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Supplements worth considering for cognition and brain aging: Omega-3s → Support neuronal membranes and help regulate inflammation Vitamin D → Low levels are linked to greater dementia risk Multivitamin → Improved memory and overall cognition in randomized trials of older adults Creatine → Showed promising cognitive results in a... show more

FoundMyFitness Clips

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11,943 views • 8 days ago •via X (Twitter)

Health & Wellness Science & Technology

Anya Rossi• Live Now

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11 Comments

FoundMyFitness Clips8 days ago

From FoundMyFitness Premium Member Q&A 86:

FoundMyFitness Clips7 days ago

FoundMyFitness Premium Members get access to live AMAs with Rhonda We host these once a month, and they're recorded if you miss it They also come with detailed show notes Details here:

Ricky Owens8 days ago

Thank you for sharing this video

Peptide Tracker8 days ago

only 1 of the 6 lines mentions a randomized trial. creatine's was 8 weeks, no control group. which ranks #2 on evidence?

TuckerThinker8 days ago

what type of Sulforaphane to you like and when do you take it?

Josh Schlottman8 days ago

Magnesium L-threonate too. Crosses blood-brain barrier sending magnesium directly into cerebrospinal fluid and neurons. "…improves overall cognition, cognitive age, working memory, reaction time."

NateDCX7 days ago

Just started Creatine a couple months ago! 5 grams. Wish I stayed on it years ago!

alex yaeger8 days ago

Always great information and at a price i adore.

Phil Isophical8 days ago

Does vitamin d increase blood levels? Been seeing that it doesn't.

CryptoScrooge (FROG)8 days ago

I thought Magnesium was one of the top ones? Thanks!

Al8 days ago

No way I'm eating broccoli when I can just inject glutathione

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Can supplements slow cognitive decline? I think a few show promise: Omega-3s (EPA and DHA) - Important for neuronal membranes, brain function, and resolving inflammation. Higher omega-3 levels are associated with lower dementia risk. Multivitamins - Daily multivitamins improved cognition in older adults in the COSMOS trials, with benefits equivalent to roughly 2 fewer years of global cognitive aging. Vitamin D - Supplementation has been associated with a 40% lower dementia risk, while low vitamin D levels are linked to a 50 to 80% higher risk. Creatine - 20 g/day for 8 weeks increased brain creatine by 11% and improved several cognitive measures in a small Alzheimer's pilot study. This one is promising, but preliminary. Sulforaphane - Increases glutathione levels in the brain. Early trials also suggest cognitive benefits. Exogenous ketones - Provide an alternative fuel for the brain, potentially compensating for impaired glucose metabolism in people with cognitive impairment. None of these is proven to prevent dementia, but they represent promising approaches to supporting brain health through nutrition, energy metabolism, and inflammation regulation. And remember, supplements should complement (not replace) the fundamentals like exercise, sleep, and metabolic health!

Can supplements slow cognitive decline? I think a few show promise: Omega-3s (EPA and DHA) - Important for neuronal membranes, brain function, and resolving inflammation. Higher omega-3 levels are associated with lower dementia risk. Multivitamins - Daily multivitamins improved cognition in older adults in the COSMOS trials, with benefits equivalent to roughly 2 fewer years of global cognitive aging. Vitamin D - Supplementation has been associated with a 40% lower dementia risk, while low vitamin D levels are linked to a 50 to 80% higher risk. Creatine - 20 g/day for 8 weeks increased brain creatine by 11% and improved several cognitive measures in a small Alzheimer's pilot study. This one is promising, but preliminary. Sulforaphane - Increases glutathione levels in the brain. Early trials also suggest cognitive benefits. Exogenous ketones - Provide an alternative fuel for the brain, potentially compensating for impaired glucose metabolism in people with cognitive impairment. None of these is proven to prevent dementia, but they represent promising approaches to supporting brain health through nutrition, energy metabolism, and inflammation regulation. And remember, supplements should complement (not replace) the fundamentals like exercise, sleep, and metabolic health!

Dr. Rhonda Patrick

56,548 views • 8 days ago

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

Dr. Rhonda Patrick

219,652 views • 11 months ago

A daily multivitamin may be one of the lowest-effort ways to make an older brain functionally younger In large randomized trials of older adults (65+), those taking a basic multivitamin (Centrum Silver) showed better overall cognition, about a 2-year reduction in global brain aging, and ~4.8 years' improvement in episodic memory (the ability to remember events and experiences) Given that ~60% of Americans are low in vitamin E, ~45–50% in magnesium, ~35% in vitamin C, and 80–90% in omega-3s (with additional gaps in vitamin K and calcium), it’s clear many brains are running on suboptimal micronutrient status For many, a basic multivitamin is a practical way to close these gaps and protect cognitive function with age

A daily multivitamin may be one of the lowest-effort ways to make an older brain functionally younger In large randomized trials of older adults (65+), those taking a basic multivitamin (Centrum Silver) showed better overall cognition, about a 2-year reduction in global brain aging, and ~4.8 years' improvement in episodic memory (the ability to remember events and experiences) Given that ~60% of Americans are low in vitamin E, ~45–50% in magnesium, ~35% in vitamin C, and 80–90% in omega-3s (with additional gaps in vitamin K and calcium), it’s clear many brains are running on suboptimal micronutrient status For many, a basic multivitamin is a practical way to close these gaps and protect cognitive function with age

FoundMyFitness Clips

186,804 views • 10 months ago

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

FoundMyFitness Clips

114,549 views • 1 year ago

5 high-impact supplements worth taking daily: • Omega-3s — 2 g/day is a strong starting point; a high omega-3 index is linked to 5 extra years of life expectancy, slower epigenetic aging, and may lower Alzheimer’s risk • Multivitamin — daily use in older adults has been linked to ~2 years less global brain aging, nearly 5 years less episodic memory aging • Vitamin D — regulates over 5% of your genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity • Magnesium — a cofactor for 300+ biological processes, including DNA repair, energy production, and sleep regulation • Creatine monohydrate — one of the most studied supplements for strength and performance; 10 g/day is a baseline for brain benefits, with higher-dose research showing benefits under sleep deprivation

5 high-impact supplements worth taking daily: • Omega-3s — 2 g/day is a strong starting point; a high omega-3 index is linked to 5 extra years of life expectancy, slower epigenetic aging, and may lower Alzheimer’s risk • Multivitamin — daily use in older adults has been linked to ~2 years less global brain aging, nearly 5 years less episodic memory aging • Vitamin D — regulates over 5% of your genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity • Magnesium — a cofactor for 300+ biological processes, including DNA repair, energy production, and sleep regulation • Creatine monohydrate — one of the most studied supplements for strength and performance; 10 g/day is a baseline for brain benefits, with higher-dose research showing benefits under sleep deprivation

FoundMyFitness Clips

31,067 views • 4 months ago

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,837 views • 1 year ago

5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits

5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits

FoundMyFitness Clips

514,545 views • 7 months ago

Taking a daily multivitamin slowed brain aging by 2 years in older adults. Rhonda Patrick highlighted three large randomized placebo-controlled trials (COSMOS) with ~5,000 participants aged 65+. The group taking a multivitamin (magnesium, B vitamins, folate, vitamin K, etc.) showed clear improvements in cognition and slower brain aging compared to placebo. Simple micronutrients making a measurable difference. What’s your take, would this make you consider adding a high-quality multivitamin to your routine?

Taking a daily multivitamin slowed brain aging by 2 years in older adults. Rhonda Patrick highlighted three large randomized placebo-controlled trials (COSMOS) with ~5,000 participants aged 65+. The group taking a multivitamin (magnesium, B vitamins, folate, vitamin K, etc.) showed clear improvements in cognition and slower brain aging compared to placebo. Simple micronutrients making a measurable difference. What’s your take, would this make you consider adding a high-quality multivitamin to your routine?

Camus

29,689 views • 4 months ago

Everyone should take a multivitamin. It's a simple, effective way to support long-term cognitive health, especially for middle-aged and older adults. About a decade ago, multivitamins were deemed useless or harmful. Recent large, randomized controlled studies provide irrefutable evidence to the contrary. Adults taking a standard multivitamin for 2 years improved cognition and episodic memory, equivalent to a 2-year reduction in cognitive aging. Multivitamins provide micronutrients missing from our diets—those important for metabolism, neurotransmission, and most importantly, reducing DNA damage and oxidative stress that contribute to aging. Think of it as nutritional insurance for your body and brain. And don't let anyone tell you it's just making "expensive urine."

Everyone should take a multivitamin. It's a simple, effective way to support long-term cognitive health, especially for middle-aged and older adults. About a decade ago, multivitamins were deemed useless or harmful. Recent large, randomized controlled studies provide irrefutable evidence to the contrary. Adults taking a standard multivitamin for 2 years improved cognition and episodic memory, equivalent to a 2-year reduction in cognitive aging. Multivitamins provide micronutrients missing from our diets—those important for metabolism, neurotransmission, and most importantly, reducing DNA damage and oxidative stress that contribute to aging. Think of it as nutritional insurance for your body and brain. And don't let anyone tell you it's just making "expensive urine."

Dr. Rhonda Patrick

257,107 views • 1 year ago

Blueberries are a low-hanging fruit for cognitive performance The equivalent of 1 cup/day has been shown in randomized trials to improve measures of memory and cognition Their standout compounds are anthocyanins, flavonoids that support vascular function and brain blood flow Rhonda's go-to: ~2 cups in a smoothie along with 3-4 kale leaves and avocado

Blueberries are a low-hanging fruit for cognitive performance The equivalent of 1 cup/day has been shown in randomized trials to improve measures of memory and cognition Their standout compounds are anthocyanins, flavonoids that support vascular function and brain blood flow Rhonda's go-to: ~2 cups in a smoothie along with 3-4 kale leaves and avocado

FoundMyFitness Clips

26,806 views • 4 months ago

For brain health in older adults, a multivitamin is no longer “optional” - it’s a high-priority basic In three large randomized trials of adults 65+, taking a standard multivitamin like Centrum Silver for one year slowed global brain aging by about 2.1 years and episodic memory aging by almost 5 years That means better retention of everyday experiences, names, faces, and events (the things families actually notice when memory starts to fade) Given how common poor diets and micronutrient gaps are, a single daily multivitamin is an easy, low-effort way to protect aging brains

For brain health in older adults, a multivitamin is no longer “optional” - it’s a high-priority basic In three large randomized trials of adults 65+, taking a standard multivitamin like Centrum Silver for one year slowed global brain aging by about 2.1 years and episodic memory aging by almost 5 years That means better retention of everyday experiences, names, faces, and events (the things families actually notice when memory starts to fade) Given how common poor diets and micronutrient gaps are, a single daily multivitamin is an easy, low-effort way to protect aging brains

FoundMyFitness Clips

94,279 views • 9 months ago

Creatine supplementation at ~10 grams/day may be a targeted way to support brain function in older adults While muscle tissues become saturated at 5 grams/day, surpassing this threshold allows more creatine to reach the brain and raise brain phosphocreatine levels Higher phosphocreatine availability supports cognitive performance specifically under brain stressors like aging, sleep deprivation, and neurodegenerative disease And because aging places ongoing metabolic demands on the brain, this additional phosphocreatine reserve may help support brain energy metabolism when it’s under strain

Creatine supplementation at ~10 grams/day may be a targeted way to support brain function in older adults While muscle tissues become saturated at 5 grams/day, surpassing this threshold allows more creatine to reach the brain and raise brain phosphocreatine levels Higher phosphocreatine availability supports cognitive performance specifically under brain stressors like aging, sleep deprivation, and neurodegenerative disease And because aging places ongoing metabolic demands on the brain, this additional phosphocreatine reserve may help support brain energy metabolism when it’s under strain

FoundMyFitness Clips

99,684 views • 9 months ago

7 science-backed ways to improve cognitive function (0:00) Exercise — it's just undeniable, getting your heart rate up and sweating will make you smarter (3:52) A multivitamin improved cognition and slowed brain aging by ~2 years in older adults (5:24) A daily equivalent of one cup of blueberries can significantly enhance cognitive function (7:15) CocoaVia contains high levels of cocoa flavanols —cocoa flavanols increase blood flow to the brain, potentially leading to an immediate cognitive boost (8:25) Kale is packed with lutein, a carotenoid shown to improve neural efficiency — meaning your brain can perform better using less energy (10:11) Eggs are high in choline, and just 500 mg daily during pregnancy boosted children's scores on intelligence tests (11:03) 2g/day of omega-3s consistently improves cognitive performance in clinical trials

7 science-backed ways to improve cognitive function (0:00) Exercise — it's just undeniable, getting your heart rate up and sweating will make you smarter (3:52) A multivitamin improved cognition and slowed brain aging by ~2 years in older adults (5:24) A daily equivalent of one cup of blueberries can significantly enhance cognitive function (7:15) CocoaVia contains high levels of cocoa flavanols —cocoa flavanols increase blood flow to the brain, potentially leading to an immediate cognitive boost (8:25) Kale is packed with lutein, a carotenoid shown to improve neural efficiency — meaning your brain can perform better using less energy (10:11) Eggs are high in choline, and just 500 mg daily during pregnancy boosted children's scores on intelligence tests (11:03) 2g/day of omega-3s consistently improves cognitive performance in clinical trials

FoundMyFitness Clips

46,039 views • 1 year ago

Rhonda Patrick dropped this on Mayim Bialik’s podcast:“As simple as a cheap daily multivitamin… it reversed brain aging by five years.” Three large randomized controlled trials showed that older adults taking a basic affordable multivitamin for a couple of years slowed cognitive aging by about 3 years and reversed episodic memory aging by roughly 5 years. The COSMOS trial and related studies found daily multivitamin use improved memory, executive function, and slowed brain aging in older adults, likely by filling common micronutrient gaps. It’s a reminder that sometimes the simplest things still pack a real punch. In our rush for fancy biohacks and expensive protocols, we often overlook basic, affordable interventions that actually have strong evidence behind them. What about you — do you take a daily multivitamin, or do you rely purely on food?

Rhonda Patrick dropped this on Mayim Bialik’s podcast:“As simple as a cheap daily multivitamin… it reversed brain aging by five years.” Three large randomized controlled trials showed that older adults taking a basic affordable multivitamin for a couple of years slowed cognitive aging by about 3 years and reversed episodic memory aging by roughly 5 years. The COSMOS trial and related studies found daily multivitamin use improved memory, executive function, and slowed brain aging in older adults, likely by filling common micronutrient gaps. It’s a reminder that sometimes the simplest things still pack a real punch. In our rush for fancy biohacks and expensive protocols, we often overlook basic, affordable interventions that actually have strong evidence behind them. What about you — do you take a daily multivitamin, or do you rely purely on food?

Camus

18,211 views • 6 months ago