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This week, we released a groundbreaking 160 entries from time-resolved #CryoEM capturing G protein activation by a #GPCR. It’s the largest data set from a single publication and describes the order of events driving G protein activation upon GTP binding!

EMDB - EMPIAR @EBI

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22,394 次观看 • 2 年前 •via X (Twitter)

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Excited to share nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵

Excited to share nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵

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Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USCDornsife

Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USCDornsife

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Simple Minds released 'Alive and Kicking' this week in 1985 as the lead single from their chart-topping album 'Once Upon a Time'.

Simple Minds released 'Alive and Kicking' this week in 1985 as the lead single from their chart-topping album 'Once Upon a Time'.

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I asked Astra to build me a protein visualization app using Spline V2, it came up with this website! It pulls the data directly from the Protein Data Bank website, so it's accurate, and it lets me switch between the 2 types of protein visualization

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We found the spike protein contains PRION-LIKE DOMAINS capable of driving a CHAIN REACTION of protein misfolding in the body. This helps explain COVID vaccine-induced CREUTZFELDT-JAKOB DISEASE and the massive WHITE FIBROUS CLOTS now seen by 75% of embalmers.

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Protein timing and distribution are important, but not more important than simply eating enough protein. This doesn’t mean timing is irrelevant. Spreading protein relatively evenly across the day is a reasonable strategy for maximizing opportunities to stimulate muscle protein synthesis. But emerging evidence challenges the idea that the body can only “use” 25-30 grams of protein at a time. In one study, researchers compared 25 g vs. 100 g of protein after exercise. The 100-g dose produced a greater and more prolonged increase in muscle protein synthesis, with very little of the additional amino acids being oxidized. The extra protein wasn’t simply “wasted.” Larger protein meals take longer to digest and absorb, extending the period during which amino acids are available to support tissue protein synthesis. Practically, consuming your daily protein across 2-3 larger meals is not inherently inferior simply because individual meals contain far more than 25-30 grams.

Protein timing and distribution are important, but not more important than simply eating enough protein. This doesn’t mean timing is irrelevant. Spreading protein relatively evenly across the day is a reasonable strategy for maximizing opportunities to stimulate muscle protein synthesis. But emerging evidence challenges the idea that the body can only “use” 25-30 grams of protein at a time. In one study, researchers compared 25 g vs. 100 g of protein after exercise. The 100-g dose produced a greater and more prolonged increase in muscle protein synthesis, with very little of the additional amino acids being oxidized. The extra protein wasn’t simply “wasted.” Larger protein meals take longer to digest and absorb, extending the period during which amino acids are available to support tissue protein synthesis. Practically, consuming your daily protein across 2-3 larger meals is not inherently inferior simply because individual meals contain far more than 25-30 grams.

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Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

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‘All The Things She Said' was released 40 years ago this month as the third single from Once Upon A Time.

‘All The Things She Said' was released 40 years ago this month as the third single from Once Upon A Time.

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Said Dr. Resia Pretorius on differentiating microclot components between Long COVID, ME/CFS and POTS: “If we can understand the protein content associated with these amyloidygenic molecules, we think we might be able to identify, in that [insoluble plasma] fraction, proteins that we can target. “In this proteomics analysis specifically, we are finding a lot of post-translational modifications. We are finding molecules suggesting there’s complement activation, neutrophil activation… If you really deep dive into the sequence of the peptides of the proteins in the structures, then a whole new world opens up.” 1/

PolyBio

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More protein doesn’t cancel out a low diet quality. Unfortunately, the “protein maxxing” trend has convinced a lot of people that it’s fine to eat ultra-processed foods as long as they’re “high protein.” But protein bars, shakes, and snacks with a long ingredient list are still processed food. If you’re going to prioritize protein, get it from whole foods first—meat, fish, eggs, dairy, and legumes—and don’t let a label of high protein become a health halo that crowds out fiber-rich plant foods and nutrient-dense animal foods.

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Are you at Devconnect? Interested in jobs at Base? Come by the Base Booth this week! I’ll be hosting a recruitment activation from 1-2pm tomorrow, Wednesday, and Thursday. This is your opportunity to meet the team! Sign up links below!

Are you at Devconnect? Interested in jobs at Base? Come by the Base Booth this week! I’ll be hosting a recruitment activation from 1-2pm tomorrow, Wednesday, and Thursday. This is your opportunity to meet the team! Sign up links below!

Connor Holliman

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We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

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I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of Johan Neyts 💊 Published today in Nature: A huge congrats to everyone involved! 🎉

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Today is World Protein Day. The purpose of this day is to raise awareness among people to increase their protein intake. It's a bit of a long read. When I started my mission of “Protein Kidhar Hai?” back in 2018, I got backlash from many educated and literate people, saying I was pushing for whey companies and harming people's kidneys. However, to date, we haven’t seen anyone come to me saying your protein campaign put me on dialysis. Anyway, Today, after 6-7 years, I am seeing a significant change on X and other social media. Everyone is talking about protein. Many senior citizens on my timeline also upped their intake, many women are now taking care of it, and many parents are making sure their kids are eating enough protein. Though we still get names called by some ignorants like protein-jeet and proteinmaxxers, we are proud of it. Collective, you me, are pushing everyone around us to eat more protein and removing the “protein deficient” tag from everyone’s plate. I just released a video on YouTube explaining how much protein you really need, as well as how much your parents, your kids, and your significant others need. This video is end to end scientifically proven and I have added all possible research and evidence for naysayers. Watch full video here: Happy Protein Day to everyone breaking all the traditionalism and conservatism of insufficient protein. Happy Protein Day to everyone who has fought with their people constantly for years to change their food intake habits. Be a proud proteinmaxxer!

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I’ve had my team of volunteers manually checking the NoBlogs data released by the deaf liberal DEI hire fed DataRepublican (small r) today….and we already know it’s incomplete. We’ve been tracking NoBlogs for years using human subject matter experts, not shitty AI analysis. We have our own dataset. And there’s data missing from the set released by Data Republican. This is just one example. Doing human analysis takes time. But shitty AI analysis by a liberal DEI hire will never defeat the work of people who do research on the ground and go undercover with Antifa and the far left.

I’ve had my team of volunteers manually checking the NoBlogs data released by the deaf liberal DEI hire fed DataRepublican (small r) today….and we already know it’s incomplete. We’ve been tracking NoBlogs for years using human subject matter experts, not shitty AI analysis. We have our own dataset. And there’s data missing from the set released by Data Republican. This is just one example. Doing human analysis takes time. But shitty AI analysis by a liberal DEI hire will never defeat the work of people who do research on the ground and go undercover with Antifa and the far left.

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The possibilities for AI-powered protein design are endless! In this case study we show how we used BindCraft to engineer a programmable maltose biosensor from scratch, including wet lab validation at Adaptyv of course. We envision a future where every biologist can make their own bespoke protein tools to investigate environmental samples, cell behaviour or create therapeutics. AI-based protein design can enable that future if powered by rapid wet lab validation. Once the cycle from design → test → application shrinks to weeks, the frontier explodes.

Adaptyv Bio

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Not one season or one match. Not from a single wicket, or a single catch. Not the 20 overs you see on screen, But the many hours of practice behind the scenes. Built over time, through effort, sweat, and belief. We are about to do it! Unlocking greatness with our protein choice - Optimum Nutrition. Because when it’s game ON — Its ON! #OptimumNutrition #UnlockYourGreatness #RCB

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