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This week on The Knowledge Project: A rare interview with Bruce Flatt, the quiet force behind 19% annual returns for 30 years, reveals the investment principles that transformed Brookfield into a $1T global powerhouse. "Our view always has been 'Buy the best.' Own the best, buy the best; continue to reinvest into the best." (00:00:54) Changes in Investing Over the Past 25 Years (00:02:50) How Private Enterprise Has Built Our Tech Infrastructure (00:05:07) Implications and Opportunities of Passive Investing (00:14:40) AI (00:19:39) Transition to Low-Carbon Energy (00:23:19) Future of Data Centers (00:25:28) De-globalization of Industry (00:27:55) Implications of Manufacturing Repatriation (00:29:06) Long-term Prospects for America (00:31:35) Changes in Real Estate (00:34:13) Approach to Risk and Debt (00:38:40) Managing Market Dislocations (00:40:22) Long-term Investing Strategy (00:42:59) History and Future of Brookfield (00:45:48) Exploration of Private Markets and Insurance (00:46:41) Investment Decision Process (00:48:34) Introduction to Annuities (00:53:10) Understanding Brookfield’s Structure (01:00:51) Focus on Downside Protection (01:02:56) Accountability in Investment Decisions (01:04:24) Understanding Investment Cycles (01:06:59) Postmortem Analysis of Investments (01:09:07) Consideration of Geopolitical Risks
1:15:17

This week on The Knowledge Project: A rare interview with Bruce Flatt, the quiet force behind 19% annual returns for 30 years, reveals the investment principles that transformed Brookfield into a $1T global powerhouse. "Our view always has been 'Buy the best.' Own the best, buy the best; continue to reinvest into the best." (00:00:54) Changes in Investing Over the Past 25 Years (00:02:50) How Private Enterprise Has Built Our Tech Infrastructure (00:05:07) Implications and Opportunities of Passive Investing (00:14:40) AI (00:19:39) Transition to Low-Carbon Energy (00:23:19) Future of Data Centers (00:25:28) De-globalization of Industry (00:27:55) Implications of Manufacturing Repatriation (00:29:06) Long-term Prospects for America (00:31:35) Changes in Real Estate (00:34:13) Approach to Risk and Debt (00:38:40) Managing Market Dislocations (00:40:22) Long-term Investing Strategy (00:42:59) History and Future of Brookfield (00:45:48) Exploration of Private Markets and Insurance (00:46:41) Investment Decision Process (00:48:34) Introduction to Annuities (00:53:10) Understanding Brookfield’s Structure (01:00:51) Focus on Downside Protection (01:02:56) Accountability in Investment Decisions (01:04:24) Understanding Investment Cycles (01:06:59) Postmortem Analysis of Investments (01:09:07) Consideration of Geopolitical Risks

The Knowledge Project

453,197 görüntüleme • 1 yıl önce

My conversation with OpenAI co-founder Greg Brockman This is the most detailed first-person account of the 72 hours after Sam Altman was fired. We also go deep on what comes next: the global race to AGI, why ChatGPT stopped showing reasoning, how much of OpenAI's own code is now written by AI ("it's hard to know what percent is not"), and the untold story of how OpenAI actually started in 2015. 00:00:00 Introduction 00:00:49 Meeting Sam Altman and Starting OpenAI 00:02:40 Building the Founding Team 00:04:25 DeepMind's Lead Over OpenAI 00:04:54 Changing OpenAI to a For-Profit Model 00:06:05 Breakthrough Moments at OpenAI 00:08:22 What Dota 2 Meant for OpenAI 00:10:04 Reasoning Versus Prediction 00:11:59 Tensions Grow at OpenAI 00:15:44 Sam Altman's Firing 00:17:49 Greg Quits OpenAI 00:19:56 Sam Explores Deal with Microsoft's Satya 00:20:28 Petition for Altman's Return 00:23:43 Ilya Sutskever Leaves OpenAI 00:24:59 Lessons Learned after Sam Ousting 00:28:22 The Thing Ilya Said that Greg Can't Forget 00:32:22 Is AI Going Parabolic? 00:33:24 How Much of OpenAI's Code is Written by AI? 00:36:21 Do AI Chatbots Tell Us What We Want to Hear? 00:38:06 The Global AI Race to Reach AGI 00:38:40 What Happens if US Doesn't Reach AGI First? 00:39:49 Are Countries Stealing AI Advancements? 00:40:38 Why ChatGPT No Longer Shows Reasoning 00:41:47 The Finite Constraints of Compute 00:43:38 On Investing Early in Data Centers 00:46:31 The Future of Data Center Specialization 00:47:52 How to Decide Whose Queries to Serve 00:49:08 OpenAI on Consumer vs Enterprise Models 00:53:05 Data Centers in Space? 01:00:56 What Should AI Regulation Look Like? 01:04:33 The Future of AI-Powered Entrepreneurship 01:04:44 AI and Job Loss 01:07:15 The Skills Young People Should Invest In 01:11:30 What Does Success Look Like For You? Full episode on X below. Also find it on: • YouTube: • Spotify: • Apple:
1:11:41

My conversation with OpenAI co-founder Greg Brockman This is the most detailed first-person account of the 72 hours after Sam Altman was fired. We also go deep on what comes next: the global race to AGI, why ChatGPT stopped showing reasoning, how much of OpenAI's own code is now written by AI ("it's hard to know what percent is not"), and the untold story of how OpenAI actually started in 2015. 00:00:00 Introduction 00:00:49 Meeting Sam Altman and Starting OpenAI 00:02:40 Building the Founding Team 00:04:25 DeepMind's Lead Over OpenAI 00:04:54 Changing OpenAI to a For-Profit Model 00:06:05 Breakthrough Moments at OpenAI 00:08:22 What Dota 2 Meant for OpenAI 00:10:04 Reasoning Versus Prediction 00:11:59 Tensions Grow at OpenAI 00:15:44 Sam Altman's Firing 00:17:49 Greg Quits OpenAI 00:19:56 Sam Explores Deal with Microsoft's Satya 00:20:28 Petition for Altman's Return 00:23:43 Ilya Sutskever Leaves OpenAI 00:24:59 Lessons Learned after Sam Ousting 00:28:22 The Thing Ilya Said that Greg Can't Forget 00:32:22 Is AI Going Parabolic? 00:33:24 How Much of OpenAI's Code is Written by AI? 00:36:21 Do AI Chatbots Tell Us What We Want to Hear? 00:38:06 The Global AI Race to Reach AGI 00:38:40 What Happens if US Doesn't Reach AGI First? 00:39:49 Are Countries Stealing AI Advancements? 00:40:38 Why ChatGPT No Longer Shows Reasoning 00:41:47 The Finite Constraints of Compute 00:43:38 On Investing Early in Data Centers 00:46:31 The Future of Data Center Specialization 00:47:52 How to Decide Whose Queries to Serve 00:49:08 OpenAI on Consumer vs Enterprise Models 00:53:05 Data Centers in Space? 01:00:56 What Should AI Regulation Look Like? 01:04:33 The Future of AI-Powered Entrepreneurship 01:04:44 AI and Job Loss 01:07:15 The Skills Young People Should Invest In 01:11:30 What Does Success Look Like For You? Full episode on X below. Also find it on: • YouTube: • Spotify: • Apple:

Shane Parrish

450,952 görüntüleme • 4 ay önce

Economy Annual Current Affairs - 100 Key Highlights for UPSC, SSC, Banking Exams by Dr.Mrunal Patel Timestamps: 00:00:00 - Introduction 00:00:24 - Headline Compilation 00:03:09 - Pillar 1: Money and Banking 00:03:31 - Deadline Enforcement 00:05:11 - Ease of Doing Business vs Public Safety 00:06:41 - Cheque Clearance Postponement 00:07:03 - UPI Updates 00:07:25 - Bitcoin Volatility and Trump 00:09:13 - Stablecoins and China Digital Yuan 00:10:19 - RBI Governors 00:11:02 - NPAs and Credit Card Issues 00:12:30 - Gold Loan Rules Relaxation 00:13:16 - IBC Code Amendments 00:13:39 - Pillar 2: Share Market 00:14:17 - Gold Price Surge and Smuggling 00:15:30 - Sovereign Gold Bonds Changes 00:16:13 - SEBI Leadership Shift 00:17:03 - Adani US Court Issues 00:18:08 - Tech Bubble Warnings 00:19:17 - Market Cap Examples 00:20:05 - Elon Musk Tesla Demands 00:20:55 - Over-Financialization Concerns 00:21:14 - F&O Trading Losses 00:22:21 - Corporate Nepotism at Reliance 00:23:09 - Pillar 1D: Insurance FDI Increase 00:23:51 - PM Jan Arogya Yojana Disputes 00:24:29 - Bima Sugam Portal 00:24:53 - Pension Incentives for Freshers 00:26:06 - Digital KYC Accessibility 00:27:12 - Pillar 2: Budget Taxation GST 00:27:38 Income tax relief 00:28:40 GST 2.0 00:30:43 Pan-Masala Cess 00:31:28 Finance Commission 00:31:48 Subsidies Revdi Culture 00:34:24 - Rupee Depreciation Reasons 00:34:59 - Trump Policies Impact 00:35:20 - Tariff Wars and Immigration 00:35:51 - Beautiful Bill and DOGE 00:36:12 - WTO Issues 00:36:56 - Democracy in Growth 00:37:21 - China Supply Chain Weaponization 00:37:51 - SCO and RIC Meetings 00:38:18 - Diplomacy No Permanent Friends 00:38:42 - FTA with UK 00:39:09 - Opportunities in Crisis 00:39:32 - EU Trade Deals 00:40:19 - Sanctions on Nayara 00:40:40 - Microsoft Reaction 00:41:02 - Digital Policy Need 00:41:26 - Pillar 4: Sectors of Economy 00:41:53 - PM Dhanya Krishi Yojana 00:42:14 - Makhana in Bihar 00:42:38 - No Major Farmer Sops 00:43:03 - Agriculture Budget 00:43:35 - Manufacturing PLI 00:43:57 - Startups and Criticism 00:44:31 - Startup Counterarguments 00:45:03 - Kolhapuri Chappal GI 00:45:52 - Four Labor Codes 00:46:16 - Engels Pause AI 00:46:42 - IT Job Losses 00:47:07 - Industrial Revolution Comparison 00:47:16 - PLFS Data 00:47:42 - GDP IMF Projection 00:48:01 - Growth vs Development 00:48:14 - Data Quality C Grade 00:48:33 - Methodology Changes 00:48:55 - Pillar 5: Infrastructure 00:49:22 - Nuclear Liability 00:50:06 - Mineral Partnerships 00:50:29 - US Exclusion 00:50:46 - Transport Pilot Rules 00:51:06 - Toll Systems 00:51:38 - Ethanol Blending 00:51:57 - Smart Cities Funding End 00:52:54 - Communication Infra 00:53:19 - Pillar 6: Census Delay 00:53:35 - Demographic Challenges 00:54:17 - Population Challenges 00:54:36 - Pension Age Debates 00:55:04 - Health Education Updates 00:55:28 - PM SHRI Scheme 00:55:40 - Open Book Exams 00:56:19 - IIT Issues 00:56:43 - Hindi Medium Initiative 00:57:05 - MGNREGA Extensions 00:57:48 - Poverty Definitions 00:58:27 - Inequality Gini 00:59:12 - HDI Rankings 00:59:43 - Other Indexes 00:59:48 - Win26 Series Announcement 01:00:10 - PCB15 Course Details 01:01:10 - Unacademy Offer 01:02:04 - Final Closing ✍🏻 Join Unacademy for UPSC Prelims + Mains Coaching:
1:02:08

Economy Annual Current Affairs - 100 Key Highlights for UPSC, SSC, Banking Exams by Dr.Mrunal Patel Timestamps: 00:00:00 - Introduction 00:00:24 - Headline Compilation 00:03:09 - Pillar 1: Money and Banking 00:03:31 - Deadline Enforcement 00:05:11 - Ease of Doing Business vs Public Safety 00:06:41 - Cheque Clearance Postponement 00:07:03 - UPI Updates 00:07:25 - Bitcoin Volatility and Trump 00:09:13 - Stablecoins and China Digital Yuan 00:10:19 - RBI Governors 00:11:02 - NPAs and Credit Card Issues 00:12:30 - Gold Loan Rules Relaxation 00:13:16 - IBC Code Amendments 00:13:39 - Pillar 2: Share Market 00:14:17 - Gold Price Surge and Smuggling 00:15:30 - Sovereign Gold Bonds Changes 00:16:13 - SEBI Leadership Shift 00:17:03 - Adani US Court Issues 00:18:08 - Tech Bubble Warnings 00:19:17 - Market Cap Examples 00:20:05 - Elon Musk Tesla Demands 00:20:55 - Over-Financialization Concerns 00:21:14 - F&O Trading Losses 00:22:21 - Corporate Nepotism at Reliance 00:23:09 - Pillar 1D: Insurance FDI Increase 00:23:51 - PM Jan Arogya Yojana Disputes 00:24:29 - Bima Sugam Portal 00:24:53 - Pension Incentives for Freshers 00:26:06 - Digital KYC Accessibility 00:27:12 - Pillar 2: Budget Taxation GST 00:27:38 Income tax relief 00:28:40 GST 2.0 00:30:43 Pan-Masala Cess 00:31:28 Finance Commission 00:31:48 Subsidies Revdi Culture 00:34:24 - Rupee Depreciation Reasons 00:34:59 - Trump Policies Impact 00:35:20 - Tariff Wars and Immigration 00:35:51 - Beautiful Bill and DOGE 00:36:12 - WTO Issues 00:36:56 - Democracy in Growth 00:37:21 - China Supply Chain Weaponization 00:37:51 - SCO and RIC Meetings 00:38:18 - Diplomacy No Permanent Friends 00:38:42 - FTA with UK 00:39:09 - Opportunities in Crisis 00:39:32 - EU Trade Deals 00:40:19 - Sanctions on Nayara 00:40:40 - Microsoft Reaction 00:41:02 - Digital Policy Need 00:41:26 - Pillar 4: Sectors of Economy 00:41:53 - PM Dhanya Krishi Yojana 00:42:14 - Makhana in Bihar 00:42:38 - No Major Farmer Sops 00:43:03 - Agriculture Budget 00:43:35 - Manufacturing PLI 00:43:57 - Startups and Criticism 00:44:31 - Startup Counterarguments 00:45:03 - Kolhapuri Chappal GI 00:45:52 - Four Labor Codes 00:46:16 - Engels Pause AI 00:46:42 - IT Job Losses 00:47:07 - Industrial Revolution Comparison 00:47:16 - PLFS Data 00:47:42 - GDP IMF Projection 00:48:01 - Growth vs Development 00:48:14 - Data Quality C Grade 00:48:33 - Methodology Changes 00:48:55 - Pillar 5: Infrastructure 00:49:22 - Nuclear Liability 00:50:06 - Mineral Partnerships 00:50:29 - US Exclusion 00:50:46 - Transport Pilot Rules 00:51:06 - Toll Systems 00:51:38 - Ethanol Blending 00:51:57 - Smart Cities Funding End 00:52:54 - Communication Infra 00:53:19 - Pillar 6: Census Delay 00:53:35 - Demographic Challenges 00:54:17 - Population Challenges 00:54:36 - Pension Age Debates 00:55:04 - Health Education Updates 00:55:28 - PM SHRI Scheme 00:55:40 - Open Book Exams 00:56:19 - IIT Issues 00:56:43 - Hindi Medium Initiative 00:57:05 - MGNREGA Extensions 00:57:48 - Poverty Definitions 00:58:27 - Inequality Gini 00:59:12 - HDI Rankings 00:59:43 - Other Indexes 00:59:48 - Win26 Series Announcement 01:00:10 - PCB15 Course Details 01:01:10 - Unacademy Offer 01:02:04 - Final Closing ✍🏻 Join Unacademy for UPSC Prelims + Mains Coaching:

Dr. Mrunal Patel (Ph.D.)

20,867 görüntüleme • 7 ay önce

Open Tab Ep 3: Ashlee Vance on new media, getting close to Elon and showing audiences where the world is headed before it gets there. 00:00 "Elon might actually bankrupt me" 00:01:08 George Hotz joyride 00:07:09 Silicon Valley watering hole 00:09:00 They thought I was a woman 00:12:07 Life before and after the Elon biography 00:15:30 Monthly dinners with Elon 00:22:05 "95% accurate" 00:25:00 Elon said "I'm gonna destroy your life" 00:27:02 Kim Dotcom raid 00:27:30 Reconciling with Elon 00:29:49 Getting access to Neuralink 00:31:00 Bryan Johnson documentary 00:33:40 Funding movies 00:35:17 EVE Online 00:36:09 Hello World: Emmy nomination 00:37:18 Audience reach: Substack vs Bloomberg 00:38:39 PR people out of touch 00:40:13 65% of YouTube viewers watching on a TV 00:42:30 Ayahuasca on assignment 00:45:06 "I had the best job in media" 00:45:30 Started media company anyway
47:56

Open Tab Ep 3: Ashlee Vance on new media, getting close to Elon and showing audiences where the world is headed before it gets there. 00:00 "Elon might actually bankrupt me" 00:01:08 George Hotz joyride 00:07:09 Silicon Valley watering hole 00:09:00 They thought I was a woman 00:12:07 Life before and after the Elon biography 00:15:30 Monthly dinners with Elon 00:22:05 "95% accurate" 00:25:00 Elon said "I'm gonna destroy your life" 00:27:02 Kim Dotcom raid 00:27:30 Reconciling with Elon 00:29:49 Getting access to Neuralink 00:31:00 Bryan Johnson documentary 00:33:40 Funding movies 00:35:17 EVE Online 00:36:09 Hello World: Emmy nomination 00:37:18 Audience reach: Substack vs Bloomberg 00:38:39 PR people out of touch 00:40:13 65% of YouTube viewers watching on a TV 00:42:30 Ayahuasca on assignment 00:45:06 "I had the best job in media" 00:45:30 Started media company anyway

Substack

23,889 görüntüleme • 3 ay önce

California is America's most populous, prosperous, and perhaps most beautiful state, and it sets trends for the rest of the country. But it's also perhaps the most broken state. Today, California Sheriff Chad Bianco is running for Governor and wants to lead California back to sanity: zero-income tax, oil independence, parental rights, and so much more. Can he do it? 00:00:00 - Intro 00:03:18 - Understanding California Governor elections 00:06:10 - Sheriff Chad’s background 00:14:40 - What does it mean to be sheriff? 00:18:12 - Gavin Newsom Rant 00:21:13 - Making life better in Riverside County 00:35:17 - Discretion in Law Enforcement 00:48:28 - Policy Differences Between Candidates 00:56:22 - Steve Hilton’s criticism of Chad 01:04:11 - First person to end the riots 01:10:59 - Eliminating Income Tax?! 01:20:00 - Wildlife 01:23:29 - Parental Rights, Education, Vaccines 01:27:53 - Pregnancy Resource Centers 01:35:19 - Why are you going to win?
1:41:15

California is America's most populous, prosperous, and perhaps most beautiful state, and it sets trends for the rest of the country. But it's also perhaps the most broken state. Today, California Sheriff Chad Bianco is running for Governor and wants to lead California back to sanity: zero-income tax, oil independence, parental rights, and so much more. Can he do it? 00:00:00 - Intro 00:03:18 - Understanding California Governor elections 00:06:10 - Sheriff Chad’s background 00:14:40 - What does it mean to be sheriff? 00:18:12 - Gavin Newsom Rant 00:21:13 - Making life better in Riverside County 00:35:17 - Discretion in Law Enforcement 00:48:28 - Policy Differences Between Candidates 00:56:22 - Steve Hilton’s criticism of Chad 01:04:11 - First person to end the riots 01:10:59 - Eliminating Income Tax?! 01:20:00 - Wildlife 01:23:29 - Parental Rights, Education, Vaccines 01:27:53 - Pregnancy Resource Centers 01:35:19 - Why are you going to win?

lilaroseshow

76,657 görüntüleme • 6 ay önce

As ever, a fascinating chat with my friend Jordi Visser on AI, crypto, and hedge funds' future... Enjoy! 00:00:00 Introduction 00:00:54 The Big Picture: AI, Crypto, and Macro 00:02:25 Jordie Visser’s Background in Macro and Finance 00:03:30 AI’s Disruptive Impact on the Economy 00:06:32 Rethinking GDP and Productivity 00:08:59 The Future of Labor and Profit Margins 00:10:49 The Rise of the Speculative Economy 00:14:41 Generational Shifts in Investing and Risk-taking 00:16:18 AI and Crypto: A Global Network Effect 00:19:38 Stablecoins and AI-Driven Market Volume Growth 00:24:28 The End of Traditional Hedge Funds? 00:31:16 Deep Research and the Power of AI Analysis 00:35:29 The Acceleration of AI and its Economic Impact 00:41:02 The Growing Crypto Adoption and Its Role in the Future Economy 00:44:22 Shifting from Fear to Optimism in Markets 00:50:27 The Political and Economic Challenges Ahead 00:56:01 Quantum Computing and the Next Leap in AI 01:02:06 Closing Thoughts: Preparing for a Radical Future
1:03:13

As ever, a fascinating chat with my friend Jordi Visser on AI, crypto, and hedge funds' future... Enjoy! 00:00:00 Introduction 00:00:54 The Big Picture: AI, Crypto, and Macro 00:02:25 Jordie Visser’s Background in Macro and Finance 00:03:30 AI’s Disruptive Impact on the Economy 00:06:32 Rethinking GDP and Productivity 00:08:59 The Future of Labor and Profit Margins 00:10:49 The Rise of the Speculative Economy 00:14:41 Generational Shifts in Investing and Risk-taking 00:16:18 AI and Crypto: A Global Network Effect 00:19:38 Stablecoins and AI-Driven Market Volume Growth 00:24:28 The End of Traditional Hedge Funds? 00:31:16 Deep Research and the Power of AI Analysis 00:35:29 The Acceleration of AI and its Economic Impact 00:41:02 The Growing Crypto Adoption and Its Role in the Future Economy 00:44:22 Shifting from Fear to Optimism in Markets 00:50:27 The Political and Economic Challenges Ahead 00:56:01 Quantum Computing and the Next Leap in AI 01:02:06 Closing Thoughts: Preparing for a Radical Future

Raoul Pal

280,189 görüntüleme • 1 yıl önce

From a Thai prison cell to a fintech empire processing $1.6B in international payments across 40+ banks and 250M+ users. Jonathan Low (Jonathan Low). Forbes 40 Under 40. Author of "Cell to CEO." We covered prison, banking for AI agents, RWA projects, the future of crypto in banking, vibe coding for trading, and the businesses that win the next 5 years. ⏱ Timestamps: 00:00:00 — Teaser 00:00:46 — Who is Jonathan Low 00:01:35 — What Jonathan's life was like before prison 00:02:13 — How and why Jonathan ended up in prison 00:02:57 — Prison conditions: expectations vs reality 00:07:33 — Prison became the greatest blessing 00:09:12 — How the entrepreneurial journey began after prison 00:10:34 — Why social capital matters 00:11:06 — Launched own club and took it to the top in 3 months 00:12:09 — Built an Axie Infinity gaming guild during COVID 00:13:49 — The beginning of the BipTap Group journey 00:17:23 — How Jonathan built his own banking system 00:20:07 — How to get a crypto card 00:22:03 — How much it costs to launch a white-label solution with BipTap 00:22:58 — Banking for AI agents 00:25:57 — How to build an RWA project 00:27:45 — Future of cryptocurrencies in banking 00:32:08 — The business verticals within Empire Group 00:32:48 — What Jonathan invests his money in 00:33:54 — How relationships with regulators are built 00:34:43 — Implementing AI in business 00:36:28 — Vibe coding in trading 00:40:06 — Advice for first-time founders 00:43:36 — From construction to trading: Ruslan Khairullin's journey 00:44:57 — Inner peace: why calmness is essential for founders 00:50:39 — Work-life balance for entrepreneurs 00:53:47 — $1.5 million in 24 hours on TST coin 00:55:11 — The best way to capture a market 00:55:57 — Banking for nations Watch the full conversation and let me know which part you liked the most 👇
58:52

From a Thai prison cell to a fintech empire processing $1.6B in international payments across 40+ banks and 250M+ users. Jonathan Low (Jonathan Low). Forbes 40 Under 40. Author of "Cell to CEO." We covered prison, banking for AI agents, RWA projects, the future of crypto in banking, vibe coding for trading, and the businesses that win the next 5 years. ⏱ Timestamps: 00:00:00 — Teaser 00:00:46 — Who is Jonathan Low 00:01:35 — What Jonathan's life was like before prison 00:02:13 — How and why Jonathan ended up in prison 00:02:57 — Prison conditions: expectations vs reality 00:07:33 — Prison became the greatest blessing 00:09:12 — How the entrepreneurial journey began after prison 00:10:34 — Why social capital matters 00:11:06 — Launched own club and took it to the top in 3 months 00:12:09 — Built an Axie Infinity gaming guild during COVID 00:13:49 — The beginning of the BipTap Group journey 00:17:23 — How Jonathan built his own banking system 00:20:07 — How to get a crypto card 00:22:03 — How much it costs to launch a white-label solution with BipTap 00:22:58 — Banking for AI agents 00:25:57 — How to build an RWA project 00:27:45 — Future of cryptocurrencies in banking 00:32:08 — The business verticals within Empire Group 00:32:48 — What Jonathan invests his money in 00:33:54 — How relationships with regulators are built 00:34:43 — Implementing AI in business 00:36:28 — Vibe coding in trading 00:40:06 — Advice for first-time founders 00:43:36 — From construction to trading: Ruslan Khairullin's journey 00:44:57 — Inner peace: why calmness is essential for founders 00:50:39 — Work-life balance for entrepreneurs 00:53:47 — $1.5 million in 24 hours on TST coin 00:55:11 — The best way to capture a market 00:55:57 — Banking for nations Watch the full conversation and let me know which part you liked the most 👇

Ruslan Khairullin

16,872 görüntüleme • 2 ay önce

Who Hijacked Bitcoin? Steve Patterson and Aaron Day on DarkHorse 00:00:00 Bitcoin: The Questions That Matter 00:03:01 Sponsor: Helix 00:05:26 The Purpose of Bitcoin 00:10:52 Digital Cash 00:18:38 The Reality of Bitcoin Transactions Today 00:27:22 Sponsor: ARMRA 00:29:46 The History of Bitcoin 00:42:14 Preempting the Bitcoin Experts 00:50:20 Bitcoin History: Two Camps Emerge 00:59:57 Bitcoin History: The Mainstream Phase 01:01:59 Bitcoin Corruption: New Information from the Epstein Files 01:04:35 Government Crackdown on Crypto 01:13:25 Is Bitcoin Really Decentralized? 01:35:16 The Connection to Howard Lutnick 01:44:41 CBDCs Should Be Top of Mind 01:45:54 The Coming Financial Collapse 01:47:13 Do We Already Have a Backdoor CBDC? 01:51:44 Tokens and The Great Taking 01:56:38 The Technocracy Movement 02:00:30 Digital Currency Naivety 02:11:32 Morality as a Constraint 02:21:43 Rights as an Irritant to Power 02:23:50 Protecting Yourself 02:25:51 Fighting Back
2:42:55

Who Hijacked Bitcoin? Steve Patterson and Aaron Day on DarkHorse 00:00:00 Bitcoin: The Questions That Matter 00:03:01 Sponsor: Helix 00:05:26 The Purpose of Bitcoin 00:10:52 Digital Cash 00:18:38 The Reality of Bitcoin Transactions Today 00:27:22 Sponsor: ARMRA 00:29:46 The History of Bitcoin 00:42:14 Preempting the Bitcoin Experts 00:50:20 Bitcoin History: Two Camps Emerge 00:59:57 Bitcoin History: The Mainstream Phase 01:01:59 Bitcoin Corruption: New Information from the Epstein Files 01:04:35 Government Crackdown on Crypto 01:13:25 Is Bitcoin Really Decentralized? 01:35:16 The Connection to Howard Lutnick 01:44:41 CBDCs Should Be Top of Mind 01:45:54 The Coming Financial Collapse 01:47:13 Do We Already Have a Backdoor CBDC? 01:51:44 Tokens and The Great Taking 01:56:38 The Technocracy Movement 02:00:30 Digital Currency Naivety 02:11:32 Morality as a Constraint 02:21:43 Rights as an Irritant to Power 02:23:50 Protecting Yourself 02:25:51 Fighting Back

The DarkHorse Podcast

88,842 görüntüleme • 5 ay önce

MONTY FRITTS: Meet the Man Challenging Blackburn for Tennessee Governor | Going Rogue with Lara Logan | Election Special Monty Fritts is a Republican gubernatorial candidate in Tennessee, veteran, and nuclear expert. Fritts shares his extensive background in uranium operations and national security before discussing his staunch Christian conservative platform, including Second Amendment rights, strict immigration enforcement, election integrity through paper ballots, and a pro-life stance from conception. Fritts also expresses strong opposition to Islam's political influence in Tennessee. He emphasizes restoring constitutional principles, protecting God-given rights, and resisting globalist agendas. 00:00:00 Islamophobia Accusations 00:00:45 Why Republican Outsider Candidates Face Relentless Media Attacks 00:02:12 Nuclear Expert, Iraq War Veteran, Tennessee Governor Candidate 00:04:37 Uranium, Plutonium, and the Weapons Supply Chain 00:05:59 How Fake Republicans Are Killing Constitutional Carry in Tennessee 00:07:25 The True Meaning of Unalienable 00:09:47 The Political Movement Threatening the American Republic 00:13:30 Did the Founders Intend to Protect Islam? 00:18:39 Tennessee's Unconstitutional Firearms Laws Exposed 00:23:03 Globalist Money, Weak Politicians, and the Hijacking of Tennessee 00:25:43 Deportation, Sanctuary Cities, and Making Tennessee the Worst State for Illegal Immigrants 00:34:23 Banning Electronic Voting and Fighting Ballot Fraud Going Rogue with Lara Logan | Monty Fritts
39:40

MONTY FRITTS: Meet the Man Challenging Blackburn for Tennessee Governor | Going Rogue with Lara Logan | Election Special Monty Fritts is a Republican gubernatorial candidate in Tennessee, veteran, and nuclear expert. Fritts shares his extensive background in uranium operations and national security before discussing his staunch Christian conservative platform, including Second Amendment rights, strict immigration enforcement, election integrity through paper ballots, and a pro-life stance from conception. Fritts also expresses strong opposition to Islam's political influence in Tennessee. He emphasizes restoring constitutional principles, protecting God-given rights, and resisting globalist agendas. 00:00:00 Islamophobia Accusations 00:00:45 Why Republican Outsider Candidates Face Relentless Media Attacks 00:02:12 Nuclear Expert, Iraq War Veteran, Tennessee Governor Candidate 00:04:37 Uranium, Plutonium, and the Weapons Supply Chain 00:05:59 How Fake Republicans Are Killing Constitutional Carry in Tennessee 00:07:25 The True Meaning of Unalienable 00:09:47 The Political Movement Threatening the American Republic 00:13:30 Did the Founders Intend to Protect Islam? 00:18:39 Tennessee's Unconstitutional Firearms Laws Exposed 00:23:03 Globalist Money, Weak Politicians, and the Hijacking of Tennessee 00:25:43 Deportation, Sanctuary Cities, and Making Tennessee the Worst State for Illegal Immigrants 00:34:23 Banning Electronic Voting and Fighting Ballot Fraud Going Rogue with Lara Logan | Monty Fritts

Lara Logan

18,765 görüntüleme • 24 gün önce

Some personal news - I am launching a podcast HD in HD Podcast to share what would normally be offline conversations with exceptional people online. Have had the great fortune of co-founding BRex which has led to several great relationships with other builders over the years. I find that the best way to learn anything is through conversations with brilliant people. To kick things off, listen in on a thoughtful conversation with Vlad Tenev. Hope you enjoy these off the script conversations. 00:00:00 Introduction 00:01:00 Decision to stop drinking 00:07:26 Day of the IPO feeling 00:12:37 How Vlad was as a kid 00:19:51 Raising kids 00:24:01 Source of motivation 00:24:48 Getting into Stanford 00:30:05 Time at Stanford 00:33:32 Grad school 00:42:25 First company 00:48:35 Second company 00:53:10 Beginning of Robinhood 00:59:54 Positioning of Robinhood 01:04:04 Being depicted in movies 01:12:06 Trader influencers 01:15:27 Serving active traders 01:20:26 Meeting wife 01:27:13 Downsides & upsides of being a CEO 01:31:30 Minimizing phone addiction 01:35:06 GameStop 01:49:02 Final learnings
1:56:22

Some personal news - I am launching a podcast HD in HD Podcast to share what would normally be offline conversations with exceptional people online. Have had the great fortune of co-founding BRex which has led to several great relationships with other builders over the years. I find that the best way to learn anything is through conversations with brilliant people. To kick things off, listen in on a thoughtful conversation with Vlad Tenev. Hope you enjoy these off the script conversations. 00:00:00 Introduction 00:01:00 Decision to stop drinking 00:07:26 Day of the IPO feeling 00:12:37 How Vlad was as a kid 00:19:51 Raising kids 00:24:01 Source of motivation 00:24:48 Getting into Stanford 00:30:05 Time at Stanford 00:33:32 Grad school 00:42:25 First company 00:48:35 Second company 00:53:10 Beginning of Robinhood 00:59:54 Positioning of Robinhood 01:04:04 Being depicted in movies 01:12:06 Trader influencers 01:15:27 Serving active traders 01:20:26 Meeting wife 01:27:13 Downsides & upsides of being a CEO 01:31:30 Minimizing phone addiction 01:35:06 GameStop 01:49:02 Final learnings

Henrique Dubugras

27,801 görüntüleme • 1 yıl önce

Bret Weinstein, Viva Frei and Jimmy Dore tangle over who shot Charlie Kirk, and how. 00:00:00 Three people, three positions, one killing 00:01:16 Sponsor: SaunaSpace 00:03:39 Sponsor: MUD\WTR 00:05:27 Where each of us has landed as of today 00:05:47 Viva Frei: it was a bullet from the Losee roof 00:08:41 Jimmy Dore: the case for a cover-up 00:16:41 When a Question Becomes an Accusation 00:18:15 Morality as a Substitute for Argument 00:21:27 Sponsor: Helix 00:22:42 A Biologist's Toolkit 00:25:35 George Zinn and the Reflex to Confess 00:29:42 Paving the Courtyard 00:38:11 The Exploding Microphone 00:45:09 Joe Kent Says He Was Stopped 00:46:50 The Mic That Should Have Recorded It 00:52:58 O'Neill, the Hamptons, and 39 Minutes 00:57:28 "You Don't Have an FBI" 00:59:26 Butler and the Roof Nobody Covered 01:06:27 Harpole, Shawn Ryan, and the Drones 01:11:48 The Prosecutor's Fallacy 01:15:29 Drones and a Plane at 200 Feet 01:22:06 Foreign Nexus, or Domestic 01:29:07 Retroactive Continuity 01:33:21 What Ballistics Can and Cannot Show 01:38:10 A Potemkin Explanation 01:44:14 TPUSA After Charlie 01:49:20 Iran, Motive, and What Charlie Opposed 01:51:26 "Who I Fear Is the People..." 01:56:31 A Nation, or Whatever Controls It 02:00:43 The Phone, the Necklace, the Car 02:04:39 The Emergency Cleanup Order 02:07:20 When No Answer Will Be Believed 02:09:34 Conspiracy Psychosis 02:10:47 Closing Thoughts
2:11:24

Bret Weinstein, Viva Frei and Jimmy Dore tangle over who shot Charlie Kirk, and how. 00:00:00 Three people, three positions, one killing 00:01:16 Sponsor: SaunaSpace 00:03:39 Sponsor: MUD\WTR 00:05:27 Where each of us has landed as of today 00:05:47 Viva Frei: it was a bullet from the Losee roof 00:08:41 Jimmy Dore: the case for a cover-up 00:16:41 When a Question Becomes an Accusation 00:18:15 Morality as a Substitute for Argument 00:21:27 Sponsor: Helix 00:22:42 A Biologist's Toolkit 00:25:35 George Zinn and the Reflex to Confess 00:29:42 Paving the Courtyard 00:38:11 The Exploding Microphone 00:45:09 Joe Kent Says He Was Stopped 00:46:50 The Mic That Should Have Recorded It 00:52:58 O'Neill, the Hamptons, and 39 Minutes 00:57:28 "You Don't Have an FBI" 00:59:26 Butler and the Roof Nobody Covered 01:06:27 Harpole, Shawn Ryan, and the Drones 01:11:48 The Prosecutor's Fallacy 01:15:29 Drones and a Plane at 200 Feet 01:22:06 Foreign Nexus, or Domestic 01:29:07 Retroactive Continuity 01:33:21 What Ballistics Can and Cannot Show 01:38:10 A Potemkin Explanation 01:44:14 TPUSA After Charlie 01:49:20 Iran, Motive, and What Charlie Opposed 01:51:26 "Who I Fear Is the People..." 01:56:31 A Nation, or Whatever Controls It 02:00:43 The Phone, the Necklace, the Car 02:04:39 The Emergency Cleanup Order 02:07:20 When No Answer Will Be Believed 02:09:34 Conspiracy Psychosis 02:10:47 Closing Thoughts

Bret Weinstein

321,391 görüntüleme • 6 gün önce

Michael Bolin (Michael Bolin) is the tech lead of the Codex open source repository at OpenAI and formerly a distinguished eng (E9) at Meta. I asked him for all the details on his career story and how he uses Codex for max benefit. Timestamps: 00:00:00 - Intro 00:00:56 - Chickenfoot 00:02:45 - Working at Google 00:06:34 - Overhauling Facebook's build system 00:16:36 - Rewriting Facebook's IDE 00:26:01 - Struggles after Principal Eng (E8) promo 00:28:39 - Building a virtual filesystem for Facebook 00:35:47 - Delayed Distinguished promo (E9) and learnings 00:39:56 - Joining OpenAI 00:43:05 - Research-led vs engineering-led cultures 00:44:53 - The story behind Codex 00:51:00 - How he uses Codex 00:57:00 - Why Codex's harness is open source 00:59:50 - Top technical book recommendations 01:05:02 - Why deep technical skills are still valuable (for now) 01:11:07 - How to start projects well 01:14:27 - Advice on writing better and career planning 01:17:06 - Advice for his younger self 01:19:10 - Outro He was a dream guest of mine and I'm excited to share his story with you all! Other places to watch: • YouTube: • Spotify: • Apple Podcasts: • Transcript:
1:20:03

Michael Bolin (Michael Bolin) is the tech lead of the Codex open source repository at OpenAI and formerly a distinguished eng (E9) at Meta. I asked him for all the details on his career story and how he uses Codex for max benefit. Timestamps: 00:00:00 - Intro 00:00:56 - Chickenfoot 00:02:45 - Working at Google 00:06:34 - Overhauling Facebook's build system 00:16:36 - Rewriting Facebook's IDE 00:26:01 - Struggles after Principal Eng (E8) promo 00:28:39 - Building a virtual filesystem for Facebook 00:35:47 - Delayed Distinguished promo (E9) and learnings 00:39:56 - Joining OpenAI 00:43:05 - Research-led vs engineering-led cultures 00:44:53 - The story behind Codex 00:51:00 - How he uses Codex 00:57:00 - Why Codex's harness is open source 00:59:50 - Top technical book recommendations 01:05:02 - Why deep technical skills are still valuable (for now) 01:11:07 - How to start projects well 01:14:27 - Advice on writing better and career planning 01:17:06 - Advice for his younger self 01:19:10 - Outro He was a dream guest of mine and I'm excited to share his story with you all! Other places to watch: • YouTube: • Spotify: • Apple Podcasts: • Transcript:

Ryan Peterman

119,601 görüntüleme • 5 ay önce

Hey Siri, why are American kids so sick? Aaron Siri on DarkHorse with Bret Weinstein : 00:00:00 Welcome Aaron Siri 00:05:22 Vaccines: Then vs. Now 00:18:04 What We Don’t Know About Childhood Vaccines 00:33:45 Financial Incentives in Vaccine Development 00:52:02 Polio Vaccine: Unintended Consequences 00:55:39 The Polio Story as a Red Pill 01:25:32 HIV Origins & Parallels to COVID 01:45:04 Rethinking the Spanish Flu 01:47:31 When Interventions Cause Harm 01:49:40 Measles Mortality Data 01:56:07 Health Before Vaccination 02:03:17 Defining “Vaccine” 02:05:01 Why Hep B Remains on the Schedule 02:11:29 Autism & Vaccines 02:20:02 The Tyranny of Vaccine Mandates 02:35:27 Scientific vs. Legal Fraud 02:53:00 Trump Administration & the Childhood Schedule 03:04:38 Think of Vaccines as a Product
3:08:34

Hey Siri, why are American kids so sick? Aaron Siri on DarkHorse with Bret Weinstein : 00:00:00 Welcome Aaron Siri 00:05:22 Vaccines: Then vs. Now 00:18:04 What We Don’t Know About Childhood Vaccines 00:33:45 Financial Incentives in Vaccine Development 00:52:02 Polio Vaccine: Unintended Consequences 00:55:39 The Polio Story as a Red Pill 01:25:32 HIV Origins & Parallels to COVID 01:45:04 Rethinking the Spanish Flu 01:47:31 When Interventions Cause Harm 01:49:40 Measles Mortality Data 01:56:07 Health Before Vaccination 02:03:17 Defining “Vaccine” 02:05:01 Why Hep B Remains on the Schedule 02:11:29 Autism & Vaccines 02:20:02 The Tyranny of Vaccine Mandates 02:35:27 Scientific vs. Legal Fraud 02:53:00 Trump Administration & the Childhood Schedule 03:04:38 Think of Vaccines as a Product

The DarkHorse Podcast

69,778 görüntüleme • 8 ay önce

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI
1:30:01

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI

Grant

205,995 görüntüleme • 28 gün önce

What is the truth about race and evolution? A philosophical biologist (me) and a biological philosopher Nathan Cofnas hash it out in the wake of the Jason Arday scandal. 00:00:00 The Rules of Engagement 00:03:46 Race Realist? 00:08:47 Lineage vs. Race 00:13:58 The Euphemism Treadmill 00:16:38 Is Morality Real? 00:24:51 Westermarck and the Kibbutz 00:35:34 The Incest Taboo Test 00:41:53 Where Moral Beliefs Come From 00:52:34 Wokeism as an Existential Threat 00:57:54 Darwinism Applied to Humans 01:02:21 Does Winter Make You Smarter? 01:07:53 Inuits and Ethiopians 01:10:46 Why Aren't We All Von Neumann? 01:18:10 What About West African Sprinters? 01:24:37 The Black Cats in the Dark 01:28:21 The Longest Childhood on Earth 01:35:07 Everything Is an IQ Test 01:40:59 What Slavery Broke 01:45:21 Ethiopia, Korea, Japan, China 01:49:32 The Second Mode of Inheritance 01:54:18 What We Actually Disagree About 01:57:47 The Arms Race Has No Ceiling
2:02:44

What is the truth about race and evolution? A philosophical biologist (me) and a biological philosopher Nathan Cofnas hash it out in the wake of the Jason Arday scandal. 00:00:00 The Rules of Engagement 00:03:46 Race Realist? 00:08:47 Lineage vs. Race 00:13:58 The Euphemism Treadmill 00:16:38 Is Morality Real? 00:24:51 Westermarck and the Kibbutz 00:35:34 The Incest Taboo Test 00:41:53 Where Moral Beliefs Come From 00:52:34 Wokeism as an Existential Threat 00:57:54 Darwinism Applied to Humans 01:02:21 Does Winter Make You Smarter? 01:07:53 Inuits and Ethiopians 01:10:46 Why Aren't We All Von Neumann? 01:18:10 What About West African Sprinters? 01:24:37 The Black Cats in the Dark 01:28:21 The Longest Childhood on Earth 01:35:07 Everything Is an IQ Test 01:40:59 What Slavery Broke 01:45:21 Ethiopia, Korea, Japan, China 01:49:32 The Second Mode of Inheritance 01:54:18 What We Actually Disagree About 01:57:47 The Arms Race Has No Ceiling

Bret Weinstein

191,189 görüntüleme • 4 gün önce

NEW: Bret Weinstein's Inside Rail on DarkHorse features Nina Teicholz (Nina Teicholz, PhD) discussing the topic of seed oils. 00:00:00 Welcome Nina Teicholz to DarkHorse 00:09:16 Defining Trans Fats 00:19:34 The History of Replacing Animal Fats in American Kitchens 00:29:35 Eat Mostly Plants? 00:34:26 The Nutrition Transition & Heart Disease 00:43:44 The American Heart Association 00:46:00 Why Did Americans Switch to Seed Oils? 00:54:57 Oxidation vs. Smoke point 01:02:00 Clinical Trials Associating Seed Oils with Cancer 01:05:58 Where is the Research on Seed Oils? 01:10:37 Big Food Companies’ Influence on Nutrition 01:16:40 The Problems with Nutrition Studies 01:22:03 Enormous Studies on Saturated Fats: “The Golden Age of Nutrition Research” 01:28:30 The Outcome of Going Against the Prevailing Wisdom 01:35:00 The Question Is: Who is Really Pulling the Strings Here? 01:36:45 Bret Weinstein Thinks You Should Start with This Question 01:39:17 The Low Carb & Ketogenic Diets 01:42:49 Public vs. Private Opinions & The Vegan Diet 01:54:59 Government Policy Has Created the Obesity Epidemic 01:57:26 Take Action: How to Restore Your Health 02:04:36 Closing with Nina Teicholz
2:05:54

NEW: Bret Weinstein's Inside Rail on DarkHorse features Nina Teicholz (Nina Teicholz, PhD) discussing the topic of seed oils. 00:00:00 Welcome Nina Teicholz to DarkHorse 00:09:16 Defining Trans Fats 00:19:34 The History of Replacing Animal Fats in American Kitchens 00:29:35 Eat Mostly Plants? 00:34:26 The Nutrition Transition & Heart Disease 00:43:44 The American Heart Association 00:46:00 Why Did Americans Switch to Seed Oils? 00:54:57 Oxidation vs. Smoke point 01:02:00 Clinical Trials Associating Seed Oils with Cancer 01:05:58 Where is the Research on Seed Oils? 01:10:37 Big Food Companies’ Influence on Nutrition 01:16:40 The Problems with Nutrition Studies 01:22:03 Enormous Studies on Saturated Fats: “The Golden Age of Nutrition Research” 01:28:30 The Outcome of Going Against the Prevailing Wisdom 01:35:00 The Question Is: Who is Really Pulling the Strings Here? 01:36:45 Bret Weinstein Thinks You Should Start with This Question 01:39:17 The Low Carb & Ketogenic Diets 01:42:49 Public vs. Private Opinions & The Vegan Diet 01:54:59 Government Policy Has Created the Obesity Epidemic 01:57:26 Take Action: How to Restore Your Health 02:04:36 Closing with Nina Teicholz

The DarkHorse Podcast

16,207 görüntüleme • 10 ay önce

We don't know what most microbial genes do. Can genomic language models help? there's only one way to find out! this is a 1 hour and 42 minute interview with an MIT professor (the famous Yunha Hwang) chatting about these questions, her work in solving them at Tatta Bio, and more. zoomer captions are back too Links in reply! Timestamps: 00:00:00 - Clips + sponsor roll from the wonderful LatchBio 00:02:07 – Introduction 00:02:23 – Why do microbial genomes matter 00:04:07 – Deep learning acceptance in metagenomics 00:05:25 – The case for genomic “context” over sequence matching 00:06:43 – OMG: the only ML-ready metagenomic dataset 00:09:27 – gLM2: A multimodal genomic language model 00:11:06 – What do you do with the output of genomic language models? 00:17:41 – How will OMG evolve? 00:20:26 – Why train on only microbial genomes, as opposed to all genomes? 00:22:58 – Do we need more sequences or more annotations? 00:23:54 – Is there a conserved microbial genome ‘language’? 00:28:11 – What non-obvious things can this genomic language model tell you? 00:33:08 – Semantic deduplication and evaluation 00:37:33 – How does benchmarking work for these types of models? 00:41:31 – Gaia: A genomic search engine 00:44:18 – Even ‘well-studied’ genomes are mostly unannotated 00:50:51 – Using agents on Gaia 00:54:53 – Will genomic language models reshape the tree of life? 00:59:18 – Current limitations of genomic language models 01:08:54 – Directed evolution as training data 01:12:35 – What is Tatta Bio? 01:19:02 – Building Google for genomic sequences (SeqHub) 01:25:46 – How to create communities around scientific OSS 01:29:06 – What’s the purpose in the centralization of the software? 01:35:37 – How will the way science is done change in 10 years?
1:42:41

We don't know what most microbial genes do. Can genomic language models help? there's only one way to find out! this is a 1 hour and 42 minute interview with an MIT professor (the famous Yunha Hwang) chatting about these questions, her work in solving them at Tatta Bio, and more. zoomer captions are back too Links in reply! Timestamps: 00:00:00 - Clips + sponsor roll from the wonderful LatchBio 00:02:07 – Introduction 00:02:23 – Why do microbial genomes matter 00:04:07 – Deep learning acceptance in metagenomics 00:05:25 – The case for genomic “context” over sequence matching 00:06:43 – OMG: the only ML-ready metagenomic dataset 00:09:27 – gLM2: A multimodal genomic language model 00:11:06 – What do you do with the output of genomic language models? 00:17:41 – How will OMG evolve? 00:20:26 – Why train on only microbial genomes, as opposed to all genomes? 00:22:58 – Do we need more sequences or more annotations? 00:23:54 – Is there a conserved microbial genome ‘language’? 00:28:11 – What non-obvious things can this genomic language model tell you? 00:33:08 – Semantic deduplication and evaluation 00:37:33 – How does benchmarking work for these types of models? 00:41:31 – Gaia: A genomic search engine 00:44:18 – Even ‘well-studied’ genomes are mostly unannotated 00:50:51 – Using agents on Gaia 00:54:53 – Will genomic language models reshape the tree of life? 00:59:18 – Current limitations of genomic language models 01:08:54 – Directed evolution as training data 01:12:35 – What is Tatta Bio? 01:19:02 – Building Google for genomic sequences (SeqHub) 01:25:46 – How to create communities around scientific OSS 01:29:06 – What’s the purpose in the centralization of the software? 01:35:37 – How will the way science is done change in 10 years?

owl

44,279 görüntüleme • 8 ay önce

That’s the end of the Austin House season! Mizkif has flown away in a Klat Airlines helicopter…. to a new journey, a new chapter!❤️ Here are the (3) VOD links and Timestamps: First VOD: 00:00/29:00 - Intro with all the old intro songs 29:00 - Start of Stream 30:00 - Reacting to TopKek 41:30 - Reacting to NEW TopKek (The Streamer Awards - Twitch Fails) 52:00 - Reacting to Erobb and Jason Second VOD: Starts Right Away with Super Mario 64 01:59:00 - Mizkif plays Minecraft Hardcore 03:46:00 - Mizkif plays Fall Guys 04:28:00 - Mizkif plays Jump King 05:28:00 - asianbunny comes over 11:50:00 - Mizkif plays Mario Kart 8 12:28:00 - Back to Minecraft Hardcore 14:27:00 - Mizkif calls MaryMaybe 14:39:00 - Mizkif plays Only Up! 15:39:00 - MaryMaybe comes over 18:33:00 - Reacting to Clips 18:43:00 - Back to Only Up! 19:19:00 - MaryMaybe returns 21:34:00 - Marbles with MaryMayne 22:40:00 - Fandy shows up 23:01:00 - Clara shows up 23:12:00 - Clara and Fandy react to ClipQueue 25:45:00 - Clara and Fandy react to the Top 100 Spotify Songs of All Time 27:06:00 - Island joins for the Pokemon Box Opening 29:02:00 - Mizkif, MaryMaybe, Clara and Fandy react to ClipQueue 30:09:00 - Mizkif calls Roflgator 30:24:00 - Clara and Fandy play Vampire Survivors (also Esfand shows up) 30:53:00 - Clara and Fandy play Map Quiz Game 31:19:00 - Esfand, Clara and Fandy play Balatro 32:29:00 - Mizkif names 100 Women 32:34:00 - Wake shows up 34:07:00 - Back to the craft 35:00:00 - Mizkif reacts to everybody else reacting to Playboi Carti not dropping his music on time 35:39:00 - One Hour of Wall Staring with Clara and Bunky (with the occasional Esfand entertainment) 37:36:00 - We are playing Minecraft again 39:05:00 - Mizkif reacts to the new Playboi Carti album 40:32:00 - Minecraft. Again. 40:46:00 - Morning Shift with MaryMaybe Third VOD: 35:00 - Mizkif and MaryMaybe play Pokemon Stadium 39:00 - Mizkif and MaryMaybe play Nintendo Switch Sports 46:00 - Juliakins shows up 2:13:00 - Sardaco shows up 3:29:00 - Simply shows up 3:51:00 - Going over Unban Requests 4:45:00 - Fireball Friday starts 4:59:00 - Mario Party with Simply, Sardaco and MaryMaybe 5:15:00 - AXIUN shows up 5:22:00 - Alinity shows up 5:30:00 - Knut and family show up 5:34:00 - asianbunny shows up 5:54:00 - Fandy and Bryce show up 6:04:00 - Jacob shows up 6:09:00 - Corey shows up 6:14:00 - Cam shows up 6:26:00 - Russel shows up 6:35:00 - ‘Goodbye Austin House’ Party Starts 6:42:00 - Wake shows up 6:47:00 - ExtraEmily shows up 6:48:00 - Aruuu, Poke and Clara show up 6:50:00 - The Final Goodbye to the House
0:29

That’s the end of the Austin House season! Mizkif has flown away in a Klat Airlines helicopter…. to a new journey, a new chapter!❤️ Here are the (3) VOD links and Timestamps: First VOD: 00:00/29:00 - Intro with all the old intro songs 29:00 - Start of Stream 30:00 - Reacting to TopKek 41:30 - Reacting to NEW TopKek (The Streamer Awards - Twitch Fails) 52:00 - Reacting to Erobb and Jason Second VOD: Starts Right Away with Super Mario 64 01:59:00 - Mizkif plays Minecraft Hardcore 03:46:00 - Mizkif plays Fall Guys 04:28:00 - Mizkif plays Jump King 05:28:00 - asianbunny comes over 11:50:00 - Mizkif plays Mario Kart 8 12:28:00 - Back to Minecraft Hardcore 14:27:00 - Mizkif calls MaryMaybe 14:39:00 - Mizkif plays Only Up! 15:39:00 - MaryMaybe comes over 18:33:00 - Reacting to Clips 18:43:00 - Back to Only Up! 19:19:00 - MaryMaybe returns 21:34:00 - Marbles with MaryMayne 22:40:00 - Fandy shows up 23:01:00 - Clara shows up 23:12:00 - Clara and Fandy react to ClipQueue 25:45:00 - Clara and Fandy react to the Top 100 Spotify Songs of All Time 27:06:00 - Island joins for the Pokemon Box Opening 29:02:00 - Mizkif, MaryMaybe, Clara and Fandy react to ClipQueue 30:09:00 - Mizkif calls Roflgator 30:24:00 - Clara and Fandy play Vampire Survivors (also Esfand shows up) 30:53:00 - Clara and Fandy play Map Quiz Game 31:19:00 - Esfand, Clara and Fandy play Balatro 32:29:00 - Mizkif names 100 Women 32:34:00 - Wake shows up 34:07:00 - Back to the craft 35:00:00 - Mizkif reacts to everybody else reacting to Playboi Carti not dropping his music on time 35:39:00 - One Hour of Wall Staring with Clara and Bunky (with the occasional Esfand entertainment) 37:36:00 - We are playing Minecraft again 39:05:00 - Mizkif reacts to the new Playboi Carti album 40:32:00 - Minecraft. Again. 40:46:00 - Morning Shift with MaryMaybe Third VOD: 35:00 - Mizkif and MaryMaybe play Pokemon Stadium 39:00 - Mizkif and MaryMaybe play Nintendo Switch Sports 46:00 - Juliakins shows up 2:13:00 - Sardaco shows up 3:29:00 - Simply shows up 3:51:00 - Going over Unban Requests 4:45:00 - Fireball Friday starts 4:59:00 - Mario Party with Simply, Sardaco and MaryMaybe 5:15:00 - AXIUN shows up 5:22:00 - Alinity shows up 5:30:00 - Knut and family show up 5:34:00 - asianbunny shows up 5:54:00 - Fandy and Bryce show up 6:04:00 - Jacob shows up 6:09:00 - Corey shows up 6:14:00 - Cam shows up 6:26:00 - Russel shows up 6:35:00 - ‘Goodbye Austin House’ Party Starts 6:42:00 - Wake shows up 6:47:00 - ExtraEmily shows up 6:48:00 - Aruuu, Poke and Clara show up 6:50:00 - The Final Goodbye to the House

Mizkif Updates

188,834 görüntüleme • 1 yıl önce