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WE! Work so HARD! Every week! We deserve a PARDY! 🥳🥳🥳 Friday is PARDY TIME!!! 👀🎬🍿 #monk #pardy #powersoca #soca 🎼 Xplicit Boy! Badjohn Republic #AndreJeffers #MachelMontano 🎥 Josiah Persad Films🏝 #TwinIslandCo 📝 #FloydDellon
23,073 次观看 • 1 年前 •via X (Twitter)
5 条评论
richgreenman 🇧🇧🇹🇹🇬🇩1 年前
@XplicitMevon @BadjohnR @josiahpersad_ Waiz dis
Kickr Games1 年前
🚨 New games alert! 🚨 The latest titles from Boldplay are just around the corner! 🎰 Dive in, grab your daily bits, and get ready to play. Big fun and rewards await! 💥 👉 Don’t miss out—start playing today! #BoldPlay #Kickr #NewGames #DailyBonus
Good Spirit1 年前
@XplicitMevon @BadjohnR @josiahpersad_ 👀
DykDwnBootz1 年前
@XplicitMevon @BadjohnR @josiahpersad_ Fete cyah duuuuun!! 💃
Akua Walters 🤽♂️1 年前
@XplicitMevon @BadjohnR @josiahpersad_ They really be letting Machel have free reign to go anywhere in Trinidad he want, eh? 😂😅😅
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🚨THE ULTIMATE DATE PHAGGING ALERT‼️🚨 il Donaldo Trumpo post on 7/5 at 11:02 EST (twice Eleven Eleven): «MY REAL PATRIOTS» = ANONS 🔥🐸🔥 The White Hat Meme Team are talking directly to us‼️😘🤓🥳 We’re getting real close to THE END 🎬🍿now so let’s unlock what they are telling us: ✴️ «November rain» sounds like a word play on «April showers»…. ☔️ ✅NOVEMBER SHOWERS (2135 Jewish 👉🏼9/11 and 201 Simple ) ➡️Christmas In July 🎁🎅🏼🥳🔥 🎁They are giving us a YUUUGE hint here‼️ ✅ NOVEMBER (👉🏼912) ➡️ Unlocking All My Code 👀 ➡️ XRP Phoenix 9-1-2 🔁 9-2-1 👉🏼 9/11-2026‼️ 2 is 11 (1+1) 2026 is 2+0+2+6 =10 is 1 🔥THE ⚽️ FINALS is on 19th of July 2026. 7/19-2026 November 🟰 July 11/19 👉🏼 9/11-1 👉🏼 Nine Eleven‼️⚽️ Look at the «April showers» Q drop. It has number 1127 👉🏼 119 🔁 911 👉🏼 9/11 👈🏼 👀 «Our comms must be this way» 👈🏼 👀 «Trust the plan.» 📑👀 ✴️ Now let’s go back to «April showers»: (perhaps April is not a month but a comm….? 🤔) ✅APRIL (170/56) 170👉🏼17 and 5+6=11 (Seven Eleven) ➡️ Moon (170👉🏼17) 🚀 ➡️ The End (56👉🏼11) 🎬 ✅SHOWERS (107 simple) ➡️Twenty April showers = April Twenty ✅APRIL TWENTY (1715/163) ➡️Jeffrey Epstein 💥 ➡️Twenty Three (🟰Pain! 💀) Is 1715 a date? 7/15-1 ? 🤔 Remember the yuuuge comms in the Q drops for April 20‼️ Here: «Signal» «Canary» 👉🏼 Epstein singing like a canary Łitecoin Bull | The News Before The News! 🌴🐤 It’s all coming together! 🔥🔥🔥 ✴️ And finally this one that we have been waiting for: ✅ RED OCTOBER = (379 jewish 👉🏼 19 and 105 simple 👉🏼 1 and 5. 👉🏼 5 is 11 🕰️ As Above So Below, so total date if we add 19 and 11 and 1 is 11/19-2026 👉🏼 7/19-2026 👉🏼⚽️) ➡️Purim (remember the colors 🟣🟡🟢) Decode here: ➡️Internet (shut down?) ➡️It is Finished ➡️Disaster 💥👀 ➡️Nine Eleven ‼️💥⚽️👀 ➡️Green Light ➡️Blood Moon Do you get it yet? 🤓 Next week looks real interesting… 🔥🔥🔥
Bendleruschka
46,898 次观看 • 16 天前
![My cousin, Jonathan Ord asked me to teach the Come Follow Me lesson to his mission yesterday over zoom. This is the video I did and the full text. Hi. I am Brad Smith. I have ALS, which is a really weird disease that kills the motor neurons in my body. That means that I lose the connections between my brain and my muscles. My mind is still running at the normal rate. So, I can understand everything you say to me, but I can’t respond very quickly! I am getting faster, though. Last November I was the 3rd person in the world to receive the Neuralink brain implant. So I am controlling this computer with my brain. This is my old voice, recreated by AI from just two hours of me talking to my phone. I have come to see ALS as a calling, and I am trying to magnify it. I used to talk easily, but now I have to choose my words carefully, because it is hard and slow to type what I want to say. I joke that the Lord gave me ALS to get me to shut up. Those who knew me when I could talk laugh the hardest. President Ord is my first cousin. So we share grandma and grandpa Smith. Our grandma Smith was a character. When she taught at church, she would put a sign up that read: “thus saith the lord:” so I will try to keep this within what the Lord has actually said, while trying to teach you to look at a basic principle of the gospel in a different way. Ironically, the first verse of Doctrine & Covenants 93 starts with “Verily, thus saith the Lord”. This is an amazing section of scripture, Jesus Christ telling us to step up and be better! You should study it often. I will start with a story. I asked AI to make a video to dramatically tell the story. During college, I lived in Damascus, Syria, for a semester. It was a fantastic and wonderful experience. I especially loved exploring the Old City of Damascus. The Old City is built around the huge beautiful Umayyad mosque. Within the walls of the old city is a maze of narrow, winding, confusing streets and one really long straight street, as Saul found out in Acts 9:11. One day when a group of us were trying to get through this maze from the mosque to the Christian quarter of the Old City, we asked a man for directions. He thought for a second, then pointed and said, “Go left and then right, and then left and then right, and then left and then right, and then left and right, and you’ll be there.” Aren’t those the most ridiculous directions you have ever heard? We could have ignored him. But, we thought, he did know the city better than we did. So, with some laughter, off we went. Left. Right. Left. Right. And so on until, much to our surprise, we popped out at our destination. Life is a confusing maze. We face difficult choices, unexpected events, surprises, sorrows, opportunities, roadblocks. The Lord has given directions on how to get through to where we want to go. Sometimes the Lord’s directions seem odd, and we may struggle with the decision to follow. The Lord will not force us. It is our choice whether to choose and follow him. Wasn’t that fun? AI is getting crazy! I will be much less entertaining for the rest, but hopefully the spirit will teach you something new. The phrase “keep the commandments” (or “keepeth my commandments”) appears at least 4 times in Doctrine and Covenants Section 93, in verses 1, 20, 27, and 28. There are other references, like “keep my sayings” in 52 and “obeyeth my voice” in 1. So, commandments are really important in this Revelation. I suggest that making the gospel a more central part of our lives depends largely on how we look at commandments. When you think of commandments, do you think “I can’t. I’m Mormon”? (That was a popular T-shirt slogan during my college years.) Although, with the recent guidance from President Nelson, it probably should be “I can’t, I’m a member of The Church of Jesus Christ of Latter Day Saints”. It’s a common reaction: “Thou shalt not do Cool Things.” People LOVE to focus on all the things we CAN’T do, as if we are trapped and deserve pity for our beliefs. No pity is needed. Commandments are opportunities, not constraints. Commandments are awesome! Allow me to illustrate. Imagine a spectrum between Good and Evil. Somewhere in the middle is “the Line” that divides Good from Evil. As a teenager, I wanted to know where the Line was, so I could get close to it without going over it. I wanted to be on the “Good” side but still be able to do as many “Cool Things" with my friends as possible. From my experience, I believe God gives us two types of commandments: 1) Get Back over the Line commandments and 2) Come Further into the Light commandments. Type 1, the Get Back over the Line commandments, could also be called “Misery Avoidance” commandments. They are designed to keep us out of misery or, if we’ve crossed the Line, to bring us out of misery and back into the Good side. These are generally commandments with a clear and defined point of success, such as “Thou shalt not kill.” You will know, at the end of each day, whether you have successfully followed that commandment. I think all of the Ten Commandments fall into this category. The law of Moses was very black and white. The children of Israel had been in Egypt without a prophet for a long time when Moses received the law, and they needed to work on the basics. So, if you follow the Type 1 commandments, you will refrain from doing things that make you miserable. You will know you are in the Good if you can answer the baptismal interview and temple recommend questions honestly and faithfully. If you can do that, you have taken the basic steps necessary to avoid misery and are on a solid foundation for the next type of commandment. Type 2, the “Come Further into the Light” commandments, are the really cool commandments. Once we are out of the misery category, we can really start to pursue joy. So, God commands us to do things that he knows will make us happier and more like Christ. These commandments are the principles of eternal development, such as “Love thy neighbor” (Matthew 22:39). There is no clear end to loving our neighbor—it requires positive and eternal progression. We can always love more, and we can always find another neighbor who needs our love. It is an eternal principle taught by Jesus Christ. And if we truly love our neighbor, refraining from killing him becomes pretty easy. It is through these commandments that we find joy in Jesus Christ. Elder Christofferson taught about this spectrum in the October 2018 general conference: “Most of us find ourselves at this moment on a continuum between a socially motivated participation in gospel rituals on the one hand and a fully developed, Christlike commitment to the will of God on the other. Somewhere along that continuum, the good news of the gospel of Jesus Christ enters into our heart and takes possession of our soul. It may not happen in an instant, but we should all be moving toward that blessed state.” Our goal is to go THAT WAY (toward Christ) as much as possible. So first, get back across the line and stop doing things that will make you miserable. Then make every effort to try and be like Jesus, to “love one another as Jesus loves you.” The gospel of Jesus Christ is more than just “not doing” stuff. It is about coming unto Christ, being perfected in him, and denying ourselves of all ungodliness. Discuss with your companion what commandments and mission rules are for “Misery Avoidance” and which are “Come Further into the Light”! And, remember, commandments are ALWAYS connected to huge blessings. The Lord promised, “There is a law, irrevocably decreed in heaven before the foundations of this world, upon which all blessings are predicated—and when we obtain any blessing from God, it is by obedience to that law upon which it is predicated” (Doctrine and Covenants 130:20–21). Whenever we obey any of God’s commandments, we will get the blessing associated with that commandment. Elder David A. Bednar said: “The gospel of Jesus Christ encompasses much more than avoiding, overcoming, and being cleansed from sin and the bad influences in our lives; it also essentially entails doing good, being good, and becoming better. Repenting of our sins and seeking forgiveness are spiritually necessary, and we must always do so. But remission of sin is not the only or even the ultimate purpose of the gospel. To have our hearts changed by the Holy Spirit such that “we have no more disposition to do evil, but to do good continually” (Mosiah 5:2), as did King Benjamin’s people, is the covenant responsibility we have accepted. “This mighty change is not simply the result of working harder or developing greater individual discipline. Rather, it is the consequence of a fundamental change in our desires, our motives, and our natures made possible through the Atonement of Christ the Lord. Our spiritual purpose is to overcome both sin and the desire to sin, both the taint and the tyranny of sin.” I LOVE this concept—and as I have paid attention, I feel like apostles are trying to teach us this all the time. Are we listening? Let me repeat what Elder Bednar said. He said that the commandments help us change what we WANT. Why is that important? Remember my teenage desires? I wanted to be as close to the line as possible so I could still look cool for my friends. That is a good example of the “tyranny” of sin. Even though I was not actually sinning (probably because I was afraid of my mother), I still had some small desire to sin. I said, “I can’t. I’m Mormon” with many dramatic sighs. Overcoming the tyranny of sin is getting to the point where the sin no longer looks remotely interesting or fun because we are too busy loving our neighbors and trying to be like Jesus. Elder Dallin H. Oaks said: “The Final Judgment is not just an evaluation of a sum total of good and evil acts—what we have done. It is an acknowledgment of the final effect of our acts and thoughts—what we have become. It is not enough for anyone just to go through the motions. The commandments, ordinances, and covenants of the gospel are not a list of deposits required to be made in some heavenly account. The gospel of Jesus Christ is a plan that shows us how to become what our Heavenly Father desires us to become.” This talk was given when I was on a mission, before most of you were born. It completely changed my perspective on the gospel of Jesus Christ. It is called The Challenge to Become” and I recommend that you study it. When the Lord says keep the commandments, he isn’t just telling us to stop sinning—he wants us to become like Christ and to have joy. Take a moment and think, Where am I on this continuum? Remember that none of us is perfect like the Savior, and we all need to lift one another. That is why we worship together. That is why we have priesthood quorums and the Relief Society, Primary, and youth organizations. The Lord taught us that truth when he said we all have different gifts: “To some is given one [gift], and to some is given another [gift], that all may be profited thereby. To some it is given by the Holy Ghost to know that Jesus Christ is the Son of God, and that he was crucified for the sins of the world. To others it is given to believe on their words, that they also might have eternal life if they continue faithful” (Doctrine and Covenants 46:12–14). The Savior is still WAY over there: a thousand miles away somewhere. That is why we have quorums. We all have a long way to go. Let’s link arms and run together. Let me finish by telling a story from my mission to support my testimony of Jesus. Years ago my mission president said something interesting: “Either the Church of Jesus Christ of Latter-day Saints is truly the kingdom of god on the earth... or it is the greatest fraud ever in history.“ It is audacious to claim to be the true Church of Jesus Christ—but let me explain exactly why I know that to be true. I always BELIEVED that I was raised in the gospel of Jesus Christ. My parents taught me well and I felt good following the commandments and studying the scriptures. That led me to serve a mission in Brazil. My turning point of testimony came when I was 20–at least 2/3rds through my mission. We were invited into a house in the “fundos” of a property—a small structure built behind a larger house. The man was polite and allowed us to share our message. As I had done hundreds of times, I shared the story of Joseph Smith, a boy who sought the truth through prayer. I recited Joseph’s own words in response to his prayer: “I saw a pillar of light exactly over my head, above the brightness of the sun, which descended gradually until it fell upon me... When the light rested upon me I saw two Personages, whose brightness and glory defy all description, standing above me in the air. One of them spake unto me, calling me by name and said, pointing to the other—This is My Beloved Son. Hear Him!" I felt the strongest feeling I had ever experienced—an undeniable confirmation that what I said was true. It hit me in a way I can never forget! I knew that Joseph Smith was truly a prophet, and therefore the Book of Mormon was the word of god. What about the man we were teaching? How had he responded to my life-affirming spiritual experience? He shrugged and politely thanked us for the message. I was stunned. I felt like the windows of heaven opened on me—and he felt nothing. I learned that receiving answers to our prayers is like tuning a radio: not everyone is on the right frequency. For some reason, the Lord decided to broadcast on my frequency that day. I received the undeniable confirmation that the Church of Jesus Christ of Latter-day Saints is true. I have built on that foundation brick by brick since then. And every time someone has challenged me on Joseph Smith, I go back to that day in Brazil. I know that he was a prophet. My life has been blessed in ridiculously good ways since then. As I have tried to follow Jesus Christ, great things have happened to me. Even my hardest and most frustrating times have turned out to have a purpose. God has upturned my best laid plans over and over. But I look back and realize that I could never have planned any better. With the prophet Nephi I say: “I know that [God] loveth his children; nevertheless, I do not know the meaning of all things." (1 Nephi 11:17) When I say that the Church of Jesus Christ of Latter-day Saints is true, that does not mean we have a monopoly on truth. I know Christians and Muslims who teach me to be better—and Members of the church who are far from disciples of Christ. We just have more truth: scriptures, living prophets, ordinances, personal revelation, and answers to many of life’s biggest questions! That is pretty cool. But we can’t be prideful about the truth we have. You have all probably met people to admire both inside and outside of the church. So, I am all in. The Church of Jesus Christ of Latter-day Saints is true—not a big fraud. And we are all trying to get closer to Christ. I know that Heavenly Father has a plan for me. Life has not been what I expected, but I trust him! I know that Joseph Smith is a prophet of Jesus Christ and that the Book of Mormon is true. This is “intelligence, or, in other words, light and truth. Light and truth forsake that evil one.” With that knowledge, keep the commandments! In the name of Jesus Christ, amen .](https://image.24vids.com/tw-1961133396144656751/amplify_video_thumb/1961127653798547458/img/nIvUNxNHuUcT9YLP.jpg)
![My fellow Kenyans, Many of you have seen my recent posts about the deadly cancer that is corruption in our country. In my last post, I tried to paint a picture of the disconnect between our potential as a country and the economic circumstances we find ourselves in today, and the connection between corruption and the incalculable pain and suffering and cruelty that is meted out every single day to the most vulnerable among us by thieves operating out of public office. And after covering the goings-on in Mandera County, I told you that in my honest opinion, our governments exist to cater for the filthy-rich lifestyles of the vilest and most corrupt among us, at the expense of everyone else. I received tremendous support from all of you, for speaking on behalf of so many struggling Kenyans who don’t have a voice, or the audience necessary to spark the much-needed discussion about where we are heading as a country. But even with all that support, I have received messages asking me to be careful. One compatriot told me: “prepare to be relentlessly pursued, threatened, enticed, guilt-tripped, and gas-lit”. This is from a someone who knows how our government operates, and how it uses violence and its monopoly on power to silence those who question why politicians are stealing so much. I am not naive about the dangers of speaking up and calling out thieves who control state machinery, and who possess the ability to shut me up in a few seconds. But I will tell you why we CAN NOT and MUST NOT keep quiet. In November of 2023, I stumbled upon the story of a young man from Turkana, Calvin Esekon Esewit , who, despite scoring an A-, and getting an acceptance into medical school, spent two years not knowing whether his dreams of becoming a doctor would ever come true. I was moved by that story in a way that I can never adequately explain. I could not understand how it is possible that, in our country, a young man who appears to be every parent’s dream child can spend two years in limbo while we as a country possess the ability to invest in our best and brightest. And so, I spent weeks trying to chase down Calvin to see how I could help him attend college. After a lot of searching, I finally found Calvin, and by this time he had managed to get some help and is now in college. While this story has a great ending, it did not to be this way. And we know that the number of cases that end like this, with some success, are a small fraction of those ones which end tragically, with broken dreams. This is what happens when corruption consumes anything and everything in a country. It destroys lives. See attached video to learn about Calvin's story. I tell you all this story because it provides context to today's topic. For one story like this one that you see on the news, there are millions that never make the news. But they are real situations, nonetheless. There are millions of your compatriots who are devastated by this killer cancer of corruption that is perpetuated by people that you and I have put into public office ostensibly to improve our lives. They go into these offices and abuse the trust you bestowed upon them and deny you and everyone else a decent opportunity in life. You see, Calvin and millions of other victims of this shameless level of corruption and plunder have no voice, and no real ability to look the thieves that are destroying lives and generations of Kenyans in eye and tell them to stop this unbearable pain and the cruelty. This is the reason I embarked on this journey to attempt to expose this shameful situation. Watch the attached video of Calvin’s situation, and I am sure that you will agree that the millions of Calvins in our country need a voice, NO MATTER THE RISK. The thieves that are destroying the futures of millions of children just so they can have beachside homes in Miami, Dubai and other places count on the idea that most people will fear for their lives, and therefore not speak up. They count on the growing apathy in the Kenyan psyche. But we cannot give in to that. We cannot cower to thieves. We must look them straight in the eye and tell them that they MUST STOP. If we don't, our children and their children are guaranteed the same level of cruelty. And so with that, today I want to talk about the utterly insane crime scene that is Turkana County. I don’t know any other way to describe it, other than, it is a “shit-show”. Just follow along, and let me know if you disagree. As I did in my previous commentary, I will ask you to indulge me a little bit, and allow me to use a couple of pictures, because pictures speak louder than a thousand words. The first picture shows the state-of-the art County Government offices, that the County Government of Turkana decided to invest an ungodly amount of money on. Close to a billion shillings. The second picture is a classroom in session. In Turkana County. These two realities are occurring in parallel in the same county, at the same time. Ladies and gentlemen, let me just tell you that I do not go out of my way to find bad news. I want stories that would help re-affirm our belief in the fundamental decency of human beings. When I find good news as I review these Counties’ decisions and how they behave with our resources, I will be the first one to report it to you. But I don’t have any good news today. I have bad news. If you read my commentary yesterday and were offended by what you saw, I am afraid you might not make it to the end of this article, because what you will hear will be quite shocking. The cancer of corruption, particularly at the County Government level, is worse than your wildest imagination. And so, as I like to do, I like to start off by putting some numbers on the table for us to use as reference points. Bear in my that all the information I put in this article is publicly available. Nothing came to me through a whistle blower. The first number is KSH 100 Billion. With a B. In the last decade or so, you and I, through the National Government, has sent over KSH 100 billion to Turkana County. To support recurrent expenditure, and development. For example, in the 2022-2023 fiscal year, we sent KSH 12.6 billion. In the 2021-2022 fiscal year, we sent KSH 11.4 billion. And on and on and on. The second number is 1 million. This is the population of Turkana County. The third number is KSH 18.4 billion. This was Turkana County’s budget for the 2022-2023 fiscal year. The fourth number is KSH 190 million. This was the amount of money that Turkana County was able to generate on its own accord within the county, from all its investments and other activities in the period in question. This number is an important proxy, in my view, for the value of the county’s economic prospects for the foreseeable future, and to people that are not driven by greed and corruption, would be an important consideration when they are thinking about how and where to deploy your money as taxpayers. If you are doing the math, Turkana County, for the 2022-2023 fiscal year, was only able to raise 1% of the funds needed to keep the lights on. 99% came from you and I, and a tiny amount from grants. The next number is KSH 129, 040. This is the average ANNUAL [emphasis added] income of a resident of Turkana County ( Keep that number in mind when we are discussing the massive theft of public funds by Turkana County leaders. The next number is 80%. 80% of the residents of Turkana County live below the poverty line. They have a really difficult time putting food on the table. ( The next number is KSH 12 Million. This is the basic salary of the Governor of Turkana County before other benefits that, as I explained yesterday, can often double the salary. Remember the “housing allowance”, the “hardship allowance”, the “commuter allowance”, the “risk allowance”, the “extraneous allowance”, etc.? Remember that? I still cannot figure out, for the life of me, what “extraneous” means in the context of County business, but we don’t time to dwell on this. The next number is 93. The Governor of Turkana County makes 93 times the average Turkana County resident’s annual income. 93 times! The next number is 82%. This was the percentage of people that were illiterate in Turkana County in 2013 ( Could not read or write. A point to note about the above literacy figure. Ten years later, and despite over KSH 100 billion is spent in Turkana County, including many billions for education, that literacy rate HAS NOT CHANGED ONE BIT. Only 20% of the population can read or write today. ( KSH 829 million. This is how much it cost to build the County Government offices. Yes, the ones shown in the first picture. KSH 120 million. The County Government decided that it was prudent to pay a contractor KSH 120 million to construct the Governor’s personal residence. Get this, even after this payment, no construction took place. The money was stolen. All of it. KSH 90 Million. This is the amount that the County Government paid to another contractor, to build the Governor a mansion, having previously lost KSH 120 million. So, the tally for the Governor’s residence now stands at KSH 210 million. Never mind that the limit allowed by law is KSH 45 million. KSH 5 billion. In the last days of his term in office, an outgoing Governor of Turkana, Koli Nanok, EGH. , sought to inflate pending bills by adding KSH 5 billion so that it can be paid to his criminal cartel. KSH 5 billion. We have our key numbers, ladies and gentlemen, so let us discuss. So, we have a county that is dead last in literacy, and in the top 2 of the poorest counties in the republic. Only 20% of the population can read. The Governor earns 92 times the average citizen. The Governor lives in a house that cost over KSH 200 million. When he leaves his house in the morning, he goes to his office that cost KSH 829 million. And this is all happening when 80% of the County residents struggle to put food on the table. Those are the facts, and they are not in dispute. During the same time, the County Government geniuses decide to build the Speaker of the County Assembly a house. And a home office, and a garage. The house was initially estimated to cost KSH 75 million. But due to circumstances that not a soul in the government could explain to auditors, the contract expired before the house was completed, and the County Government found a new contractor to complete the job for an additional KSH 29 million. But this palace in the jungle worth apparently worth over KSH 100 million in Turkana County was not enough. The County proceeded to build the Speaker a guest house for another KSH 19 million, and a few other amenities, and so the whole cost went to KSH 276 million! The legal limit for a Speaker’s house is KSH 35 million, and they spent close to KSH 130 million just for one residence. By this time, I am sure you are getting tired of these obscene numbers. You and I work, and pay taxes. Nobody pays you 92 times the income your average neighbor is making. And for sure nobody will drop KSH 100 million to build you a house. These are the perks of working in government in a poor country. Go figure. And so, as a country, we need to answer for ourselves the question I posed yesterday, which is, what is the point of government? What is its role in our lives. If this level of criminality and pillaging can occur in our country in the midst of so much poverty, questioning the need for government is a totally valid question. I said in my last post that, when the average citizen looks at the thug on the street and the government, and is unable to discern any meaningful difference between them, that society from that point on is on its journey to becoming a failed state. A journey to anarchy. Over the last two months or so, Kenyans have been shouting at the top of their lungs, begging for their government to listen. To hear them out. Kenyans have asked that their government stop this unbelievable level of plunder. Dozens of Kenyans have died, thousands injured, and many more are missing today. To this day, the people that govern us continue to use the power of the gun to subdue Kenyans, until they can take everything in their sight. And so, as a society, we all have to ask whether today there is any difference between the thug on the street and our governments. Every Kenyan will have to answer this question for themselves. And before answering this question, everyone needs to remember the many Calvins in our society. Smart, upright children whose only crime is to be born in an unforgiving, lawless, and corrupt purgatory that is Kenya today. For myself, I have concluded that there is no difference between the thug on the street and our governments, county and national alike. If you can see any meaningful difference, let me know. I am willing to listen. So despite over KSH 100 billion in money sent to Turkana County, there is almost no measurable improvement in people’s life today. None. And it makes sense, when you look at how that money is spent. I want you to forget for a second the obscene obsession by the County Government with spending ungodly amounts of money on themselves. The houses, etc. If you step back and look at how the government is actually spending the hard-earned money on other things, you will be depressed. I am telling you that I wept three times in the middle of the night trying to make sense of this crazy situation in Turkana County. Three times. I have never imagined that human beings can be so greedy and cold-blooded. Think about this: In the couple of years I reviewed, the County spent around KSH 400 million annually in “tourism” initiatives, including marketing, and apparently upgrading certain facilities. KSH 400 million for tourism. In Turkana County. In 1 year. KSH 400 million per year in marketing and other money pits. The government’s own website says that the county gets around 3000 visitors per month. Around 36,000 per year. That’s them saying that, on their website. Are you curious to know the return on that KSH 400 million investment? I have an answer for you. Remember that I told you that the County has never raised more than KSH 200 million in a year within the county, despite its KSH 18.4 billion budget? Let me walk you through the breakdown of the absolutely embarrassing shit-show that is the County Government’s “own source revenue” operations. In 2022-2023, the County Government collected KSH 190 million locally against their KSH 18.4 billion budget. 1% of the budget. Remember, there is absolutely no requirement on the County to cut costs, or achieve certain local revenue targets today. So they raised KSH 45 million in single business permits, KSH 72 million in CESS, KSH 8 million in market fee, KSH 9 million in “slaughter fees”. And then finally, there is the return on the tourism investment that you were looking for. A whopping KSH 209, 000 in “park fees”. KSH 209,000 in fees, after investing KSH 400 million. And so, take this as an example and extrapolate it across the entire budget, and you can see how one can spend KSH 100 billion and get NOTHING in return. You don’t need to be a genius to see the absurdity of this situation. Let me explain using an example that should illustrate the utter dimwittedness of this situation. Remember the KSH 100 billion sent to Turkana by you and me? Part of this amount is supposed to be for “service delivery”, or “recurrent expenditure”. Usually about 70% of the budget. The balance, 30%, is designed to go to development projects. With that in mind, from KSH 100 billion, the County apparently has made KSH 30 billion worth of investments, right? 30% of the KSH 100 billion. Now, if you employed someone to run a business for you, and they asked you to invest KSH 30 billion, which is no small fortune, at some point you would have to start seeing returns, right? That’s common sense, isn’t it? So, when we look at the revenues streams that make up this paltry sum of KSH 190 million, and see things like “slaughter fees’ and “market fees”, what does it tell you? It tells me there is no real “development” happening in that county. Trust me, if you had real development totaling KSH 30 billion, you would have corporate taxes in the hundreds of millions or billions, a booming real estate market, rising wages and standards of living, etc., low unemployment, etc. You would not have 80% of the people living hand-to mouth, and a County Government that can not afford to support itself for 5 days out of the year that has 365 days! We do not have enough time, trust me, to deal with the shit-show that is Turkana County. Dealing with that mess would require a forensic team. I will just highlight a few of other “in your-face” type of theft of public funds, and then conclude my submission. A government that has a budget of KSH 18.4 billion annually, and which has never raised more than 1% of its budget had the wisdom to do the following with your money: · Spend KSH 222 million on a project building something that NOBODY uses. You got that right. They spent KSH 222 million on a facility that NOBODY uses. KSH 222 million gone to waste, in a county that is dead last in pretty much all measures of human progress. · Remember the County Government offices that cost KSH 829 million? The County spent KSH 82 million on “air-conditioning” for that building. · Despite the County Spending hundreds of millions for the top three officers of the County, the Governor and his Deputy, in the 2022-2023 year, illegally charged the county (you and I) KSH 2.2 million in housing allowance! · Built two facilities for KSH 16 million, that were completed, but NOBODY uses them. · Entered into a contract for the construction of a plastic use facility for KSH 13 million in 2021. The contractor gets paid KSH 4.9 million, and has never been seen since. · Paid out KSH 62 million in salaries that were not supportable in just one year. They could not point to anybody and say, that is who we paid. · Paid out KSH 27 million in legal fees that nobody could say what they related to. And the County’s Legal Advisor, who, in 2022-2023, had a budget of KSH 123 million, apparently did not know anything about it! · Had an outstanding bill at Kenya Revenue Authority in the amount of KSH 486 million, that did not show up on the County Government’s financial statements. Think about that. KSH 486 million owned to the Kenya Revenue Authority, and that liability is not on the financial statements! This only means that someone took those funds for themselves, which is why the liability would be missing from the county’s books. · Could not account for KSH 367 million in expenditures for 2022-2023. KSH 367 million, in unexplained expenses. · Awarded a contract worth over KSH 200 million to a bidder with no bank statement, against the law. This contract was entered into and approved before the statutory time after the bidding process lapsed. Someone was in a hurry to get paid. KSH 200 million, illegally awarded to a bidder who did not have a 6-month bank statement. · Apparently purchased KSH 1.5 billion in assets in 2022-2023, but kept no records of the said assets. For this reason, NOBODY can verify where these assets are located. KSH 1.5 billion. Let me just say this. In my last article, the most common critique was that it was too long. Too many words. I did not intend to make another long article. Trust me when I tell you this, we do not have the time to detail half of the problems in Turkana County. For just 1 year! We do not. Now, you recall my point about how societies descend to madness and anarchy. In our country today, our leaders are accusing those of us who are agitating for honest and transparent governance of being traitors to the country. They call us anarchists, criminals, and merchants of chaos. They are questioning our patriotism. You have all seen the government and its horde of propagandists threatening the Ford Foundation and others because they may have helped civil society keep the lights on, and investigative journalists to have the capacity to continue to do the Lord’s work of investigating criminality in government. As though citizens are so dumb and ignorant, that they cannot see what is going on. The reason why millions of Calvins in this country will never graduate from college and earn a decent living is not because of the Ford Foundation. No. It is because of the thieves we have in office today, like the ones in Turkana County. In this post, I copy our leaders, the President and his deputy. I copy them because I want them to help Kenyans understand the following conundrum, about crime and criminals. There is nothing so special or peculiar about criminals or where they pop up. There are criminals in the US, Canada, France, and other places. Just like we have criminals in Kenya. The difference between banana republics and failed states, and civilized societies, is WHAT we do to and about criminals. In civilized societies, criminals are prosecuted and punished heavily. They are shunned. In some places, those charged with serious crimes such as corruption are executed. These are societies that are committed to sending the message that corruption, which robs citizens of their rights, is not acceptable. And they demonstrate this commitment by heavily punishing those who steal from the most vulnerable in society. In Kenya, we see the opposite. Criminals are exalted. They are promoted and embraced in government. It was just last week that the president unveiled his nominees for his Cabinet. Among them, are the likes of Hassan Ali Joho, EGH. , @GovWOparanya , and Davis Chirchir, ALL people who have been accused or charged with massive corruption against Kenyans. And am sure you remember that I mentioned Koli Nanok, EGH. , the man who tried to steal KSH 5 billion in his last days in office. Would you believe it if I told you that he works in government, at State House? He plunded billions of your money, got no measurable improvement in the lives of his subjects, and now has a government job in State House. Let that sink in. And so, the question is, how is it that in a country of 55 million people, with thousands of highly qualified people who have never ever stolen from Kenyans, he ends up with the criminals and thieves in the government, despite the fact that their crimes are in the public domain? How is this possible? Is it possible that these thieves possess a certain unique ability to run government, save Kenyans billions, and solve problems in a way that the president performs a cost-benefit analysis, and the benefits outweigh the costs of their theft? If not, what message does it send to Kenyans, when their own president puts into office known thieves? I think that is a fair question, don’t you? Dr. Ekuru Aukot Rigathi Gachagua William Samoei Ruto, PhD Okiya Omtatah Okoiti Citizen TV Kenya Nation Breaking News TI-Kenya CNN County Government of Turkana](https://image.24vids.com/tw-1818840969066037558/ext_tw_video_thumb/1818834432502951936/pu/img/ab9du2ECDO-A_5N7.jpg)
!["What are the fruits of Joseph Smith?" There are dozens of good fruits I can list-- our language training program the government tries to copy, our ministering program other faiths try to copy (and fail), our youth and missionary culture-- and so much more. But I'll focus on the three most important fruits: 1. The Book of Mormon I can't overemphasize this one. The Book of Mormon is the keystone of our whole religion-- a "sudden death proposition." All our claims live or die based on the veracity of that book. If it's a fraud, then Joseph, his revelations, the church he organized, priesthood authority, Joseph's successors-- everything goes with it. On the other hand, if it's true (as I know it is), then all that it implies is true, too: living Prophets and Apostles, priesthood, revelation, temples, dorky prom invites and carrots in your jello (obvious jk on those last two 😉). For 196 years, this book has been critically analyzed perhaps like no other book in modern religious history. No critic can account for how an uneducated farm boy correctly wrote inexplicable Hebraisms, dozens of short and long Near Eastern style poems, a story more intricate than Lord of the Rings with an internally consistent geography, verified distinct wordprints across characters, hundreds of names, interwoven storylines, rich theology, etc. Then to leave easter eggs for archaeologists and linguists to discover centuries later. He supposedly made scores of ridiculous (at the time) guesses about the Old and New World that were eventually corroborated by archaeology—making Joseph an astronomically good guesser if he wrote the thing. Oh, and he dictated one of history's most rich and complex religious texts in a single draft over about 65 work days. When you begin to study it, you'll find the case for the Book of Mormon is deeply impressive. The evidence, in the words of Farrer, "does not create belief, but it maintains a climate in which belief may flourish." For those who say "Well the Bible says any other scripture is impossible," we respectfully suggest that you're reading that message into 2-3 Bible verses when it's not there, and we'd be happy to explain why there is ample space in the Bible for continued revelation. 2. The lives of the people Charles Dickens (yes, that Charles Dickens) boarded a ship of Latter-day Saint immigrants. He fully expected to find the "Mormons" would fit the stereotypes he'd heard, and was prepared to write about all the horrid things he saw. But after observing the Saints, he wrote: "To my great astonishment they did not deserve it; and my predispositions and tendencies must not affect me as an honest witness. I [felt] it impossible to deny that, so far, some remarkable influence had produced a remarkable result, which better known influences have often missed... [they are] in their degree, the pick and flower of England." Most people who join our Church don't become interested by an ad for a free copy of the Book of Mormon or a 19-year-old in a suit. It's because they knew members of our Church and could tell, like Dickens, that there was something wonderfully different in their lives. And it's not anecdotes; it's quantifiable. The Church of Jesus Christ of Latter-day Saints produces higher outcomes in longevity, marital happiness, family togetherness, income, education, health, and virtually every other positive socioeconomic indicator there is. They are more devoted to God and more biblically literate than any other Christian faith per Pew Research. If you're interested in the stats, Clint Teeples has made it his hobby to accumulate all that data-- check his account for the receipts. Latter-day Saints are happier, more devoted to God, and successful in their personal lives than virtually any other group in America. That's because of the truths we build our lives on-- the truths we learned from the revelations of Joseph Smith. What about the "bad fruits?" "He was a con man, a fraud, an adulterer, etc!" None of those things are true. Dig past Reddit anti-Mormonism and look at the actual history. It's not that hard-- this was the nineteenth century-- not the ninth, after all. Thousands and thousands of documents-- journal entries and meeting minutes and newspaper accounts, etc. And I'm sure it will come as a shock 😉, but most credentialed historians aren't Latter-day Saints. Yet what do they see when they study his life? A get-rich-quick scheme? No. He lived and died penniless (and often houseless). He died in debt in large part because he was too generous with people who came asking. And he broke the mold by insisting members not be paid for their part-time service in the Church. A sorcerer and a gold-digger? No. He was as superstitious as other 19th-century rural Americans as a youth, then abandoned his superstitions when he began his work as a prophet. A philanderer? No. And the inspired, temporary practice of polygamy is a subject deserving a much longer explanation than a few sentences here. Historians as a group do not accept Joseph as a Prophet. But they almost universally acknowledge Joseph was sincere-- that Joseph truly believed God had spoken to him, that he believed the revelations he received. Even to the extent that as he knew he was about to die, he turned to the Book of Mormon (which he supposedly fabricated) for comfort and inspiration as he went to his Maker. Get past the sound bytes and caricatures and get to know Joseph Smith. 3. The ultimate fruit: Revelation I have studied the fruits of the Book of Mormon for 30 years. I have studied the fruits of Church membership for a little longer than that. I have studied Joseph's life and read the gamut of literature from apologetic to apoplectic. Most importantly, I have prayed to God about these things and received pure light and knowledge to my mind-- not "some warm fuzzies," but a divine witness, a seal, confirming to my spirit and my intellect the authenticity of the Book of Mormon and all that it implies. I echo all the words of Elder Jeffrey R. Holland below and likewise ask that my testimony "be recorded by men on earth and angels in heaven." I wish I could make the whole world know that I know. The Book of Mormon is true. And Joseph Smith was a Prophet of God.](https://image.24vids.com/tw-2038820841790521857/amplify_video_thumb/2038819396295233537/img/GdtoQAQS3FKxVKfx.jpg)
![An interview by VERY DARK AND CORRUPT Wall Street Journal aired today [1] WSJ's terrible "journalists" (and I use that term lightly) made many false statements about Sarepta's worthless, dangerous drug and Vinay Prasad's firing [1,2] I explain how the FDA sausage is made in excruciating detail Buckle up To get readers up to speed -> In June, corrupt pharma company Sarepta Therapeutics paid $40,000 to lobbying group Michael Best Strategies (MBS) to deal with a problem [3] -> MBS had recently hired Chris LaCivita, who had close connections with "MAGA" influencer Laura Loomer [4] -> With stock down 88%, Sarepta needed to sell their very bad, very dangerous drug or the company would go bankrupt [5] -> After several deaths from the drug this year, FDA official Vinay Prasad said "no way" and kicked the drug to the curb [2,6] -> Sarepta panicked and paid MBS (we believe) to deal with Prasad [3,4] -> If this story is right, LaCivita recruited Laura Loomer to take down Prasad [4,7] -> Loomer said she was defending Trump, but she was lying [7] -> She was defending taxpayer-funded payouts to a worthless, corrupt company [7] -> Laura Loomer so brave A history of bad drugs and regulatory failure -> This is one of the worst pharma scandals in American history and corrupt mainstream media isn't covering it -> Sarepta has a very long, troubled history [8] -> For more than a decade, every major Sarepta FDA drug approval has required INTENSE political intervention [8,9] -> Scientists at FDA have been repeatedly overruled [8,9] -> Many scientists have resigned, very publicly, over these POLITICAL decisions, some writing scathing public criticisms of these terrible decisions [10,11] -> The most recent resignation by Vinay Prasad is not something new; it follows in a long tradition [2,10] -> In fact, standards have dramatically deteriorated since the first controversies about the company's drugs in the 2010s [8,9] -> Prasad was trying to hold the line in the face of rapidly deteriorating standards at the agency [2,6] -> For that, pharma launched a coup--a literal coup of a drug regulator [4,6] -> This is unprecedented -> Banana republic sht, unbelievably corrupt 2016: first Sarepta drug approval and the "highly unusual" decision -> The first Sarepta drug approved by FDA was called Exondys 51 [8] -> This drug was for patients with mutations in dystrophin, a muscle protein [8] -> This is a debilitating and fatal disease affecting children [8] -> Exondys 51 increased dystrophin by 0.2% of normal levels [8,12] -> Unsurprisingly, there was no good evidence the drug worked [8,12] -> Why would it? It increases the protein from zero to 1/500th of normal levels -> One reviewer wrote: "I can find no precedent of an accelerated approval for a marketing application where the effect size on the surrogate endpoint is as small as 0.3%." [12] -> The study submitted by the company included no proper control group [12] -> The techniques used were so bad not even a first-year PhD student would do a study that way -> This the level of work you would expect from a mediocre undergraduate with no guidance -> It's almost like it was so bad on purpose -> (Narrator: it was on purpose) -> Nerd time: -> One reviewer wrote: "The Western blots submitted by the applicant for Study 201 were oversaturated, unreliable, and uninterpretable." [12] -> Another wrote: "Because CDER also determined that the conditions under which the original IHC analysis was performed were inadequate, including that the reader was not masked to sequence and time, the Center requested a re-reading of the stored images by three masked pathologists under different conditions. The IHC results from the reread were not nearly as favorable, as compared to the initial IHC results reported by Sarepta." [12] -> "The lack of concordance between the IHC and the Western Blot results is 'striking'" [12] -> "Study 201/202 had fundamental flaws, including baseline biopsies from external controls who could differ in unknown ways from study subjects, Week 180 biopsies from different muscles than baseline, and potential protein degradation in stored baseline samples." [12] -> And on and on. -> FDA commissioner Robert Califf wrote at the time: the submitted study was "characterized by major flaws in the clinical study design" and "Blinded experts assembled by the FDA fundamentally debunked this study, which has yet to be retracted and continues to be cited" [9,12] -> That's right, the FDA commissioner expressed dismay that the study that the company used to gain approval hadn't yet been retracted, it was so bad [9] -> Senior FDA official Janet Woodcock decided to approve before scientific review team had even voted [9,12] -> Woodcock be like: yeah i'm going to decide before you guys can because i know what you're going to say lol -> Despite external intense pressure, FDA scientists voted against Exondys 51's efficacy [9,12] -> They then voted against its accelerated approval [9,12] -> The review team filed an appeal with FDA commissioner after "passionate" disagreement with Woodcock [9,12] -> One reviewer called Woodcock's decision "unprecedented" [12] -> In a 126-page report, FDA commissioner Califf called Woodcock's decision "highly unusual" [9] -> The FDA board wrote: "[Woodcock's] involvement here appears to have upended the typical review and decision-making process. ... Care should be taken to avoid the appearance of interfering with the integrity of scientific reviews at the lower levels of a Center." [9] -> Again, the data were unbelievably bad, literally every technique in the study was inappropriately used [12] -> I would fire an undergraduate student who did science like this, immediately -> FDA's chief scientist accused Sarepta of "serious irresponsibility" for selectively publishing only some of the data [9] -> Even Woodcock, who approved the drug, called the research "seriously deficient" [12] -> Yes, even the person who approved the drug over the heads of FDA's scientists said the research was horrible [12] -> Still, FDA tried to bury their heads in the sand and beg that, basically, Sarepta pretty please do a better job next time -> FDA commissioner: "The utmost attention should be paid to optimizing the methodological rigor of [future] trial[s]" [9] -> FDA also demanded a clinical trial "to verify the benefit" of the drug [8] -> Welp, this was in 2016 [8] -> The trial results are supposed to be available in 2026, maybe [13] -> Or maybe later, depending on how much money needs to be made first -> As an article published in Nature three years later despaired of the decision: "The approval was conditional on the company agreeing to conduct a two-year post-approval trial to show Exondys 51’s efficacy. But by August 2019, the company had yet to begin such a trial and in the meantime had profited from sales of $300 million in 2018." [13] -> If it sounds like Sarepta used political pressure to get its drug approved and then tried to avoid actually publishing the study showing it didn't work, it sounds that way because that's exactly what happened [13] -> FDA commissioner after deferring to Woodcock: "I am confident this unique situation will not set a general precedent for drug approvals under the accelerated approval pathway, as the statute and regulations are clear each situation must be evaluated on its own merits based on the totality of data and information." [9] -> This statement was profoundly naive, and the historical record bears this out [8,14] -> Three FDA scientists resigned, including the lead reviewer of the drug, understanding the grave implications of the collapse of scientific standards and where they would lead [10,11] -> One was John K. Jenkins, M.D. Director, Office of New Drugs Center for Drug Evaluation and Research/FDA [10] -> In a presentation given just before his resignation, he wrote: -> "Path taken by Sarepta NOT a good model for other development programs" [10] -> Crucially: -> "Upholding statutory standards for approval in face of hopes and desires of patients, families, sponsors, and investors is a very difficult job" [10] -> "Personal attacks on FDA reviewers creates an atmosphere of distrust and isolation rather than collaboration" [10] This brings us to WHY Sarepta's drug was approved Facebook FDA -> So why did the drug get approved? -> Basically, Sarepta propagandized extremely desperate patients [9,15] -> They used miraculous snake oil promises and patients believed them -> Remember that this is life or death for patients, and they are extremely vulnerable -> Sarepta also professionally trained some patients to give testimonials to FDA and congress [15] -> The patients then went to congressmen who don't have time to understand the science [15] -> They gave emotional stories to congressmen [15] -> The result: -> Letter from 109 House members [15] -> Letter from 24 Senate members [15] -> And a media circus documented in the New York Times [16] -> Patients screaming at scientists during meetings [9] -> 2,792 emails written to FDA urging approval [12] -> One of them: "Dear Dr. califf: How is it that everyone in and around DMD understands this simple Idea and the science geniuses at FDA don't? You stupid fckers are costing each and every DMD kids days of their lives with your Moronic Dystrophin dance. Time to get a fcking clue" [12] -> Upon approval, a journalist for Reuters wrote: "owing to pressure from patient advocates, the U.S. Food and Drug Administration on Monday approved a treatment for Duchenne muscular dystrophy even though an outside panel of experts and the agency's own reviewers questioned the drug's efficacy" [17] -> A commentary in Nature Medicine was also published called "Railroading at the FDA" [9] -> Its author wrote: "In the words of one FDA committee member, Exondys lowers the agency's evidentiary standard for drug effectiveness 'to an unprecedented nadir.'" [9] -> A highly critical commentary was also published in Science, titled "Sarepta gets an approval - Unfortunately" [18] -> The article's author pharma veteran Derek Lowe wrote: "The company... called up Duchenne-affected boys and their families to plead with the FDA, and won over Janet Woodcock, and that appears to be enough. Is this going to be the new way to get a drug approved? Run a trial in a dozen people, generate unconvincing data, and then lobby Janet Woodcock? I share the worries that this might open the floodgates, because after all, Sarepta got their drug through." [18] -> One FDA reviewer ended in an equally grim note: ". Approval of this NDA would send the signal that political pressure and even intimidation – not science – guides FDA decisions, with extremely negative consequences. The public is well aware of this development program: the meager size of the study population, the marginal (at best) effect size, the Division’s dim view of the efficacy data, and the robust activism of some members of the DMD community. Many would be amazed at an approval action, because other DMD drugs, recently turned down for approval, appeared to provide stronger evidence of efficacy. ...The ramifications here are profound. The public will perceive that it was their unprecedented lobbying efforts that made the difference and earned eteplirsen its accelerated approval. For the future, this will have the effect of strongly encouraging public activism and intimidation as a substitute for data, which is one of the worst possible consequences for communities with rare diseases. This type of activism is not what was envisioned for patient-focused drug development." [12] -> A new era was born -> Activism had replaced data -> Facebook had fried people's brains -> And now Facebook-fried brains had fried FDA too -> FDA's credibility as a regulatory agency would now be hollowed out -> FDA's Facebook age had begun -> But the worst was yet to come Sarepta approvals: 2016 to present -> Three more drugs were approved from Sarepta on the same shoddy basis, proving Califf's promises that Exondys 51 was an isolated case empty [8,14] -> But things would take a turn for the worse with Sarepta's newest drug Elevidys in 2024 [19] -> At last a rigorous clinical trial looking at actual clinical outcomes was published [19,20] -> All would be put to rest -> At long last the issue could be resolved with HARD CLINICAL DATA -> There was only one problem -> The trial failed to show any benefit according to the primary outcome [19,20] -> The surrogate biomarker of micro-dystrophin meant absolutely nothing; it wasn't actually helping patients [19,20] -> What did FDA scientists do? They voted against approval. Of course [19] -> How could they not? The drug didn't actually work in the clinical trial [19] -> It's the only thing that made sense, since FDA is a scientific agency -> AND THEY WERE OVERRULED AGAIN BY PETER MARKS [19] -> YES THAT'S RIGHT, OVERRULED YET AGAIN -> PHARMA WINS AGAIN -> HAHAHAHAHAHA PHARMA ALWAYS WINS YOU FOOLS -> What happened is that Marks crossed his eyes somewhat, trying to make the words on the page blurry -> He prayed really hard, "my god please give me a sign, something, anything, I need this for my career" -> lzzosolsolzzolzozlslzolosllslozllzlzl -> Marks was trying really hard to see SOMETHING, come on come on, give me SOMETHIGN he said -> And he said: wait, look, there are these secondary, exploratory endpoints and a two of them look pretty good, I'LL APPROVE [19,20] -> AHAHAHHAHAHA YES PHAMRA WINS AGAIN -> And Marks said, "Thank you pharma go- I mean god, not pharma god, why did I just say that, FCK" -> The trial was explicitly designed for what Marks did NOT to happen [20] -> Once the primary endpoint was not met, the secondary endpoints couldn't even be statistically tested [20] -> And the trial explicitly said that they could not be interpreted the way Marks interpreted them [20] -> They were not adjusted for multiplicity and they were, like expression of dystrophin, simply bad endpoints [20] -> These two secondary endpoints were time to rise from lying on the floor and the 10-meter walk/run tests [20] -> Subjects who received the Elevidys performed, on average, about 0.5 seconds better than placebo recipients on these tasks [20] -> However several facts must be borne in mind when interpreting these: -> 1. At the time of testing, patients receiving the drug were receiving more corticosteroids than placebo patients, biasing the results [20] -> 2. Blinding might have been broken because those receiving the drug experienced lots of nausea and vomiting from the drug (~70%) [20] -> 3. These differences were tiny and may be attributable to chance, since the natural course of the disease varies widely [20] -> Marks knows this but who cares? Pharma I mean Facebook needed to be placated Elevidys: the drug -> To understand why this is so messed up, one must understand a few things -> On a Bayesian basis, one must assume that Elevidys is harmful until proven otherwise, for two reasons: -> 1. All drugs are potentially "toxic", but some toxins heal: by default you must assume it is a toxin that does not heal because this is what is actually usually the case; you need evidence that it actually heals -> 2. Elevidys IN PARTICULAR must be assumed to be harmful until proven otherwise because of the very nature of the drug -> Let's do a breakdown of the basic science of Elevidys that supports this (Bayesian) hypothesis: -> Gene therapy that permanently integrates into human genome [21] -> Meant to replace dystrophin, the protein that these patients cannot produce themselves [21] -> Preferentially targets muscle but gets expressed everywhere [21] -> Killed three people this year [6,21] -> Costs $3.2 million per injection [21] -> Truncated version of the protein it is supposed to replace [21] -> 3X shorter than the real protein [21] -> Has to be truncated because the technology cannot create the full protein [21] -> Because it's an abnormal protein, it's foreign, so immune system attacks it [21] -> Patients injected with drug are basically given an autoimmune disease [21] -> Patients have to be given anti-inflammatories to fight the disease that the drug causes [21] -> Causes terrible muscle inflammation [21] -> Inflames the heart, heart walls thicken because of the inflammation [21] -> Blows up the liver, causes acute liver injury and death [21] Drug should actually be assumed harmful, not beneficial -> Given all of the above, since the drug failed to meet its primary endpoint, it should actually be considered harmful by default, not beneficial [19,20] -> In other words, what we would actually expect if we added more patients and did an even larger study... -> Is that the drug would do worse than placebo, i.e., patients taking the drug would do worse than those taking placebo -> Why isn't this the default interpretation? -> They are reading the study with an intervention bias -> An intervention bias is natural, which is why "do no harm" is such a central tenet of medicine -> If I may put forward a thesis: most of Vinay Prasad's 500+-paper body of work has been dedicated to demonstrating the "do no harm" principle empirically [22] -> Rose-colored glasses study interpreters are simply not applying this principle properly and are thus failing scientifically in the most fundamental way -> Incomprehensible -> Back in 2016, scientists were adamant that the approval of Sarepta's first drug indicated the profound deterioration of scientific standards [8,9] -> But this latest approval is even worse: actual clinical data is now being overruled -> No standards at all are being enforced anymore; anything can now be approved based on any evidence whatsoever -> What Vinay was trying to do was simply to stop the unrelenting downslide -> And his firing punctuated that downslide for what it was The WSJ segment -> When Elevidys was approved, former FDA chief scientist and one of the original reviewers of Sarepta's first drug Luciana Borio said: -> "I don’t know what to say. Peter Marks makes a mockery of scientific reasoning and approval standards that have served patients well over decades. This type of action also promotes the growing mistrust in scientific institutions like the FDA." [23] -> To return to this video, these two WSJ reporters show an incredible level of ignorance and arrogance -> Finley says that the drug is "clearly" beneficial by misreading the secondary endpoints, just like Marks did -> An FDA memo from last year says about these endpoints: "Under these circumstances, they are misleading and cannot guide any stakeholders—including patients, family members and caregivers, and prescribers—in making informed decisions about the potential benefit of treatment with ELEVIDYS." [20] -> It really doesn't get any clearer than that -> But these two journalists are overruling the actual scientists, just like Marks did -> One of the most incredible comments during this interview was the complaint that "90% of clinical trials fail", as if that's bad thing [1] -> It's actually a good thing; most drugs suck; failing in clinical trial actually allows us to use only the drugs that don't suck -> These people don't understand the most fundamental purpose of the clinical trial -> They think clinical trials failing is a bad thing, as if it means that patients now won't get to use a useful drug -> No, it's a good thing, because it means that patients won't be exposed unnecessarily to a useless drug that might harm them -> The level of ignorance really is unbelievable -> What's worse is that these "journalists" defend their decision -> But what they did is exploit social media hysteria caused by Laura Loomer [1,7] -> Following up on her heels with editorials, using her as pharma attack dog [1,4] -> This is a huge blow to WSJ's credibility, and they know it -> Unbelievably shameful Where do we go from here? -> The Vinay Prasad firing creates a serious crisis of credibility at FDA [2,6] -> Up to this point, we could call these approvals a difference of opinion, but as we've seen, that's a huge stretch -> But any illusion of that is now shattered: the firing shows that drug regulation is explicitly political -> Janet Woodcock: approve, keep job -> Peter Marks: approve, keep job -> Vinay Prasad: block, transparently fired -> Make a decision that is anti-pharma and lose your job: that's the message -> Who can trust any decision at FDA anymore? -> RFK Jr. and Marty Makary both stand behind Vinay Prasad [24] -> Trump went along with lockdowns, he went along with mask mandates, he went along with all of the Covid pseudoscience that he now decries -> He should reverse course and not go along with this -> Trump has created a profound crisis of credibility at FDA and needs to fix it](https://image.24vids.com/tw-1952294845248114806/amplify_video_thumb/1952292444621451264/img/SPXp7ZpvQZ3FQV7_.jpg)