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The Ultimate Guide to BPC-157 The strongest healing tool on the planet - Why BPC changed my life - Exactly why it works miracles - How to use it THREAD 🧵

NootBro

83,453 subscribers

627,563 Aufrufe • vor 2 Jahren •via X (Twitter)

Bildung Gesundheit & Wellness Wissenschaft & Technologie

Anya Rossi• Live Now

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18 Kommentare

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NootBrovor 2 Jahren

Disclaimer: This is meant for informational purposes only based on my experience & research. This is NOT medical advice. Consult a physician prior to using any peptide, supplement, drug, etc. I am not a doctor.

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NootBrovor 2 Jahren

BPC-157 is legit I'd even call it the most useful peptide on the planet Why? It can enhance healing in EVERY part of the body: - Gut - Cardiovascular System - Brain (including TBI) - Spinal Cord - Muscle - Bones - Ligaments - Tendons - Achilles You name it, BPC can heal it

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NootBrovor 2 Jahren

In my case, BPC was the ONLY tool to fully heal my "leaky gut" 1 week in at 1000mcg/day, I started to notice benefit Less bloating, fatigue, & brain fog After 4 weeks, I considerably better After 6 weeks: 100% I use this

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NootBrovor 2 Jahren

But this isn't a random lucky experience According to researchers: "No other single agent has portrayed a similar array of effects” in repairing the gut Very useful for: - IBS - IBD - Crohn's - Stomach Ulcers - Diverticulitis - Ulcerative Colitis

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NootBrovor 2 Jahren

So how does it work? Most gurus will tell you BPC-157 enhances angiogenesis (new blood vessel formation) They're correct BPC does this via enhancing VEGF signaling (upregulates VEGFR2) This boosts blood flow to damaged parts of the body But this isn't the whole story...

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NootBrovor 2 Jahren

BPC also: 2) Boosts growth hormone (GH) signaling by upregulating GH receptors 3) Increases fibroblast activity and thus the production of collagen (crucial for repair) 4) Helps replace Type III collagen fibers with the stronger & more durable Type I collagen fibers

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NootBrovor 2 Jahren

4) Improves blood flow & blood pressure via enhancing endothelial nitric oxide 5) Exerts systemic antioxidant & anti-inflammatory effects These effects are seen even in hard-to-reach tissue and will rescue cells from death

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NootBrovor 2 Jahren

6) BPC also modulates EGR-1 expression This gene is not only heavily involved in wound healing But also affects nearly EVERY factor in neuroplasticity - Neurotransmitter Transport/Release - Synaptic Architecture - Protein Metabolism

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NootBrovor 2 Jahren

Long story short: BPC increases neuroplasticity & can help the brain return to homeostasis For example: BPC not only reduces the intoxicating & euphoric effects of drugs - Alcohol - Amphetamine - Opioids But also reduces the withdrawal & cravings after stopping them

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NootBrovor 2 Jahren

BPC's homeostatic effect is also seen in animal studies where it: - Improves TBI - Improves spinal cord injury - Counteract serotonin syndrome - Reduce depression & anxiety Don't get me wrong, research here is still in the early stages Full thread on BPC in the brain soon

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NootBrovor 2 Jahren

The best part about BPC is this: It's tolerated extremely well Nearly all animal & human studies report virtually no side effects In fact, researchers haven’t even been able to find a toxic dose (LD1)

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NootBrovor 2 Jahren

The one hypothetical concern is that it will worsen the spread of existing cancers (via VEGF/angiogenesis) But the 1 available study says the exact opposite (see image) This is a prime example of BPC being a modulatory/homeostatic peptide Would still avoid if I had cancer

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NootBrovor 2 Jahren

REMINDER: BPC will lessen the effects of most drugs This applies to Adderall especially Use BPC with caution if you are prone to anhedonia or you are a heavily dependent on amphetamine stimulants This is really the only group that ever has problems with BPC

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NootBrovor 2 Jahren

DOSING Unlike most peptides, BPC-157 can be taken orally And will remain stable in gastric juice for hours I'd use 1000mcg/day of BPC-157 Acetate until you're healed (8 weeks max) Oral is best for gut, but it will also work systemically I use this

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NootBrovor 2 Jahren

If you’re using BPC-157 to heal a severe injury related to muscle, tendons, bones, etc You may want to inject (subQ) closer to the site of injury (work with a practitioner) 300-500mcg/day injected subcutaneously until healed Don't use longer than 4 weeks

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NootBrovor 2 Jahren

You can get the injectable version for research purposes below - Made in USA - 3rd party lab-tested for quality - 15% off code is nootbro

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NootBrovor 2 Jahren

For injuries outside of the gut, pair BPC with TB-500 It's BPC's right-hand man and works synergistically (via the actin & VEGF pathways) 2mg 2x/week (subQ) for 4 weeks Limitless also has this for research purposes

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NootBrovor 2 Jahren

Anyways, that's all for now If you want to see more threads like this, show me some love on the original post If you have any questions, ask away Will answer as much as possible over next 24 hours

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BPC-157 is the peptide almost everyone starts with. Here is my full masterclass on it. 00:00 Intro and why BPC-157 01:44 What BPC-157 actually is 03:58 How it works in the body 07:32 Healing, inflammation and the brain 12:18 Who it is for and who skips it 14:20 Contraindications and cautions 15:52 Dosing tiers and timing 19:50 Cycling and time off 23:16 Pairing and the Wolverine stack 25:14 Reconstitution and injection 30:44 Troubleshooting and side effects 33:34 Legal status and FDA update 34:44 Oral vs injectable 36:20 The cancer debate 44:34 Final verdict

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Where BPC-157 peptide comes from and how it affects the body: - Croatian research group in the '90s isolated BPC-157 from a much larger 40,000-unit peptide naturally found in the gut - it is 15 amino acids long and is not something the body produces on its own. - Researchers theorized the stomach contained a cytoprotective compound after Pavlov's gastric juice experiments showed healing effects on GI tissue. - BPC-157 accelerates repair by upregulating VEGF signaling (new blood vessel formation), boosting nitric oxide synthesis, and increasing growth hormone receptors on tendons. - Corticosteroids normally halt wound healing - BPC-157 administered alongside them maintained or even improved healing outcomes in animal models. - In mouse models, BPC-157 reduced intoxication, blunted alcohol withdrawal symptoms, and appears to modulate dopaminergic signaling - effects that get far less attention than its musculoskeletal uses. Abud Bakri MD on Andrew D. Huberman, Ph.D.

Where BPC-157 peptide comes from and how it affects the body: - Croatian research group in the '90s isolated BPC-157 from a much larger 40,000-unit peptide naturally found in the gut - it is 15 amino acids long and is not something the body produces on its own. - Researchers theorized the stomach contained a cytoprotective compound after Pavlov's gastric juice experiments showed healing effects on GI tissue. - BPC-157 accelerates repair by upregulating VEGF signaling (new blood vessel formation), boosting nitric oxide synthesis, and increasing growth hormone receptors on tendons. - Corticosteroids normally halt wound healing - BPC-157 administered alongside them maintained or even improved healing outcomes in animal models. - In mouse models, BPC-157 reduced intoxication, blunted alcohol withdrawal symptoms, and appears to modulate dopaminergic signaling - effects that get far less attention than its musculoskeletal uses. Abud Bakri MD on Andrew D. Huberman, Ph.D.

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BPC-157 is not your typical pharmaceutical compound that forces a single outcome, but rather it restores conditions that allow the body to do what it already knows how to do. Gary Brecka and his team have put thousands of people on BPC-157. None of them had any adverse effects.

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BPC-157 and TB-500 are two of the most talked-about peptides in fitness, bodybuilding, and biohacking. Together they’re often called the “Wolverine Stack” — a peptide combination rumored to dramatically accelerate healing of tendons, ligaments, muscles, and injuries. But do BPC-157 and TB-500 actually work in humans, or is the Wolverine Stack just another example of internet bro-science? In this evidence-based deep dive, Dr. Alex Tatem (board-certified urologist and men’s health specialist) breaks down the real science behind BPC-157 and TB-500 — including their biochemical mechanisms, animal research, potential healing effects, safety concerns, and why pharmaceutical companies have never brought these peptides through full FDA clinical trials. We explore the nitric oxide signaling, angiogenesis, VEGF pathways, actin regulation, and tissue repair biology behind these compounds and explain why rodent studies look promising — but why human clinical evidence is still extremely limited. You’ll also learn about: • What BPC-157 (Body Protection Compound-157) actually is • TB-500 vs Thymosin Beta-4 explained • The origin of the Wolverine Stack peptide protocol • Peptides for tendon healing and ligament injuries • BPC-157 for gut healing and musculoskeletal repair • TB-500 and actin-mediated tissue regeneration • Why most peptide research comes from one Croatian research group • The patent law problem preventing pharmaceutical development • Real risks of grey-market peptide contamination • Why WADA bans BPC-157 and TB-500 in competitive athletes • Theoretical cancer risks related to angiogenesis • What the current scientific literature actually shows If you've ever searched: “Does BPC-157 work?” “What is TB-500?” “Peptides for healing injuries” “BPC-157 tendon repair” “Wolverine Stack peptides explained” — this video breaks down the science. The peptides may be promising. But promise and proof are not the same thing. Drop a comment below: Have you ever used BPC-157, TB-500, or other peptides? What was your experience? 👍 Like the video if you want more evidence-based breakdowns of supplements, PEDs, and peptides. Subscribe for deep dives on testosterone, steroids, peptides, supplements, and men’s health science.

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Superpower co-founder Max Marchione says his company is in the early stages of conducting a BPC-157 clinical trial. He believes there's more to support the argument that BPC-157's benefits are not placebo effects than the argument that it doesn't work:

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my thoughts on BPC-157 is that IF you are going to use it, you should absolutely NOT use it if you have a history of or have hereditary malignancies. you should also not continuously take BPC-157. while we don't have enough data, BPC's promotion of VEGF in mostly rodent studies is enough to deter me from using it even in the short term. when dosing stops, VEGF seems to return to normal so it's insane for me to hear that people are "blasting and cruising" this compound especially in neurotic tech circles

my thoughts on BPC-157 is that IF you are going to use it, you should absolutely NOT use it if you have a history of or have hereditary malignancies. you should also not continuously take BPC-157. while we don't have enough data, BPC's promotion of VEGF in mostly rodent studies is enough to deter me from using it even in the short term. when dosing stops, VEGF seems to return to normal so it's insane for me to hear that people are "blasting and cruising" this compound especially in neurotic tech circles

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The man with 20+ years researching peptides and steroids explains the exact BPC-157 dosage to use for recovery. "How much BPC-157 should I take?" Chase Irons: "That one's a little tricky and kind of depends on your funding and how fast you want to heal." Chase Irons: "I would say the ultimate would be taking a milligram first thing in the morning and before you go to bed at night." Chase Irons: "A lot of people do just fine doing half a milligram every day, but I probably wouldn't take it any lower than that." Chase Irons: "Currently I take 1mg of BPC-157 daily." Chase Irons: "If I've had an injury, I would do a milligram in the morning and a milligram at night to speed up recovery." Chase Irons: "But for me, my maintenance dose, I stick with 1mg per day."

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BPC-157 causing cancer? FDA shutting down peptide trials? “No human RCTs have ever been done on peptides?” In this video, Dr. Alex Tatem — board-certified urologist and fellowship-trained men’s health specialist — reacts to viral claims made on Shawn Ryan Show about BPC-157, TB-500, peptides, angiogenesis, cancer risk, and peptide safety. We break down: • Whether BPC-157 actually causes cancer • The truth about angiogenesis and tumor growth • FDA regulation of peptides and compounding • Why the “no randomized controlled trials” claim is completely false • Human clinical trial data on peptides • The real history of BPC-157 clinical studies • Huberman’s correction of viral peptide misinformation • Why peptide fearmongering could push patients toward unsafe gray-market sourcing This is not bro-science or influencer hype. This is a deep dive into the actual published literature, peptide pharmacology, FDA policy, and performance medicine. Topics covered include: BPC-157, TB-500, peptides, angiogenesis, cancer biology, GLP-1 drugs, Ozempic, tirzepatide, semaglutide, TRT, peptide therapy, biohacking, longevity, anti-aging medicine, compounding pharmacies, peptide legality, Andrew D. Huberman, Ph.D. , Shawn Ryan Show, FDA peptide regulation, growth hormone history, and performance medicine. If you’ve ever wondered whether BPC-157 is dangerous, whether peptides are legal, or whether the internet is fearmongering about peptide therapy — this video is for you.

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I healed leaky gut! How did i do it? I used the basic gut prep from the RemissionBiome MECFS/LongCovid Patient-Led Science protocol and added the peptide BPC-157, probiotics, L-glutamine and zinc-carnosine, and antibacterial herbs like oregano, garlic, and artemesia. Get started on healing your leaky gut!

I healed leaky gut! How did i do it? I used the basic gut prep from the RemissionBiome MECFS/LongCovid Patient-Led Science protocol and added the peptide BPC-157, probiotics, L-glutamine and zinc-carnosine, and antibacterial herbs like oregano, garlic, and artemesia. Get started on healing your leaky gut!

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45,807 Aufrufe • vor 3 Jahren

Joe Rogan takes BPC-157. Huberman takes BPC-157. The US Health Secretary called himself a “big fan” of peptides. Your doctor has never heard of it. BPC-157. 15 amino acids. Found in your own stomach juice. Rogan had elbow tendonitis nothing could fix. BPC-157 — gone in two weeks. Called it “Wolverine shit.” Huberman had chronic back pain from a herniated disc. Two injections. Years of pain — gone. He’s a Stanford neuroscientist. He doesn’t exaggerate. RFK Jr. uses peptides for his own injuries. The FDA is now reclassifying BPC-157 toward legal access. in studies: → REGREW severed nerves → REBUILT torn ligaments — oral worked → REATTACHED tendon to bone → 90% relief in 16 knee patients → REVERSED alcohol damage across 7 organs → HEALED bone defects comparable to grafts “doesn’t it cause cancer?” let me be clear: → in 30+ years of research — NOT ONE documented case of BPC-157 causing or promoting cancer. not one. → a 2018 study actually REDUCED tumor formation → the angiogenesis BPC triggers is REGULATED — it heals damaged tissue and stops. tumor growth uses different pathways entirely. but — if you have an active cancer diagnosis, don’t take it. not because the data shows harm. because it hasn’t been tested in cancer patients specifically. that decision belongs to your oncologist. not me. not a podcast. your oncologist. 30 years. zero lethal dose. zero cancer. used by the biggest names in health. your doctor won’t mention it. your stomach already makes it. I take it daily. source in the comments ↓

Joe Rogan takes BPC-157. Huberman takes BPC-157. The US Health Secretary called himself a “big fan” of peptides. Your doctor has never heard of it. BPC-157. 15 amino acids. Found in your own stomach juice. Rogan had elbow tendonitis nothing could fix. BPC-157 — gone in two weeks. Called it “Wolverine shit.” Huberman had chronic back pain from a herniated disc. Two injections. Years of pain — gone. He’s a Stanford neuroscientist. He doesn’t exaggerate. RFK Jr. uses peptides for his own injuries. The FDA is now reclassifying BPC-157 toward legal access. in studies: → REGREW severed nerves → REBUILT torn ligaments — oral worked → REATTACHED tendon to bone → 90% relief in 16 knee patients → REVERSED alcohol damage across 7 organs → HEALED bone defects comparable to grafts “doesn’t it cause cancer?” let me be clear: → in 30+ years of research — NOT ONE documented case of BPC-157 causing or promoting cancer. not one. → a 2018 study actually REDUCED tumor formation → the angiogenesis BPC triggers is REGULATED — it heals damaged tissue and stops. tumor growth uses different pathways entirely. but — if you have an active cancer diagnosis, don’t take it. not because the data shows harm. because it hasn’t been tested in cancer patients specifically. that decision belongs to your oncologist. not me. not a podcast. your oncologist. 30 years. zero lethal dose. zero cancer. used by the biggest names in health. your doctor won’t mention it. your stomach already makes it. I take it daily. source in the comments ↓

Healthy Alfred 🌴🥥

323,463 Aufrufe • vor 3 Monaten

BPC-157 strips are interesting. No needles or reconstitution, plus, they're much easier to use consistently. Still very early, but I’m curious how they compare to injections in the real world. Has anyone here actually tried them?

BPC-157 strips are interesting. No needles or reconstitution, plus, they're much easier to use consistently. Still very early, but I’m curious how they compare to injections in the real world. Has anyone here actually tried them?

Michael Morelli

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The complete guide to JLS: new characters who can do the tech, new combos, and why it works

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Sunfield

512,402 Aufrufe • vor 3 Jahren

I would take KPV over BPC-157 and TB-500 any day. Here's my full masterclass on it. 03:24 What KPV actually is and where it comes from 05:34 NF-kappa B: the master inflammation switch KPV shuts off 07:54 Why KPV targets inflamed tissue and leaves healthy tissue alone 11:48 Who benefits: IBD, Crohn's, ulcerative colitis 12:56 Breaking the BPC and TB-500 plateau 14:02 Autoimmune, skin conditions and MCAS 15:42 Dosing Tier 1: 250mcg 16:54 Dosing Tier 2: 500mcg for active healing 17:16 Dosing Tier 3: 1mg+ for severe inflammation 26:56 Sequencing: calm the fire before you rebuild 31:36 Stacking with BPC-157, TB-500, LL-37 and GLPs 40:34 Long COVID and MCAS 43:20 KPV is the peptide that calms the room

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Hunter Williams

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Oxidative State

61,498 Aufrufe • vor 1 Monat

Elon Musk highlights how OpenAI’s changed model is opposite to why exactly it was made in the first place. #WGS25 #WorldGovSummit

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We chatted to Sam Bowman Sam Bowman about why he launched an online magazine Works in Progress during the pandemic 🗞️🗞️ 🇬🇧🇪🇺We discuss his piece on why Britain has become so poor and how it compares to European counterparts Quick thread summarising the piece 🇬🇧🧵👇 /1

Jimmy McLoughlin 🐑

35,422 Aufrufe • vor 2 Jahren

"BPC-157 is the biggest scam I've ever seen. It does absolutely nothing. There's no redeemable value to it." - Martin Shkreli "Why are we going backwards? Why don't we go forwards? What is this urge by the Valley — and I blame the Valley — to go backwards through time and space?" "This is nonsense. This is not science. Science is controlled experiments that are well-done, very carefully documented, and so forth."

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TBPN

269,287 Aufrufe • vor 6 Monaten