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This week, we released a groundbreaking 160 entries from time-resolved #CryoEM capturing G protein activation by a #GPCR. It’s the largest data set from a single publication and describes the order of events driving G protein activation upon GTP binding!

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EMDB - EMPIAR @EBI

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22,394 просмотров • 2 лет назад •via X (Twitter)

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EMDB - EMPIAR @EBI2 лет назад

#EMDB: #PDBe: #Paper: Check all the 352 latest entries now @

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Excited to share nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵

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Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USCDornsife
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We found the spike protein contains PRION-LIKE DOMAINS capable of driving a CHAIN REACTION of protein misfolding in the body. This helps explain COVID vaccine-induced CREUTZFELDT-JAKOB DISEASE and the massive WHITE FIBROUS CLOTS now seen by 75% of embalmers.

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Protein timing and distribution are important, but not more important than simply eating enough protein. This doesn’t mean timing is irrelevant. Spreading protein relatively evenly across the day is a reasonable strategy for maximizing opportunities to stimulate muscle protein synthesis. But emerging evidence challenges the idea that the body can only “use” 25-30 grams of protein at a time. In one study, researchers compared 25 g vs. 100 g of protein after exercise. The 100-g dose produced a greater and more prolonged increase in muscle protein synthesis, with very little of the additional amino acids being oxidized. The extra protein wasn’t simply “wasted.” Larger protein meals take longer to digest and absorb, extending the period during which amino acids are available to support tissue protein synthesis. Practically, consuming your daily protein across 2-3 larger meals is not inherently inferior simply because individual meals contain far more than 25-30 grams.

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Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week
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I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of Johan Neyts 💊 Published today in Nature: A huge congrats to everyone involved! 🎉

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I’ve had my team of volunteers manually checking the NoBlogs data released by the deaf liberal DEI hire fed DataRepublican (small r) today….and we already know it’s incomplete. We’ve been tracking NoBlogs for years using human subject matter experts, not shitty AI analysis. We have our own dataset. And there’s data missing from the set released by Data Republican. This is just one example. Doing human analysis takes time. But shitty AI analysis by a liberal DEI hire will never defeat the work of people who do research on the ground and go undercover with Antifa and the far left.

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