Video yükleniyor...

Video Yüklenemedi

Bu video yüklenirken bir sorun oluştu. Bu geçici bir ağ sorunundan kaynaklanıyor olabilir veya video kullanılamıyor olabilir.

Ana Sayfaya Dön

The Baker Lab designs protein on/off switches 1/🧵 Instead of optimizing for how tightly a given protein binds to a target, Adam and team develop a method to control the duration of binding.

Deniz Kavi

2,095 subscribers

32,423 görüntüleme • 10 ay önce •via X (Twitter)

Bilim & Teknoloji

Anya Rossi• Live Now

Private livecam show

0 Yorum

Yorum bulunmuyor

Orijinal gönderinin yorumları burada görünecek

Benzer Videolar

Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work. We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets. We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.

Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work. We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets. We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.

Anthropic

3,884,030 görüntüleme • 2 gün önce

Researchers from the The Clevers Lab developed a method to grow organoids using a bacterial protein: Invasin. The study, published today in PNASNews, shows that Invasin offers a sustainable, affordable and animal-free alternative to current methods.

Researchers from the The Clevers Lab developed a method to grow organoids using a bacterial protein: Invasin. The study, published today in PNASNews, shows that Invasin offers a sustainable, affordable and animal-free alternative to current methods.

Hubrecht Institute

18,349 görüntüleme • 1 yıl önce

Sculpture of the Ras protein (G12C) bound to GDP and the drug Sotorasib (AMG510). The protein is half bronze and half steel with a copper seam between the two metals. Represents how the drug locks the protein in a unique conformation that blocks its function and cancer growth.

Sculpture of the Ras protein (G12C) bound to GDP and the drug Sotorasib (AMG510). The protein is half bronze and half steel with a copper seam between the two metals. Represents how the drug locks the protein in a unique conformation that blocks its function and cancer growth.

Bryan Welm

55,959 görüntüleme • 1 yıl önce

Excited to share MeshUp ⬆️, a framework for deforming a mesh into a blend of various target concepts! MeshUp offers control over the influence of each concept by changing the associated weights. Project page: 🧵1/

Excited to share MeshUp ⬆️, a framework for deforming a mesh into a blend of various target concepts! MeshUp offers control over the influence of each concept by changing the associated weights. Project page: 🧵1/

Rana Hanocka

23,296 görüntüleme • 1 yıl önce

Our PROTEINLOCK™ process uses advanced filtration to concentrate milk’s natural protein and reduce sugar — creating ultra-filtered milk that’s smooth, delicious, and made to help you hit your protein goals. ✅ 32g of protein ✅ 3g of sugar ✅ 150 calories ✅ lactose free ✅ no carrageenan Available now on Amazon Target The Vitamin Shoppe

Our PROTEINLOCK™ process uses advanced filtration to concentrate milk’s natural protein and reduce sugar — creating ultra-filtered milk that’s smooth, delicious, and made to help you hit your protein goals. ✅ 32g of protein ✅ 3g of sugar ✅ 150 calories ✅ lactose free ✅ no carrageenan Available now on Amazon Target The Vitamin Shoppe

DrinkPrime

288,866 görüntüleme • 7 ay önce

"I don't have time for a high protein breakfast." Yes you do. You just don't have the right recipes. Here are 5 that take under 2 minutes and hit 40+ grams of protein: = Thread = 1. Greek Yogurt + Whey Protein Bowl

"I don't have time for a high protein breakfast." Yes you do. You just don't have the right recipes. Here are 5 that take under 2 minutes and hit 40+ grams of protein: = Thread = 1. Greek Yogurt + Whey Protein Bowl

Hannah - Apex Fitness Advisory

188,989 görüntüleme • 2 ay önce

Eggs used to be a cheap protein. Now they’re practically a delicacy. We’ve got to pump the breaks on the overspending in Washington in order to get inflation under control.

Eggs used to be a cheap protein. Now they’re practically a delicacy. We’ve got to pump the breaks on the overspending in Washington in order to get inflation under control.

Kevin McCarthy

3,429,156 görüntüleme • 3 yıl önce

Are you ‘all in’ on protein? Khloud x Fanatics Casino just hit the jackpot! Play FanCash Spins for a shot at an all expense paid trip to Las Vegas + a year’s supply of Khloud Protein Chips! Khloud hits big with 7g of protein per serving! And if you know you know: the best things land on lucky 7 — slots, dice, roulette, you name it. Ready for a big win? See the Fanatics Casino App for details 👀 #Khloud #FanaticsCasino #FanCashSpins

Are you ‘all in’ on protein? Khloud x Fanatics Casino just hit the jackpot! Play FanCash Spins for a shot at an all expense paid trip to Las Vegas + a year’s supply of Khloud Protein Chips! Khloud hits big with 7g of protein per serving! And if you know you know: the best things land on lucky 7 — slots, dice, roulette, you name it. Ready for a big win? See the Fanatics Casino App for details 👀 #Khloud #FanaticsCasino #FanCashSpins

Pop Tingz

255,152 görüntüleme • 4 ay önce

Welcome to Beyond The Plant Protein Company. A new chapter begins, rooted in the power of plants. Plants have superpowers. Our team is dedicated to unlocking and delivering them to you. Join us. Go Beyond. Feed a better future. 🌿

Welcome to Beyond The Plant Protein Company. A new chapter begins, rooted in the power of plants. Plants have superpowers. Our team is dedicated to unlocking and delivering them to you. Join us. Go Beyond. Feed a better future. 🌿

Beyond Meat

22,379 görüntüleme • 5 ay önce

High-Protein single-serve Pancake Bowls Ingredients (for one bowl) 1 egg 50g (3tbsp) Greek yoghurt 100ml (1/3 cup) milk of choice 30g protein powder 30g (1/4 cup) self-raising flour Topping ideas: Blueberries and white chocolate Banana and a sprinkle of coconut sugar Banana and chocolate chips Almond butter, almond flakes and a sprinkle of icing sugar How to: Preheat your oven to 180°C. Whisk all the ingredients in your oven-safe Kilner containers. Add your toppings. Bake for 20 - 25 minutes until the centre is set. 🎥 ajfoodie | IG

High-Protein single-serve Pancake Bowls Ingredients (for one bowl) 1 egg 50g (3tbsp) Greek yoghurt 100ml (1/3 cup) milk of choice 30g protein powder 30g (1/4 cup) self-raising flour Topping ideas: Blueberries and white chocolate Banana and a sprinkle of coconut sugar Banana and chocolate chips Almond butter, almond flakes and a sprinkle of icing sugar How to: Preheat your oven to 180°C. Whisk all the ingredients in your oven-safe Kilner containers. Add your toppings. Bake for 20 - 25 minutes until the centre is set. 🎥 ajfoodie | IG

𝕏 Cuisines

37,081 görüntüleme • 1 ay önce

Crashing out on the sidelines after losing to go to a 1-2 record instead of being 3-0 and leading a division. “Why would he want to leave San Fran and that team for Pittsburgh” was said all off season. That’s why.

Crashing out on the sidelines after losing to go to a 1-2 record instead of being 3-0 and leading a division. “Why would he want to leave San Fran and that team for Pittsburgh” was said all off season. That’s why.

Baku 🐧

2,760,166 görüntüleme • 1 yıl önce

Big Protein has convinced an entire generation they need a gram per pound of bodyweight. They don't. They're being sold way more protein than they can actually use, and a tub to mix it in. The ceiling for muscle protein synthesis sits closer to 0.7g per pound of bodyweight. Above that, the magic stops. You're not building extra muscle. You're deaminating the surplus, dumping nitrogen as urea, and lazily converting the rest into glucose. Premium steak, burnt as second-rate fuel. Congratulations. And here's the bit the protein bar adverts somehow forget to mention. Excess protein becomes weak, glucose-adjacent energy that taxes the liver and the kidneys, when the body would have vastly preferred to be running on fat. Dense. Stable. Clean. The fuel big animals are actually built for. But no, by all means, choke down your fourth chicken breast of the day. Hit that arbitrary number some bloke on a podcast invented in 2008. Your kidneys will write you a lovely thank-you note. Eat enough protein to build. Get the rest of your energy from fat. Everything past that point is just expensive urine.

Big Protein has convinced an entire generation they need a gram per pound of bodyweight. They don't. They're being sold way more protein than they can actually use, and a tub to mix it in. The ceiling for muscle protein synthesis sits closer to 0.7g per pound of bodyweight. Above that, the magic stops. You're not building extra muscle. You're deaminating the surplus, dumping nitrogen as urea, and lazily converting the rest into glucose. Premium steak, burnt as second-rate fuel. Congratulations. And here's the bit the protein bar adverts somehow forget to mention. Excess protein becomes weak, glucose-adjacent energy that taxes the liver and the kidneys, when the body would have vastly preferred to be running on fat. Dense. Stable. Clean. The fuel big animals are actually built for. But no, by all means, choke down your fourth chicken breast of the day. Hit that arbitrary number some bloke on a podcast invented in 2008. Your kidneys will write you a lovely thank-you note. Eat enough protein to build. Get the rest of your energy from fat. Everything past that point is just expensive urine.

Sama Hoole

122,677 görüntüleme • 2 ay önce

Big news from Boltz - our biggest update yet! 🚀 Today we’re releasing two new state-of-the-art models for protein and small molecule design with extensive wet lab validation and a new API to run all of our models on scalable GPUs wherever you (or your agents) work! 🔥

Big news from Boltz - our biggest update yet! 🚀 Today we’re releasing two new state-of-the-art models for protein and small molecule design with extensive wet lab validation and a new API to run all of our models on scalable GPUs wherever you (or your agents) work! 🔥

Gabriele Corso

137,241 görüntüleme • 2 ay önce

With 40 grams of protein and 1 gram of sugar, Muscle Milk Pro helps build muscles so Candace Parker can own her strength on and off the court.

With 40 grams of protein and 1 gram of sugar, Muscle Milk Pro helps build muscles so Candace Parker can own her strength on and off the court.

MUSCLE MILK

36,265,460 görüntüleme • 3 yıl önce

THE EURO. THE AND-1. Ant shows off the hang time and body control with a pair of incredible drives to the cup 😮‍💨 Wolves leading in the 3Q looking to take a 3-1 series lead on ESPN!

THE EURO. THE AND-1. Ant shows off the hang time and body control with a pair of incredible drives to the cup 😮‍💨 Wolves leading in the 3Q looking to take a 3-1 series lead on ESPN!

NBA

954,379 görüntüleme • 1 yıl önce

⚽️👇 Activity Instructions This is a switch of play rondo from This rondo is designed to develop quick and intelligent switches of play in possession. The game begins with a 3v1 in one area of the grid while two additional defenders are positioned to screen the central zone. Possession players must complete a set number of passes (e.g., 5) before attempting to switch play to the opposite side. Switches can be made in two ways - via the wide unopposed players for 1 point, or through the central zone for more points due to the difficulty and risk involved. This setup encourages decision-making, timing, and awareness of space and pressure. 🎨 Animation Created on The Tactics App

⚽️👇 Activity Instructions This is a switch of play rondo from This rondo is designed to develop quick and intelligent switches of play in possession. The game begins with a 3v1 in one area of the grid while two additional defenders are positioned to screen the central zone. Possession players must complete a set number of passes (e.g., 5) before attempting to switch play to the opposite side. Switches can be made in two ways - via the wide unopposed players for 1 point, or through the central zone for more points due to the difficulty and risk involved. This setup encourages decision-making, timing, and awareness of space and pressure. 🎨 Animation Created on The Tactics App

The Coaches Zone

11,885 görüntüleme • 1 ay önce

A new study found COVID shot mRNA and spike protein INVADE the human placenta and fetal cells, even in mothers vaccinated BEFORE pregnancy. 37% of placentas from COVID vaccinated mothers contained the LETHAL spike protein, and 30% had spike protein inside fetal immune cells.

A new study found COVID shot mRNA and spike protein INVADE the human placenta and fetal cells, even in mothers vaccinated BEFORE pregnancy. 37% of placentas from COVID vaccinated mothers contained the LETHAL spike protein, and 30% had spike protein inside fetal immune cells.

Nicolas Hulscher, MPH

113,153 görüntüleme • 9 gün önce

🚀 Introducing Frank 🤖—a whole-body robot control system for day-to-day household chores. Frank has been in works for the past year—a tightly coupled hardware and a remote teleoperation interface co-led by Michelle, Nandini, and Pulkit Agrawal. Thanks to Aditya Agarwal and Shankara Narayanan for the awesome help with recording the videos! 🎥 🧵[1/6]

🚀 Introducing Frank 🤖—a whole-body robot control system for day-to-day household chores. Frank has been in works for the past year—a tightly coupled hardware and a remote teleoperation interface co-led by Michelle, Nandini, and Pulkit Agrawal. Thanks to Aditya Agarwal and Shankara Narayanan for the awesome help with recording the videos! 🎥 🧵[1/6]

Bipasha Sen

51,137 görüntüleme • 1 yıl önce

A lone Komodo dragon stalks through the brush, targeting a baby goat distracted by its own feeding. With a sudden, explosive burst of speed, the dragon closes the gap before the goat can react. Utilizing its powerful, serrated teeth and muscular jaws, the Komodo dragon secures a firm grip on the small prey. Because of its highly flexible skull and ability to expand its throat, the dragon does not stop to tear the carcass apart. Instead, it maneuvers the baby goat and gobbles it down whole in a matter of seconds. This efficient feeding method allows the dragon to consume a massive amount of protein instantly, leaving no trace behind as it retreats back into the shadows of the island scrub.

A lone Komodo dragon stalks through the brush, targeting a baby goat distracted by its own feeding. With a sudden, explosive burst of speed, the dragon closes the gap before the goat can react. Utilizing its powerful, serrated teeth and muscular jaws, the Komodo dragon secures a firm grip on the small prey. Because of its highly flexible skull and ability to expand its throat, the dragon does not stop to tear the carcass apart. Instead, it maneuvers the baby goat and gobbles it down whole in a matter of seconds. This efficient feeding method allows the dragon to consume a massive amount of protein instantly, leaving no trace behind as it retreats back into the shadows of the island scrub.

Nature Chapter

25,525 görüntüleme • 3 ay önce

I got a message from a lead engineer at one of the largest AI companies freaking out over my use of media they never thought of for high protein AI training data. So I went live to have him listen in. “How the hell did you know all of this and for over 30 years”. 10-4.

I got a message from a lead engineer at one of the largest AI companies freaking out over my use of media they never thought of for high protein AI training data. So I went live to have him listen in. “How the hell did you know all of this and for over 30 years”. 10-4.

Brian Roemmele

184,757 görüntüleme • 11 ay önce