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Systemwide multiprotein complex formation visualized! CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways ➡️

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Max Planck Institute of Biochemistry (MPIB)

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18,693 views • 3 years ago •via X (Twitter)

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Max Planck Institute of Biochemistry (MPIB)'s profile picture
Max Planck Institute of Biochemistry (MPIB)3 years ago

CAND1 mediates disassembly and assembly of Cullin-RING E3 ubiquitin ligase complexes by rock-n-roll structural mechanism. @KheewoongBaek @DanielS20127197 @LukasHenneberg @labs_mann @stjuderesearch

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