Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in Cell!

We reconstructed lineage trees for >1.4 million cells across 16 mouse embryos staged at half-day intervals from E7.5 to E10.0 resolving ~75% of cell divisions. Full thread on what we found here:

It’s an exciting time for lineage tracing: check out a complementary paper in @ScienceMagazine from @JShendure and colleagues reconstructing a >1.3 million cell tree for the E13.5 mouse embryo.

You can explore our data at – lineage trees, gene expression, and fate restriction dynamics, no coding needed.

We've also put together a Python tutorial for working with the trees and matched expression data, so you can run your own analyses.

🍾 Huge congratulations to @LukeKoblan @WilliamNColgan and many thanks to our wonderful collaborators Zachary Smith @YaleMed and MPIMG, @nir_yosef1 @WeizmannScience, @ZhuangLab @HarvardCCB, and Kyle Loh @Stanford

@WilliamNColgan @YaleMed @nir_yosef1 @WeizmannScience @ZhuangLab @HarvardCCB @Stanford Thank you to @czi @hhmi_science @WhiteheadInst @NIH for supporting this work.

@shi_lingting @CellCellPress Hearty congratulations 🎈🎊🎉🍾

@CellCellPress Brilliant