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When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get...

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John Cumbers

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305,874 просмотров • 6 месяцев назад •via X (Twitter)

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Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair
2:59

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

Longevity

32,630 просмотров • 6 месяцев назад

I am a physicist and I'm profoundly opposed to any idea of non-physical explanations that contradict physics. So that's a no-no and really doesn't make sense. However, there are ways in which both emergent properties such as minds and life and so on have an effect. And as you said, also abstractions. Now the fact that the theory of good explanations led to the idea that abstractions are real things was slightly surprising to me. I wasn't expecting the link, at least wasn't expecting it to be so strong as it is. But the thing is, if you think about how to explain events, physical events like a footprint on the moon, how do you explain how that happened? Well, it happened because of human ideas, of science. And human ideas, you could say in this reductionist sense that as you rightly say is the prevailing mode of explanation and the prevailing idea is to look down on other modes of explanation, that those ideas are nothing more than configurations of atoms. So some physicists, some rocket scientists put their brain into certain configurations of atoms and those atoms then acted on other atoms which then ended up making a footprint on the moon. Now what that misses is the explanation of why certain configurations of atoms put footprints on the moon while others, the overwhelming majority of configurations that human brains, even human brains have been put into in history, do not have that effect. And it's because there's a certain type of information. And this information can't in my view be reduced to statements about atoms because if you think about what that information does, it is in brains but the same information then gets transferred into, let's say, sound waves in air and then it gets transferred into ink on paper and then it gets transferred into magnetic domains inside a computer which then control a machine that instantiates those ideas in bits of steel and silicon and so on and so on. There's an immense chain of instantiations of the same information. And it's only special kinds of information that have this property that they are preserved and instantiated in successive physical modes. So what is being transmitted, what is having the causal effect is not the atoms but the fact that the atoms instantiate certain kinds of information and not other kinds. So therefore it is the information that is having the causal effect. If a particular instantiation of that information were damaged, then processes would come along to fix it, whether or not they could fix the physical instantiation. For example, if the computer goes wrong, then we don't use the corrupted information. We go back and rescue the information from a different computer and we throw away the atoms that at one point instantiated it. So the information causes itself to remain in existence. Now I think there's no way out of that mode of explanation. And if explanation is going to be the fundamental thing about our criterion, for example, about what is or isn't real, then we have to say that information and this particular kind which we call knowledge is real and really does cause things. David Deutsch
6:05

I am a physicist and I'm profoundly opposed to any idea of non-physical explanations that contradict physics. So that's a no-no and really doesn't make sense. However, there are ways in which both emergent properties such as minds and life and so on have an effect. And as you said, also abstractions. Now the fact that the theory of good explanations led to the idea that abstractions are real things was slightly surprising to me. I wasn't expecting the link, at least wasn't expecting it to be so strong as it is. But the thing is, if you think about how to explain events, physical events like a footprint on the moon, how do you explain how that happened? Well, it happened because of human ideas, of science. And human ideas, you could say in this reductionist sense that as you rightly say is the prevailing mode of explanation and the prevailing idea is to look down on other modes of explanation, that those ideas are nothing more than configurations of atoms. So some physicists, some rocket scientists put their brain into certain configurations of atoms and those atoms then acted on other atoms which then ended up making a footprint on the moon. Now what that misses is the explanation of why certain configurations of atoms put footprints on the moon while others, the overwhelming majority of configurations that human brains, even human brains have been put into in history, do not have that effect. And it's because there's a certain type of information. And this information can't in my view be reduced to statements about atoms because if you think about what that information does, it is in brains but the same information then gets transferred into, let's say, sound waves in air and then it gets transferred into ink on paper and then it gets transferred into magnetic domains inside a computer which then control a machine that instantiates those ideas in bits of steel and silicon and so on and so on. There's an immense chain of instantiations of the same information. And it's only special kinds of information that have this property that they are preserved and instantiated in successive physical modes. So what is being transmitted, what is having the causal effect is not the atoms but the fact that the atoms instantiate certain kinds of information and not other kinds. So therefore it is the information that is having the causal effect. If a particular instantiation of that information were damaged, then processes would come along to fix it, whether or not they could fix the physical instantiation. For example, if the computer goes wrong, then we don't use the corrupted information. We go back and rescue the information from a different computer and we throw away the atoms that at one point instantiated it. So the information causes itself to remain in existence. Now I think there's no way out of that mode of explanation. And if explanation is going to be the fundamental thing about our criterion, for example, about what is or isn't real, then we have to say that information and this particular kind which we call knowledge is real and really does cause things. David Deutsch

Deutsch Explains

45,735 просмотров • 2 лет назад

🚨 This is why folks like Secretary Kennedy are asking questions. Our children are sicker than ever — something has to change. Dr. Andrew Huberman shared a story that shows just how broken our medical schools really are. ↓ “A good friend of mine who’s a chair of neurosurgery, perhaps one of the greatest neurosurgeons ever to live — I asked him, ‘What percentage of the information in medical school textbooks in the United States and elsewhere is inaccurate and we know it?’” “And he said, ‘At least half, given the new information.’” “And then a good friend of mine said to him in the same conversation, ‘What do you think the impact of that is on human health and the treatment of disease?’” “And he said, ‘Incalculable.’” Andrew D. Huberman, Ph.D.
0:46

🚨 This is why folks like Secretary Kennedy are asking questions. Our children are sicker than ever — something has to change. Dr. Andrew Huberman shared a story that shows just how broken our medical schools really are. ↓ “A good friend of mine who’s a chair of neurosurgery, perhaps one of the greatest neurosurgeons ever to live — I asked him, ‘What percentage of the information in medical school textbooks in the United States and elsewhere is inaccurate and we know it?’” “And he said, ‘At least half, given the new information.’” “And then a good friend of mine said to him in the same conversation, ‘What do you think the impact of that is on human health and the treatment of disease?’” “And he said, ‘Incalculable.’” Andrew D. Huberman, Ph.D.

Children’s Health Defense

34,748 просмотров • 11 месяцев назад

This is a common misconception which Peter Zeihan probably heard from Dr. Michio Kaku. The catch here is that the only way to extract information from a qubit is by measuring it, which gives you only one bit of information (0 or 1).
0:23

This is a common misconception which Peter Zeihan probably heard from Dr. Michio Kaku. The catch here is that the only way to extract information from a qubit is by measuring it, which gives you only one bit of information (0 or 1).

Dulwich Quantum Computing

42,747 просмотров • 2 лет назад

YOU CAN'T GO BACK: [Michael Shellenberger] shakes his head in horror and disbelief as Senator Alex Antic explains the Labor Government and the Australian parliament are trying to push forward a bill that will create an "independent" body (government funded) to decide what the truth is. The misinformation and disinformation bill is being debated NOW. "if you were to allow the government, or the intelligence community, or some political party, or some group with an agenda to take control of those information channels, that's totalitarianism" Michael Shellenberger (CBR Chair of Politics, Censorship & Free Speech) "I think to really underscore how dangerous and scary the moment is, which is to remind people that [you] can't go back to this period of the printing press and print materials everybody gets their information in the same way, which is from a small number of internet platforms" "You can't go back to this period of the printing press and print materials everybody gets their information in the same way, which is from a small number of internet platforms and if you were to allow the government, or the intelligence community, or some political party, or some group with an agenda to take control of those information channels, that's totalitarianism, [that's] dictatorship...I'm not [gonna] sugarcoat it for people, that's very very disturbing [and] you just can't have a democracy, you can't solve problems, if you have people with an agenda, who are deciding what can and cannot be said online" "they call misinformation like the number one threat to democracy, it's the most Orwellian idea you know that allowing other people to share their point of view is a threat to democracy... no you're the threat to democracy...you think that there's too much free speech, you're the threat to democracy" "the people don't want censorship and yet these characters they're all demanding global control of information [and] I continue to be shocked by it. Sometimes, even when I have a victory like Ireland, you get like one week to celebrate and the next thing, you know Australia's on the verge [of] basically [the] government controlling the social media companies [and] it's very concerning" The Labor Government used the US election as an opportunity to stop all other parliamentary debate, to push through the disinformation bill will less media scrutiny, because they knew the ABC (who would have televised the Parliamentary broadcast) media was pre-occupied with the American election. Putting the Draconian Misinformation bill aside, the way they proceeded with the debate ALL NIGHT during the elections, in itself, is just plain sneaky
3:35

YOU CAN'T GO BACK: [Michael Shellenberger] shakes his head in horror and disbelief as Senator Alex Antic explains the Labor Government and the Australian parliament are trying to push forward a bill that will create an "independent" body (government funded) to decide what the truth is. The misinformation and disinformation bill is being debated NOW. "if you were to allow the government, or the intelligence community, or some political party, or some group with an agenda to take control of those information channels, that's totalitarianism" Michael Shellenberger (CBR Chair of Politics, Censorship & Free Speech) "I think to really underscore how dangerous and scary the moment is, which is to remind people that [you] can't go back to this period of the printing press and print materials everybody gets their information in the same way, which is from a small number of internet platforms" "You can't go back to this period of the printing press and print materials everybody gets their information in the same way, which is from a small number of internet platforms and if you were to allow the government, or the intelligence community, or some political party, or some group with an agenda to take control of those information channels, that's totalitarianism, [that's] dictatorship...I'm not [gonna] sugarcoat it for people, that's very very disturbing [and] you just can't have a democracy, you can't solve problems, if you have people with an agenda, who are deciding what can and cannot be said online" "they call misinformation like the number one threat to democracy, it's the most Orwellian idea you know that allowing other people to share their point of view is a threat to democracy... no you're the threat to democracy...you think that there's too much free speech, you're the threat to democracy" "the people don't want censorship and yet these characters they're all demanding global control of information [and] I continue to be shocked by it. Sometimes, even when I have a victory like Ireland, you get like one week to celebrate and the next thing, you know Australia's on the verge [of] basically [the] government controlling the social media companies [and] it's very concerning" The Labor Government used the US election as an opportunity to stop all other parliamentary debate, to push through the disinformation bill will less media scrutiny, because they knew the ABC (who would have televised the Parliamentary broadcast) media was pre-occupied with the American election. Putting the Draconian Misinformation bill aside, the way they proceeded with the debate ALL NIGHT during the elections, in itself, is just plain sneaky

Humanspective

490,688 просмотров • 1 год назад

"The control of humanity is very simple." David Icke points to Covid as a perfect example of how centralised control of information enables the mass shaping of public behaviour—and how obedience and fear both enable tyranny, while non-cooperation ultimately brings it down. "We behave as we do because we perceive as we do. And where does perception come from if you go one step back? It comes from the information that we receive." "If you control the mainstream media... and if you control the education system... then you have an extremely powerful position to feed information—much of it not true—to your target population, and therefore impose their perceptions of reality."
5:24

"The control of humanity is very simple." David Icke points to Covid as a perfect example of how centralised control of information enables the mass shaping of public behaviour—and how obedience and fear both enable tyranny, while non-cooperation ultimately brings it down. "We behave as we do because we perceive as we do. And where does perception come from if you go one step back? It comes from the information that we receive." "If you control the mainstream media... and if you control the education system... then you have an extremely powerful position to feed information—much of it not true—to your target population, and therefore impose their perceptions of reality."

Wide Awake Media

89,129 просмотров • 9 месяцев назад

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.
0:55

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,517 просмотров • 9 месяцев назад

MacFarlane: What ABC is doing is making this argument with which I'm sympathetic of: it's not 1978 anymore. We don't all just watch Laverne and Shirley reruns and Gunsmoke. There's plenty of places to find information in the information ecosphere. You don't have to worry about what the three channels on the TV are giving you.
1:29

MacFarlane: What ABC is doing is making this argument with which I'm sympathetic of: it's not 1978 anymore. We don't all just watch Laverne and Shirley reruns and Gunsmoke. There's plenty of places to find information in the information ecosphere. You don't have to worry about what the three channels on the TV are giving you.

Acyn

76,725 просмотров • 5 месяцев назад

"Myocarditis in kids wasn't showing up until 2021. That's one piece of information. Second piece of information is that you have yet to see a case in which one of those myocarditis kids didn't have the shot."
0:59

"Myocarditis in kids wasn't showing up until 2021. That's one piece of information. Second piece of information is that you have yet to see a case in which one of those myocarditis kids didn't have the shot."

The DarkHorse Podcast

135,646 просмотров • 11 месяцев назад

Reminder: the 2026 Canada Census starts in 3 days. The Census of Population is a survey conducted to enumerate (or count) the entire Canadian population based on a "usual place of residence," that is, at the location where a person lives most of the time. The data collected helps paint a statistical portrait of Canada's population and the places we live. Seventy-five percent (75%) of Canadian households receive a short-form Census of Population questionnaire, which collects basic demographic information. A sample of 25% of Canadian households receive a long-form questionnaire. The long-form questionnaire collects the same demographic information as the short-form questionnaire, as well as information about the social and economic situation of people across Canada and about the dwellings they live in. Canadians are about to reveal a lot of personal information about themselves to the government. 1/
0:30

Reminder: the 2026 Canada Census starts in 3 days. The Census of Population is a survey conducted to enumerate (or count) the entire Canadian population based on a "usual place of residence," that is, at the location where a person lives most of the time. The data collected helps paint a statistical portrait of Canada's population and the places we live. Seventy-five percent (75%) of Canadian households receive a short-form Census of Population questionnaire, which collects basic demographic information. A sample of 25% of Canadian households receive a long-form questionnaire. The long-form questionnaire collects the same demographic information as the short-form questionnaire, as well as information about the social and economic situation of people across Canada and about the dwellings they live in. Canadians are about to reveal a lot of personal information about themselves to the government. 1/

Martyupnorth®- Unacceptable Fact Checker

29,335 просмотров • 5 месяцев назад

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:
1:43

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:

John Cumbers

27,280 просмотров • 6 месяцев назад