

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