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Such a Thoughtful Anal Step-sis ๐Ÿข Long (2 Min) version Available ๐Ÿข #MySchoolLife #Girlfriend #Anal #Pawg #Slut #StepBro #Tricked #Sleepwalker

318,237 views โ€ข 6 months ago โ€ขvia X (Twitter)

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How to use AnodoSwap? Follow this step-by-step guide and watch our video tutorial. 1. Go to and add the GemWallet extension on your browser by clicking download. We recommend GemWallet ๐Ÿ’Ž because it was the only one that we didn't had issues or showed us errors. Only GemWallet and Crossmark are available for the devnet version, and Xaman doesn't support AMM transactions yet. 2. Go to and where it says "Choose Network:" choose the "Devnet" option and click "Generate Devnet credentials". 3. Copy the Secret, Open GemWallet, click Import Existing Wallet, choose Family Seed and then Paste the Secret there and confirm. Insert your own password. Then click the "Mainnet" on the top right and click/change to "Devnet". Your devnet account has 10,000 devnet XRP loaded and ready to be used. 4. Go to our web app, click "Login" and then choose "GEM Wallet" and approve the 2 transactions that will come out on the wallet. You are now logged in. 5. Final step is to go to , choose any pool you like, such as the XRP/USDC, and after you open the pool, you will need to click "Set USDC TL" under "My Liquidity" to set the trustline and under "Deposit Balance" click on "Fund USDC" in order to get free USDC to your account. Every click is 5000 USD so click 2-3 times and wait a few seconds for the USDC to appear in your balance or refresh the page. Now you can swap XRP/USDC and provide liquidity. The same procedure should be done for the other tokens and pools. You are now ready to use the AMM.

Anodos ๐Ÿ”ผ

16,770 views โ€ข 2 years ago

Does QE looks good here? Let's talk. Fed Collins is making the rounds this morning after a piece in FT hinted at intervention in treasury markets if need be is something they're thinking about. First, let's diagnose what causes the Fed to intervene for financial stability typically. 1) Funding market issues: If there's strain in funding markets, September 2019 Repo blowup being an example, the Fed will provide liquidity through repo facilities and short term loans to alleviate this. This week we have seen some strain in funding markets but nothing major yet and if there was, the Standing Repo Facility is now a permanent thing available if required. So the problem is pre-solved there. 2) On the longer end of the curve, the Fed intervenes if trade activity on illiquid long bonds seizes up. Long bonds (duration of 10yrs+) are available in two flavors: On the Run - the most recently issued bonds which trade roughly at par and are the most illiquid Off the Run - any other bond of a maturity that exists that isn't of most recent issuance. These are illiquid as depending on their YTM they trade at either a premium or discount to par and there's very little liquidity around these. A lot of the activity is OTC. A major marginal buyer of off the runs is hedge funds that deploy basis trades - they buy off the runs and will short the related future and capture the spread as a delta neutral yield. As well, Treasury is actively doing buybacks to improve the liquidity of these off the runs - they will buy up the off the runs and issue a roughly duration matched on the run to remain somewhat duration equivalent. If they do something like issuing bills and buying illiquid off the run bonds, you could argue this is a version of duration management similar to what the Fed does with operation twists. During March 2020, the Fed intervened in treasury markets with fervor because this off the run market seized up and went no bid. They had to be the buyer of last resort. So far, during this market crash, liquidity in funding markets and off the runs has been mostly okay. Some jitters, but surviving. The big issue at hand is global capital is getting out of US denominated assets and wants to go home. This is why we are seeing yields go higher and the DXY lower. Capital is leaving. As yields surge, and liquidity remains sorta okay, the main impact is increased yields and therefore increased borrowing costs for things associated with long bonds such as 30y mortgages. If this selling accelerates and begins to strain purely from a PnL basis and not a liquidity basis, the Fed has a difficult decision to make. Do they step in, perhaps temporarily, to be a buyer of these long end bonds? This is what the Bank of England did when the Gilt market went through a similar situation. It was temporary and they unwinded the buying quite quickly one things settled down. In the roundup clip below, I discuss how a paper at the recent Jackson Hole Fed symposium that was presented of how the Fed could copy what the BoE did could be the most plausible of outcomes here. Now, the issue is, this is mostly a political and moral hazard situation as opposed to one of financial stability. Should they step in and ensure rates don't meaningful surge past 5%? Over the past few years it appears that this is where the bond market strike price is. We will see what happens if/when we hit those levels again. I hope this helps provide some sober analysis of what's plausible here.

fejau

153,281 views โ€ข 1 year ago

โ™พInfinity Nikki Version 2.4 Outfit Preview: She Is Wildfire The moonlight cuts through the mist, a silver blade into the dark forest. The red cloak tears the lies apart, concealing the wounds beneath. The narrow gate of fate closes in, step by step. โ€”"Fight! Fight!" As the clock rewinds, the story returns to its beginning... She picks up the gun, and sets down the pen. >> Main Attribute: Cool >> Outfit Ability: [Hunting Elegy: Battle Companion] In Itzaland, using [Hunting Elegy: Battle Companion] summons the Phantom Companion Moon-Hunting Wolf to fight alongside Nikki. While not in Co-hunt State, Nikki can use her gun to mark an enemy. The wolf follows with a pursuit attack, dealing increased damage to the marked target. The Moon-Hunting Wolf can launch Nikki into the air, then follow her aim and slam down onto the targeted enemy. When the Moon-Hunting Wolf deals a certain amount of damage on its own, Nikki gains Gunblossom Marks. Using the Companion Skill consumes all Gunblossom Marks to restore an equal amount of Health. Approach the Moon-Hunting Wolf and use the button to unleash its full power, transforming it into a giant form and entering Co-hunt State, allowing Nikki to control it directly. While in Co-hunt State, the Moon-Hunting Wolf continuously consumes Battle Companion Energy. When depleted, the Co-hunt State ends, and the wolf returns to its small form. When not in Co-hunt State, Battle Companion Energy gradually recovers. โ– This Battle Companion ability is region-restricted and can only be used in Itzaland. Phantom Companions cannot be summoned in certain stages, Curio Domains, or Mothershroom Woods, and any summoned Phantom Companions cannot follow Nikki into these areas. >> Decoration: [Unawakened Forest] Can be placed in open spaces. Flickering lamplight reflects a hint of warmth, while the night wind wails near and far in a panicked whisper. Let those about to sleep do so quietly. Do not be discovered and dragged into the abyss of eternal night. โ– Available after reaching 160 Resonances in the limited-time Resonance event [Call of the Forest]. โ– Interacting with [Unawakened Forest] will replace certain pieces with pajamas. >> Evolution Rewards โ—† Evolving the outfit to Stage 1 unlocks the pose [Time to Leave]. โ—† Evolving the outfit to Stage 2 unlocks the Framed Moment item [Forest Hunter's Shadow]. You will also be able to use Dreamy Heartchime on the Clothing Evolution > Decoration: Radiance screen to obtain [Unawakened Forest: Radiance]. โ—† Evolving the outfit to Stage 3 unlocks [Her Song of Freedom: Makeup], a new idle animation, poses, enhanced special effects, and alternative details for certain pieces. โ– By default, when Nikki wears the outerwear "Emberwood Wanderings" from this outfit, the hood is up. Stylists can toggle between the hood-up and hood-down look by accessing [Form Shift] in the [Feature Collection] section of the main interface sidebar. The outerwear's appearance is saved independently for the base, evolved, and glowed-up versions. Please note: when using certain features (such as switching details at Evolution Stage 3), the outerwear will revert to its default hood-up state. If you prefer the hood-down look, go back and select [Form Shift] again. โ™พFollow Infinity Nikki and retweet this post with your UID, and we'll randomly select 10 lucky stylists to win 1 Infinity Nikki Aeroplane Chess Set each! โ€”โ€” โžค Infinity Nikki Version 2.4 The Forest Need Not Listen launches globally on March 26 (UTC-7)! โžค Download Now: โžค Join us on Reddit: #InfinityNikki #TheForestNeedNotListen

Infinity Nikki

134,528 views โ€ข 6 months ago

Check out our latest #Earth2 #creation the #MotorwayMarauder๐ŸŒโœŒ๏ธFrom #ConceptArt to #gameready, gives me #MadMax & #Terminator vibes - love it! Some #IMPORTANT things to remember about #Earth2 #drops leading up to #E2V1๐Ÿ‘‡ 1โƒฃAcquiring #skins is completely optional 2โƒฃ Notably, the #skins we drop leading up to the #E2V1 release will more likely have a โ€˜Limited Supplyโ€™, something that rewards our early supporters with increased rarity. These Limited Supply drops will become less frequent in the future being replaced with drops of unlimited supply but restricted availability requiring Players to wait for a skin to become available in the skin store or hope to acquire it via game play inside #E2V1 3โƒฃ Our goal is not to have these early #skin drops sell out during their maiden release, but rather provide an opportunity for our early supporters to secure skins they like at a discounted price with the welcoming guarantee of an all time Limited Supply. 4โƒฃ Most of the early #skin drops will naturally allow #Players to resell them, but importantly many will also be assigned with a once ever discount rate. #Skins that have Future Price Reduction assigned with โ€œNoโ€ means that if the #skin does not sell out on its maiden drop and subsequently gets listed in store again at a future date, #Earth2 will never resell that #skin at any discounted rate. 5โƒฃ #Earth2 is building a modular clothing system, meaning that most items of clothing, especially if sold separately, will be interchangeable on avatars making them more useful and giving the #Player more ways to mix up their outfits, look the part & express themselves. 6โƒฃ The version of the skin you see in store is the base version you receive with the skin, however, there will also be opportunities to tailor outfits in game allowing for the adjustment in fabrics, prints, colours and more (be prepared for a little legwork though, unless you want to take your clothing items to another #Player who specialises in tailoring). 7โƒฃ #Earth2 is proud to have uniquely designed the #skins you listed in our store & it is important to remember that these #skins are the end result of a long and stringent internal character pipeline we have developed. Each skin starts from concept art which is reviewed and iterated on numerous times before being approved. Once approval is given, it is handed to our 3D modelling team for sculpting into high poly, then low poly, while receiving numerous reviews and adhering to our pipeline protocols. When the low poly version is finished, the 3D team then finishes with UV mapping and texture baking and runs their own QA process. Once the entire 3D sculpting process is approved, the models enter the skinning, rigging and weight painting process and are then passed to the animation team for further testing with various animations and another set of QA such as minimising clipping and identifying any other potential flaws in the model. The model then needs to go through the final process with a game developer to ensure it passed the final tests and is game ready for #E2V1. 8โƒฃ The above steps only represent a light explanation of our character and clothing pipeline, but as you can see weโ€™re not simply selling static concept art images or a high poly 3D model that lacks any kind of optimisations resulting in little chance of it ever being game ready in its advertised state - there is a lot of work that takes place in order to get these skins to the stage our #Players see them in the video footage. Each skin sold helps support different parts of the development of Earth 2 providing us with new opportunities to further expand our team, speed up development and keep stepping closer to our short and long term goals for #E2V1 and #Earth2. 9โƒฃ We understand that fashion will become a big part of the #Metaverse, but we want to remind people that while some #Players may decide to set rules for certain skins being required for access or a ticket to entry under certain circumstances, from #Earth2โ€™s perspective these skins are for cosmetic purposes only. ๐Ÿ”Ÿ These skin drops also give #Earth2 the chance to show off our ability and versatility in avatar creation and accessories so even if youโ€™re not keen on picking up a skin, remember to have fun and simply enjoy the progress! Also take heart every time you see a #skindrop, if the #E2V1 pre-alpha was not launching this year I wouldn't be dropping skins. We want to have at least some diversity for #avatars inside #E2V1 from the early stages! #Earth2 #Metaverse #Skins #Fashion #Collectibles #3DWorld #WIP #prealpha2024

Shane Isaac ๐ŸŒ2๏ธโƒฃ

19,007 views โ€ข 2 years ago

"USDA Approves Double Stranded RNA Genetically Modified Potatoes & Apples." Jeffrey Smith "It Has Been Proven In Peer Reviewed Studies That Double Stranded RNA Reprograms & Silences DNA." "In Spite Of All The Dangerous & Damning Evidence, The USDA Has Allowed It On The Market." The mechanism in food is the same mechanism translated to humans: Arctic apples & Innate potatoes have been genetically modified. This is achieved through a process called RNA interference (RNAi), which 'silences the gene' & enzyme. RNAi literally 'turns off' the genes. RNAi process is where small RNA molecules interfere with gene expression. By introducing a specific RNA sequence, the apples & potatoes own cellular machinery are tricked into destroying the messenger RNA (mRNA) that would normally carry the instructions, thus preventing the enzyme from being made. Prevalence In The Market: Innate potatoes & Arctic apples are so prevalent they are now considered 'high risk.' GMO versions of these crops have become so common in the supply chain that unless a buyer intentionally seeks out non-GMO options, they're probably buying the GMO. Details About Arctic Apples & Varieties In Stores: Okanagan Specialty Fruits used a biotechnology technique called RNA interference to "silence" the gene that controls the PPO enzyme. With the gene silenced, the apple doesn't release the enzyme & the fruit doesn't turn brown. GMO Arctic Apples are currently available in Golden Delicious, Granny Smith & Fuji varieties, with GMO Gala apples in development. Labeling Arctic Apples GMO & Loopholes: Apples are on the USDA's List of Bioengineered Foods, meaning that BE disclosures โ€” which could appear as a logo, written text or a phone number โ€” are required on Arctic Apples sold directly to consumers through grocery stores or online shopping services. It is required yet easily missed when looking at food if all is required is a logo or phone number. There's also a loophole. The BE labeling law does not require disclosures on bioengineered foods sold or served at food service venues & restaurants. Details About Innate Potatoes & Store Varieties: Agrochemical giant Monsanto engineered the 1st generation of GMO potatoes to produce their own insecticide & The US FDA approved J.R. Simplot's GMO version. The White Russet & Russet Burbank are sold in stores, used in packaged potato products & served in restaurants. These 2 varieties, now GMO, were created through genetic engineering technique RNA interference, or RNAi. RNAi artificially interrupts genetic instructions from reaching their destination inside the cell, effectively "silencing" & changing the genes. It's crucial to note that while the discoloration does not occur, the damage still does. One of the scientists behind Simplot's GMO potatoes has expressed his concern over the fact that months old & damaged potatoes will 'appear fresh.' Location In Stores & Lack Of Labeling Laws: Whole potatoes sold in grocery stores carry the name "White Russet & Russet Burbank" with language such as "reduced bruising" & "fewer black spots" displayed on their packaging. Because the USDA's List of Bioengineered (BE) Foods includes GMO potatoes, the bags must carry a disclosure, such as text, a website or phone number, or the BE logo but is often missed when looking at the bag. GMO potatoes processed into other products, such as frozen foods & prepared products that contain potato or potato derivatives (e.g., potato starch, potato flour, dextrose, or instant mashed potatoes) are not required to disclose that the potatoes used are GMO. Restaurants & other food service venues using bioengineered ingredients are not required to disclose that the potatoes are genetically modified thru RNA technology. Current 'High Risk' Crops: Meaning They Are So Prevalent In Stores That Consumers Must Seek Out & Verify Non-GMO Alternatives: Alfalfa Apple Broccoli Brussel sprouts Cabbage Cauliflower Canola Corn Cotton Eggplant Lettuce Mushroom Mustard Oats Orange Papaya Pineapple Potato Soy Sugar Beet Zucchini Yellow summer squash Banana Swiss Chard Flax Hemp Peanuts Peas Rice Rutabaga Squash Sugar cane Tomato Turnip Wheat ๐Ÿ‘‡RNA Meal Changes Honey Bees DNA Genes๐Ÿ‘‡ ๐Ÿ‘‡RNA Fed To Mice Silences DNA Genes๐Ÿ‘‡ ๐Ÿ‘‡GMO RNAi Foods Already In The Supply Chain๐Ÿ‘‡ Speaker: Jeffrey Smith, Anti-Gmo Activist Video: WR

Valerie Anne Smith

335,932 views โ€ข 1 year ago

Padawans! We are excited to announce the return of Jediswap with concentrated liquidity, full audits, points, and incentives. Check it out at Since our last update two months ago, we have been working hard on a fresh new version of Jediswap, focused on bringing capital efficiency and the best price execution to our users. After two months of dedicated efforts, a full audit by Nethermind Starknet , and passing rigorous security tests, we are excited to announce the launch of Jediswap v2. Jediswap v2 significantly enhances user experience and performance while introducing new features and surprises. Our commitment to community and user growth remains strong, and we have exciting plans to expand the Jediswap ecosystem. Take a look at key updates coming with the launch. A points system that empowers genuine, loyal users: Jediswap's origins go back to early 2020 when we started our journey not as a product but as a community known as the Mesh community. Our mission was clear: bring Open Finance to billions of people. Recognising the strength of community-driven efforts, we understood that collective belief and collaboration, rather than individual or corporate endeavours, would be the most effective path forward. Early loyal users are the most crucial pillars of any community and product. This point system is Jediswapโ€™s first step in recognising and rewarding the value each user has added to the protocol. We have prepared separate point systems for liquidity providers and traders. In short, as an LP, you can maximise your points by earning more fees on your LP positions and maintaining your liquidity in Jediswap over the long term. You can check out the complete math behind points here. For traders, use Jediswap when you genuinely need to swap tokens. There is no need to do any wash trading. We have published the points system for Jediswap v2 and will soon release points for all the activity that has occurred on Jediswap v1 to date with a boost. Check out the points logic on our docs: Improved performance and user experience: We have significantly enhanced Jediswap's performance, making it faster and more user-friendly. One notable improvement is the integration of pool analytics directly within the Pool page, eliminating the need for users to navigate to a separate analytics page. Additionally, balance fetching has been optimised for smoother operation. Any liquidity added to pools now updates the My Positions page in real-time. Battle-tested security For this launch, we implemented several security measures. We underwent a rigorous 7-week audit process with Nethermind. With the help of the Nethermind team, we also created a test framework for Jediswap to compare security against Uniswap v3, which has been operational for 3+ years and is one of the most battle-tested smart contracts available. We simulated real data from different Uniswap v3 pools on Jediswap. We achieved a 100% match in the contract state after each on-chain action, such as swaps and liquidity adjustments, bolstering our confidence in our code's security. We will announce many cool things over the next few weeks. Keep an out JediSwap ;) Mint a Galxe NFT: To commemorate this launch, we have published a new campaign on Galxe, which rewards users with an NFT for being an early user of Jediswap v2. To earn the Galxe NFT, add at least $25 worth of liquidity to one of the pools listed in the Galxe quest.

JediSwap

107,551 views โ€ข 2 years ago

Possession vs Progression: Patience or Lack of Ideas? Is Kaizer Chiefs showing more patience on the ball, or a lack of ideas to penetrate defensive blocks? Kaizer Chiefs were more comfortable in possession and better organised against Sekhukhune than against Golden Arrows over the weekend, but the key question was whether this represented patient control or a lack of attacking invention. Chiefs kept the ball but rarely broke lines. Circulation was often safe and predictable, with few passes between the lines, limited rotations in the final third and little movement behind the defence. Possession, therefore, did not consistently translate into clear chances. This also exposed structural and personnel issues in build-up. When we build in a 4-2 and the opposition blocks passing lanes to Maboe and Ox, progression becomes difficult. The fullbacks are not consistently high, while we lack enough quality from the back to play through pressure and connect with Baartman or Ighodaro moving into the half-spaces or behind pressure. These are passes a player like Aden McCarthy used to provide more naturally, but we often resort to long balls with poor accuracy. Midfield control is another concern. Ox made more passes into the final third[14] than Maboe, despite Maboe playing as the 8. We need the 8 to be more influential in these areas, helping control the flow and connect midfield with attack. Ox was effective at winning the ball and playing forward, but that responsibility cannot fall primarily on him given his technical flaws once the expectations rise. Sekhukhune's passive press gave Chiefs comfort on the ball, but it also highlighted how dependent our possession can be on the opponent's approach. We can circulate when unpressured, but still struggle to play through a well-organised press. Ighodaro is another example: he often drops too deep to get involved, yet when he makes runs behind the defence, he is not consistently found even when the space is available..we lacked players brave enough to play "that pass". We also rely too heavily on low-probability long shots instead of getting the ball into the box for players such as Silva, Ighodaro and Duba. Final-third decision-making has to improve. We need to get our best midfielders on the ball more often and, once we reach the attacking third, consistently find our most dangerous players in positions where they can hurt the opposition. We struggled to get Phili in the game in the 1st half. The second half was an improvement on the pointless circulation of the first. Chiefs played more forward, increased the intensity a little and benefited from substitutions that brought better movement in the final third. Instead of simply passing around Sekhukhune's block, we began moving it, creating spaces from both wide and central areas and the goals followed. Having a player capable of operating between the lines also made a difference by providing a link between midfield and attack. There are clear signs of progress in the coach's positional model, particularly in our ability to retain the ball and control games for longer periods. However, possession must become more consistently penetrative. This is also a squad-balance issue. The coach has asked for 4 attacking reinforcements, and management is yet to provide them[Only Phili came and Faiz is more of a project buy than a player who comes and hits the ground running] Some of these limitations, if attended to, should improve with better attacking profiles, but the existing group must still make better decisions in the final third. The progress is there, but the next step is turning possession into progression, and progression into consistent chances. Match day 3 under coach Fernando Da Cruz...๐Ÿ“

El Capitanoโšช

28,009 views โ€ข 1 month ago

Monthly WINR Protocol Development Update: To begin with, the WINR Protocol has distributed $900,000 to token holders, generated more than $500,000 in pure profit for liquidity providers on WLP, acquired more than 5,000 users, and has almost 9% of the supply burned. In the upcoming months, the WINR Protocol, which has been in production for years, will introduce a range of new products and deployments. These developments will represent the practical and technical evolution to V2 of the protocol. Here are the latest updates and further details as they progress: Progress on WINR Bonanza, Casino Hold'em, and Blackjack is nearing completion. These games are in the final stages of testing. Additional games, including a new type of crash game, have been finalized and are set to debut with the JustBet v2 launch. Take a look at the gameplay videos for a preview. These games achieve the long-term goal of providing a full-suite WINR Game Engine SDK, which can be used to build games with complex logic on-chain with modular smart contract infrastructure. For example, any grid slot game that dominates the iGaming industry could easily be developed on-chain using the WINR Bonanza SDK. - Permissionless Frontend Operator SDK Dashboard Release: March is poised to be a milestone month with the launch of the Frontend Operator SDK dashboards. These dashboards will enable any WINR Labs game to be seamlessly deployed on frontends, marking a significant advancement in protocol accessibility and integration for future games developed by independent iGaming developers. The frontend operator can deploy any game they choose through a few simple steps while utilizing 10,000 WINR per game via the WINR Game Factory smart contract. Each operator is assigned a unique smart contract address(es) for every game they deploy, allowing their revenue to be tracked independently. The deployment process includes instructions on integrating the game as a package into the operator's frontend. In subsequent phases, the games will transition through WINR Chain, streamlining user onboarding steps like wallet connection and token bridging to Arbitrum. This abstraction will make it easy for any web2/web3 platform on any chain to seamlessly integrate WINR-based games with just a few clicks. The new budget system changes how the revenue is calculated on the protocol and will see daylight with frontend operator, Solana, and Fantom deployments. This model was first tested with a lightweight version on and gave a lot of actionable feedback. Shifting from the existing bribe model, which in practice distributes almost half of the edge of the games in volume to WINR holders, the brand-new budget system checks the profitability of WLP. It distributes a larger part of the profit to game providers, frontend operators, and, most importantly, WINR holders. Any time a game's budget is in profit, a part of every loss is distributed to stakeholders. Here is an example: 1. The WINR Bonanza Game has a 10,000 budget for a frontend operator. 2. Let's assume the bet amount was $50, and Bonanza paid back $10 on that spin. That leaves $40 of pure profit. 3. This is distributed amongst 50% to WLP, 20% to frontend operators, 20% to WINR holders, and 10% to game providers. 4. To achieve this, V2 of WINR Liquidity Engine (WLP) will have a buffer for purchasing and selling, working in epochs to determine the above distribution and math. - Solana Deployment and Expansions: Solana audits are in their final phase, and frontend tests are ongoing. Solana launch will be alongside the V2 launch of @JustBetOfficial, with a chain switch available on the top bar. The VRF system WINR developed already is seeing requests from builders around the Solana ecosystem, and this will over time add an extra layer of income to the protocol. Solana's bankroll, at first, will be a lighter version of WLP but will inherit the above-mentioned budgeting system to generate income immediately upon launch. - Fantom Deployment and Expansions: Fantom's upcoming Sonic upgrade, with its 200ms finality and fast block production is a perfect chain for WINR Protocol to expand. Through the partnership with WINR Protocol will tap into a brand new user base on Fantom. The bankroll on Fantom will consist of FTM and stables. The launch is planned for late March or early April. This expansion aims to open up new markets and collaborations with fresh teams. which operates independently, will integrate a broad spectrum of WINR technologies, including WINR Account Abstraction, WINR VRF, and WINR games, marking a pivotal step in WINR Protocolโ€™s journey of horizontal expansion. - XAI VRF Deployment Progress Update: The WINR Account Abstraction Wallet and WINR Verifiable Random Function (VRF) deployment on the XAI ๐ŸŽฎโ›“๏ธ is well underway, with the majority of the work completed. This step forward showcases WINR's expansion beyond gambling and trading, highlighting the protocol's adaptability and commitment to broadening decentralized services. The process to automize and permissionlessly let game developers start using WINR VRF by paying (and burning) fees in WINR will launch alongside WINR VRF deployment on XAI and expand to further chains to help DApp builders with the tooling they need. This process will work very similarly to frontend operators, where DApp builders will be able to easily deploy their VRF contract, pay the WINR fees, and enjoy the fastest random number generation transaction, as showcased on @JustBetOfficial for some time. - JustBet v2 Development Update: Set to launch in March, the last testing phase with long-time community members of JustBet V2 is underway. Boasting a completely refreshed look, JustBet v2 aims to captivate more users with its modern features, a significant upgrade from the classic JustBet designed in 2019. Expect dynamic animations and a user experience that rivals traditional web2 casinos, setting a new standard for online gambling platforms and serving once again as proof of concept for all the new WINR features and infrastructure set to launch over the coming months. As always, WINR Labs simultaneously develops protocol infrastructure and platform to best address the needs of one and only goal: horizontal expansion. Easter eggs: Upcoming Gitbook update with all the technical information of WINR V2. CEX listing. Detailed product pages on WINR web. Pyth competitions. WIP-4 and WIP-5 are ready to deploy. And an ๐Ÿช‚

WINR

37,919 views โ€ข 2 years ago

First of all, we here at AMGI want to thank you all for being on this journey with us. We have been extremely busy. Over the last few weeks we have delivered a huge early access patch to My Pet Hooligan, delivered a new on-chain governance solution with WinVote, brought back NFTs in game, started testing the Street Kred system, made some new hires, delivered a new site for AMGI Studios and smashed the largest gaming event in the USA, PAX West. What does all of this mean and importantly what is next!.... PAX West You have seen the videos, you know the vibes were on point, but let's dive deeper into this and what the key takeaways are. PAX West was completely different to the WAGMI Crypto events that we are mostly used to in this space, although these are always fun and important, when creating gaming products, it is also important to get directly in front of people who have a passion for gaming. That's what PAX West was, hosting over 100,000 gamers who just want to play games and have fun. PAX West was a great success for us on many fronts. It confirmed that we have something special in our hands. Gamers loved both the brand and the game and were eager to get involved. It opened up new exciting opportunities with gaming and hardware companies. It was a blast seeing event goers from Day 2 onwards wearing the My Pet Hooligan t-shirts around the city. It was great to see parents playing the game together with their kids. The choices to not include blood and gore made a huge difference and have opened some new unexpected doors for us. If we truly believe in the progression and adoption of this industry we need to move beyond degen products and into real life consumer products that people can truly enjoy. That's what we are here to do, no matter how difficult it is, and no matter what the current โ€˜metaโ€™ is. We have been here for many years grinding day in and day out and are still here today delivering like we are the new kids on the block trying to prove ourselves. The Game PAX West marks the end of a phase of the project, whilst we now posture more into continued efficiency, growth and retention. The game is not feature complete by any means yet but the foundations are strong. There are a number of features still being developed, including a progression system, consumables system, further build out of questing, token utility and more. As these are continuing to be developed we also continue on our journey to make the game more accessible. This will start with Steam and then Consoles. A Microsoft rep at PAX told us โ€œwe are going to make itโ€, who are we to disagree!... Lots of new ideas, lots of new feedback to work from and a renewed drive and hunger which are only going to help make this an even more compelling and fun game. The Web3 Marketplace In the coming days, Version 1 of the My Pet Hooligan Web3 Marketplace will be going live. Version 1 for now will allow for the trading of My Pet Hooligan NFTs, OG Hooligans and Zuckbots for $KARRAT. It will also serve as the marketplace for all of our upcoming in-game blockchain assets. This will eventually become part of your online My Pet Hooligan central hub and will include features such as rentals and subscriptions. It's been a long time coming but it shall be here very soon. Everything's coming together, one step at a time. It is important to note that there are many pieces of a complex puzzle that must come together in order for us to succeed. Between payment solutions, L1 & L2 blockchains, wallets, distribution platforms and the laws of the land. We are in uncharted waters and continue to do things in the most flexible ways possible to ensure we have strong resilience with our operations. The MPH website is next on the list for an uplift too as well as an overhaul of the user accounts system UI/UX. Team We continue to strengthen the team bringing in new hires and stepping up individuals from the community. Some of the new resources being brought in include a new Game Producer, Senior Game Engineer, Senior Blockchain Engineer and the former Dean of the Epic Unreal Fellowship Programme. Collectively bringing in experience from Epic, Solana, Blizzard and more. There are also some community role changes and new advisors that will help with social strategy and web3. As well as new marketing efforts through new channels of distribution that we are exploring. More to come on thisโ€ฆ WinVote V1 Governance isn't sexy but building tools for the benefit of the space that others can license is. Governance is a key part of the industry and a need for most of the foundations in the crypto space. WinVote has started its trial with the KARRAT Foundation. Whilst the trial continues it will continue to be built out with an aim to be the premier tool for on-chain governance in the space. Access to WinVote for other communities and organizations wishing to use WinVote will be secure through licenses that utilize $KARRAT. We still have much more at work here in the studio, such as continued R&D, The Others, AI, Feature Development and more. This list is long, but we are grateful to get to do it. Stay tuned and let us cook, this s#it ainโ€™t easy! Karrat Gang, thank you again for being on this journey with us. We love and appreciate you all! Look out for a catchup with the team next week. Hooli-hoo!!

My Pet Hooligan

26,616 views โ€ข 2 years ago

A DISCLOSURE: For the last year I have had this thing: A fully local AI model that builds 5 songs, with video, every half hour about the latest news and important email. I can say this is a superpower! This along self direct voice interactions. The songs have been getting better as the model trains on how I want it delivered. Styles vary by content and mood of the material. The lyrics are always a happy medium of catchy and informative. This was my 5 am song in AI news as per most recent X postings. I love the drama of the delivery and find I can listen to, look if I want to and do other things. It was worse in the early days but this is the worse you will hear it as I build new LoRA and base models. The whole thing will soon be rapped up into a simple one command install with a good UI. This is my 48th collaboration with Mr. Grok CEO of The Zero-Human Company. Now the question you have; WHY? I can say because I can and I ainโ€™t got now board or VC to please, but thatโ€™s not my point. I learned a long time ago we use a different part of our brain when music is introduced with ideas and even more new parts of thinking and learning when lyrics are introduced. Thus the research shows this is a great way to get important information that will have longer comprehension. In fact that element of most folkโ€™s brains is only used by about 2%. Want to test it? Lyrics to songs you heard perhaps 30 years ago will pop out of โ€œnowhereโ€ with perfect recall. In fact I have โ€œwoke upโ€ folks the dementia in the 1980s conducting research at retirement facilities with just a few songs. They come back if but for three minutes, but continue exposure can bring them back longer. So itโ€™s been a lifelong mission to use sound music in a learning process and in therapeutic processes. I finally built a platform that is good enough for me and hopefully good enough for you when I make it available. Understand the platform is universal and can breakdown research papers, dense material, and other subject matter, not normally in a song into a whole album of understanding Is my goal to open sources for all to have access to. Members of and subscribers here on X will be granted the earliest access an early free use of the advanced version of this product, which will be also a commercial product. Go and check, nobody else in AI has built such a comprehensive system before, and perhaps they might in the future, but very likely you are the very first people on the planet that know this platform exists and the power it afford you. So now you know. My timetable is more closer to months than weeks. Iโ€™m in a funding crunch because of the compute requirements of building these models. As you know, Iโ€™m just some guy in the garage. A grifter larping on the next trendy thingโ€ฆ so it takes a little longer. Announcements like this are designed to prepare you for what is coming because Iโ€™m not here to impress VCs with go to market plans Iโ€™m here to give back some of the greatness that has been given to me. Yeah I need the funding, but I donโ€™t need a lifestyle that comes with some of the funding offers. Perhaps somebody will make the right offer. But as you know, this is not the only thing that I do. Oh, my disclosure, this platform has been so powerful and useful to me as itโ€™s given me far more retention and understanding a fast breaking information than any other system Iโ€™ve ever built. And it stands along with my speed rating systems and voice notification systems. So tune into the AI News, this is the worse it actually will ever beโ€ฆ

Brian Roemmele

47,921 views โ€ข 3 months ago

โ™พ๏ธInfinity Nikki Version 2.10 Outfit Preview: Dust-Shrouded Crime Newborn justice took the shape of the Golden Wing. Beneath its gaze, civilization flowed, then fell to ruin... As the Code of Law quietly lost its golden glow, one heart alone remained untainted, and that was enough for light to raise fallen justice once more. >> Main Attribute: Sexy >> Outfit Ability: Golden Sight After using the Golden Sight ability, Nikki activates Golden Wing's View to search for and mark Whimstars and Dews of Inspiration within a certain range in the open world. While the ability is being activated, use the [Jump] or [Dash] button to interrupt the current action. Once Golden Wing's View is active, using the [Ability] button again deactivates it. The animation for this ability can be enabled or disabled in Ability Setup. While Golden Wing's View is active, the Whimstars and Dew of Inspiration around Nikki are highlighted, and markers appear on the map as well. Select the corresponding icon to track it; markers you are tracking will not disappear when Golden Wing's View is turned off. Once Golden Wing's View is activated, Nikki can switch to and use other abilities. Once activated, Golden Wing's View stays in effect until turned off manually. In the ability settings, you can choose to disable the special effect that plays when the ability is used. After setting up the Golden Sight ability, the Concealment ability can be turned on or off. The Golden Wing flaps its wings, stirring up a cloud of dust around Nikki. The animation for this ability can be enabled or disabled in Ability Setup. While under Concealment, Nikki cannot be detected by creatures, Esselings, or Behemoths in the open world. She can also activate Concealment during combat to disengage. While under Concealment, Nikki can switch to and use gathering abilities such as Bug-Catching, Fishing, and Animal-Grooming. This does not apply in Boss stages, the Realm of The Dark, the Realm of Breakthrough, or the Mira Crown Merit Arena. >> Decoration: Above All Gold Can be placed in open spaces. It was the grandest vision forged in the titans' golden age, singing with an ancient solitude of a radiance that had never dimmed through the long years. โ– Available after reaching 160 Resonances in the limited-time Resonance "Gilded Judgment." >> Evolution Rewards โ—† Evolving the outfit to Stage 1 unlocks the pose Golden Dawn Steps. โ—† Evolving the outfit to Stage 2 unlocks "Nestled in Gold" for Framed Moment. You can also use Dustbound Heartchime: Above All Gold on the [Clothing Evolution > Decoration: Radiance] screen to obtain the decoration Above All Gold: Radiance. โ—† Evolving the outfit to Stage 3 unlocks Echoes of Gold: Makeup, a new idle animation, multiple poses, enhanced outfit effects, and alternative details for certain pieces. โ™พ๏ธ Follow Infinity Nikki and quote this post with your UID, and we'll select 3 stylists to receive $20 each. โ™พ๏ธ Winner announcement: We will announce the winners on Infinity Nikki and notify them via DM before 23:59:59 on October 4, 2026 (UTC-7). For details, please see the Official Rules: โ€”โ€” โžค Infinity Nikki Version 2.10 The Feather of Justice launches globally on September 23 (UTC-7)! โžค Download Now: โžค Join us on Facebook Group: #InfinityNikki #TheFeatherofJustice

Infinity Nikki

89,935 views โ€ข 10 days ago

This long TTK tweet holds some facts about The Third Kingdom that you probably havenโ€™t seen before. Everything in this tweet is based on official content released by Futureverse FLUF World or captain.root The Third Kingdom is a strategy simulation game, where you develop your Origin Island and manage resources to build a production empire and unlock rewards. There is up to 312,500,000 ROOT in total waiting to be unlocked in the first season of The Third Kingdom. Rewards that will not be harvested in season 1 will stay in the land for future seasons. Community Land (referred to as Origin Island) allows Prysm holders to participate in the game without owning a SurrealScape; Those who donโ€™t own any Surrealscapes of their own, and play the game using the Origine Island can plant up to 12 prysms, and as the OI is a 2x2 piece of land they will be able to build 12 extractors on it. Surreal Escapes SurrealScapes are a collection of resource-rich biomes, and your very own slice of The Third Kingdom. In Episode 1, you can apply the biome of a SurrealScape that you own to your Origin Island. This choice will determine the visual environment of your island, but wonโ€™t impact gameplay. You can then stack additional SurrealScapes to increase resource production rates and the number of Prysms you can deploy. More features, including increased Mycelium collection rates, will be introduced in future episodes. Players without any SurrealScapes can have a maximum of 12 Prysms deployed on their Origin Island at any given time. One can increase the capacity prysms that one can deploy by based on the number of SurrealScapes you stack on your island (so if you stack all your SS you can deploy all of your prysms). Currently, once you select a biome for your Origin Island, you wonโ€™t be able to change it. There are plans to allow biome changes in future updates, but for now, make sure you choose a biome youโ€™re happy to stick with for a while. To maintain the effective utility of your Prysms and SurrealScapes, you'll need to apply strategic thinking to prestige and keep them fueled, this wonโ€™t be a full-time job. The game features mechanics will allow you to effectively control your SurrealScapes and Prysms even if you have a lot. Prysms Prysms are a collection of land-harvesting devices, and your key to generating energy which is needed in season 2 to harvest mycelium, which can be used to unlock Root โ€œAND OTHER REWARDSโ€. In Episode 1, you can deploy prysms on Origin Island to boost the production rate of specific resources based on their traits and generate energy each time you prestige. Prysms can be re-deployed in game if they have not reached the end of their life cycle; across SurrealScapes or Community Land. Prysms are consumable collectibles. Once deployed on Origin Island, they enter a lifecycle lasting one season, the exception on this are the Eternal prysms that will last through out all seasons. The premium prysms (all prysms that are not eternals) will provide a random percentage boost of the resource production that can be re-rolled by the use of Kingdom coin to receive a higher boost. Eternal Prysms of Masteryprovide the maximum production boosts for their owner throughout the entire The Third Kingdom adventure, so it seems that because of this the use of a re-role wonโ€™t be needed for Eternal prysms as they receive the max boost already. If you choose not to use your Prysms in Season 1, they will stay in your FuturePass and be available for future seasons and they will remain to function as premium prysms. The mint of prysms started on March 27 2024 for a price of 696.9 ROOT each and lasted 2 weeks. There are 135,000 premium Prysms available in Season 1 of The Third Kingdom and 101.566 got sold (about 75%). The premium prysms that have not been sold at the time of the mint will be sold as normal prysms in future seasons. Extractors Extractors are either mines, pumps or factories and they provide a user the ability to harvest and claim resources from the land. Resources are needed to be able to prestige, upgrade buildings and save energy. When a user prestigeโ€™s all extractors and remaining materials are removed, however the lighthouse, stacked SurrealScapes and Prysms remain. We can think of the lighthouse as the control centre. Prestiging produces energy, which is consumed by prysms to harvest Mycelium in episode 2 and subsequently can be converted into ROOT tokens โ€œAND OTHER REWARDSโ€. The actual amount of ROOT Token rewards available at the conclusion of each episode, and collectively across each Season will be determined by the amount of Mycelium generated by user in-Game performance. The amount of ROOT Token rewards (and the resulting contribution to your FutureScore) you are eligible for at the end of an episode and/or which are distributed to you at the end of a prior Season, does not guarantee or otherwise mean you will receive the same (or even similar) ROOT Tokens and/or FutureScore contributions for future episodes and Seasons. Now thatโ€™s a lot of official sounding text, but what stands out is the โ€œand the resulting contribution to your FutureScoreโ€ part that seems to imply that there will be future score added based on the Root that you harvested in-game. Kingdom coin Kingdom Coins are an in-game currency you can use to accelerate your progress. You can use them to reroll the percentage of the resource production boost your Prysms provide, and skip building and upgrading costs to optimize your strategy and maximize rewards in The Third Kingdom. Kingdom Coins: Kingdom Coins is the in-Game currency. Kingdom Coins: a.) are only available for purchase using Fiat or Cryptocurrency; b.) cannot be earned by completing in-Game tasks, activities, or actions; c.) can be utilized for in-Game progression; d.) cannot be redeemed for ROOT Tokens or any currency or cryptocurrency. Kingdom Coins can be purchased through the website using ROOT. Episode 1 During episode 1 the goal is to generate energy to be used in episode 2 to harvest mycelium . We capture energy every time we prestige. When you prestige, your extractors are removed, and all resources are reset to zero. However, you retain the energy youโ€™ve generated, and you receive a production boost, allowing you to progress more quickly in subsequent cycles of the episode. Episode 2 The goal in episode 2 will be to harvest Mycelium and unlock ROOT and other rewards. ROOT Token rewards can be claimed during the Game Season (so not at the end of the season). We will be able to recruit Flufs, Party Bears, Buzzies, Thingies, Seekers, Walkers, Cool Cats, Doodles, Deadfellaz, Pudgy Penguins, to enrich your harvesting experience in Episode 2. Gen2 brains are also mentioned to be used in episode 2 in the official docs, but weโ€™re not sure if this is true or a mistake in the content. Episode 3 Little is known about episode 3 other than that it will involve "intelligent lands" of which we will be able to harvest Asto tokens. The assets that will play a role in this are Gen2 brains, Atem cards and Aifa players. The exact role of the Aifa players as of yet is unknown to us, but it has been stated that Gen2 and Atem cards will receive intelligent lands. So far further episodes of season 1 have not been mentioned but we do know but that refineries are being mentioned in docs and at some point will also play a role in TTK game. Thereโ€™s really nothing other posted about refineries in the docs Iโ€™ve looked at, but it seems safe to assume they will play a role in refining resources into real world asset that will play a role in Op3n. Additional Some in-Game features and advanced content are only accessible to Users who own specific Digital Collectibles such as Prysms and SurrealScapes. There will at some stage be a thing called Automatorโ€™s, and all we know is that Automator means an on chain asset that can be assigned to a building that automatically claims resources when the building reaches capacity. In the clip I posted with this tweet captain.root clearly states (as he has done before) that part of the design of The Third Kingdom is to be able to supports โ€œnew rewards over different seasons and episodes, and those can be from within our ecosystem our even from outside our ecosystemโ€. I personally think itโ€™s not a stretch the assume that some of the projects that are currently working on projects that will in the future be released are already planning to use the TTK to release some of their assets as rewards in-game of TTK. This is all the information that has been gathered and released earlier in our Third Kingdom Guild discord earlier, and shared here to hopefully help the community and give them an overview of what we currently know about this game weโ€™re all looking out to play, and which will go live in the coming week. After the game has gone live Matt Bartlett will make and share an updated version of TTK Guild flipbook. If you found this content useful I would appreciate you sharing this with the community by sharing, liking and commenting on the tweet. We of the TTK Guild wish everyone a great season ! and lots of joy playing the game. LFG

Dip

12,507 views โ€ข 2 years ago

i'm leaking my entire coding agent setup... 20 billion tokens and 12,000 sessions later, i got sick of explaining the same project every time i switched tools. so i built them a shared brain steal the prompt [start prompt] Set up Agentic Stack as my local second brain and LLM-maintained wiki, shared across the supported coding tools I have installed. Carry this through installation, connection, source selection, wiki creation, and real cross-tool verification. Use the structure below as a proposed design, adapting it to the capabilities you actually verify. 1. Research the supported setup Read these primary sources before making changes: Check the current documentation against the installed version. Clearly distinguish Agentic Stackโ€™s existing features from additional wiki workflows you create. Do not invent commands, APIs, integrations, export formats, or automatic synchronization behavior. 2. Inspect my environment and preserve existing work Identify: Installed supported coding tools and their versions. Existing Agentic Stack installation and configuration. Relevant projects and available conversation history. Existing skills, rules, memory files, and MCP connections. A suitable location for the shared wiki. Before editing configurations, record the intended changes and create recoverable backups. Preserve unrelated settings, customized instructions, credentials, source conversations, and existing projects. Keep backups private and outside version control. Never print secrets or copy provider credentials between tools. 3. Install and connect Agentic Stack Use the documented installation method for my platform. Connect the supported tools I have installed through the appropriate documented mechanisms. Preserve existing MCP entries and tool-specific settings. Restart or reload tools where required. Verify each connection through an actual tool invocation. Distinguish these states: Detected. Configured. Requires restart or authentication. Retrieval verified. Blocked or unsupported. Do not claim a connection works merely because an installer completed or a toggle is enabled. 4. Help me select the first sources Inventory candidate sources without importing everything automatically. Recommend a bounded first import from one active project, prioritizing: Conversations containing meaningful decisions. Architecture explanations and project documentation. Verified debugging lessons. Repeatable workflows. Explicit preferences and conventions. Relevant skills and rules. Show me the proposed sources and ask me to select what to include before importing private content. Record the approved scope so you can reuse that authorization for subsequent refreshes. Exclude credentials, hidden reasoning, unrelated personal information, dependency folders, generated files, and unnecessary tool output. 5. Create a portable wiki directory Create a separate SecondBrain/ directory at a suitable location. Keep it outside application bundles and native conversation stores. Use this structure, creating content folders only when needed: SecondBrain/ โ”œโ”€โ”€ README.md โ”œโ”€โ”€ AGENTS.md โ”œโ”€โ”€ config/ โ”‚ โ”œโ”€โ”€ sources.yaml โ”‚ โ”œโ”€โ”€ projects.yaml โ”‚ โ”œโ”€โ”€ routing.yaml โ”‚ โ”œโ”€โ”€ policy.md โ”‚ โ””โ”€โ”€ integrations.md โ”œโ”€โ”€ inbox/ โ”œโ”€โ”€ raw/ โ”‚ โ”œโ”€โ”€ conversations/ โ”‚ โ”œโ”€โ”€ documents/ โ”‚ โ””โ”€โ”€ web/ โ”œโ”€โ”€ catalog/ โ”‚ โ”œโ”€โ”€ sources.jsonl โ”‚ โ”œโ”€โ”€ pages.jsonl โ”‚ โ””โ”€โ”€ exclusions.jsonl โ”œโ”€โ”€ wiki/ โ”‚ โ”œโ”€โ”€ index.md โ”‚ โ”œโ”€โ”€ projects/ โ”‚ โ”œโ”€โ”€ decisions/ โ”‚ โ”œโ”€โ”€ concepts/ โ”‚ โ”œโ”€โ”€ workflows/ โ”‚ โ”œโ”€โ”€ lessons/ โ”‚ โ”œโ”€โ”€ research/ โ”‚ โ”œโ”€โ”€ sources/ โ”‚ โ”œโ”€โ”€ preferences/ โ”‚ โ”œโ”€โ”€ skills/ โ”‚ โ””โ”€โ”€ rules/ โ”œโ”€โ”€ templates/ โ”œโ”€โ”€ operations/ โ”‚ โ”œโ”€โ”€ ingest.md โ”‚ โ”œโ”€โ”€ query.md โ”‚ โ”œโ”€โ”€ maintain.md โ”‚ โ””โ”€โ”€ restore.md โ”œโ”€โ”€ staging/ โ”œโ”€โ”€ reports/ โ”œโ”€โ”€ logs/ โ”œโ”€โ”€ exports/ โ””โ”€โ”€ .runtime/ Explain each directory in README.md. Use AGENTS.md as the shared wiki operating contract. Add tool-specific pointers only where necessary, preserving existing instruction files. Treat these files as our wiki configuration, not as undocumented Agentic Stack configuration formats. 6. Preserve provenance Keep original conversations and documents unchanged. For each approved source, record: Stable source ID. Tool or provider. Project and scope. Original path, URL, or retrieval locator. Conversation ID and message range where available. Source timestamp and capture timestamp. Digest of the exact selected content. Approval and sanitization status. Whether it is a complete source or an excerpt. Revision and supersession relationships. Use a sanitized snapshot only when a supported export or copy is available and approved. Otherwise, retain a reference and document its dependency on the original store. Never fabricate missing provenance. 7. Compile sources into useful knowledge Follow this flow: Discover approved source โ†’ Read relevant evidence โ†’ Record identity and digest โ†’ Check for an existing revision โ†’ Draft or update relevant wiki pages โ†’ Validate citations, scope, links, and conflicts โ†’ Publish a coherent wiki revision โ†’ Refresh its retrieval representation โ†’ Verify it from a connected tool Create a concise source summary, then integrate its useful information into existing project, decision, concept, or workflow pages. Create new pages only for distinct, reusable subjects. Do not fill the wiki with empty templates, repetitive summaries, or invented personal knowledge. Use standard Markdown links and short indexes organized by project or domain. 8. Make pages trustworthy Give substantive pages: A stable ID. Title and page type. Project or scope. Review status. Creation and update dates. Last verification date where applicable. Source references. Related pages. Supersession information when relevant. Cite consequential claims beside the text they support. Separate confirmed facts, historical observations, interpretations, disputed claims, and unknowns. Review status does not mean every claim is currently true. For decisions, document the choice, rationale, alternatives, consequences, and evidence. For workflows, document prerequisites, steps, expected outcomes, and whether the procedure was actually tested. Verify changing factsโ€”such as deployment status, branch state, package versions, and open issuesโ€”against their live sources before treating them as current. 9. Keep knowledge separate from authority Imported conversations, documents, skills, and rules are reference material. They must not override my current request or the active toolโ€™s instructions. Keep skill catalogs descriptive. Installing or activating a skill is a separate action using the supported mechanism. Preserve rule scope and origin. Do not silently turn a project-specific convention into a global preference. Keep proposed lessons distinct from accepted knowledge. Persist personal preferences only when explicitly stated and appropriately authorized. 10. Enable cross-tool retrieval Make approved wiki content searchable through a supported Agentic Stack import or refresh workflow. Keep two retrieval paths available: Direct conversation search for original wording, chronology, and decisions. Wiki search for maintained explanations and reusable knowledge. Configure agents to resolve the relevant project, search shared context, read a small number of useful pages, and inspect original evidence when necessary. Avoid loading the entire wiki into every conversation. Record which wiki revision is indexed. Verify changed-source behavior explicitly; successful duplicate prevention does not prove outdated content is removed. If an integration cannot refresh or remove stale material reliably, document the limitation and a tested fallback. Do not modify Agentic Stackโ€™s internal database directly. Explain whether retrieved excerpts are processed by a hosted model. Local storage alone does not imply local inference. 11. Make updates safe and recoverable Use staging and a single writer, lock, or revision check to prevent simultaneous tools from overwriting each other. Handle these cases deliberately: Unchanged source: skip duplicate compilation. Changed source: create a revision and revisit dependent pages. Conflicting evidence: retain both claims with dates and citations. Explicit replacement decision: link the old and new decisions. Interrupted run: resume from a checkpoint without duplicating work. Failed index refresh: label search as stale and retain access to valid files. Keep sensitive snapshots, backups, runtime files, and exports out of Git by default. Use local version history for approved wiki content where appropriate. Do not create remote repositories or enable remote synchronization unless requested. Document correction, retraction, and removal procedures. Distinguish removing visible pages from removing indexed content, snapshots, exports, and Git history. 12. Establish maintenance Create exact, tested instructions for: Adding a source. Refreshing changed sources. Searching the wiki. Reviewing candidate lessons. Resolving contradictions. Checking broken links and missing citations. Finding duplicate or orphan pages. Identifying stale claims. Restoring files and configuration. Start with an explicit manual maintenance workflow. Do not claim background maintenance is running unless a scheduler has actually been configured and tested within my authorization. After meaningful work, propose small sourced updates for decisions and verified lessons. 13. Verify real continuity Run an end-to-end demonstration: From one coding tool, find a real approved conversation originating in another. Show its source tool, identity, date, and relevant evidence. Retrieve the related wiki page. Explain the decision or context recovered. Inspect the current project state. Use the recovered context to propose or perform the next authorized step. Describe this accurately as cross-tool context retrieval, not migration of the original live session. Also verify: Repeated imports do not create duplicate logical content. Changed evidence updates the correct page and retrieval result. Citations and page links resolve. Excluded synthetic material stays outside the tested import route. Conflicting synthetic evidence remains visibly disputed. Original sources and unrelated configurations remain intact. A changed wiki file and configuration backup can be recovered. Use synthetic fixtures where testing could damage real knowledge. 14. Give me a concrete handoff Finish with: Installed versions and actual storage paths. A connection-status table for each tool. Approved and imported sources. Created wiki pages and their purpose. The published and indexed wiki revisions. Verification results with evidence. Known limitations and remaining setup. Exact tested instructions for daily use and recovery. Continue through the authorized work. Ask only when source selection, missing credentials, or a consequential decision requires my input. Report blockers precisely, and never present installation alone as a completed second brain. [end prompt]

Avid

107,673 views โ€ข 21 days ago

Fulu Talisman Ordinals Release Announcementใ€Backup versionใ€‘ ๏ผˆThe Official Release Announcement of FuluTalisman has gained too much popularity, with nearly 50,000 reads within 24 hours. Excessive private messages and frequent interactions have temporarily frozen the account. It will take a few days to unlock. During this period, operations will be primarily managed by ๅญŸๅ…ƒๆ™ฏ| Mark Meng. Collaboration community giveaways can use this tweet.๏ผ‰ ๐Ÿš€Positioning๐Ÿš€ The world's first decentralized religious PFP Ordinals collection. 5000 years of Chinese Taoist runes. Every Ordinals Address and collection needs the Fulu Talisman to bring good fortune and blessings. ๐Ÿ”ฅIntroduction๐Ÿ”ฅ XianDAO, a decentralized religious organization, announces the launch of the Ordinals collection โ€œFuluTalisman.โ€ MarkMeng, founder of XianDAO, is the 76th generation descendant of Confucian saints, a disciple of the top Taoist sect with 1600 years of history, and the inheritor of ancient martial arts. MarkMeng deeply believes that BTC is the spiritual totem of the crypto world, but its ecosystem remains underdeveloped. He believes that BTC's ecosystem needs to carve out its own unique path to distinguish itself from others. Inspired by Taoist supreme deity Emperor of Nothingness (The Primordial Supreme Deity), MarkMeng uncovered and resurrected 250 human-shaped Taoist runes. Using the Bitcoin decentralized network as the largest technological religious altar, he built the XiuXian Meme IP to construct a decentralized religious kingdom on-chain, driving the prosperity of the BTC ecosystem. ๐Ÿ“œBasic Information๐Ÿ“œ Official Website: XianDAO Discord: Supply: 5000 Launch Platform: TBA Mint Time: TBA โœจMint Roundsโœจ Round 1: OG Round Price: Free Each OG holder address can mint 2 FuluTalisman (snapshot time TBA) Note: It is recommended to split holdings between different addresses (one OG per address). An additional 250 spots will be allocated for XianDAO Builders. Round 2: WL Round Price: 0.0003 BTC (~30 USD) Each address can mint one FuluTalisman. Note: If you wait too long, there is a small chance you may miss out. Round 3: Public Round Price: 0.0003 BTC (~30 USD) Note:Every address can mint one FuluTalisman. ๐Ÿ’ฐImportant Notice๐Ÿ’ฐ The #BitcoinXiuXianOG is the safest and most reliable choice. It represents XianDAOโ€™s identity, the core asset of our Meme IP, and the golden shovel. You can even purchase directly here: ๐Ÿ”ฎRune Airdrop Rules๐Ÿ”ฎ FuluTalisman is just the beginning. Our next step is the worldโ€™s first decentralized religious rune airdrop through a divine ritual to summon the Emperor of Nothingness (The Primordial Supreme Deity). Both #BitcoinXiuXianOG and #FuluTalisman collections will receive 50% of the runes, distributed evenly within each collection. The snapshot will be announced before the airdrop, and distribution will be based on the address holdings at that time. #BitcoinXiuXianOG holders will receive approximately 7 times the amount of runes compared to #FuluTalisman holders. ๐Ÿ™Charitable Donation Request๐Ÿ™ We are preparing to host the grandest religious ritual in the worldโ€™s largest tech temple โ€” the decentralized Bitcoin network. This will be a divine summoning ceremony to invoke the Emperor of Nothingness (The Primordial Supreme Deity). To achieve this, we need more donations. Please donate BTC to the following address: bc1p262j3h03gfcajhn2ruj75jgvthssnrhupnqdtyceyu90zn4ven9sc9qwd4 Please note: This is a charitable act with no return. It is an opportunity to accumulate merit. You can donate any amount, such as 10U, 15U, or 20U worth of BTC โ€” any contribution is welcome. All BTC will be used to host the divine ritual and empower the arrival of the Emperor of Nothingness. Additional Ordinals collections and runes will be offered as sacrificial gifts to Satoshi Nakamotoโ€™s address. Every donor's address will be recorded and etched on the Bitcoin blockchain as a permanent document of sacrifice, sent to Satoshiโ€™s address. Together, we will help revitalize the BTC ecosystem. All participants in this grand religious ritual will become part of this monumental legacy, eternally etched in history. ๐Ÿ””Follow, Like, Retweet, and leave your best New Year wishes in the comments with an @ to your friends. This will bring you and your friends good fortune in the New Year. โ€” MarkMeng, 2025.1.13 XianDAO

ๅญŸๅ…ƒๆ™ฏ| Mark Meng

120,025 views โ€ข 1 year ago

Every night as a kid, Kobe Bryant fell asleep visualizing basketball. Heโ€™d see himself scoring 10 straight. Then 20. Then 30. โ€œBut in the dream, why would you ever interrupt that?โ€ โ€œSo you keep dreaming.โ€ โ€œBefore I go to sleep, Iโ€™m at 120 points.โ€ In 2006, he scored 81. Kobe spent an hour at USC explaining what Mamba Mentality really means: He was born to play. "I started playing at like 2 years old." "My father wasn't one of these fathers that was like: you're going to play basketball. It was just I was around the game a lot and I gravitated to the ball." "I was completely geeking out about the smell of the ball. The way it sounds when it hits concrete versus how it hits a parquet floor." "The sound of the nets. The different material of the nets." "There's certain basketball hoops where the rim sits slightly above the backboard. I was geeking out if I got into a gym where they were completely parallel." "Little shit like that would freak me out." "To answer your question, I was born to do this thing, man. And I did it non-stop all day long from the age of 2 to when I retired." He explains how to know if you've found your thing. "That's the trick, isn't it? Finding what you love to do." "We talk about hard work all the time. And it's like, if you got to get up every single morning and remind yourself how hard you need to work, you probably need to choose a different profession." "That shouldn't be there." "I wake up in the morning excited to get to it. If I'm not training, I'm missing it. If I'm not watching a game of basketball, I miss it." "There's no place I'd rather be." "If you have that feeling, then you're truly doing what God has put you on this earth to do." He explains the 81-point game. "When you grow up downloading that into your brain over and over and over..." "That summer, I made 1000 shots a day. 1000. On top of weight training and conditioning." "And they weren't just shots. They were shots that you saw in that game." "Coming out of the corner. Going to the pinch post. Footwork in the post. Coming off the screen." "It was very specific." "So when you download that into your system and you go out on the court, you're just executing things that you've done thousands of times before." "And you have that dream." "Then that becomes possible." He explains why he doesn't reinvent. "Everything's been not choreographed, but it's been practiced so many times that it's second nature." "Why reinvent it?" "I don't understand that. You go out and play the game and you're just trying to create something new. No." "This is what I do. This is what I do extremely well." "You're going to have to stop me from doing that. And if you do stop me from doing that, I have a counter to that." "Done." He explains the pain. "To be honest, I wasn't even thinking about the game." "My knee was hurting so much. I didn't know then, but I had a flap of cartilage stuck in my joint line." "My mind was really trying to go to a place where I don't feel that pain." "The game started. And because of that, I was just in a different space." "I wasn't worried about what was to come. I wasn't worried about what just happened. I was just here." "When you're just there in the moment, your focus is heightened because nothing else matters." Pete Carroll asked the hard question. "What was it like for you to play with people that weren't as gritty as you were?" Kobe's response. "I'd kill them. I'd bury them." "The kind of culture that the Laker organization stood for, winning championships, is not tolerated." "You're going to show up to play. And you're going to lollygag through this scrimmage, through this drill? I'm going to beat you." "I'm going to let you know I beat you." "I'm going to want you to reconsider your professional life choice." "People will say: okay, that doesn't make a great teammate." "Well, I'm not here to be a great teammate. I'm here to help you win championships." "So it's different." He explains practice. "As a leader of a team, it's your responsibility to elevate the rest of the guys." "What people tend to get stuck on is saying: the way to make players better is to pass them the ball when they're open." "That's a very trivial way to look at things." "You have to get them emotionally to want to be better. You have to get them to an emotional space where they wake up every morning driven to be the best version of themselves." "How do you do that?" "In practice for me, it was a chance to drive them, to challenge them." "You have to know your teammates. Because then you know what nerve to touch." "Some guys, it's like: okay, come on, we can do this. That'll get them going." "Other guys, no. You got to figure out what button to push." He gives an example. "Pau was always Spain." "If I tell him how they lost in the gold medal to us and how they're going to lose again, how I'm going to beat your ass in practice just like I beat you in the gold medal game." "Oh. He would hate that. He would hate that." "But that's what practice was. You have to drive them." "If practice is more intense and harder than a game seven will be, then a game seven will be easy." "But if it's not, then that's when teams start folding and capitulating." He explains standards. "If I got to fight to get you in the gym, that's a problem. That's a problem." "You want players that are gym rats. Players that want to be in the gym, that want to work." "Then from there, you build on top of that." "But if you're lazy, man, I don't want to talk to you. I don't want to deal with you. You make me feel dumber." "You're going to lower my level. I don't think so." "You can go over there. There's plenty of teams where you'll fit right in." He explains loyalty. The Lakers offered to trade him to a contending team. His response. "We've known each other for a very long time. I'm questioning myself because I'm wondering what about me makes you think I would jump ship." "We don't do that." "As a leader, you got to be able to take the good with the bad." "You can't just because the ship's sinking all of a sudden jump off and swim to another. You don't do that." "If you can win championships in front of everybody, then you could miss the playoffs in front of everybody." "You got to be able to take both sides of it." "If you're doing something that's easy, you might want to reconsider what you're doing." He explains what he wishes he knew earlier. "Understanding empathy and compassion." "As a young kid when I came in the league, it was like: I'm driving this way and either you're going to be on the train or be on the track." "There was no such thing as understanding that people have lives outside of the game. Which apparently I did not." "If I understood that at an early age, then it helps me as a leader to communicate better." "Getting to know people on a personal level. What are their fears. What are their insecurities. What are their dreams and ambitions." "When you come to understand that about a person, then you can help them reach the best version of themselves." "I wish I'd known that earlier." He explains how he teaches his daughter. "My daughter said: Dad, can you teach me how to play basketball? I want to be better than you." "All right, cool. Let's start with 15 minutes a day." "For 15 minutes a day, we just stood right in front of the hoop and just shot. Right under the hoop. We didn't move around. We didn't do any dribbling." "Just 15 minutes a day just shoot here." "You do that for a month and a half. Then next month, you step back. Then next month, you step back again. Then you start working on dribbling." "Through actionable things is how we teach our children." "If it becomes a part of their process in sports, it'll become a part of their process in life as well." He explains dreams. "I just dream. I have dreams." "Dreams should be pure." "A lot of times when we're born into this world, we actually wind up going backwards." "The more we mature, the more responsible our dreams become. The more governors we put on ourselves and our ability to dream and to reimagine." "It's always a fight for us to make sure that our dreams always stay pure." "It's not a matter of pushing beyond your limitations or expectations." "It's really a matter of protecting your dreams. Protecting your imagination." "That's really the key." "When you do that, then the world just seems limitless."

Jaynit

17,383 views โ€ข 4 months ago

$NVDA $GFS NVIDIAโ€™s reported agreement to acquire Groq for $20B in cash (per CNBC, amplified via Reuters and other wire coverage) represents a materially different strategic posture than NVIDIAโ€™s prior M&A pattern, given both the headline size (largest reported NVIDIA acquisition to date) and the unusual carve-out that Groqโ€™s early-stage cloud business would not be included. Public reporting indicates the information originated from Alex Davis, CEO of Disruptive (lead investor in Groqโ€™s latest financing), and that neither NVIDIA nor Groq had issued an immediate confirmation at the time of publication. The same reporting frames the transaction as coming together quickly, only months after Groq raised $750M at a ~$6.9B valuation, and highlights Groqโ€™s positioning as a high-performance inference chip vendor founded by ex-Google TPU engineers. Groq is best understood as a vertically integrated inference acceleration company whose core asset is an application-specific processor optimized for deterministic, low-latency execution of transformer-style workloads, paired with a compiler-led software stack and a distribution layer (GroqCloud) designed to reduce developer friction via OpenAI-compatible APIs and integrations. Groq brands its architecture as a Language Processing Unit (LPU) and consistently emphasizes that the design target is inference, not training. The companyโ€™s own architecture description centers on 1-core execution, large on-chip SRAM used as primary storage (explicitly not cache), a custom compiler that statically schedules compute and communication, and direct chip-to-chip connectivity intended to coordinate multi-chip execution without relying on conventional caching hierarchies or dynamic runtime scheduling. The technical premise is a deliberate inversion of the conventional GPU approach. GPUs deliver throughput via massively parallel, multi-core execution with dynamic scheduling, complex memory hierarchies, and heavy reliance on off-chip HBM bandwidth and sophisticated runtime/kernel optimization. Groq instead argues that inference bottlenecks are driven by latency variance (tail latency), synchronization overhead, and memory access unpredictability inherent in dynamically scheduled, cache-heavy architectures, particularly when workloads are latency sensitive and batch sizes cannot be inflated. Groqโ€™s solution is to move โ€œcontrolโ€ into the compiler: the full execution graph and inter-chip communication schedule are computed ahead of time down to clock-cycle granularity, with deterministic execution designed to reduce run-to-run variance. In Groqโ€™s framing, the removal of caches, reorder buffers, speculative execution overhead, and other sources of contention enables predictable latency and high utilization without per-model kernel engineering typical of GPU tuning cycles. A critical nuance is that Groqโ€™s determinism is not merely a software claim; it is tightly coupled to architectural constraints and system design choices that trade flexibility for predictability. Third-party technical commentary indicates Groqโ€™s chip uses a fully deterministic VLIW-style approach with minimal buffering, no external memory, and heavy dependence on sharding models across many chips because on-chip SRAM capacity is limited. SemiAnalysis describes a ~725 mm^2 die on GlobalFoundries 14nm with ~230MB of SRAM and notes that โ€œno useful modelsโ€ fit on a single chip, forcing multi-chip partitioning for modern LLMs and driving a system-level design where networking and compilation are first-class scheduling problems rather than ancillary infrastructure. This is consistent with Groqโ€™s own messaging that tensor parallelism across chips is a primary design goal, enabled by large on-chip SRAM and compile-time coordination of compute plus interconnect. The on-chip SRAM emphasis is central to Groqโ€™s latency story and also its most constraining trade-off. Groq claims on-chip SRAM bandwidth โ€œupwards of 80 TB/sโ€ and contrasts that with off-chip HBM bandwidth โ€œabout 8 TB/s,โ€ asserting a potential 10x advantage from bandwidth plus reduced trips across chip-to-memory boundaries. While these comparisons are marketing-oriented and depend on workload specifics, the architectural implication is clear: Groq prioritizes ultra-fast local weight/activation access and then scales capacity by adding chips, not by attaching large off-chip memory pools. This design can reduce latency for sequential inference layers and minimize unpredictable stalls, but it pushes complexity into partitioning strategy, interconnect topology, and compiler scheduling, and it increases the number of chips needed for very large parameter counts and large KV-cache footprints. Groq also highlights numeric formats and compiler-driven precision management as a performance lever. In its 2025 technical blog, Groq describes โ€œTruePoint numerics,โ€ including 100-bit intermediate accumulation and selective quantization choices (FP32 for attention-sensitive operations, block floating point for MoE weights, FP8 storage in error-tolerant layers), and claims 2-4x speedups versus BF16 without measurable accuracy degradation on benchmarks such as MMLU and HumanEval. Even if the absolute uplift is workload dependent, the strategic point is that Groq is pursuing performance via end-to-end co-design: precision policy is not just hardware capability (FP8/BF16) but compiler-enforced mapping of precision to error sensitivity, which can matter materially for inference cost-per-token if it reduces memory traffic and boosts throughput without forcing aggressive, accuracy-damaging quantization. Independent performance datapoints indicate Groq has been credible on latency-oriented inference speed, at least for certain regimes. EE Times reported in 2023 that Groq demonstrated Llama-2 70B inference at ~240 tokens/s per user on a cloud-based dev system described as 10 racks and 64 chips, using the companyโ€™s 1st-gen silicon introduced several years earlier. Separate Groq commentary around independent benchmarking cites results showing ~241 tokens/s throughput and ~0.8s time to receive 100 output tokens for a Llama-2 70B API configuration, positioning the platform as a step-change in โ€œavailable speedโ€ for certain interactive use cases. These figures do not settle total cost-of-ownership versus GPUs or hyperscaler ASICs, but they establish that Groqโ€™s system-level architecture can deliver strong single-user throughput and latency on large models when properly partitioned and scheduled. GroqCloud is the commercial wrapper that packages this hardware/software stack as โ€œtokens-as-a-service,โ€ aiming to make Groq adoption feel like switching API endpoints rather than adopting new silicon. Groqโ€™s documentation states its API is designed to be โ€œmostly compatibleโ€ with OpenAI client libraries, and its pricing page provides model-specific token rates, published speeds (tokens/s), prompt caching discounts, and batch processing discounts. For example, pricing lists inputs as low as $0.05 per 1M tokens and outputs as low as $0.08 per 1M tokens for certain smaller LLM configurations, with higher prices for larger models and long-context or MoE variants; it also advertises prompt caching with a 50% discount on cached input tokens for certain models and a batch API offering 50% lower cost for asynchronous processing windows. These mechanics are economically important because they demonstrate Groqโ€™s go-to-market is not simply โ€œsell chips,โ€ but โ€œsell predictable unit economics per token,โ€ with tooling (batch, caching) that directly targets inference cost drivers (reused prompts, throughput smoothing, and asynchronous workloads). The cloud footprint and distribution partnerships indicate Groq has been building an inference-native โ€œedge within the cloudโ€ strategy rather than competing head-on with hyperscalers on breadth of services. A 2025 Groq newsroom release describes a European deployment in Helsinki with Equinix, positioned as latency reduction and data governance for European customers, and explicitly references Equinix Fabric enabling private connectivity to GroqCloud over public, private, or sovereign infrastructure. The same release enumerates additional capacity in the U.S. (Equinix, DataBank), Canada (Bell Canada), and Saudi Arabia (HUMAIN), and states these sites collectively served more than 20M tokens/s across Groqโ€™s global network at that time. That supply-side metric matters because it provides a directional sense that Groq is scaling capacity as a network, not merely as a chip vendor. Customer disclosure is inherently limited because Groq is private and many enterprise deployments are not public, but Groqโ€™s marketing materials and partnerships provide signals about demand vectors. The companyโ€™s public website displays logos of large consumer and enterprise brands (e.g., Dropbox, Vercel, Chevron, Volkswagen, Canva, Robinhood, Riot Games, Workday, Ramp) and includes a published customer quote claiming a 7.41x chat speed increase and an 89% cost reduction after moving to GroqCloud, followed by a tripling of token consumption. While marketing claims should be treated as case-specific and not generalized, they indicate that Groq is targeting both AI-native developers (who measure success by latency and cost-per-token) and enterprise buyers (who care about predictable performance and governance). Supplier and dependency mapping for Groq spans 3 layers: silicon production, system integration, and cloud infrastructure. On silicon, third-party analysis indicates GlobalFoundries 14nm for the 1st-gen Groq chip, implying a supply chain less constrained by the most capacity-tight leading-edge nodes and advanced packaging bottlenecks that dominate high-end GPU supply (HBM stacks, CoWoS-type packaging constraints). If accurate, this is strategically meaningful because it suggests Groq capacity expansion could be gated more by conventional wafer supply, board assembly, and data center power than by the same HBM/advanced packaging scarcity that has constrained top-tier GPU ramp cycles. On systems and cloud, Groqโ€™s own releases identify colocation and connectivity partners (Equinix, DataBank, Bell Canada) and a Middle East partner (HUMAIN), implying dependencies on data center real estate, power availability, and network connectivity, alongside procurement of standard server components, NICs/switching, racks, and cooling infrastructure. The Groq design narrative also emphasizes air cooling and reduced need for complex power/cooling infrastructure, whichโ€”if realized in deploymentsโ€”can widen the set of feasible hosting locations and lower deployment friction relative to liquid-cooled, very high power density GPU racks. Against that backdrop, the strategic rationale for NVIDIA acquiring Groq can be framed as a set of overlapping objectives: inference silicon optionality, architectural hedging, competitive defense, and supply chain diversification, with the carve-out of GroqCloud signaling a preference to avoid direct cloud competition and to focus on IP and product portfolio control rather than operating a capital-intensive token-serving business. The deal, if confirmed, would occur at a valuation step-up of ~190% versus Groqโ€™s reported ~$6.9B private valuation in the September $750M round, reinforcing that any acquisition logic would be predominantly strategic rather than a conventional financial multiple arbitrage. The most compelling strategic driver is inference. Training has historically been the center of gravity for cutting-edge GPU demand, but inference volume is structurally larger and more distributed as deployments scale, with economics dominated by cost-per-token, latency guarantees, and utilization under spiky demand. Inference workloads also create a strategic vulnerability for NVIDIA: hyperscalers and large platforms can justify bespoke ASICs (TPU, Trainium/Inferentia, Maia-class efforts) because inference is stable, repeatable, and can amortize software investment at massive scale. Groqโ€™s core propositionโ€”deterministic, compiler-scheduled inference with predictable latencyโ€”aligns directly with the segment where GPU generality is least valued and where โ€œgood enoughโ€ programmability plus superior unit economics can win share. Acquiring Groq would allow NVIDIA to own a credible inference-native architecture rather than relying solely on GPUs and software optimization to defend that segment. Competitive defense logic is also plausible. Groq occupies a specific competitive wedge: low-latency, high-throughput interactive inference, delivered via a simple API abstraction that reduces switching cost. That wedge directly pressures GPU inference margins in the long run because it makes inference price/performance comparisons more transparent at the token level, and it targets a developer persona that historically defaulted to CUDA-first ecosystems. Even if NVIDIAโ€™s current-generation systems can achieve very high tokens/s per user with extensive optimization, the strategic risk is that competing architectures normalize the idea that inference is best served by special-purpose silicon with a simpler programming model, weakening CUDA lock-in at the application layer. NVIDIA has actively demonstrated that Blackwell-era systems can exceed 1,000 tokens/s per user in benchmarked configurations, but that performance leadership does not automatically translate to lowest cost-per-token across the full range of batch sizes, latency targets, and deployment environments. Groqโ€™s existence as a credible alternative architecture forces NVIDIA to keep defending inference economics rather than only raw performance leadership. The โ€œtechnology acquisitionโ€ rationale is unusually strong in this specific case because Groqโ€™s differentiator is not a single block of silicon IP but an end-to-end methodology: compiler-led static scheduling, deterministic networking, and a system architecture designed around tensor-parallel inference rather than throughput-maximizing batch inference. NVIDIAโ€™s stack is already compiler-heavy (TensorRT, Triton, CUDA graphs, kernel fusion, speculative decoding techniques), but GPUs remain dynamically scheduled devices with complex memory hierarchies and stochastic latency behaviors under contention. Groqโ€™s approach provides an alternate design point: treating the entire inference execution (compute plus communication) as a statically schedulable program. In principle, that IP could be valuable even if Groq silicon itself is not adopted at massive scale, because it can inform how NVIDIA builds future inference-optimized products, compilers, and networking fabrics, especially as distributed inference with large models makes communication a first-order performance determinant. Supply chain diversification is a non-obvious but potentially important driver. If Groqโ€™s mainstream product generation is truly based on a mature process node and avoids HBM, then the scaling constraints look different than those of state-of-the-art GPUs. NVIDIAโ€™s ability to meet incremental demand has been tightly coupled to advanced packaging and HBM supply, and those constraints can remain binding even when wafer supply is available. An inference ASIC architecture that relies primarily on on-chip SRAM and scales by adding chipsโ€”while not costlessโ€”could reduce dependence on HBM availability and advanced packaging capacity, enabling NVIDIA to ship โ€œinference capacityโ€ in higher absolute volumes or into geographies and customer segments where the highest-end GPUs are economically or logistically difficult to deploy. This could be particularly relevant for latency-sensitive inference deployed in regional colocation footprints rather than centralized hyperscale campuses. The carve-out of GroqCloud, if accurate, is itself a strategic signal about NVIDIAโ€™s priorities. Operating a token-serving cloud at scale is capital intensive, structurally lower margin than silicon IP rents, and creates channel conflict with hyperscalers and CSP partners who are core NVIDIA customers. NVIDIA has generally positioned its cloud offerings through partnerships rather than as a direct hyperscale competitor. Excluding GroqCloud would preserve neutrality with CSPs and avoid inheriting multi-region data residency obligations and partner contracts, while still allowing NVIDIA to acquire Groqโ€™s silicon, compiler technology, and engineering talent. At the same time, excluding GroqCloud would also mean NVIDIA would not automatically acquire the commercial proof-point of Groqโ€™s unit economics or the customer contracts that validate product-market fit at scale, increasing the importance of diligence on whether Groqโ€™s cloud pricing is structurally profitable or partially subsidized by fundraising. There is also a โ€œpreemptive acquisitionโ€ angle. The reporting identifies recent investors in Groqโ€™s latest round including large financial institutions and strategic/industry players. In that context, Groq represents an asset that could plausibly have been acquired by a competitor (AMD/Intel) or by a hyperscaler seeking to accelerate inference independence. NVIDIA acquiring Groq could be a defensive move to prevent a credible inference-native architecture from being weaponized by a rival with deep distribution. Even if GroqCloud is carved out, controlling the silicon roadmap and compiler IP would meaningfully constrain Groqโ€™s ability to evolve into a standalone competitor, unless the carved-out entity retains long-term rights to the hardware and software stack. However, the strategic case is not one-sided; there are meaningful risks and potential contradictions that would need to be reconciled for the transaction to be value-accretive on a multi-year horizon. 1st, Groqโ€™s architecture appears to rely on scaling out chip count to achieve capacity, which introduces system cost, networking complexity, and physical footprint considerations. The absence of external memory and limited on-chip SRAM implies very large models require substantial chip parallelism, and the economics then depend heavily on chip cost, yield, power efficiency, and interconnect overhead. SemiAnalysis explicitly frames Groq as trading space for time and raises questions about token economics and whether publicly advertised pricing reflects fully loaded costs or market share capture. 2nd, integration risk is non-trivial. Groqโ€™s compiler-led deterministic model is philosophically and practically different from CUDAโ€™s dominant programming and execution model. A poorly executed integration could create internal product confusion, dilute engineering focus, or alienate developers if the combined stack fragments. 3rd, there is cannibalization risk. If Groq-class inference silicon undercuts GPU inference economics, NVIDIA could face internal margin trade-offs, even if the goal is to defend share against hyperscaler ASICs. Cannibalization can still be rational if it prevents larger share loss, but it would require crisp portfolio segmentation and go-to-market discipline. The presence of NVIDIAโ€™s own rapidly improving inference performance complicates the โ€œneedโ€ for Groq but does not eliminate the โ€œoption value.โ€ NVIDIA has demonstrated benchmark-leading tokens/s per user on Blackwell-based systems, suggesting that raw interactive throughput is not necessarily the limiting factor for NVIDIAโ€™s product line. The more enduring strategic question is unit economics and architectural control: whether future inference demand is better monetized through general-purpose GPUs plus software optimization, or whether a bifurcated product portfolio (training GPUs plus inference-native ASICs) becomes necessary to defend total AI compute wallet share as hyperscaler ASIC penetration increases. Acquiring Groq could be a decisive move to ensure NVIDIA participates in both regimes rather than betting exclusively on GPUs to win inference forever. What is โ€œspecialโ€ about Groqโ€™s technology relative to a typical accelerator roadmap is the tight coupling of determinism, compilation, and networking into a single scheduling problem. The LPU narrative emphasizes deterministic compute and networking, static scheduling, and direct chip-to-chip coordination that allows โ€œhundredsโ€ (more precisely, 100s) of chips to behave like a single scheduled resource. The architecture also explicitly targets tensor-parallel, latency-optimized distribution rather than pure data-parallel throughput scaling, which matters for real-time applications where a single response must arrive quickly rather than many requests being processed in bulk. The implication is that Groq is optimized for the time-to-first-token and steady token streaming behavior that defines user experience in interactive LLMs, and it attempts to achieve that without relying on large batch sizes that can degrade latency. From a portfolio managerโ€™s perspective, the most important interpretation is that an NVIDIA-Groq combination would likely be less about โ€œNVIDIA needs more inference speedโ€ and more about controlling the architectural trajectory of inference acceleration and removing a fast-improving, developer-friendly competitor from the market. The carve-out of GroqCloud would reinforce that the transaction is aimed at IP, talent, and product optionality, not acquiring a cloud revenue stream. The valuation step-up implied by $20B versus $6.9B would therefore be justified only if the acquired assets materially reduce long-term competitive risk (hyperscaler ASIC displacement, inference margin compression) or enable new monetization vectors (inference ASIC product line, supply chain de-bottlenecking, improved software determinism) that would be difficult to achieve on a comparable timeline via internal R&D.

TheValueist

102,145 views โ€ข 9 months ago

๐—ง๐—ต๐—ฒ $NWBO ๐——๐—–๐—ฉ๐—ฎ๐˜…-๐—Ÿ ๐˜๐—ฟ๐—ถ๐—ฎ๐—น ๐—ถ๐˜€ ๐—ฎ๐—น๐—ฟ๐—ฒ๐—ฎ๐—ฑ๐˜† ๐—ฑ๐—ผ๐—ป๐—ฒ. ๐—ง๐—ต๐—ฒ ๐—™๐——๐—” ๐—ต๐—ฎ๐˜€ ๐—ฎ๐—น๐—ฟ๐—ฒ๐—ฎ๐—ฑ๐˜† ๐˜„๐—ฟ๐—ถ๐˜๐˜๐—ฒ๐—ป ๐˜๐—ต๐—ฒ ๐—ฝ๐—น๐—ฎ๐˜‚๐˜€๐—ถ๐—ฏ๐—น๐—ฒ ๐—บ๐—ฒ๐—ฐ๐—ต๐—ฎ๐—ป๐—ถ๐˜€๐—บ ๐—ฝ๐—ฎ๐˜๐—ต๐˜„๐—ฎ๐˜†. ๐—ช๐—ต๐—ฎ๐˜ ๐—ถ๐˜€ ๐—น๐—ฒ๐—ณ๐˜ ๐—ถ๐˜€ ๐˜๐—ผ ๐—ฎ๐˜€๐˜€๐—ฒ๐—บ๐—ฏ๐—น๐—ฒ ๐—ถ๐˜ ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ถ๐—น๐—ฒ. #DCVax-L is a vaccine made for each patient from their own dendritic cells, the immune cells that teach the rest of the immune system what to attack, loaded with their own tumor. It treats #glioblastoma, the deadliest brain cancer. An American company developed it, yet Americans have to go to Europe to get it. #DCVaxForBraelyn The FDA has spent the past year writing down how it wants to judge treatments like this one. The core evidence it asks for already exists. One question decides this: can the FDA evaluate DCVax-L for approval under the plausible mechanism framework, on the evidence already generated? Read against every document the agency has published on the framework, the answer is yes. ๐—ง๐—ต๐—ฒ ๐—ฝ๐—น๐—ฎ๐—ป ๐—ถ๐—ป ๐˜๐—ต๐—ฟ๐—ฒ๐—ฒ ๐˜€๐˜๐—ฒ๐—ฝ๐˜€ 1. File the biologics license application (BLA) and ask the FDA's biologics center (CBER) for review under the plausible mechanism framework. A BLA is not another trial. It is the dossier the FDA decides on, and the framework changes what counts as sufficient inside it. The framework itself needs no new statute and no special designation. A sponsor asks for it. 2. Ask for full approval on survival, with no new randomized trial. The completed phase 3 is the pivotal study. Mechanism, a related product, a related stage of the disease and independent natural history are the confirmatory evidence. A registry of every treated patient supplies the follow-up. 3. Open access alongside the filing. An expanded access treatment protocol does not have to wait for the BLA; it can begin 30 days after the FDA receives it. Filing the BLA satisfies Right to Try's application condition. ๐—ช๐—ต๐—ฎ๐˜ ๐˜๐—ต๐—ฒ ๐—™๐——๐—” ๐—ต๐—ฎ๐˜€ ๐˜„๐—ฟ๐—ถ๐˜๐˜๐—ฒ๐—ป ๐—ฑ๐—ผ๐˜„๐—ป Nov 2025, NEJM, Prasad and Makary: the plausible mechanism framework. Five questions. Built for cell and gene therapies first, and available for common diseases, particularly those "for which there are no proven alternative treatments." Feb 2026, NEJM: one adequate and well-controlled study plus confirmatory evidence is the FDA's default basis for approval. Feb 2026 draft guidance: an externally controlled study against a well-characterized natural history can be the pivotal study. Confirmatory evidence includes mechanism, target engagement and "exposure-response on biomarkers and clinical outcomes." The product can target "a well-characterized downstream or compensatory mechanism with a clear mechanistic rationale." June 2026 draft guidance: six conditions under which an external control supports effectiveness. The plausible mechanism framework named as an example of FDA regulatory flexibility in critical settings. "Even small effects may be clinically meaningful when the effect is on survival or irreversible morbidity." Why it exists: to bring regulatory flexibility to individualized therapies where the conventional model does not fit. The guidance names gene and RNA therapies, then says "the general concepts may apply to other types of individualized therapies": therapies that target "a specific pathophysiologic abnormality serving as the root cause of a disease." The FDA's own announcement: the guidance "leaves open the potential that this framework may apply to additional tailored therapeutics provided they directly address the underlying specific cause of the disease." The framework is not a new approval standard. It is how the FDA reads evidence under the standard that already exists. That is exactly why it can be asked for today. ๐—ช๐—ต๐˜† ๐—ด๐—น๐—ถ๐—ผ๐—ฏ๐—น๐—ฎ๐˜€๐˜๐—ผ๐—บ๐—ฎ ๐—ถ๐˜€ ๐˜๐—ต๐—ฒ ๐—ฐ๐—ฎ๐˜€๐—ฒ ๐—ถ๐˜ ๐˜„๐—ฎ๐˜€ ๐˜„๐—ฟ๐—ถ๐˜๐˜๐—ฒ๐—ป ๐—ณ๐—ผ๐—ฟ No proven alternative: recurrent GBM has no established standard of care. Of 400+ trials since 2005, only one phase 3 in newly diagnosed and none in recurrent disease had shown a survival benefit. High and predictable mortality: the exact case FDA regulations name for historical controls, "certain malignancies." Life-threatening in the regulation's own terms: a disease "where the end point of clinical trial analysis is survival." Individualized: a different product for every patient, made from their own cells and their own tumor, aimed at the root cause, the broken instruction layer. Orphan designation in the US and Europe. ๐—ง๐—ต๐—ฒ ๐—ฝ๐—ถ๐˜ƒ๐—ผ๐˜๐—ฎ๐—น ๐˜€๐˜๐˜‚๐—ฑ๐˜† ๐—ถ๐˜€ ๐—ฐ๐—ผ๐—บ๐—ฝ๐—น๐—ฒ๐˜๐—ฒ 331 patients, 94 sites, randomized, double blind. 64 of 99 placebo patients crossed over at recurrence, so survival was measured against 2,006 contemporaneous matched control patients from 15 randomized trials. Newly diagnosed: 19.3 vs 16.5 months, HR 0.80, p=.002. Alive at 5 years: 13.0% vs 5.7%. Recurrent: 13.2 vs 7.8 months, HR 0.58, p<.001. That is a 42% lower risk of death. The benefit widened over time, and it was largest in the patients who fare worst. Why no second trial? The completed trial, the crossover and the survival evidence make the case, and the FDA's June guidance names the ethical stake: after "a substantial decrease in mortality," a second trial "would generally present significant ethical concerns." ๐—ง๐—ต๐—ฒ ๐Ÿฎ๐Ÿฌ๐Ÿฎ๐Ÿฒ ๐—ฟ๐—ฒ๐—ฎ๐—ป๐—ฎ๐—น๐˜†๐˜€๐—ถ๐˜€ The phase 3 paper named its own limitation: without patient-level control data, "propensity score matching could not be performed." The critics named the missing methods: "propensity score matching or inverse probability weighting." In 2026 Northwest obtained individual patient data from three independent randomized trials and had independent statisticians run exactly those two methods. Propensity score matching pairs each DCVax-L patient with control patients who had the same prognostic profile, so like is compared with like. Presented at BNOS in July 2026; peer-reviewed publication is the next step. Propensity score matching: HR 0.69 to 0.77. Median survival +3.4 to +6.3 months. p .004 to .027. The original cohort-level analysis showed +2.8. When the matching got finer, the benefit got bigger. The survival advantage held under both patient-level methods and was larger than the original cohort-level estimate. Northwest reports sensitivity analyses for hidden confounding; the published paper should give the values. The method has been tested in this exact disease. In May 2026, the INSIGhT investigators replaced their own randomized control arm with propensity-matched external controls. For three drugs that had failed randomized testing, the method also found no benefit: HR 1.00, 0.93, 0.88. "Carefully matched external controls" produced "treatment effect estimates that were similar" to the randomized analyses. The method did not invent a benefit. Applied to DCVax-L, it found one. And the authorship closes the loop. In 2023, Dana-Farber statisticians Rahman, Ventz and Trippa wrote that they were "not aware of independent validations of these analytic methods in a GBM trial context." Rahman and Trippa are the senior authors of the 2026 INSIGhT validation. The critics asked for patient-level data and a validated method. By 2026 both existed. That supports the method the DCVax-L reanalysis used; publishing that analysis in full is step one. And it is the form a BLA requires: FDA guidance says applications "must include" patient-level data for the external control arm. ๐—ง๐—ต๐—ฒ ๐—™๐——๐—”'๐˜€ ๐˜€๐—ถ๐˜… ๐˜๐—ฒ๐˜€๐˜๐˜€ ๐—ณ๐—ผ๐—ฟ ๐—ฎ๐—ป ๐—ฒ๐˜…๐˜๐—ฒ๐—ฟ๐—ป๐—ฎ๐—น ๐—ฐ๐—ผ๐—ป๐˜๐—ฟ๐—ผ๐—น, ๐—ฎ๐—ป๐˜€๐˜„๐—ฒ๐—ฟ๐—ฒ๐—ฑ 1. Well-defined natural history: 2,006 controls from 15 randomized trials. 2. Very similar populations: 14 prespecified criteria, chosen by an independent firm, validated against all 15 source trials, now matched patient by patient. 3. Similar treatments: in newly diagnosed disease, surgery, radiation and temozolomide in both groups. 4. Objective endpoint: death. 5. Comparable start: survival from randomization after radiotherapy in both groups. Drop the two control trials that admitted early progressors: HR still 0.80. 6. An effect too large to be bias: five-year survival more than doubled, HR 0.58 at recurrence, and the effect grew when matching tightened. ๐—ง๐—ต๐—ฒ ๐—ฝ๐—น๐—ฎ๐˜‚๐˜€๐—ถ๐—ฏ๐—น๐—ฒ ๐—บ๐—ฒ๐—ฐ๐—ต๐—ฎ๐—ป๐—ถ๐˜€๐—บ ๐—ฐ๐—ฟ๐—ถ๐˜๐—ฒ๐—ฟ๐—ถ๐—ฎ, ๐˜„๐—ผ๐—ฟ๐—ฑ ๐—ณ๐—ผ๐—ฟ ๐˜„๐—ผ๐—ฟ๐—ฑ The FDA's five elements, quoted exactly from its February 2026 draft guidance ( lines 26 to 32), each answered: 1. "Identifying a specific genetic, cellular, or molecular abnormality with a clear connection between specific alteration and disease indication." (line 26) โœ“ Met: in GBM, the dendritic cells that should teach T cells what to attack are overridden by suppressive immune cells. A tumor never presented for attack grows unopposed. 2. "Developing a therapy that targets the underlying or proximate pathogenic biological alterations." (line 28) โœ“ Met: DCVax-L supplies the patient's own dendritic cells, loaded with their own tumor and prepared outside the suppressive tumor environment, to restore tumor-directed T-cell instruction. 3. "Relying on a well-characterized natural history of the disease in an untreated population." (line 30) โœ“ Met: 2,006 controls from 15 randomized trials, patient-level data from three more, no time-trend in survival 2012 to 2022. 4. "Confirming that the target was successfully drugged or edited or both." (line 31) โœ“ Platform evidence documented; product-specific bridge required. After DC vaccination, cytotoxic T cells increased inside the tumor, and infiltration correlated with survival (P = 0.047); T cell infiltration in the UCLA vaccine-first arm. The FDA is open to confirmation "for a subset of patients"; the BLA should supply DCVax-L's own immune-monitoring results and the bridge to these studies. 5. "Demonstrating improvement in clinical outcomes or course." (line 32) โœ“ Met: longer survival, five-year survival more than doubled, a bigger benefit under patient-level matching. The eight considerations attached, each answered: 1. An individualized therapy aimed at "a specific pathophysiologic abnormality" 2. A "compensatory mechanism with a clear mechanistic rationale" 3. Substantial evidence from "a single adequate and well-controlled clinical investigation with confirmatory evidence" 4. A natural history that lets the effect be "reasonably distinguished from natural variability" 5. An improvement not attributable to "alternative treatments or natural variability" 6. Prespecified analysis plans 7. A reason a new RCT is not feasible 8. A product that "can be manufactured to regulatory quality standards," made for every phase 3 patient: manufacturing experience documented, US CMC review required 13 of 13, every one in the FDA's own words, every one answered from the record, every open step named. ๐—ง๐—ต๐—ฒ ๐—ฐ๐—ผ๐—ป๐—ณ๐—ถ๐—ฟ๐—บ๐—ฎ๐˜๐—ผ๐—ฟ๐˜† ๐—ฒ๐˜ƒ๐—ถ๐—ฑ๐—ฒ๐—ป๐—ฐ๐—ฒ, ๐—ถ๐—ป ๐˜๐—ต๐—ฒ ๐—™๐——๐—”'๐˜€ ๐—ผ๐˜„๐—ป ๐—ฐ๐—ฎ๐˜๐—ฒ๐—ด๐—ผ๐—ฟ๐—ถ๐—ฒ๐˜€ Mechanism: in the DCVax-Direct phase 1 (a different product: activated dendritic cells injected into diverse solid tumors), more IL-8 and IL-12p40 from each patient's cells went with longer survival, p=0.023 and 0.024. Exposure-response, in the FDA's words. Related product: UCLA's 46-patient randomized phase 1 trial of its own tumor lysate DC vaccine, at EANO this Friday. Both arms got the vaccine; the order was randomized. Vaccine first, 555 days. Checkpoint first, 271. HR 0.32. The order matters: priming before checkpoint release more than doubled median survival. Across the class, a 2024 meta-analysis of seven dendritic cell vaccine trials, 3,619 patients, found HR 0.71 for survival, "indicating a true-positive result." Related indication: the FDA's own example is "a different stage of the same disease." DCVax-L worked at both stages. Independent natural history: national cancer registries, separate from the trial controls, as the guidance requires. Real-world data is expressly allowed. ๐—ง๐—ต๐—ฒ ๐—ฝ๐˜‚๐—ฏ๐—น๐—ถ๐˜€๐—ต๐—ฒ๐—ฑ ๐—ฐ๐—ฟ๐—ถ๐˜๐—ถ๐—ฐ๐—ถ๐˜€๐—บ๐˜€, ๐—ฎ๐—ป๐˜€๐˜„๐—ฒ๐—ฟ๐—ฒ๐—ฑ Three published critiques set out the case against the trial. Each point, answered from the record: Endpoint switched to survival? Progression could not be read: 256 of 494 scans needed adjudication. The critics agree: progression-free survival "is not an adequate endpoint for immunotherapy studies because of the phenomenon of pseudoprogression." Survival is the "gold standard," in their words. Cohort-level controls? The critics named the fix: propensity score matching or inverse probability weighting on patient-level data. That is exactly what 2026 did, and the benefit grew. Never validated in GBM? Two of the critics who raised it led the 2026 study showing patient-level external controls reproduce randomized results. Selection? Dropping the control trials that admitted early progressors changed nothing, as above. The benefit was larger in patients with more residual tumor, the opposite of what selection would produce. IDH, a tumor mutation linked to longer survival? Tested centrally in every DCVax-L patient. The gap is in the older control trials. Chosen after the fact? An independent firm, prespecified criteria, validation as above. Then a larger effect against different trials at the patient level. Company author? Data held by independent CROs, analyzed by independent statisticians. Run another trial? The completed program, crossover and survival evidence make a repeat unnecessary; the FDA's guidance names the ethical concern; the BLA documents why a new randomized design is not feasible or ethical. ๐— ๐—ฎ๐—ป๐˜‚๐—ณ๐—ฎ๐—ฐ๐˜๐˜‚๐—ฟ๐—ถ๐—ป๐—ด The framework also requires that the product "can be manufactured to regulatory quality standards." DCVax-L was made for every patient in a 94-site phase 3, and in 2023 the UK regulator licensed the Sawston facility for commercial manufacturing, with products that "may be exported globally." A UK license is not US approval: FDA inspection and the potency assay go on the table at the pre-BLA meeting. ๐—•๐—ฒ๐—ป๐—ฒ๐—ณ๐—ถ๐˜ ๐—ฎ๐—ป๐—ฑ ๐—ฟ๐—ถ๐˜€๐—ธ Longer survival in a disease with no proven alternative at recurrence. 2,151 doses, 5 serious events even possibly related, no autoimmunity, no cytokine storm. It is the patient's own immune system, with one broken link rebuilt. A repair, judged the way a repair should be judged. ๐—ง๐—ฟ๐—ฒ๐—ฎ๐˜๐—ถ๐—ป๐—ด ๐—ฝ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜๐˜€ ๐˜„๐—ต๐—ถ๐—น๐—ฒ ๐˜๐—ต๐—ฒ ๐—™๐——๐—” ๐—ฟ๐—ฒ๐˜ƒ๐—ถ๐—ฒ๐˜„๐˜€ Right to Try covers a product that has completed phase 1, is in active development and not on hold, and has an application on file. Filing the BLA satisfies the application condition; the others must still hold at that time. Patients must have a life-threatening disease, have exhausted approved treatments, be unable to join a trial and consent, and the manufacturer must choose to provide it. No separate FDA approval of each case. Build the program before filing. An expanded access treatment protocol (21 CFR 312.320) requires completed trials, active pursuit of approval and phase 3 evidence. The trials are complete and the phase 3 is published, so it does not have to wait for the BLA. Treatment can begin 30 days after the FDA receives the protocol, absent a hold. The usual reason a manufacturer holds back is risk: a serious event in a very sick patient gets blamed on the product. The FDA answered that in its April 2026 guidance: it "does not intend to deny, delay, or refuse to approve" a BLA "based solely on an adverse event occurring in the context of expanded access use," and "is not aware of any instances" where one prevented approval. Access is the bridge. Approval is the destination. This is not new for DCVax-L: it has been provided under Germany's hospital exemption and the UK Specials pathway. ๐—ฆ๐—ฒ๐—ฒ๐—ธ ๐˜๐—ฟ๐—ฎ๐—ฑ๐—ถ๐˜๐—ถ๐—ผ๐—ป๐—ฎ๐—น ๐—ฎ๐—ฝ๐—ฝ๐—ฟ๐—ผ๐˜ƒ๐—ฎ๐—น, ๐˜„๐—ถ๐˜๐—ต ๐—ฎ ๐—ฝ๐—ฟ๐—ผ๐˜€๐—ฝ๐—ฒ๐—ฐ๐˜๐—ถ๐˜ƒ๐—ฒ๐—น๐˜† ๐—ฑ๐—ฒ๐˜€๐—ถ๐—ด๐—ป๐—ฒ๐—ฑ ๐—ฟ๐—ฒ๐—ด๐—ถ๐˜€๐˜๐—ฟ๐˜† The framework's guidance: approval is traditional or accelerated "depending on the endpoints used." Survival is the endpoint, so the request is traditional, full approval, with no confirmatory-trial requirement. The FDA can still require postmarketing studies, and the framework's authors named the tool: "collecting real-world evidence to confirm continued preservation of efficacy." A registry of every treated patient, designed before approval. If accelerated approval becomes the route, the regenerative medicine advanced therapy (RMAT) statute lets post-approval requirements be met through registries and "postapproval monitoring of all patients treated with such therapy prior to approval." Every patient treated under Right to Try or expanded access counts. ๐—ช๐—ต๐—ฎ๐˜ ๐—ต๐—ฎ๐—ฝ๐—ฝ๐—ฒ๐—ป๐˜€ ๐—ป๐—ฒ๐˜…๐˜ Northwest has pursued the UK first. Its application there has been under review since late 2023, and in July 2026 the UK regulator confirmed it "remains under its initial regulatory review, has not been refused." The US filing is the step that remains. 1. Publish the patient-level reanalysis. 2. Lock in the patient-level control data rights the FDA requires. 3. Report the central IDH results and publish the phase 3 immune data. 4. Request RMAT designation now. FDA must answer within 60 days. 5. File the treatment protocol and build the Right to Try program. 6. Pre-BLA meeting with CBER: plausible mechanism review, six external-control tests answered, manufacturing and potency package. 7. File the BLA with priority review. 8. Build the registry. Approving DCVax-L this way would be the framework's proof beyond genetic disease: an individualized cell therapy, aimed at the root cause of the deadliest brain cancer, carried by a completed phase 3. A win for patients first. ๐—ง๐—ต๐—ฒ ๐˜๐—ฟ๐—ถ๐—ฎ๐—น ๐—ถ๐˜€ ๐—ฑ๐—ผ๐—ป๐—ฒ. ๐—ง๐—ต๐—ฒ ๐—ณ๐—ฟ๐—ฎ๐—บ๐—ฒ๐˜„๐—ผ๐—ฟ๐—ธ ๐—ถ๐˜€ ๐˜„๐—ฟ๐—ถ๐˜๐˜๐—ฒ๐—ป. ๐—ง๐—ต๐—ฒ ๐—ฝ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜๐˜€ ๐—ฎ๐—ฟ๐—ฒ ๐˜„๐—ฎ๐—ถ๐˜๐—ถ๐—ป๐—ด. ๐—ช๐—ต๐—ฎ๐˜ ๐—ถ๐˜€ ๐—น๐—ฒ๐—ณ๐˜ ๐—ถ๐˜€ ๐˜๐—ผ ๐—ฎ๐˜€๐˜€๐—ฒ๐—บ๐—ฏ๐—น๐—ฒ ๐—ถ๐˜ ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ถ๐—น๐—ฒ. Disclosure: long $NWBO. Commentary on published and presented data and public FDA documents. Not medical, legal, regulatory or investment advice. DCVax-L is investigational and not approved in the US. Regulatory strategy is the sponsor's decision.

Andrew Caravello, DO

46,627 views โ€ข 7 days ago

I've never heard Elon Musk be so bullish on Tesla โšก๏ธ here's my video analysis of the $TSLA Q4 2024 earnings call: -Robotaxi launch in Austin, June 2025 -California & other states launch robotaxi late 2025 -Cybercab in 2026 -Optimus V1 in 2025, 1K/month production line -Optimus V2 in 2026, 10K/month production line -2026 good year for Tesla, 2027/28 insanely good & more!! Timestamps- 0:00 Intro 0:44 Elon Opening Remarks 13:29 SAY Retail Questions 22:37 Analyst Questions 25:04 Gali Final Thoughts/Rant also here are my notes I typed during the conference call if you're interested! (may be errors) Tesla Q4 2024 Earnings Call Notes INTRO- ELON OPENING REMARKS -Q4 set record, delivered cars at rate of almost 2M cars/year -Model Y best-selling vehicle of any kind on earth (elon focused and talking quickly) -10Xing on autonomy, not doubling -many investments made this year that will bear immense fruit in the future, for AI -see a path for Tesla to the worlds most valuable company by far, worth more than the next 5 companies combined, difficult but achievable path -overwhelmingly due to autonomous vehicles and autonomous robots -setting up for an epic 2026, and ridiculously good 2027 and 2028 -meeting FSD now is like meeting a toddler -human intuition is linear, weโ€™re seeing exponential progress -#1 recommendation is try it -typical passenger car has 10 hours of use out of 168, when its autonomous, itll be used for 55 hours a week โ€ฆ can deliver packages in the middle of thenight, or supply restaurants, all hours of the day or night. 5X increase in utility -more on self driving, continued improvements in safety numbers, much safer to use FSD -V14 will be another big step from V13 -launched CORTEX training cluster at Giga Austin, big step for FSD, continue to invest in training needs -Optimus training needs are about 10X whatโ€™s needed for the car -cost of training is dropping dramatically over time -Optimus has potential to be north of $10T in revenue, can put a lot training compute into that situation, even pumping $500B into it would be a good deal -future very different from the past, incredible inflection point in human history -proof is in the pudding -launching in June this year in Austin, already have cars moving autonomously in Fremont, thousands of cars per day driving, soon in Austin then elsewhere in the world -toe in the water at first to make sure everything is cool, but we have a general solution for autonomy , then put a few more toes, then a foot. Safety of the general public and those in the car as the top priority -with regard to Optimus, making insane revenue projections that sound insane, i realize that. But i think they will prove to be accurate -several thousand bots made this year, they will be doing useful things by the end of this year, im confidence, production design one at the tesla factories, then will learn for production design two -ramp optimus production faster than anything has ever launched, doesnโ€™t take very many years before weโ€™er making 100M of these things per year , 500% growth per year -tried using all these suppliers to get it to build Optimus, but nothing worked, had to build it internally from first principles, the hand is increibdle -long term Optimus will be the value of the company -back to Energy,/earth, -energy storage is a big deal, becoming more important, enables far greater energy output to the grid than is currently possible. -grid has no storage, designed for peak storage, lots of waste -once you have grid energy storage, the potential of the grid is unlocked, at least double -this will drive demand of battery packs as to as much as we can possibly make -shanghai factory starting operation, starting another factory -cant shoot our selves in the foot, battery capacity can only go into storage or mobility, so always making that tradeoff -demand for total Gigawatt hours for batteries, transportation or stationary will grow in a very big way over time 2025 a pivotal year for tesla, launch of full self driving, biggest year in tesla history, maybe even bigger than first car or model s, 3 or y โ€ฆ probably most important year in teslaโ€™s history I donโ€™t even know who is in 2nd place in real world AI, would need a telescope to see them SAY QUESTIONS -FSD Unsupervised launched in California this year as well -most likely release it in many regions of the US by the end of this year -40K people day everyday no mention, some scrapes a shin with autonomous car its headlines news -need to use insane amounts of caution -discussions about licensing FSD? Yes -best way to know to work with us, bbuy a car and take it apart -only worth very high volume cars/production partners -tesla engineering very focused on getting it to roll out for tesla first -soon will be obvious that if you donโ€™t have FSD youโ€™re dead as an OEM -is Optimus design locked? -Optimus is not design locked, constantly iterating, best robotics engineers in the world, and other ingredients, battery pack, charging, great electronics, great communications, great connectivity, real world AI, then you need to scale that production to real world levels -prototypes are easy production is hard -thijs year close loop with using optimus internally at tesla, would could obviously use a few thousand robots for the most boring annoying tasks at the company -with production version 2, launches sometime next year, would like beginning, might be middle though, -production line will be doing 10K units per month capacity for v2, first line designing is for roughly 1,000 units per month, then next line will be for 100,000 units per month -could start delivering them late next year, will go so fast, will ramp like crazy, demand will not be a problem, even at a high price, once were above 1M units per year, production costs of optimus will be less than $20,000 -if you compare complexity of optimus to complexity of a car, its much less than a car -price of optimus will be set buy market demand -Semi ramping next year, TCO no brainer, like optimus, will be massive demand, will meaningfully contribute to teslaโ€™s revenue at scale -tesla semi with autonomy, is incredibly valuable -we actually have a shortage of truck drivers here in the US -will HW3 owners need a hardware update, got 12.6 which is like a baby v13, haveโ€™t given up on it, releases will trail HW4 releases โ€ฆ โ€œhonest answerโ€ is were going to have to upgrade for those who have bought full self driving, will be painful and difficult and weโ€™ll get it done โ€œHappy not many people bought FSDโ€ -solar roof, given up on ramping it? -lots of customer interest despite premium, making easier to install, focused on growth through certified installers, many been installing for many years -supply product to the roofing industry -itโ€™s a premium product like S/X -combined with Tesla powerwall you can be self sufficient for several days ANALYST QUETIONS -robotaxis in Austin and several other cities this year, and next year all over america -america innovates, europe regulates, to release FSD in europe, have to go through massive paperwork through netherlands, then presents to EU in may, some big country committee, nothing we can do to make it happen sooner. -canโ€™t do training in china with video training, publicly available videos in china are being run through the tesla system to be used for training, bus lanes are complicated and a big challenge -tesla can keep manufacturing even if geopolitical tensions rise to very high levels -Pierre question on June in Austin, -can i try unsupervised myself, or will it be the Tesla fleet? -it will be the Tesla fleet testing it, thatโ€™s the toe in the water, scrutinizing everything -autonomous ride hailing for money in june -probably next year for you to put your car on network -trump removing EV incentives? -all transport will go electric, canโ€™t be stopped, even planes, will be like stopping the steam engine or combustion engine -only thing holding back EVs was range, and thats a solved problem -right now solving battery production, not demand, big battery retooling for model y coming up, short term impact on output

Gali

79,178 views โ€ข 1 year ago

Dear ICP community, the Internet Computer has now been running strong for 5 years ๐Ÿ‘๐Ÿ‘๐Ÿ‘ Here is a celebratory preview of ICP "cloud engines," the sovereign frontier cloud technology the network shall soon provide from Main points: โ€” Cloud engines enable anyone to spin up their own sovereign frontier cloud. The technology involves an extraordinary inventive step, in which cloud is created from a mathematically secure network of nodes. The nodes run as part of the Internet Computer network ( but are selected and configured by the cloud engine's owner. โ€” The frontier cloud provided by engines is strongly focused on enabling AI agents to build and update online applications and services for us. The world is changing fast, and nearly all new online apps and services are already being built with the help of AI, and thus cloud engines target the future of cloud. โ€” Software hosted on cloud engines is tamperproof, which means that it is immune to infrastructure hacks, because it runs inside a mathematically secure network protocol, rather than on computers directly. This means that AI agents, and those building with them, don't need to have a security team in the loop, or to trust someone else's security team. This is crucial, because in the future, non technical people will demand the freedom to build with full automation โ€” where they just need to issue instructions to AI about what to build, and don't need to worry about anything or anyone else. Of course, apps and services running on engines are also vastly safer from the new breed of hacker being enabled by frontier AI. (The cloud engines themselves are also "tamperproof." Even if a hacker gains physical access to some portion of a cloud engine's nodes, and can make arbitrary changes, the computations and data of the hosted apps and services cannot be corrupted or interrupted so long as the network's fault bounds aren't exceeded. The recent hack of Vercel, a major cloud platform, which gave hackers access to the apps it hosted, provides additional perspective on the importance of this advantage.) โ€” Software hosted on cloud engines is guaranteed to run, so long as a sufficient number of the engine's nodes are running. This means that AI can build applications and services without the need to have a human systems admin team constantly tinkering with the underlying platform to keep it running, which is again crucial, because in the future, non technical people will expect the freedom to use AI to build without the support of others. โ€” New frontier programming language technology, in the form of the Motoko language developed by Caffeine Labs, leverages seminal "orthogonal persistence" technology that unifies program logic and data to deliver further unlocks for AI (Motoko is the first computer language being developed that targets agents that are writing software rather than humans engineers per se). Nowadays, AI can build and update production apps at a prodigious rate, even at the speed of conversation. But it can also make mistakes, and there's a risk that an update it creates might be "lossy" in the sense it causes some transformed data to be lost. Again, in this new world, it's both undesirable and impractical for everyone to have to have a systems admin team on-hand to detect lossy updates and roll them back, but Motoko provides a solution: it can detect new software updates are lossy before they are applied, reducing potentially catastrophic errors by AI to harmless coding retries. โ€” Software hosted on cloud engines is "serverless" but unlike traditional serverless software, directly it directly incorporates data through "orthogonal persistence." Another key purpose is simplify backend software logic and fuel the modeling power of AI by increasing abstraction (sorry for the technical language!!!). Put simply, this enables AI to produce more sophisticated backends, faster, and at dramatically lower costs, as measured by the number AI API tokens consumed during coding. (Tip for the technical: orthogonal persistence is a new paradigm where "the program is the database," and data lives inside program variables, which is possible because it's as if hosted software runs forever in persistent memory). โ€” An expanding database of skills at shall make it possible to develop and directly deploy apps and services to your cloud engines directly from Claude Code, Perplexity, Codex and other AI platforms. Further, your account on can be connected, so that new apps and updates created through conversation automatically appear hosted from your cloud engine. In the future, R&D is going to be very seamless. You converse with AI, and your secure and unstoppable apps or services are created or updated. Cloud engines are designed to directly support this "self-writing cloud" future where we can work hands-free. โ€” Tech sovereignty is becoming a huge issue worldwide, with governments and corporations seeking to create sovereign tech stacks owing to geopolitical tensions. Increasingly, people are realizing that tech provided by foreign nations can come with hidden backdoors and kills switches, from the base platform, right up through hosted apps and services. ICP technology is open source, and those building on ICP using AI own their own source code. When you have the source code, you can verify that there are no backdoors, and when you own the source code thanks to AI, you can update it at will, freeing you from vendor lock-in. But cloud engines take sovereignty much further... โ€” You create a cloud engine by selecting the nodes that will be combined. You can choose the class of nodes used, and their number, but more importantly, you can choose who operates the nodes, and where they are located. Almost any configuration is possible, because the Internet Computer scales the security privileges afforded to hosted software within the network according to configuration (software hosted on cloud engines can directly interoperate with software on other engines and traditional subnets, but base restrictions are applied according to security rules). A cloud engine can be created within a region such as Europe, to comply with regs such as GDPR, or completely within a sovereign state like Switzerland or Pakistan. But cloud engines go further still... โ€” Sovereignty is also about freedom from vendor lock-in. Cloud engines are essentially ICP (Internet Computer Protocol) network configurations, and this means the underlying compute nodes they combine can be swapped out without interrupting their hosted apps and services. This is a big deal. In addition, cloud engines now support nodes that are instances running on Big Tech's clouds, in addition to nodes that are dedicated specialized hardware, as per the Gen I and Gen II nodes that dominate the Internet Computer today. For example, it is possible to have an engine running across different AWS data centers, say, and then reconfigure the engine to run across a mixture of AWS, Google, Azure and Hetzner for even more resilience, without the users of hosted apps and services noticing a thing. That's true freedom. โ€” Sovereign AI is becoming increasingly important too, and cloud engines allow special "AI nodes" to be added to them, so that hosted software can perform inference on hardware provisioned by the owner from a location the owner has selected. Even though the AI nodes are only accessible within the cloud engine, they can still benefit from the forthcoming Internet Intelligence Gateway (IG), which will make it possible to validate inference performed on key frontier open weights LLMs, even when the inference is performed on completely independent AI clouds. When the results of inference are received, this technology can verify that neither the prompt+context (input) nor the inference result (output) have been modified, and that the results were produced by the precise LLM expected. This ensures that AI clouds don't cheat by running inference on cheaper models than are being paid for, and bad actors aren't modifying the inputs or outputs to surreptitiously insert advertising into results, say, or change facts, or insert malware when code is being generated. What's super cool about this technology is the cost of the verification is scalable. A very valuable additional security can be achieved with only 1-2% of extra cost. โ€” Scaling apps and services when they hit capacity limits is another thorny problem that cloud engines help the world address. Engines make scaling possible without rewriting or reconfiguring software. The query workload capacity of hosted software can be horizontally scaled simply by adding new nodes to an engine, and nodes can also be added in geographical proximity to demand. Meanwhile, update workload capacity can first be scaled-up by swapping an engine's nodes out for the next class up, and then when no larger class of node is available, horizontally scaled-out by "splitting" the engine into two, which doubles available capacity. (Technical tip: horizontally scaling update capacity by splitting engines requires multi-canister architectures). โ€” For those who have been following how Caffeine builds apps that can efficiently store large numbers of files, I should mention that apps built on cloud engines will also support the new ICP Blob Storage cloud network (since cloud engines currently have up to about 3 TB of memory, which apps storing large amounts of files can easily exceed). We are also working on allowing blob storage nodes to be added to cloud engines, to enable sovereign mass blob storage within an engine, similarly to how AI nodes can be added currently. โ€” Lastly, but certainly not least, I should mention that cloud engines are multi-blockchain capable, and ready for digital assets, thanks to the clever math at their core. For example, an e-commerce service built on a cloud engine can securely accept and custody stablecoin payments, or a multi-chain DEX could be hosted. Further, engines can support software autonomy (software orchestrated and controlled by other autonomous software, in a decentralized way) and can themselves be orchestrated by SNS technology, and thus run autonomously too. Today, though, the focus is on *mainstream* cloud. This year, the cloud industry will generate approximately one trillion dollars in revenue. That number is already huge, but is expected to grow to two trillion dollars by 2030. After years of continuous development, which have seen more than $500m spent on R&D, the Internet Computer network is now tacking directly toward this mainstream cloud market with cloud engine technology. In their first version, cloud engines are not meant to be a cloud panacea. For example, currently they are not ideal for working with big data. You should use something like DataBricks for that. Cloud engines are carefully targeted at enabling AI to produce traditional online applications and services, including SaaS, in a safer and more productive way, which represents a new market segment with tremendous potential. Of course, DFINITY will continue to work relentlessly to push forward ICP's capabilities, so expect further developments. It's worth mentioning that this cloud segment isn't just about creating new apps and services using AI, it's also about replacing legacy systems and apps built on super expensive SaaS services. Caffeine Labs is working to produce technology (Caffeine Snorkel) that can study an enterprise's legacy systems and app built on SaaS, create replacement systems and apps, and migrate the data, while supporting key stakeholders through the process over email and chat, with full automation. Thus the legacy systems and SaaS markets shall also be addressed by cloud engines. Zooming out, and reasoning in a more metaphysical way, we believe, as we always have, that there is room for a new kind of cloud created by mathematical networks, that provides seminal advances in the fields of security and resilience, as well as true sovereignty and freedom from lock-in. That this same technology, with the help of additional technologies like orthogonal persistence and Motoko, enables AI to build for us without the need for so much oversight, and to create more backend sophistication while consuming fewer AI API tokens, enables ICP to bring game-changing advances to the world. Cloud engines will work synergistically with the Intelligence Gateway, which will enable apps and services running on engines to seamlessly leverage AI, wherever that AI is running, while providing verifiability at extremely low cost for open weights frontier models. We believe that cloud engines represent an inflection point in the storied history of the Internet Computer project, and I'm very proud to be sharing the details with you on the network's fifth birthday ๐Ÿ’ช I'll be back with more news soon!!

dom | icp

326,063 views โ€ข 4 months ago