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Use of AI to integrate plaque composition characteristics that increase risk for ACS 1. delta FFR across lesion 2. Plaque location & burden at site 3. Total plaque volume 4. Low attenuation plaque volume 5. Percent myocardial blood flow Lumen narrowing not as important !! #snackablehealth s/b HeartFlow

11,933 次观看 • 2 年前 •via X (Twitter)

3 条评论

Gemina 的头像
Gemina2 年前

👌

Dr Bart Olechowski 的头像
Dr Bart Olechowski2 年前

very interesting and promising 💯👏🏻

Mirand 的头像
Mirand2 年前

@DavidErlinge Maybe your field can help me.

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There’s been a lot of buzz—and confusion—about the new Keto-CTA study, examining plaque progression in Lean Mass Hyper-Responders (LMHRs). Much of the social media debate has centered on whether high LDL on keto is safe or dangerous, driven largely by how to interpret the supplemental table comparing this study to others on LDL and plaque progression. In this episode of the Metabolic Mind Podcast, we sit down with Dr. Matthew Budoff, a world-renowned cardiologist, cardiac CT researcher, and the study's lead investigator, to discuss the the supplemental table, what the plaque markers mean, and how this fits into the discussion of high- vs -low-risk plaque progression. In this episode, we cover: ✅ What PAV (Percent Atheroma Volume) is, what it actually measures, and why it matters ✅ Why a 50% increase in plaque may sound scary, but can be deceiving ✅ The difference between “treatment-naive” and “treated” participants ✅ What the Miami Heart Study comparison reveals about keto, LDL, and plaque ✅ Why LDL alone may not tell the whole story about heart disease risk ✅ How some high-risk individuals may still benefit from statins and other therapies This study doesn’t answer whether keto causes heart disease or not. Instead, it shows that high LDL on a ketogenic diet is not a reliable predictor of plaque progression across all individuals. What is predictive? The presence of existing plaque. 💡 Key takeaway: Relying on surrogate markers of heart disease, like LDL and ApoB, is not the best way to assess heart disease risk in all populations. If you're concerned about how elevated LDL may be affecting your heart health, the best next step is to speak with your doctor about cardiac imaging to directly assess plaque and gain a clearer picture of your individual risk. Expert Featured: - Dr. Matthew Budoff - X: - Resources Mentioned: Plaque Begets Plaque, ApoB Does Not CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope Brain Energy: The Metabolic Theory of Mental Illness Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at

Metabolic Mind

98,147 次观看 • 1 年前

Heart disease is the number 1 cause of death. Mainstream advice like cutting fat, red meat and taking statins isn’t working... They don’t fix the real causes of heart disease. Here are the top 6 science-backed supplements to reduce your risk of heart disease (bookmark this):👇 1. Nattokinase. This enzyme helps dissolve blood clots and plaque by breaking down fibrin. There aren't even meds that can reverse plaque buildup. Take 10,000 FU every day. 2. Magnesium glycinate. Magnesium relaxes blood vessel walls, allowing them to dilate and improve blood flow. It also reduces blood pressure and calms your nervous system. But most Americans are deficient in it. Take 400-500mg before bed. 3. Fish oil (Omega-3s). They reduce inflammation that damages your arteries and lower triglycerices. They can even lower blood pressure by improving arterial elasticity. Take 2-3g of combined EPA/DHA daily. 4. CoQ10. Your heart beats 100,000 times per day and requires massive amounts of energy. CoQ10 fuels your cardiac muscle cells, protects against oxidative damage and improves endothelial function. Your levels naturally drop with age. Take 200-300mg every day. 5. Vitamin D3. Vitamin D deficiency stiffens arteries and impairs endothelial function. Most Americans are deficient yet the healthcare system completely ignores it. Take 5,000-10,000 IUs daily with a meal containing fat and get more sunlight. Aim for blood levels of 50-70 ng/mL. 6. Vitamin K2. It activates a protein called MGP that keeps calcium out of your arteries where it becomes plaque and sends it to your bones. Take 100-200mcg of the MK-7 form every day. You can also get some in organ meats, red meat and aged cheeses. Lifestyle changes with your: - Nutrition - Exercise - Sleep & stress levels Are what's most important to reduce your risk of heart disease but these supplements significantly help. Bookmark this tweet to save these supplements 👇

Chris Boettcher

50,502 次观看 • 6 个月前

🚨SHOCKING: Cholesterol SAVES Lives – It's CALCIUM that's the REAL Killer! Why Are We Still Popping Statins? You've been lied to. Cholesterol isn't the villain – Dr. Hal Huggins nails it: "Cholesterol Is The Most Important Molecule In The Body...Don't Blame Cholesterol For The Harm That Calcium Causes." Here's the science-backed truth: • **Plaque Reality Check**: Arterial plaque is ~90% calcium buildup, with just 1.5% fat (0.5% cholesterol). Unstable plaques are lipid-rich, but calcification stabilizes them – yet docs blame cholesterol? (NEJM, 1997: Davies on plaque composition) • **Brain Powerhouse**: 60% of your brain is fat; 30% of that is cholesterol – essential for neurons, memory, & mood. Low levels? Linked to depression & dementia. (StatPearls: Cholesterol's role in cell membranes & hormones) • **Longevity Boost**: Higher LDL (100-189 mg/dL) = LOWER mortality risk in adults 50-89. Elderly with high LDL live LONGER! (BMJ Open, 2016: Inverse association in 92% of cohorts; Nutrients, 2025: 40% lower mortality risk) • **Inflammation, Not Cholesterol**: Atherosclerosis is an inflammatory disease – driven by endothelial damage, not LDL. (NEJM, 1999: Ross's landmark review; Nature, 2022: Chronic inflammation key driver) Root causes to crush inflammation: • Low Vit D, Mg, K2 deficiencies • Seed oils, processed sugars/carbs • Insulin resistance, obesity, stress • Toxins, poor sleep, no exercise Fix with: Low-carb, animal-based whole foods. Aim for TG/HDL ratio <1.5 – ultimate heart health marker! Total Cholesterol Benefits For Levels Over 200 mg/dL, Which Is 5.2 mmol/L In Other Countries: -detoxification of chemicals, toxins & heavy metals. -protection against dementia & cognitive decline. -produces all steroid hormones & absorption of Vitamins A, D, E & K. -protects against stroke, heart disease, cancer & all cause mortality. -immune system protection against infections, bacteria, pathogens & viruses. -critical for digestion, liver health & production of bile acids. -important for lung health & airway integrity. -building block of every cell & mitochondria in the body. -maintains bone density & prevents osteoporosis. -lowers risk of depression, suicide, stress, high cortisol & anxiety.

Valerie Anne Smith

164,611 次观看 • 6 个月前

97% Of The Population Is Deficient In The Nutrient That Will Prevent Heart Disease & Clear Existing Plaque. The Nutrient K2, Found In Animal Sourced Foods, Is So Essential For Health That It Not Only Prevents Atherosclerosis...It Will Actually Clear Calcified Arterial Plaque. Yet, 97% Of The Population Is Deficient Because Of The Lie That A Fat Free Plant Based Diet Is Healthy. Atherosclerosis, the hardening & calcification of the arteries, plagues the global population. Arterial plaque is not a normal byproduct of aging, it is Vitamin K2 deficiency. Put simply, Vitamin K2 activates proteins that support healthy calcium balance – directing calcium to the bones where it is needed, while inhibiting calcium from depositing in arteries & soft tissues where it can do harm. Yet recent research shows us that 97% of the global population is deficient in Vitamin K2 for bone & cardiovascular health. Clinical evidence demonstrates that adding animal sourced Vitamin K2, which is in the MK-4 form, to the diet absolutely leads to positive health outcomes, in adults as well as children. And now the medical community is driving the latest Vitamin K2 research — because Vitamin K2 is the only compound to date clinically shown to prevent & treat hardening of the arteries. A diet based on animal sourced foods, rich in vitamin K2 in the MK-4 form, prevents arterial stiffness, stops & reverses progression of vascular & valvular calcification, lowers the incidence of diabetes & coronary artery disease, & decreases cardiovascular mortality. A groundbreaking study showed those who consumed the highest amounts of animal sourced foods, rich in Vitamin K2, had 52% lower risk of heart attack mortality & a 57% lower risk of death from all causes compared to those deficient in Vitamin K2. Their sources of K2 were eggs, meats & dairy which are the most bioavailable form as MK-4. Vitamin K1, the form found in plants, showed no benefit to prevent or clear arterial plaque, provide cardiovascular protection nor any prevention to the onset of diabetes & insulin resistance. This effect comes from animal sourced Vitamin K2 alone, not K1 from plant foods. Studies show that a person’s risk of dying from heart disease falls by 9% for every additional 10 micrograms of K2 consumed a day, but found no association or benefit with plant sourced Vitamin K1 intake. Additional Benefits From Animal Sourced K2: Strong Bones & Teeth: K2 directs & deposits calcium into our skeletal system & away from blood circulation. Anti-Cancer: K2 has the ability to stop cancer cell growth, reverse cancer cell growth & prevent reoccurrence of cancer. Heart Health: K2 keeps blood vessels smooth & flexible ensuring healthy circulation, preventing harmful blood clots & heart disease. Optimal Daily Intake Of Vitamin K2 Is At Least 300 mcg. Animal Foods Rich In Vitamin K2 Per 100 gr Serving: Goose Liver 369 mcg Beef Liver 263 mcg Pork 75 mcg Dark Chicken 60 mcg Bacon 35 mcg Egg 75 mcg Butter 21 mcg Aged Cheese 50 mcg Ground Beef 10 mcg Beef Tallow 14 mcg Required Cofactors Needed With Vitamin K2: *⃣ Vitamin D3 *⃣ Magnesium Glycinate or Threonate *⃣ Zinc Picolinate 👇High K2 Intake Prevents Coronary Plaque👇 👇K2 Reduces Risk Of Coronary Heart Disease👇 👇Worldwide Prevalence Of K2 Deficiency👇 Speaker: Craig McCloskey

Valerie Anne Smith

30,735 次观看 • 1 年前

yesterday someone leaked a full quant trading system on GitHub before they deleted it i forked everything 5,000 lines of code. 7 modules. 25 mathematical factors funds use this system to manage millions i studied it for a week. then pointed it at crypto markets on polymarket here's the full breakdown you can feed this to your claude and build the same thing for just $200 ARCHITECTURE: Python thinks, analyzes, calculates C++ executes orders in 5-10ms data → factors → AI → strategy → risk → execution DATA. 4 streams simultaneously: - Binance WebSocket: prices every second, orderbook at 20 levels - AlphaVantage: news with sentiment score from -1 to +1 -X: mention volume, engagement, influencer activity - On-chain: BTC flows to/from exchanges cache in Redis ( target price) = N(d1) d1 = [ln(current/target) + (σ²/2)T] / (σ√T) then 4 adjustments on top: - momentum: +/-5% - AI sentiment: +/-7% - order flow: +/-2% - historical patterns: +/-8% compare final probability against polymarket price if edge > 10%: enter RISK - Quarter Kelly for position sizing - max 5% bankroll per trade - drawdown 15% = bot stops - VaR < 3% per day - correlation between positions < 0.7 - never take more than 1% of market liquidity key insight is don't hold to expiry. trade the movement, not the outcome cost: → Binance API: free → OpenAI: $50-100/month → AWS EC2: $120/month → monitoring: free - total: $200-300/month - code is open source. formulas above. you already have claude the only thing between you and a working system is one free evening

Archive

249,528 次观看 • 4 个月前

"The Higher Your LDL, The Longer You're Going To Live." Cardiologist Dr Aseem Malhotra & Study Co-Author. "The Greater The Financial Interest In A Given Field, The Less Likely The Research Findings Are to be True." "The Most Lucrative Drug In The History Of Medicine Are Statins." $19 Billion Dollar Profit Industry Totalling 818 Million Prescriptions Annually. "The Benefit Of Statins For Both Low Risk & High Risk Primary Prevention Is ONLY 1%...1 In 100." "There Is No Correlation Between Elevated LDL Level & Events Of Cardiovascular Disease. In Fact, It's The Inverse. There Is A Correlation Between Higher LDL Level & Longevity." "The Higher The LDL, The Longer You're Going To Live, Because It Has A Vital Role In Your Immune System." "Just Because Cholesterol Is At The Scene Of the Crime, Doesn't Mean It's The Perpetrator." Cholesterol is trying to clear the inflammation & put out the fire caused by other lifestyle issues in order to get the body to return to Homeostasis. Atherosclerosis Is An Inflammatory Disease, Not A Cholesterol Disease or A Statin Deficiency. A Fireman shows up to put out a fire. He's not the cause of the fire. Cholesterol shows up to put out the fire of Inflammation in the Arterial Wall. Cholesterol is not the cause of the Inflammation that turns to Plaque. Eliminate The Root of The Inflammation Which Causes The Damage & Atherosclerosis: Chronic Stress High Blood Pressure Type 2 Diabetes Obesity Smoking Sugar Consumption Carbohydrates/Insulin Resistance Ultra Processed Foods Seed Oils Environmental Toxins Poor Sleep Low Vitamin D Level Low Magnesium Level Lack of Exercise These Are All Modifiable Risk Factors. Most Chronic Disease Happens Within Us, It Does Not Happen To Us. 👇Dr Aseem Malhotra's Co Authored Analysis 👇 👇Higher LDL, Greater Longevity👇 👇LDL Does Not Cause Cardiovascular Disease👇 👇Full Episode: The Ultimate Human Podcast👇

Valerie Anne Smith

204,369 次观看 • 1 年前

Did you know 128hz is a penetrative frequency that goes through the tissues into the bones and helps release nitric oxide into your cells? Grok: Nitric oxide (NO) is a naturally produced signaling molecule in the body that plays a critical role in many physiological processes. It acts primarily as a **vasodilator**, relaxing and widening blood vessels to improve blood flow, deliver oxygen and nutrients more efficiently, and support overall cellular communication. Here are the key benefits of nitric oxide in the body, based on its established physiological functions: ### 1. Cardiovascular Health and Blood Pressure Regulation Nitric oxide helps relax the smooth muscles in blood vessel walls, leading to vasodilation. This increases blood flow, reduces vascular resistance, and helps maintain healthy blood pressure levels. It also protects the endothelium (the inner lining of blood vessels), reduces arterial stiffness, inhibits platelet aggregation (lowering clot risk), and may decrease inflammation and plaque buildup. Low NO levels are linked to endothelial dysfunction, hypertension, and higher cardiovascular disease risk. ### 2. Improved Exercise Performance and Muscle Function By enhancing blood flow to working muscles, nitric oxide improves oxygen and nutrient delivery while helping remove waste products like lactate. This can boost endurance, increase exercise tolerance (especially in less-trained individuals), reduce muscle soreness, and support better recovery. It may also influence muscle contraction speed and mitochondrial efficiency in cells. ### 3. Support for Erectile Function and Sexual Health Nitric oxide is a primary mediator of penile erection, as it promotes relaxation of smooth muscle in blood vessels, allowing increased blood flow. Supplements that boost NO (such as L-arginine or L-citrulline) have shown potential benefits for mild to moderate erectile dysfunction (ED) in some studies. It may also support sexual arousal more broadly. ### 4. Immune System Defense Nitric oxide acts as a key player in immune responses. It helps immune cells (like macrophages) kill bacteria, viruses, and even some cancer cells by producing higher levels during infection or inflammation. It also modulates inflammation—providing anti-inflammatory effects at normal physiological levels while aiding targeted defense at higher concentrations. ### 5. Brain and Nervous System Function As a neurotransmitter and neuromodulator, nitric oxide facilitates communication between brain cells. It supports cerebral blood flow, learning, memory, and other neurological processes. Adequate levels may help protect against cognitive decline by improving brain oxygenation and circulation. ### 6. Other Potential Benefits - **Wound healing and tissue repair**: Enhanced blood flow and signaling support recovery processes. - **Respiratory support**: In medical settings, inhaled NO helps relax lung blood vessels in certain conditions (like pulmonary hypertension in newborns). - **Anti-aging and metabolic effects**: By supporting circulation, reducing oxidative stress in balanced amounts, and aiding hormone regulation, it contributes to overall vitality. It may also play roles in reducing risks associated with diabetes complications or arthritis inflammation. Note that nitric oxide has a dual nature: beneficial at physiological (low-to-moderate) levels, but excessive production (often in chronic inflammation) can contribute to tissue damage or pro-inflammatory effects. The body produces NO via enzymes (nitric oxide synthase) from precursors like L-arginine, or through nitrate-nitrite pathways from diet. **Natural ways to support nitric oxide levels** include eating nitrate-rich foods (beets, leafy greens like spinach/arugula, garlic), consuming antioxidants (to preserve NO), regular exercise (which stimulates production), nose breathing, and maintaining good sleep and cardiovascular habits.

𝒦𝑒𝓁𝓁𝓎࿎☽

21,956 次观看 • 3 个月前

If you want to actually train your Chest as efficiently/effectively as possible instead of WASTING YOUR TIME…. I’d recommend doing something like this each week: Upper A - Incline (Clavicular Pecs) Machine Press x 2-3 Sets - Pec Fly Machine x 2-3 Sets Upper B (Performed 3-4 days after Upper A) - Flat/Seated (Sternal Pecs) Machine Press x 2-3 Sets - Seated Low to High Cable Flys x 2-3 Sets This will result in you doing somewhere between 8-12 sets of direct Chest work per week Low likelihood you need any more volume than that to improve your Chest mightily if following the notes below: 1) The ideal rep range to be using when performing the exercises mentioned is the 5ish to 10ish rep range — Choose a weight you can do for 5, 6, 7 reps @ 0-2 RIR…once you can do that weight for 8, 9, 10ish reps, increase the load by 5ish pounds 2) You should perform all reps of all the listed exercises with a controlled (but not overly slow) eccentric and an explosive (but still controlled) concentric 3) You should perform these exercises very early in your workout to ensure they are as efficient/effective as possible — If you perform them later on, you will not get as robust a growth stimulus from the sets because of the outstanding fatigue that will be present from the earlier sets/exercises in your workout Additional notes: - You may sub any of these exercises for comparable exercises due to preferences and/or equipment availability — Ex: Flat/Seated Machine Press subbed for Flat Smith Machine Bench Press or Flat Barbell Bench Press - I probably forgot something that I should’ve mentioned…if I think of it I’ll drop it in the post below

Dean Turner

40,600 次观看 • 3 个月前

"A Low Salt Diet Causes Insulin Resistance & High Blood Pressure." Dr Ben Bikman, PhD "A Physician Should Never Tell A Patient To 'Cut Back On Salt'...This Causes Higher Insulin & Higher Blood Pressure." Salt Is The 2nd Major Constituent In The Body & We Need Salt At All Times. When salt intake is restricted, the body activates hormonal systems to retain sodium & cause insulin resistance: 🛞 Activation of the renin-angiotensin-aldosterone system (RAAS): Restricting sodium causes the body to release hormones like renin, aldosterone & angiotensin II to help retain sodium. This increases insulin resistance. 🛞 Increased stress hormones: Low sodium intake increases the body's levels of stress hormones, such as noradrenaline. Elevated levels of these hormones cause insulin resistance. 🛞 Reduced blood flow to muscles: A drop in blood volume due to sodium restriction reduces blood flow to skeletal muscles. This impairs the delivery of insulin & glucose to muscle tissue, worsening insulin resistance. 🛞 Increased insulin levels: The body responds to salt restriction by increasing fasting insulin levels as a compensatory measure to retain sodium. This is a risk factor for developing type 2 diabetes. 5 Ways Insulin Resistance Causes High Blood Pressure: 🛞 Sodium & water retention: When insulin resistance occurs, the pancreas produces excess insulin to manage blood sugar. The high levels of insulin overstimulate the kidneys to reabsorb more sodium & water, which increases blood volume & raises blood pressure. 🛞 Vascular dysfunction: Healthy insulin signaling promotes the production of nitric oxide (NO), a molecule that relaxes blood vessels & improves blood flow. In an insulin-resistant state, this process is halted & blood pressure rises to dangerous levels. 🛞 Increased sympathetic nervous system activity: High insulin levels overstimulate the sympathetic nervous system, which controls the body's "fight or flight" response. This increases heart rate, constricts blood vessels & activates the RAAS system, which further promotes sodium & water retention. 🛞 Chronic inflammation & oxidative stress: Insulin resistance causes low-grade chronic inflammation & oxidative stress throughout the body. These processes damage the lining of blood vessels (the endothelium). 🛞 Vascular stiffening: Over time, the chronic inflammation & other issues leads to arterial remodeling & stiffening. This makes arteries less flexible & more resistant to blood flow, forcing the heart to pump harder & elevating blood pressure. Salt is not created equal....table salt is highly processed & toxic. The chemical processing of table salt strips it of all minerals, leaving only isolated sodium chloride. Table salt is bleached & then ingredients like sodium ferrocyanide, ammonium citrate, aluminium silicate, sugar(dextrose) & anticaking agents are added. Healthy salt is unrefined mineral salt...unprocessed celtic or grey salt that retains all of the 80+ trace minerals. Seek out ones that are microplastic, heavy metals & contaminant free. 👇Sodium Restriction Causes Insulin Resistance👇 👇Low Salt Diet Increases Insulin Resistance👇 👇Insulin Resistance Causes Hypertension👇 Speaker: Dr Benjamin Bikman, PhD

Valerie Anne Smith

500,976 次观看 • 8 个月前

"Calcium Supplements Are Dangerous...The Best Calcium Supplement To Take Is NONE." "Synthetic Vitamins Increase Your Likelihood Of Dying." Dr Josh Axe Calcium Supplements Do Not Fortify Bones. They Cause Kidney Stones, Colon Polyps, Cancer, Blood Clots, Heart Attacks & Stroke. "There Is No Evidence That Calcium Supplements Fortify Bones...But There Is A Massive Body Of Evidence That They Are Harmful." Synthetic calcium supplementation is not processed in the body the same way as it is when ingested from a food source. Multiple studies have found that there’s no benefit to taking calcium supplements for the prevention of fractures & Osteoporosis. On the other hand, there is massive research proving calcium supplements cause colon polyps, serrated growths in the large intestine that lead to cancer & calcium supplements also cause kidney stones, which are hard masses formed in the kidneys from an accumulation of calcium. Calcium supplements increase the risk of calcium buildup in the heart’s arteries. This calcification leads to cardiovascular disease resulting in blood clots, heart attacks & strokes. Dr Erin Michos, MD...associate director of preventive cardiology, "I’m very concerned about calcium supplements contributing to heart attacks & heart disease. The body can process 500 milligrams of calcium at a time from your food, from dietary natural calcium. If you take a synthetic calcium supplement, your body has to do something with the excess. Higher calcium levels in the blood trigger blood clots & that calcium also gets deposited along artery walls, which causes narrowing of blood vessels." Synthetic Calcium Supplementation And... 1⃣ Colon Polyps...calcium supplements cause 2.5 times the rate of sessile serrated colon polyps, which are pre-cancerous polyps. 2⃣ Colon Cancer...synthetic calcium supplements increase bowel lesions putting you at risk for cancer. 3⃣ Kidney Stones...calcium supplements bind with oxalic acid found in food, causing toxic levels of oxalate in the urine & form calcium oxalate kidney stones. 4⃣ Atherosclerosis...high calcium levels from synthetic supplements cause hardening of the arteries & arterial calcification. 5⃣ Blood Clots...calcium supplements produce a hypercoagulable state where blood clots more easily. This increases the risk of blood clots in the heart & brain, including deep vein thrombosis (DVT). 6⃣ Heart Attacks...calcium supplementation increases cardiovascular risk, including coronary heart disease & myocardial infarction. 7⃣ Strokes...synthetic calcium supplements significantly increase risk of acute myocardial infarction, ischemic stroke & death. For strong bones...what is essential is weight bearing exercise to build bone. Bones are 50% protein & require 1 gram of protein per 1 pound of ideal body weight in the daily diet. A 150lb person needs at least 150 grams of nutrient dense animal protein per day to rebuild bone & to prevent Osteoporosis in the 1st place. Bones require an array of unrefined minerals including Boron, Zinc & Magnesium which can be obtained by daily use of unrefined mineral salt & in whole foods. Strong bones also require Vitamin D from daily sun exposure &/or infrared light. 👇Calcium Supplements & Colon Cancer👇 👇Calcium Supplements Cause Serrated Polyps👇 👇Calcium Supplements Cause Urinary Stones👇 👇Calcium Supplements Cause CVD & Stroke👇 Speakers: Alex Clark & Dr Josh Axe

Valerie Anne Smith

95,351 次观看 • 1 年前