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Cornelius Gati

@CorneliusGati • 3,199 subscribers

Assistant Professor @USC. Structural biologist studying biophysics and pharmacology of GPCRs.

Shorts

An opioid with a literal, light-sensitive 'on/off switch' to avoid fatal side effects, that works in vivo? Look no further - Azomorphine-3 (AM3)! The most exciting study I've been part of, thus far. With Seva Katritch Dirk H. Trauner and Josh Levitz lab.

An opioid with a literal, light-sensitive 'on/off switch' to avoid fatal side effects, that works in vivo? Look no further - Azomorphine-3 (AM3)! The most exciting study I've been part of, thus far. With Seva Katritch Dirk H. Trauner and Josh Levitz lab.

15,554 Aufrufe

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Excited to share nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵

Excited to share nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵

33,648 Aufrufe • vor 8 Monaten

Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USCDornsife

Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: USC USCDornsife

29,044 Aufrufe • vor 1 Jahr

Thrilled to present our manuscript out today in Cell. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human.

Thrilled to present our manuscript out today in Cell. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human.

33,139 Aufrufe • vor 2 Jahren

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