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[SUNRISE HACK] Here's the cheat code for the Southernmost Point: Sunrise. No lines. No crowds. No waiting. Just you and that golden morning light. Maybe a few locals jogging by. Maybe a cruise ship on the horizon. And definitely worth setting that early alarm. Because the best Keys memories?...

10,291 views • 1 year ago •via X (Twitter)

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THE SUNRISE IS THE MOST POTENT CIRCADIAN STIMULUS. A 2020 paper published in Current Biology identified a previously unknown retinal circuit explaining precisely why the spectral contrast of sunrise so powerfully entrains the circadian system. The key neuron is the M1 intrinsically photosensitive retinal ganglion cell (ipRGC), which projects directly to the suprachiasmatic nucleus (SCN), the brain’s master circadian pacemaker. In primates, M1 ipRGCs are wired to perform a spectral comparison between yellow/red and blue light via two simultaneous pathways. ***This cone-based circuit is just one of several mechanisms by which morning light entrains the circadian system. Going outside after sunrise still delivers meaningful melanopsin stimulation as overall irradiance builds, and that sustained signal remains highly beneficial. The spectral contrast mechanism described here is simply the most precisely tuned and potent stimulus the system has, one that outdoor morning light delivers far more effectively than any indoor environment. As yellow and red wavelengths increase at sunrise, L and M cones drive LM-ON bipolar cells, which directly excite the M1 ipRGC. Simultaneously, the relative decrease in short-wavelength light reduces S-cone activation, quieting S-ON bipolar cells, which reduces drive to a newly identified S-cone amacrine cell, releasing its inhibitory input onto the ipRGC. Disinhibition and excitation converge on the same cell simultaneously. Melanopsin, the ipRGC’s intrinsic photopigment peaking at ~480nm, is slower and requires sustained high irradiance, taking over as morning light intensity builds. The result is a temporal relay: the cone circuit delivers a rapid spectral signal at the horizon transition, then melanopsin sustains entrainment through the morning. No indoor lighting replicates this. The sunrise delivers the exact stimulus this circuit evolved over hundreds of millions of years to detect. #science #circadian #sunrise #neuroscience #biology

Jonathan Jarecki

10,637 views • 4 months ago

Jordan Peterson: "People don't have mental illnesses, they have lives too complicated to manage" "I actually think complexity is the fundamental problem. The terror management theorists think that death is the fundamental problem, and that's a good argument, because it is definitely a fundamental problem. But I think death is a subset of the complexity problem." Peterson explains why: "Sometimes people's lives become so complex that they'd rather be dead. The reason they seek death through suicide is to make the complexity go away. Because complexity causes suffering if it's uncontrolled. Things just get beyond your control." He describes how this happens: "You get hit by three or four catastrophes at the same time. Maybe the political system collapses. There's hyperinflation. You lose your job. Someone you love dies, or two people die. Maybe you get cancer. These things happen to people. And they just think: there's no getting out of this. It's just too much." Peterson shares what he learned as a psychologist: "One of the things that's very interesting about being a psychologist is what you learn: people come to you with mental illnesses, and that's almost never true. People come to you because their lives are so damn complicated they cannot stay on top of them in any way that doesn't make it look like they're just going to get more complicated. And then that causes symptoms." He uses a metaphor for genetic susceptibility: "Take a balloon and blow it up until it's beyond its tolerance. It's going to blow out at the weakest point. That's sort of what genetic susceptibility is. If I just keep adding complexity on top of you, at some point you'll blow out at your weakest point. Maybe you'll get physiologically ill. Maybe you'll start drinking. Maybe you'll develop an anxiety disorder. Maybe you'll get OCD. Maybe you'll get depressed. Whatever, there'll be something about you that's the weakest point. If I just push, that's where you blow out." Peterson reframes what we call "mental illness": "Those things almost never just happen. Sometimes, but not very often. Usually, people have just been hammered two or three different ways, and then they collapse in the direction of their biological weakness. Then maybe you put them back together. But it's almost always a complexity-related phenomenon rather than a mental illness-related phenomenon. Not always, but almost always."

Jaynit

186,125 views • 5 months ago