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WANT TO AGE IN REVERSE? AI'S CRACKING THE CODE Scientists can now rewind human cells back to age 20: brain, heart, skin, all reset to their prime. The secret? A Nobel-winning discovery from 2012, supercharged by OpenAI’s protein-designing AI. In just a week, one lab managed to reverse aging...

85,284 次观看 • 11 个月前 •via X (Twitter)

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"we take 92-year old human skin cells back to a biological age of around 25 using OSK." David Sinclair says AI could help make age reversal a reality. 👀 - AI screened up to 1 trillion molecules in just a few months, a task that would have taken hundreds to thousands of years using traditional drug discovery. - AI narrowed 1 trillion molecules to around 200 promising drug candidates for laboratory testing. - Researchers used Google DeepMind's AlphaFold protein predictions to virtually test molecules against human proteins before entering the lab. - AI is also helping determine whether human cells have become biologically younger simply by analyzing images of the cells. - Sinclair says his lab can already reprogram 92-year-old human skin cells to a biological age of around 20-25 using OSK partial cellular reprogramming. - "All my students can do this." - "It's not hard at all to reverse aging in isolated human cells." - "The hard part over the last 10 years has been turning it into a safe and effective drug for people." - Biological age is measured using DNA methylation clocks, which Sinclair says are more informative than relying only on telomeres. - Sinclair believes that one day you may no longer be able to tell how old someone is just by looking at them. - Sinclair says his team has early evidence that lost memories can return after brain rejuvenation, adding that the work has not yet been published. - He believes Alzheimer's patients may still retain their memories but have difficulty accessing them. - He believes making the entire body biologically younger could one day cure diseases that are currently incurable. 🤯 - He also said, making the entire body biologically younger could enable it to heal diseases that are currently incurable. Sinclair's approach is simple: "Make the body young, and it will heal itself."

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10,180 次观看 • 29 天前

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

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🔥 SURGEON WARNS THE BIGGEST BREAKTHROUGH IN HUMAN HISTORY IS HAPPENING RIGHT NOW — “BIGGER THAN AI” A surgeon is going viral after claiming scientists may have already discovered a way to partially REVERSE aging at the DNA level… and he says the implications are bigger than AI, social media, smartphones, or even the internet itself. Dr. Buck Parker’s claim: “The fountain of youth has been discovered.” “This is bigger than the Industrial Revolution. Bigger than the advent of the internet. Bigger than Amazon, Apple, the iPhone, Google, social media… bigger than AI.” And according to Dr. Parker… it’s already happening RIGHT NOW. The core claim revolves around something called “Yamanaka factors,” proteins discovered by Nobel Prize-winning researcher Shinya Yamanaka that can reportedly reset damaged cells back to a younger biological state. According to Dr. Parker: •Scientists have reportedly reversed visible signs of aging in animals •Wrinkled skin in test subjects appeared to become youthful again •Researchers are now experimenting with literally “turning back” cellular age •Human trials are reportedly beginning •Some scientists now believe aging itself may simply be accumulated DNA damage His warning: “If you’ve been alive for the last 40 years… you’ve seen some wild sh*t happen. It’s about to get more wild.” If this became available tomorrow… would you actually take it? I’m lining up ‼️‼️‼️😂😂😂 Note that while Yamanaka factors are real (Shinya Yamanaka won the Nobel Prize in 2012 for induced pluripotent stem cells), the dramatic claims about immediate “fountain of youth” breakthroughs and human trials should be approached with caution and verified through scientific sources.

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286,177 次观看 • 3 个月前

🚨 SURGEON WARNS THE BIGGEST BREAKTHROUGH IN HUMAN HISTORY IS HAPPENING RIGHT NOW — “BIGGER THAN AI” A surgeon is going viral after claiming scientists may have already discovered a way to partially REVERSE aging at the DNA level… and he says the implications are bigger than AI, social media, smartphones, or even the internet itself. Dr. Buck Parker’s claim: “The fountain of youth has been discovered.” “This is bigger than the Industrial Revolution. Bigger than the advent of the internet. Bigger than Amazon, Apple, the iPhone, Google, social media… bigger than AI.” And according to Dr. Parker… it’s already happening RIGHT NOW. The core claim revolves around something called “Yamanaka factors,” proteins discovered by Nobel Prize-winning researcher Shinya Yamanaka that can reportedly reset damaged cells back to a younger biological state. According to Dr. Parker: • Scientists have reportedly reversed visible signs of aging in animals • Wrinkled skin in test subjects appeared to become youthful again • Researchers are now experimenting with literally “turning back” cellular age • Human trials are reportedly beginning • Some scientists now believe aging itself may simply be accumulated DNA damage His warning: “If you’ve been alive for the last 40 years… you’ve seen some wild sh*t happen. It’s about to get more wild.” If this became available tomorrow… would you actually take it? 📹: drbuckparker

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