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This is PSP, right? Neurodegenerative and progressive, right? Wrong. This is autoimmune encephalitis associated with autoantibodies directed against the GABAB receptor. Great teaching case presented by Mustafa, Garg and colleagues Movement Disorders Clinical Practice Key Points: - Progressive recurrent backward falls for 3 months. - Slowness w/ unclear speech,... body stiffness and a poker face. - Abnormal walking for one month (ataxic). - Vertical upgaze palsy w/ preserved vestibulo-ocular reflexes. My take: The clue was the subacute onset of atypical parkinsonism w/ a PSP-like phenotype accompanied by gait ataxia. Mark Hallett always says in Aspen, think about autoimmune ataxia when there is a subacute presentation. Be aware that the anti-GABAB receptor-mediated encephalitis can be observed in "drug refractory epilepsy, anterograde amnesia, limbic encephalitis and rapidly progressive dementia." Only half of cases will end up being associated with a hidden cancer. Docendo discimus – we learn by teaching – and we should be aware that PSP-like phenotypes can rarely be associated with autoimmune disorders. #PSP Parkinson's Foundation Norman Fixel Institute for Neurological Diseasesshow more

Michael Okun

39,635 subscribers

13,330 Aufrufe • vor 1 Jahr •via X (Twitter)

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8 Kommentare

Profilbild von Abhishek Lenka

Abhishek Lenkavor 1 Jahr

@MDCP_Journal Nice case @Divyani_Garg

Profilbild von Elise Oyin

Elise Oyinvor 1 Jahr

We don't allow no progesterone antagonist to operate even 0.1% and we ban all anti-progesterone activity, and for there to be no switch of any kind in regards to progesterone from agonists to antagonist in Elise Oyinkromeineifa's body even 0.1% in the name of Jesus Christ u9ges

Profilbild von The Wolf of College Street

The Wolf of College Streetvor 1 Jahr

@MDCP_Journal I would have thought IgLON5 tbh Interesting case

Profilbild von CorpusGAL"awe"sum

CorpusGAL"awe"sumvor 1 Jahr

@MDCP_Journal Which antibodies have you seen commonly associated with this?

Profilbild von Shilpa Chitnis, M.D., Ph.D., FAAN.

Shilpa Chitnis, M.D., Ph.D., FAAN.vor 1 Jahr

@MDCP_Journal @natalievitek

Profilbild von Dr. Abu Shuraih Sakhri

Dr. Abu Shuraih Sakhrivor 1 Jahr

@MDCP_Journal @DrFarsanaNeuro

Profilbild von Yet Ze

Yet Zevor 1 Jahr

@MDCP_Journal Do you have the case report for free? I can't download it please

Profilbild von ArianeK 💜 #Care4Complex (she/her)

ArianeK 💜 #Care4Complex (she/her)vor 1 Jahr

@MDCP_Journal This is also what my case of toxic encephalitis and drug induced Parkinsonism looked like. Onset over a few weeks and then worsened badly over months as the medication reaction was presumed to be autoimmune encephalitis, so I was wrongly kept on the drug causing it (prednisone).

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Here is your humbling case of the day that was just published? ' Will you miss this 17 year old who comes in with a year and a half of behavioral change, loss of appetite, weight loss, and folks have suggested he has a functional movement disorder. Did you think PERM? Key Points: - It is actually progressive encephalomyelitis with rigidity and myoclonus (PERM) - Considered part of the large spectrum of stiff-person-syndrome - Think brainstem and autonomic involvement in addition to axial and limb rigidity, CNS hyperexcitability - Autoantibodies against glycine receptor in 70% of PERM cases - Other antibodies include glutamic acid decarboxylase (GAD), dipeptidyl peptidase-like-protein-6 (DPPX), and of course amphiphysin - This case was anti-DPPX-associated PERM My take: One word: humbling....

Here is your humbling case of the day that was just published? ' Will you miss this 17 year old who comes in with a year and a half of behavioral change, loss of appetite, weight loss, and folks have suggested he has a functional movement disorder. Did you think PERM? Key Points: - It is actually progressive encephalomyelitis with rigidity and myoclonus (PERM) - Considered part of the large spectrum of stiff-person-syndrome - Think brainstem and autonomic involvement in addition to axial and limb rigidity, CNS hyperexcitability - Autoantibodies against glycine receptor in 70% of PERM cases - Other antibodies include glutamic acid decarboxylase (GAD), dipeptidyl peptidase-like-protein-6 (DPPX), and of course amphiphysin - This case was anti-DPPX-associated PERM My take: One word: humbling....

Michael Okun

95,682 Aufrufe • vor 2 Jahren

Measles is making a comeback as less people are getting vaccinated. Can you spot the neurological manifestations (SSPE)? Check out this great case by Garg and colleagues Movement Disorders Clinical Practice where in addition to myoclonus and other features you will observe a sensory trick. Key Points: - A late complication of measles is called subacute sclerosing panencephalitis (SSPE). - Sensory tricks are maneuvers that temporarily improve dystonic posture. - Another name is 'geste antagoniste' derived from the description of the 'phenomenon in cervical dystonia by Henry Meige and Eugene Feindel in 1902.' - The movement of a trick, as Dr. Hallett points out, 'does not always need to be antagonistic or in the opposing direction of the dystonia and the term antagonistic might be better thought of in terms of a trick reversing the dystonia.' - Patel et al. recently introduced the alternative term, alleviating maneuver. - In the current case, check out the video of a progressive cognitive decline, behavioral issues, myoclonus and abnormal posturing of the neck and upper limbs in a 15 year old. - Jerky movements of upper limbs are actually myoclonus. - Could touch chin on the right side with either hand, to reduce neck posturing and forward position of the head. - He could also occasionally insert a finger into the right side of the mouth for symptomatic relief. - This boy was not vaccinated. My take: It will be important for clinicians around the world to be on the lookout for measles and the late SSPE potential manifestations. The geste antagonist in this case was incredible, and I personally have never observed this dystonic manifestation in the setting of measles. Finem respice – consider the outcome of not vaccinating. Read about sensory tricks by Mark Hallett #Measles #vaccination #SSPE #dystonia #myoclonus

Measles is making a comeback as less people are getting vaccinated. Can you spot the neurological manifestations (SSPE)? Check out this great case by Garg and colleagues Movement Disorders Clinical Practice where in addition to myoclonus and other features you will observe a sensory trick. Key Points: - A late complication of measles is called subacute sclerosing panencephalitis (SSPE). - Sensory tricks are maneuvers that temporarily improve dystonic posture. - Another name is 'geste antagoniste' derived from the description of the 'phenomenon in cervical dystonia by Henry Meige and Eugene Feindel in 1902.' - The movement of a trick, as Dr. Hallett points out, 'does not always need to be antagonistic or in the opposing direction of the dystonia and the term antagonistic might be better thought of in terms of a trick reversing the dystonia.' - Patel et al. recently introduced the alternative term, alleviating maneuver. - In the current case, check out the video of a progressive cognitive decline, behavioral issues, myoclonus and abnormal posturing of the neck and upper limbs in a 15 year old. - Jerky movements of upper limbs are actually myoclonus. - Could touch chin on the right side with either hand, to reduce neck posturing and forward position of the head. - He could also occasionally insert a finger into the right side of the mouth for symptomatic relief. - This boy was not vaccinated. My take: It will be important for clinicians around the world to be on the lookout for measles and the late SSPE potential manifestations. The geste antagonist in this case was incredible, and I personally have never observed this dystonic manifestation in the setting of measles. Finem respice – consider the outcome of not vaccinating. Read about sensory tricks by Mark Hallett #Measles #vaccination #SSPE #dystonia #myoclonus

Michael Okun

29,754 Aufrufe • vor 2 Jahren

Check out the unusual gait pattern worsened by levodopa in this case of a PARKIN gene related Parkinson's. This is why we call it Parkinson's diseases plural as there are so many different manifestations, with or without known gene mutations. Nice case by Mehta and colleagues in Movement Disorders Clinical Practice. Key Points: - 26 year old Parkin gene-related early-onset Parkinson's. - Paradoxical response to levodopa, dopamine worsened dystonia. - Amantadine seemed to help. - Complaint was tightness of lower limbs when walking. - Had heterozygous PRKN mutations, w/ a 'missense pathogenic mutation in exon 7 (c.850G > C (p. Gly284Arg) and a deletion mutation in exon 3 (241 bp),' - 'Forward walking was characterized by bilateral hip flexion and abduction, flexed knees, ankle inversion and plantar flexion rebound during the stance phase on the left foot and reduced arm swing bilaterally.' My take: Some of these PARKIN and genetic PD cases may respond to anticholinergics or dopamine agonists, however in this case this was not helpful. The improvement w/ amantadine was humbling and unexpected. The authors suggest to us to try amantadine, if dopamine is worsening dystonia or gait in the setting of PARKIN. 'Parkinsons diseases, every day we learn something new.' A close look at the video suggests the amantadine helped however did not resolve the challenge. DBS may be a reasonable next step to consider. #Parkinsons

Check out the unusual gait pattern worsened by levodopa in this case of a PARKIN gene related Parkinson's. This is why we call it Parkinson's diseases plural as there are so many different manifestations, with or without known gene mutations. Nice case by Mehta and colleagues in Movement Disorders Clinical Practice. Key Points: - 26 year old Parkin gene-related early-onset Parkinson's. - Paradoxical response to levodopa, dopamine worsened dystonia. - Amantadine seemed to help. - Complaint was tightness of lower limbs when walking. - Had heterozygous PRKN mutations, w/ a 'missense pathogenic mutation in exon 7 (c.850G > C (p. Gly284Arg) and a deletion mutation in exon 3 (241 bp),' - 'Forward walking was characterized by bilateral hip flexion and abduction, flexed knees, ankle inversion and plantar flexion rebound during the stance phase on the left foot and reduced arm swing bilaterally.' My take: Some of these PARKIN and genetic PD cases may respond to anticholinergics or dopamine agonists, however in this case this was not helpful. The improvement w/ amantadine was humbling and unexpected. The authors suggest to us to try amantadine, if dopamine is worsening dystonia or gait in the setting of PARKIN. 'Parkinsons diseases, every day we learn something new.' A close look at the video suggests the amantadine helped however did not resolve the challenge. DBS may be a reasonable next step to consider. #Parkinsons

Michael Okun

16,865 Aufrufe • vor 2 Jahren

Can you identify 'belly dancer dyskinesia?' Hint: look for undulating or circular abdominal contractions. Nice case by Cho, Hallett and colleagues in Movement Disorders Clinical Practice Key Points: - Spinal cord or basal ganglia lesions. - If spinal cord origin, the movements tend to continue during sleep. - An MRI may be helpful if a structural lesion is present. - Physiological studies can be helpful. My take: This case they present turned out to be a 'functional movement disorder' and the movements disappeared with sleep. There was no exposure to a dopamine blocking medication. There was no history of abdominal surgery. The authors remind us to uncover possible 'suggestibility, entrainability, and distractibility.' Physiologically the BP potential is actually present WITH functional myoclonus. Many propriospinal myoclonus cases have turned out to be functional movement disorders. HUMBLING even for the experts. … #dyskinesia #bellydancer #functionalmovementdisorder

Can you identify 'belly dancer dyskinesia?' Hint: look for undulating or circular abdominal contractions. Nice case by Cho, Hallett and colleagues in Movement Disorders Clinical Practice Key Points: - Spinal cord or basal ganglia lesions. - If spinal cord origin, the movements tend to continue during sleep. - An MRI may be helpful if a structural lesion is present. - Physiological studies can be helpful. My take: This case they present turned out to be a 'functional movement disorder' and the movements disappeared with sleep. There was no exposure to a dopamine blocking medication. There was no history of abdominal surgery. The authors remind us to uncover possible 'suggestibility, entrainability, and distractibility.' Physiologically the BP potential is actually present WITH functional myoclonus. Many propriospinal myoclonus cases have turned out to be functional movement disorders. HUMBLING even for the experts. … #dyskinesia #bellydancer #functionalmovementdisorder

Michael Okun

12,768 Aufrufe • vor 1 Jahr

Can you identify an oculogyric crisis? @ChristosGanos and colleagues teach us about the intriguing possibility that the rolling eyes we frequently see after administration of a drug, may be localized to a brain lesion network associated with a brain dopaminergic transcriptomic signature. Read about it in a new paper Brain. Key Points: - Oculogyric crises what are they? Acute episodes sustained, typically upward, conjugate deviation of the eyes. - Common cause? Acute D2-dopamine receptor blockade by a drug. - The authors used data from 14 previously reported cases of lesion-induced oculogyric crises and employed' lesion network mapping' to search for shared connections. - What was the common network? Basal ganglia, thalamic, brainstem nuclei and cerebellum. - A look at the gene expression profiles showed spatial overlap specifically with the gene coding for dopamine receptor type 2 (DRD2). - The very cool part: spatial overlap with DRD2 and DRD3 gene expression seemed to be 'specific to brain lesions associated with oculogyric crises when contrasted to lesions that led to other movement disorders.' My take: I love the use of multiple modalities to chase down a common neural network for oculogyric crises. We should keep in mind that these were cases associated with brain lesions, and as we all contribute by reporting more cases and sharing their MRI scans we will likely further refine our understanding of the network. For clinicians when you see this, look down that medication list for the 'dopamine blocker' as your first step in diagnosis. This video by Elan Louis provides a nice illustration of oculogyric crisis to help you to identify them in your practice. #Parkinsons #oculogyric

Can you identify an oculogyric crisis? @ChristosGanos and colleagues teach us about the intriguing possibility that the rolling eyes we frequently see after administration of a drug, may be localized to a brain lesion network associated with a brain dopaminergic transcriptomic signature. Read about it in a new paper Brain. Key Points: - Oculogyric crises what are they? Acute episodes sustained, typically upward, conjugate deviation of the eyes. - Common cause? Acute D2-dopamine receptor blockade by a drug. - The authors used data from 14 previously reported cases of lesion-induced oculogyric crises and employed' lesion network mapping' to search for shared connections. - What was the common network? Basal ganglia, thalamic, brainstem nuclei and cerebellum. - A look at the gene expression profiles showed spatial overlap specifically with the gene coding for dopamine receptor type 2 (DRD2). - The very cool part: spatial overlap with DRD2 and DRD3 gene expression seemed to be 'specific to brain lesions associated with oculogyric crises when contrasted to lesions that led to other movement disorders.' My take: I love the use of multiple modalities to chase down a common neural network for oculogyric crises. We should keep in mind that these were cases associated with brain lesions, and as we all contribute by reporting more cases and sharing their MRI scans we will likely further refine our understanding of the network. For clinicians when you see this, look down that medication list for the 'dopamine blocker' as your first step in diagnosis. This video by Elan Louis provides a nice illustration of oculogyric crisis to help you to identify them in your practice. #Parkinsons #oculogyric

Michael Okun

15,398 Aufrufe • vor 2 Jahren

Russian-speaking [Ukrainians] are a disease that must be eradicated,” says children’s writer (!) Larysa Nitsoi in the media. And apparently no one sees a problem. No one stops her. No one holds her criminally accountable for hate speech, for inciting hostility, or for rhetoric that can be read as a call for violence against the “wrong kind” of Ukrainians. This is what contemporary fascistic Ukraine looks like: a country where millions of its own citizens can be branded by representatives of the post-Maidan intelligentsia as a “disease” to be “treated” or “eradicated” because they speak the "wrong" language. When human beings are described as a contagion, when an entire linguistic community is pathologized and presented as something the national body must be cleansed of, we are no longer talking about an innocent “language debate.” This is the vocabulary of dehumanization. It is the logic of eugenics. It is the rhetoric historically associated with fascism and Nazism. And all of this is unfolding in a state politically, financially, and militarily backed by the West.

Russian-speaking [Ukrainians] are a disease that must be eradicated,” says children’s writer (!) Larysa Nitsoi in the media. And apparently no one sees a problem. No one stops her. No one holds her criminally accountable for hate speech, for inciting hostility, or for rhetoric that can be read as a call for violence against the “wrong kind” of Ukrainians. This is what contemporary fascistic Ukraine looks like: a country where millions of its own citizens can be branded by representatives of the post-Maidan intelligentsia as a “disease” to be “treated” or “eradicated” because they speak the "wrong" language. When human beings are described as a contagion, when an entire linguistic community is pathologized and presented as something the national body must be cleansed of, we are no longer talking about an innocent “language debate.” This is the vocabulary of dehumanization. It is the logic of eugenics. It is the rhetoric historically associated with fascism and Nazism. And all of this is unfolding in a state politically, financially, and militarily backed by the West.

Marta Havryshko

70,515 Aufrufe • vor 1 Monat

This woman’s case is one of the many reasons I think psychiatry will be gone in 100 years. Her psychotic episode was due to anti-NMDA receptor encephalitis. It's an autoimmune condition where the immune system attacks NMDA receptors in the brain. She was put on a psych ward where they gave her high doses of antipsychotics while her condition deteriorated. Her family had to fight for the tests that revealed the illness. A psychotic episode should always be a medical emergency until proven otherwise. There should be a standard panel of tests for everything from B12 deficiency to encephalitis. A psychiatrist sent me home from an ER mid-heart attack because I presented with impending doom and stomach pain. I was diagnosed with psychosis and somatic delusions. It turned out that I had non-occlusive messenteric ischemia along with the heart attack. What makes me mad is that I may or may not have been in psychosis (I couldn’t eat, had lost 3 kilo that week and was in extreme pain) but the psychiatrist didn’t even treat the condition he thought I had- a sudden onset of psychosis as a medical emergency. It always is. The coming years, I hope families, friends and loved ones continue to push for medical workups and that people diagnosed with mental illness stop dying before their peers of treatable illnesses

This woman’s case is one of the many reasons I think psychiatry will be gone in 100 years. Her psychotic episode was due to anti-NMDA receptor encephalitis. It's an autoimmune condition where the immune system attacks NMDA receptors in the brain. She was put on a psych ward where they gave her high doses of antipsychotics while her condition deteriorated. Her family had to fight for the tests that revealed the illness. A psychotic episode should always be a medical emergency until proven otherwise. There should be a standard panel of tests for everything from B12 deficiency to encephalitis. A psychiatrist sent me home from an ER mid-heart attack because I presented with impending doom and stomach pain. I was diagnosed with psychosis and somatic delusions. It turned out that I had non-occlusive messenteric ischemia along with the heart attack. What makes me mad is that I may or may not have been in psychosis (I couldn’t eat, had lost 3 kilo that week and was in extreme pain) but the psychiatrist didn’t even treat the condition he thought I had- a sudden onset of psychosis as a medical emergency. It always is. The coming years, I hope families, friends and loved ones continue to push for medical workups and that people diagnosed with mental illness stop dying before their peers of treatable illnesses

Sarah Nadav

32,264 Aufrufe • vor 10 Tagen

Do you remember the case of the 'frozen addict' from recreational drug use (MPTP). Is there a 'new frozen addict syndrome' caused by methcathione (ephedrone). YES. This psychostimulant leads to release of brain catecholamines. Check out this case and video by Thayler and Gurevitch which responded to amantadine and check out the link to manganese. Key points: - Methcathione (ephedrone) can be used as a recreational drug and use has been documented in Eastern Europe and other world locations. - This chemical is synthesized by oxidation of ephedrine or pseudoephedrine w/potassium permanganate. - It is usually given IV and the 'parkinsonism' is thought to be caused by manganese. - It is unlike the MPTP frozen addict as in this case levodopa does not work to treat. - The authors point out that the syndrome tends to be more symmetrical than in idiopathic PD; the clinician should look for bradykinesia, dystonia, and gait impairment. - Check out this 41 year old case w/ a normal flurodopa PET and an abnormal MRI. - He was treated with a 5-day course of IV amantadine followed by oral amantadine. My take: It is humbling to think about the history of a recreational drug which provided one of our best overall animal models of PD (the MPTP model). Now we are observing another form of recreational drug induced parkinsonism, and this one seems to be related to manganese. It is interesting in this case to observe the response to IV and oral amantadine; which as a therapy has multiple mechanisms of action including on dopamine, acetlycholine and glutamate pathways. In the USA, we have not used IV amantadine so this will be a new trick for us. One important aspect of this case was that the clinicians resisted the urge to 'dismiss the person' as an addict or as functional case. Similar to Bill Langston's experience with the MPTP frozen addict, these authors persisted, made the diagnosis and designed and implemented a treatment. BRAVO. Remember, we will all (one day) come down with a disease or diseases and Fortuna est caeca; Fortune is blind. #Parkinsons #manganese #methcathione #ephedrone

Do you remember the case of the 'frozen addict' from recreational drug use (MPTP). Is there a 'new frozen addict syndrome' caused by methcathione (ephedrone). YES. This psychostimulant leads to release of brain catecholamines. Check out this case and video by Thayler and Gurevitch which responded to amantadine and check out the link to manganese. Key points: - Methcathione (ephedrone) can be used as a recreational drug and use has been documented in Eastern Europe and other world locations. - This chemical is synthesized by oxidation of ephedrine or pseudoephedrine w/potassium permanganate. - It is usually given IV and the 'parkinsonism' is thought to be caused by manganese. - It is unlike the MPTP frozen addict as in this case levodopa does not work to treat. - The authors point out that the syndrome tends to be more symmetrical than in idiopathic PD; the clinician should look for bradykinesia, dystonia, and gait impairment. - Check out this 41 year old case w/ a normal flurodopa PET and an abnormal MRI. - He was treated with a 5-day course of IV amantadine followed by oral amantadine. My take: It is humbling to think about the history of a recreational drug which provided one of our best overall animal models of PD (the MPTP model). Now we are observing another form of recreational drug induced parkinsonism, and this one seems to be related to manganese. It is interesting in this case to observe the response to IV and oral amantadine; which as a therapy has multiple mechanisms of action including on dopamine, acetlycholine and glutamate pathways. In the USA, we have not used IV amantadine so this will be a new trick for us. One important aspect of this case was that the clinicians resisted the urge to 'dismiss the person' as an addict or as functional case. Similar to Bill Langston's experience with the MPTP frozen addict, these authors persisted, made the diagnosis and designed and implemented a treatment. BRAVO. Remember, we will all (one day) come down with a disease or diseases and Fortuna est caeca; Fortune is blind. #Parkinsons #manganese #methcathione #ephedrone

Michael Okun

13,007 Aufrufe • vor 2 Jahren

Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in Movement Disorders Clinical Practice. Key Points: - When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.' - In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.' - In their study they showed a sensitivity of 76% and a specificity of 65% for the sign. My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's. #Parkinsons Smiles induced by DBS: Spontaneous and posed smiles in Parkinson: Motor cortex and facial smiling in primates by Morecraft: #Parkinsons #smilefest2024 #smile

Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in Movement Disorders Clinical Practice. Key Points: - When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.' - In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.' - In their study they showed a sensitivity of 76% and a specificity of 65% for the sign. My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's. #Parkinsons Smiles induced by DBS: Spontaneous and posed smiles in Parkinson: Motor cortex and facial smiling in primates by Morecraft: #Parkinsons #smilefest2024 #smile

Michael Okun

12,724 Aufrufe • vor 2 Jahren

Palantir CEO Alex Karp says the left and right are converging: "The functional allies of our adversaries now, who claim to want these progressive things—both far-right and far-left, which are actually structurally very similar—are helping to fight for structures that would not include anyone like them." "I want a society where it is: the best people succeed." "There's a right of free speech, whether you like the person or not." "There's a right of privacy, whether you like the person or not." "There's a right to put checks on the government, whether they like you or not." "The people who are working the hardest to destroy those concepts, and are the most effective in destroying those concepts, call themselves progressive. They're not progressive. "Or they call themselves, super far right. They're not even right-wing." "The people on the far left, and the people I hung out with in the Frankfurt School, which was left of center of where I was—true progressives—would be somewhat not amused to know that the actual philosophical background of most modern non-progressive progressives is not Marx, it's Heidegger." "They're not actually left-wing. They're actually asking for things that are classically right-wing." "What are those things? They're asking for: we all get to be the same. We're all defined by who we are, by how we were born, or what we impute ourselves to be. There are only rights for a sector of people. The rights do not apply to people who are not like us because of wealth or because they think differently, and that we want a society that essentially looks communal." "These are like prototypical, non-progressive, classically right-wing thoughts just reapplied to people who call themselves progressive." "That's the society that Palantir and I are effectively working against." "By giving people more sovereignty, whether they believe it or not, protecting people from terrorism with civil liberties, by making businesses wealthier and better, where the businesses keep their actual alpha, and by helping Ukraine, Israel, and America establish a dominant position." Via Mathias Döpfner

Palantir CEO Alex Karp says the left and right are converging: "The functional allies of our adversaries now, who claim to want these progressive things—both far-right and far-left, which are actually structurally very similar—are helping to fight for structures that would not include anyone like them." "I want a society where it is: the best people succeed." "There's a right of free speech, whether you like the person or not." "There's a right of privacy, whether you like the person or not." "There's a right to put checks on the government, whether they like you or not." "The people who are working the hardest to destroy those concepts, and are the most effective in destroying those concepts, call themselves progressive. They're not progressive. "Or they call themselves, super far right. They're not even right-wing." "The people on the far left, and the people I hung out with in the Frankfurt School, which was left of center of where I was—true progressives—would be somewhat not amused to know that the actual philosophical background of most modern non-progressive progressives is not Marx, it's Heidegger." "They're not actually left-wing. They're actually asking for things that are classically right-wing." "What are those things? They're asking for: we all get to be the same. We're all defined by who we are, by how we were born, or what we impute ourselves to be. There are only rights for a sector of people. The rights do not apply to people who are not like us because of wealth or because they think differently, and that we want a society that essentially looks communal." "These are like prototypical, non-progressive, classically right-wing thoughts just reapplied to people who call themselves progressive." "That's the society that Palantir and I are effectively working against." "By giving people more sovereignty, whether they believe it or not, protecting people from terrorism with civil liberties, by making businesses wealthier and better, where the businesses keep their actual alpha, and by helping Ukraine, Israel, and America establish a dominant position." Via Mathias Döpfner

Jawwwn

13,461 Aufrufe • vor 2 Monaten

🚨ZELENSKYY REPEATED ONE MORE TIME THAT UKRAINE WILL NOT JOIN TRUMP’S BOARD OF PEACE, BECAUSE THERE IS NO PEACE WITH RUSSIA AT THIS POINT Q: You said that Putin is a terrorist and a war criminal, does he belong on something called a board of peace in your view? ZELENSKYY: Look, this is the initiative of President Trump. It's not my initiative. I'm not the president of the United States. We've been invited. To be honest with you, in the 20 points plan, when we spoke about security guarantees and how to monitor one of the important first steps like a ceasefire, the American side proposed that they will need partners who will monitor with the United States, and it can be like council of peace, and it will be two sides of the war. It means Russians and Ukrainians because we are on the contact line, we have to monitor, yes, by drones and technology issues, and they said it will be also Americans and some other Europeans. I mean, it's not the news about this council for me. I didn't know how it will be, that it will be in Davos, and whom President Trump will involve or propose invitation. I didn't know. It's up to him. But I said that for us, it's understandable that we will be in this board when the war will end. Now with Russians, we are enemies. Belarussia is allie of Russians. We can't be with them. And it's already in the package, in the 20 points plan. So it will work, I think so, it will work with monitor mission only after the war will end. Maybe there are some others issues like Gaza. I'm not talking about us to be involved in Gaza and other questions. So we are only speaking about these partners who will monitor ceasefire and security guarantees.

🚨ZELENSKYY REPEATED ONE MORE TIME THAT UKRAINE WILL NOT JOIN TRUMP’S BOARD OF PEACE, BECAUSE THERE IS NO PEACE WITH RUSSIA AT THIS POINT Q: You said that Putin is a terrorist and a war criminal, does he belong on something called a board of peace in your view? ZELENSKYY: Look, this is the initiative of President Trump. It's not my initiative. I'm not the president of the United States. We've been invited. To be honest with you, in the 20 points plan, when we spoke about security guarantees and how to monitor one of the important first steps like a ceasefire, the American side proposed that they will need partners who will monitor with the United States, and it can be like council of peace, and it will be two sides of the war. It means Russians and Ukrainians because we are on the contact line, we have to monitor, yes, by drones and technology issues, and they said it will be also Americans and some other Europeans. I mean, it's not the news about this council for me. I didn't know how it will be, that it will be in Davos, and whom President Trump will involve or propose invitation. I didn't know. It's up to him. But I said that for us, it's understandable that we will be in this board when the war will end. Now with Russians, we are enemies. Belarussia is allie of Russians. We can't be with them. And it's already in the package, in the 20 points plan. So it will work, I think so, it will work with monitor mission only after the war will end. Maybe there are some others issues like Gaza. I'm not talking about us to be involved in Gaza and other questions. So we are only speaking about these partners who will monitor ceasefire and security guarantees.

Kateryna Lisunova

68,599 Aufrufe • vor 8 Monaten

🚨 SHOCKING MEDICAL TWIST: Doctors diagnosed a man with a brain tumor… until they realized his head was packed with WORMS. A 60-year-old man showed up with progressive headaches and personality changes. Scans looked like classic metastatic brain cancer. Case closed… right? Wrong. High-resolution MRI revealed the “tumors” were actually fluid-filled cysts loaded with the larvae of Taenia solium — tapeworm. Neurocysticercosis, not cancer. And it’s not an isolated nightmare. A woman seeking help for memory problems and depression had surgeons pull a live, wriggling 8 cm worm straight out of her brain. Another family described “spaghetti-like worms” being extracted from a lung during what was supposed to be lymphoma surgery. Parasites are master mimics. They can perfectly imitate brain tumors, cancers, neurological disorders, autoimmune conditions, and more — while the real invader quietly does damage. This is critical: In many modern medical schools (especially in non-endemic areas), ruling out parasites is no longer a routine first step in the differential diagnosis. Symptoms get labeled as something else, treatments miss the mark, and patients suffer longer. You have to be your own best advocate. If something feels off and the standard answers aren’t working, ask to be tested for parasites. Demand the right imaging, stool tests, blood work, or specialist referral. Your body may be fighting an uninvited guest that mainstream protocols overlook. Real cases. Real worms. Real reason to stay alert.🪱

🚨 SHOCKING MEDICAL TWIST: Doctors diagnosed a man with a brain tumor… until they realized his head was packed with WORMS. A 60-year-old man showed up with progressive headaches and personality changes. Scans looked like classic metastatic brain cancer. Case closed… right? Wrong. High-resolution MRI revealed the “tumors” were actually fluid-filled cysts loaded with the larvae of Taenia solium — tapeworm. Neurocysticercosis, not cancer. And it’s not an isolated nightmare. A woman seeking help for memory problems and depression had surgeons pull a live, wriggling 8 cm worm straight out of her brain. Another family described “spaghetti-like worms” being extracted from a lung during what was supposed to be lymphoma surgery. Parasites are master mimics. They can perfectly imitate brain tumors, cancers, neurological disorders, autoimmune conditions, and more — while the real invader quietly does damage. This is critical: In many modern medical schools (especially in non-endemic areas), ruling out parasites is no longer a routine first step in the differential diagnosis. Symptoms get labeled as something else, treatments miss the mark, and patients suffer longer. You have to be your own best advocate. If something feels off and the standard answers aren’t working, ask to be tested for parasites. Demand the right imaging, stool tests, blood work, or specialist referral. Your body may be fighting an uninvited guest that mainstream protocols overlook. Real cases. Real worms. Real reason to stay alert.🪱

Dr. Dawn Michael

78,508 Aufrufe • vor 2 Monaten

As Africans we must promote revolutionary democracy and the will of the people over militia rule We were lucky in the case of Burkina Faso, that progressives led the military uprisings and isolation of France, a phenomenon that revealed itself as time progressed. On the flip side, the coup in Guinea in 2021 was led by a mercenary of French and Israeli interests, who has entrenched France’s imperial control. It is therefore correct to assert that the trend is one to be read with caution, and dealt with according to ever developing conditions. In many instances, the West utilizes rebels and militia to undermine African democratic will and destabilize the continent for mineral extraction and profit maximization. We saw this in Libya, an imperialist coup effort supported by the Jacob Zuma regime. Coups can work for us today, and work for the imperialist enemy tomorrow. A productive conversation would be how do coups that represent anti-colonialism, transition towards democracy after unseating neo-colonial regimes - the coup may have been a means, but should not be an end. The principle must always be democracy, and support of what we stand for through the popular will of the people. Revolutionaries should not rely on military might, but on their ability to capture the imagination of the people, lest tomorrow your progressive government is also removed through a coup. As real progressives, we must reflect on international politics with nuance, not some shallow “gotcha” politics of opportunists. That being said, Viva to the progressives in the Sahel Region! The EFF is with you!

As Africans we must promote revolutionary democracy and the will of the people over militia rule We were lucky in the case of Burkina Faso, that progressives led the military uprisings and isolation of France, a phenomenon that revealed itself as time progressed. On the flip side, the coup in Guinea in 2021 was led by a mercenary of French and Israeli interests, who has entrenched France’s imperial control. It is therefore correct to assert that the trend is one to be read with caution, and dealt with according to ever developing conditions. In many instances, the West utilizes rebels and militia to undermine African democratic will and destabilize the continent for mineral extraction and profit maximization. We saw this in Libya, an imperialist coup effort supported by the Jacob Zuma regime. Coups can work for us today, and work for the imperialist enemy tomorrow. A productive conversation would be how do coups that represent anti-colonialism, transition towards democracy after unseating neo-colonial regimes - the coup may have been a means, but should not be an end. The principle must always be democracy, and support of what we stand for through the popular will of the people. Revolutionaries should not rely on military might, but on their ability to capture the imagination of the people, lest tomorrow your progressive government is also removed through a coup. As real progressives, we must reflect on international politics with nuance, not some shallow “gotcha” politics of opportunists. That being said, Viva to the progressives in the Sahel Region! The EFF is with you!

Sinawo Thambo

35,290 Aufrufe • vor 1 Jahr

EPSTEIN, INTELLIGENCE, & THE ELITE. BLACKMAIL IS MORE POWERFUL THAN PROSECUTION. Blackmail is the weapon of choice for intelligence agencies because of its vast and infinite amount of control. Once you have it, it never goes away, and can control an individual for life. A dystopian robotic-like system, compromised and controlled interchangeable politicians and citizens in all aspects of society that make our world go round, pushing legislation and looking the other way when needed, all controlled by fear, aka, blackmail. This is why it must be eradicated from our system, government, and control mechanisms. We will never have a true honest system and move forward in a positive direction because of the "Hidden Hand in control." The main factor in which the Epstein list or certain information will not be exposed is because of it's connections and on going operations with our intelligence agencies and others. What we wanted was a list of the clients of Epstein because everyone knows there were hundreds of them and thousands of victims and videos which implicate very important people. What we want is accountability and consequences for the ones involved and justice for the victims. Why does it always have to be about the elite? This should be about the lives that were destroyed by the elite and intelligence agencies. If you go through the evidence and testimonies of the victims, you can easily find the people involved and associated with Epstein. Just because you think it's over doesn't mean it is. The information and comments made over the last couple months and the new video that was released really doesn't prove anything but loudly exposes a cover up operation. It seems almost intentionally done that way to highlight certain individuals or the matter in general in a way that will still don't fully understand yet. Everything was sloppy and very uncoordinated and points to something bigger happening. After all the time, promises, posts, and information dropped over the years paints a picture of a bigger operation at play. This is not just a simple one layered situation, and I don't see people changing their tone and promises made over years, simply overnight. There are many theories at the current moment, but one, logical, in particular one is that the blackmail is now being used against the deep state. There are still individuals within the administration that are compromised and are not working for, but against the trump administration and might also be apart of why this concluded this way. We will still continue to fight for justice no matter what and over the next few weeks we will learn more and understand the bigger picture because this isn't over yet and their are still thousands of kids that we need to save. There is a reason for everything transpiring, with layers, optics, and timing procuring for that specific reason in order to complete the original objective, which was to destroy the deep state cabal and shatter it into a million pieces, and we're not stopping until we do. I know right now is difficult but there is more to this story, and when the time is right, it will be exposed. We have to stick together and help one another and continue to fight this fight together. Whoever the enemy turns out to be. Stay strong, have faith and Godspeed.

EPSTEIN, INTELLIGENCE, & THE ELITE. BLACKMAIL IS MORE POWERFUL THAN PROSECUTION. Blackmail is the weapon of choice for intelligence agencies because of its vast and infinite amount of control. Once you have it, it never goes away, and can control an individual for life. A dystopian robotic-like system, compromised and controlled interchangeable politicians and citizens in all aspects of society that make our world go round, pushing legislation and looking the other way when needed, all controlled by fear, aka, blackmail. This is why it must be eradicated from our system, government, and control mechanisms. We will never have a true honest system and move forward in a positive direction because of the "Hidden Hand in control." The main factor in which the Epstein list or certain information will not be exposed is because of it's connections and on going operations with our intelligence agencies and others. What we wanted was a list of the clients of Epstein because everyone knows there were hundreds of them and thousands of victims and videos which implicate very important people. What we want is accountability and consequences for the ones involved and justice for the victims. Why does it always have to be about the elite? This should be about the lives that were destroyed by the elite and intelligence agencies. If you go through the evidence and testimonies of the victims, you can easily find the people involved and associated with Epstein. Just because you think it's over doesn't mean it is. The information and comments made over the last couple months and the new video that was released really doesn't prove anything but loudly exposes a cover up operation. It seems almost intentionally done that way to highlight certain individuals or the matter in general in a way that will still don't fully understand yet. Everything was sloppy and very uncoordinated and points to something bigger happening. After all the time, promises, posts, and information dropped over the years paints a picture of a bigger operation at play. This is not just a simple one layered situation, and I don't see people changing their tone and promises made over years, simply overnight. There are many theories at the current moment, but one, logical, in particular one is that the blackmail is now being used against the deep state. There are still individuals within the administration that are compromised and are not working for, but against the trump administration and might also be apart of why this concluded this way. We will still continue to fight for justice no matter what and over the next few weeks we will learn more and understand the bigger picture because this isn't over yet and their are still thousands of kids that we need to save. There is a reason for everything transpiring, with layers, optics, and timing procuring for that specific reason in order to complete the original objective, which was to destroy the deep state cabal and shatter it into a million pieces, and we're not stopping until we do. I know right now is difficult but there is more to this story, and when the time is right, it will be exposed. We have to stick together and help one another and continue to fight this fight together. Whoever the enemy turns out to be. Stay strong, have faith and Godspeed.

The SCIF

42,483 Aufrufe • vor 1 Jahr

“Unless you're comparing a vaccine against saline, how can you say it’s safe?” Dr. Sherri Tenpenny just exposed Pharma’s “safe and effective” narrative as a complete sham. “There has never been—on any one of the vaccines that are currently given—a truly placebo-controlled trial where in one set of children they were given the new vaccine, and then the other set of children it was a true saline placebo.” “All of the vaccine trials are a vaccine compared to another vaccine,” Alex Clark: “How long were the majority of the safety trials done on the vaccines on the childhood schedule?” Dr. Tenpenny: “The average length of time is probably somewhere between 15 and 30 days.” “It’s been as short as 4 days.” “When they brought the first hepatitis B vaccine to market, they followed to see if there were any side effects for 5 days.” “The second hepatitis B vaccine that came to market, they followed side effects for 4 days.” “That is not a safety trial.” “It can take months to years to develop autoimmune diseases, neurological complications, other types of things like [gastrointestinal] disorders.” “Encephalitis can start right away, but it can be slow brewing for a long period of time.” Dr Sherri Tenpenny

“Unless you're comparing a vaccine against saline, how can you say it’s safe?” Dr. Sherri Tenpenny just exposed Pharma’s “safe and effective” narrative as a complete sham. “There has never been—on any one of the vaccines that are currently given—a truly placebo-controlled trial where in one set of children they were given the new vaccine, and then the other set of children it was a true saline placebo.” “All of the vaccine trials are a vaccine compared to another vaccine,” Alex Clark: “How long were the majority of the safety trials done on the vaccines on the childhood schedule?” Dr. Tenpenny: “The average length of time is probably somewhere between 15 and 30 days.” “It’s been as short as 4 days.” “When they brought the first hepatitis B vaccine to market, they followed to see if there were any side effects for 5 days.” “The second hepatitis B vaccine that came to market, they followed side effects for 4 days.” “That is not a safety trial.” “It can take months to years to develop autoimmune diseases, neurological complications, other types of things like [gastrointestinal] disorders.” “Encephalitis can start right away, but it can be slow brewing for a long period of time.” Dr Sherri Tenpenny

Children’s Health Defense

49,833 Aufrufe • vor 9 Monaten

Hasan responds to the Michigan State Rep & Graham Platner dropping events he’s involved in, cites Hasan Derangement Syndrome "Could be..I have no idea who the Michigan reps are..there are malleable lower level politicians that can be pressured that don't know who I am" "I didn't even know this was a Progressive Victory event until they released it..they've been constantly asking me to be part of it for the last week or so..and I was like why not..and Prog Victory has revealed..scheduling conflict from the start" "All of these F Hasan derangement syndrome losers literally think that this dude is backing out..bc I'm also participating..are u out of ur mind..dudes on the internet run on drama..they think that Graham Platner was like omg Hasan is going to be a part of this..I can't touch this w a 10 ft pole"" "I think a guy like Graham Platner has a lot more consequential red flags..that he has dealt w successfully..than being associated w someone like myself..liberals are so funny, after literally calling him a neona*zi for months, they fantasized a world where's actually anti me..just operate on Hasan derangement syndrome..I'm a twitch streamer..wake tf up"

Hasan responds to the Michigan State Rep & Graham Platner dropping events he’s involved in, cites Hasan Derangement Syndrome "Could be..I have no idea who the Michigan reps are..there are malleable lower level politicians that can be pressured that don't know who I am" "I didn't even know this was a Progressive Victory event until they released it..they've been constantly asking me to be part of it for the last week or so..and I was like why not..and Prog Victory has revealed..scheduling conflict from the start" "All of these F Hasan derangement syndrome losers literally think that this dude is backing out..bc I'm also participating..are u out of ur mind..dudes on the internet run on drama..they think that Graham Platner was like omg Hasan is going to be a part of this..I can't touch this w a 10 ft pole"" "I think a guy like Graham Platner has a lot more consequential red flags..that he has dealt w successfully..than being associated w someone like myself..liberals are so funny, after literally calling him a neona*zi for months, they fantasized a world where's actually anti me..just operate on Hasan derangement syndrome..I'm a twitch streamer..wake tf up"

yeet

102,128 Aufrufe • vor 6 Monaten

American Farmer Heads Into The Grocery Store To Warn Americans About What You’re Eating Popular Name Brand Foods Contain In Their Ingredients Antibiotics Only Available By Prescription Right Alongside “Wood Fibers” “This is a farm boy. We're in a grocery store today to look up some things that might be or may not be in your foods. One of them is called natamycin. Know what that is? That is a medicine by prescription, and it's in a lot of your foods. And I'll take you and show you what what's going on here. See that brand name right there? You flip this over. If you look real close, you can see it. See it? Sure is. That is a medicine by prescription. It is in a great many of shredded cheeses. They use, if you can see here on this list, you will be able to see that it has Natamycin in that. See that brand name? America's favorite. Let's see what it has to offer. Lookie right there. Natamycin. Wonder what's up with that. And for those of you that's on a diet and you think eating protein products like these breakfast sausage winners are good for you, well, let's take a look at that. How about that crap? Oh my gosh. Now that may not seem like much to you, but that nadamycin, well, that's an antifungus medicine by prescription. Yep. It's for your eyes a lot of times. Now they're putting it in our food right along with wood cellulose products. Yep. When you see cellulose, you know you're getting wood fibers. And what they're using that for is a preservative, and they're using that as an anti caking and anti fungus. They're putting antibiotics right in your food. This is a farm boy, thought you'd like to know that.”

Wall Street Apes

1,233,561 Aufrufe • vor 2 Jahren