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Danielle Beckman

@DaniBeckman • 39,377 subscribers

PharmD, MS in Biophysics, PhD in Biochemistry I like taking photos of weird things inside the brain 🔬 🇧🇷 Rio 🇺🇸 Sacramento 🇩🇪 Munich

Shorts

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend Harsharan Bhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys.

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend Harsharan Bhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys.

31,356 次观看

Charging $42,250 for an HIV drug that can be sold for $40 a year and still make 30% profit is criminal. This drug has outstanding results in preventing #HIV transmission. People at the #AIDS2024 conference protesting today.

Charging $42,250 for an HIV drug that can be sold for $40 a year and still make 30% profit is criminal. This drug has outstanding results in preventing #HIV transmission. People at the #AIDS2024 conference protesting today.

171,219 次观看

Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid

Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid

107,272 次观看

This video shows a duck infected with #H5N1. What do you see? This duck is showing signs of Parkinson's disease. This video inspired researcher Richard Smeyne to explore the connection between viral infection and neurodegeneration many years ago. #BirdFlu

This video shows a duck infected with #H5N1. What do you see? This duck is showing signs of Parkinson's disease. This video inspired researcher Richard Smeyne to explore the connection between viral infection and neurodegeneration many years ago. #BirdFlu

47,167 次观看

Happy #3DThursday! I'm quantifying some microglia morphology and trying to figure out why sometimes these cells start eliminating neuronal synapses🧐 Markers: IBA1 for microglia, PSD95 for synaptic protein. Z-stack image acquired with ZEISS Microscopy, analysis with Imaris 3D/4D Imaging

Happy #3DThursday! I'm quantifying some microglia morphology and trying to figure out why sometimes these cells start eliminating neuronal synapses🧐 Markers: IBA1 for microglia, PSD95 for synaptic protein. Z-stack image acquired with ZEISS Microscopy, analysis with Imaris 3D/4D Imaging

32,020 次观看

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Had fun putting this video together 😎 Whole-body imaging is opening new possibilities for biology. Two new preprints from Deep Piction showcase what's possible when whole-body imaging meets molecular biology: 🔬 DISCO-seq: anatomically guided single-cell transcriptomics. 🚀 LipiGo: next-generation targeted lipid nanoparticles. Seeing the whole picture changes the questions we can ask. Happy #FluorescenceFriday!

Had fun putting this video together 😎 Whole-body imaging is opening new possibilities for biology. Two new preprints from Deep Piction showcase what's possible when whole-body imaging meets molecular biology: 🔬 DISCO-seq: anatomically guided single-cell transcriptomics. 🚀 LipiGo: next-generation targeted lipid nanoparticles. Seeing the whole picture changes the questions we can ask. Happy #FluorescenceFriday!

Danielle Beckman

47,623 次观看 • 2 天前

Imagine being a badass scientist, MIT Physics, Forbes 30u30, and having millions of followers on multiple social media communicating about sciences. Just married, full of hopes and dreams. Suddenly, this is everyday life for you. This is the reality of Dianna Cowern and so many others. It can happen to anyone. #LongCovid #NotjustaFlu

Imagine being a badass scientist, MIT Physics, Forbes 30u30, and having millions of followers on multiple social media communicating about sciences. Just married, full of hopes and dreams. Suddenly, this is everyday life for you. This is the reality of Dianna Cowern and so many others. It can happen to anyone. #LongCovid #NotjustaFlu

Danielle Beckman

3,624,403 次观看 • 2 年前

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at Deep Piction🤩🔬

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at Deep Piction🤩🔬

Danielle Beckman

38,077 次观看 • 13 天前

People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.

People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.

Danielle Beckman

48,641 次观看 • 1 个月前

We are not talking enough about this? An Idaho health department isn’t allowed to give #COVID19 vaccines anymore. The first in the nation.

We are not talking enough about this? An Idaho health department isn’t allowed to give #COVID19 vaccines anymore. The first in the nation.

Danielle Beckman

277,608 次观看 • 1 年前

My last post about being sick with #COVID19 attracted much attention, good and bad. For those who wished me well, thank you very much! I have already recovered my sense of smell and taste and am improving from Covid symptoms every day. For the denialists who took precious time of their lives to come to my post and say that the virus does not exist or that it is just a common cold, just a message: I directly see the virus in the brain using microscopy, and you can see it as well in the video I made below. Viral protein (red, viral nucleocapsid) is found mainly inside neurons (blue, neun) in the olfactory cortex. Glial cells such as astrocytes (white, gfap) and microglia (green, iba1( are attacking these infected neurons, trying to slow down the viral spreading across the brain. Although beneficial, this mechanism also generates more neuroinflammatory propagation, with additional collateral damage to the circuits besides the death of infected neurons. You can deny as much as you want that this is happening, but science is here clearly proving what is going on. Our first study was published last year: We are currently also looking at how vaccines can modulate this type of neuronal damage. So far, it seems that, although not able to prevent neuronal infection, vaccination reduces the neuroinflammatory response generated by the immune system in the brain. More to come soon! #FluorescenceFriday

My last post about being sick with #COVID19 attracted much attention, good and bad. For those who wished me well, thank you very much! I have already recovered my sense of smell and taste and am improving from Covid symptoms every day. For the denialists who took precious time of their lives to come to my post and say that the virus does not exist or that it is just a common cold, just a message: I directly see the virus in the brain using microscopy, and you can see it as well in the video I made below. Viral protein (red, viral nucleocapsid) is found mainly inside neurons (blue, neun) in the olfactory cortex. Glial cells such as astrocytes (white, gfap) and microglia (green, iba1( are attacking these infected neurons, trying to slow down the viral spreading across the brain. Although beneficial, this mechanism also generates more neuroinflammatory propagation, with additional collateral damage to the circuits besides the death of infected neurons. You can deny as much as you want that this is happening, but science is here clearly proving what is going on. Our first study was published last year: We are currently also looking at how vaccines can modulate this type of neuronal damage. So far, it seems that, although not able to prevent neuronal infection, vaccination reduces the neuroinflammatory response generated by the immune system in the brain. More to come soon! #FluorescenceFriday

Danielle Beckman

387,777 次观看 • 2 年前

This video that covers our work showing how SARS-CoV-2 spreads in the brain and can cause #LongCovid is from almost 2 years ago. Unbelievable to see so little progress was made in this area... #CovidIsNotOver

This video that covers our work showing how SARS-CoV-2 spreads in the brain and can cause #LongCovid is from almost 2 years ago. Unbelievable to see so little progress was made in this area... #CovidIsNotOver

Danielle Beckman

392,482 次观看 • 2 年前

Dianna Dianna Cowern keeps showing us that there is hope for the millions of people suffering out there after infections. To everyone affected by #LongCovid and #MECFS, recovery can be slow, but it is possible! Don't give up! ❤️‍🩹

Dianna Dianna Cowern keeps showing us that there is hope for the millions of people suffering out there after infections. To everyone affected by #LongCovid and #MECFS, recovery can be slow, but it is possible! Don't give up! ❤️‍🩹

Danielle Beckman

185,731 次观看 • 1 年前

Can we please put this on street video boards all over and air it as a commercial on every channel?? #AIRBORNE #COVID

Can we please put this on street video boards all over and air it as a commercial on every channel?? #AIRBORNE #COVID

Danielle Beckman

173,627 次观看 • 1 年前

It shouldn't surprise anyone that infections can trigger cancers. It also shouldn't be a surprise that repetitive infections with a very contagious airborne virus can trigger high cancer rates in young people. #LongCovid

It shouldn't surprise anyone that infections can trigger cancers. It also shouldn't be a surprise that repetitive infections with a very contagious airborne virus can trigger high cancer rates in young people. #LongCovid

Danielle Beckman

147,451 次观看 • 1 年前

Sarah Sarah Buckel, another person affected with severe #LongCovid, opted to end her life and applied for assisted suicide. I feel so helpless and heartbroken. Too many are suffering from a disease that most people choose not to think about. It is just the flu, they say. These stories need to be seen. Please help us spread awareness about Long Covid.

Sarah Sarah Buckel, another person affected with severe #LongCovid, opted to end her life and applied for assisted suicide. I feel so helpless and heartbroken. Too many are suffering from a disease that most people choose not to think about. It is just the flu, they say. These stories need to be seen. Please help us spread awareness about Long Covid.

Danielle Beckman

152,676 次观看 • 1 年前

If you have to watch one single video in your life about Myalgic Encephalomyelitis (#MECFS), please watch the one below by Jennifer Brea🦒. Since the pandemic started, the number of people suffering like this has skyrocketed. The time to inform ourselves is now. #LongCovid

If you have to watch one single video in your life about Myalgic Encephalomyelitis (#MECFS), please watch the one below by Jennifer Brea🦒. Since the pandemic started, the number of people suffering like this has skyrocketed. The time to inform ourselves is now. #LongCovid

Danielle Beckman

159,365 次观看 • 2 年前

This is what Jay Bhattacharya, the new head of NIH, has to say about vaccinating kids for #COVID. This interview was conducted 3 months ago. He doesn't see a benefit because the kids are not dying, completely dismissing the millions getting impaired with #LongCovid.

This is what Jay Bhattacharya, the new head of NIH, has to say about vaccinating kids for #COVID. This interview was conducted 3 months ago. He doesn't see a benefit because the kids are not dying, completely dismissing the millions getting impaired with #LongCovid.

Danielle Beckman

92,178 次观看 • 1 年前

I am just a microscopist with social anxiety. But seeing #Covid impact on the brain through the lenses of the microscope has affected me. It’s hard not to feel for the millions sick everywhere. Below is a 2021 video about our research. Can we please keep talking about #LongCovid

I am just a microscopist with social anxiety. But seeing #Covid impact on the brain through the lenses of the microscope has affected me. It’s hard not to feel for the millions sick everywhere. Below is a 2021 video about our research. Can we please keep talking about #LongCovid

Danielle Beckman

54,763 次观看 • 1 年前

What We Know About Covid’s Impact on Your Brain? By Jason Gale for Bloomberg A clip of the video for those behind the paywall. Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition. #NeuroCovid

What We Know About Covid’s Impact on Your Brain? By Jason Gale for Bloomberg A clip of the video for those behind the paywall. Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition. #NeuroCovid

Danielle Beckman

61,935 次观看 • 1 年前

Imagine being able to visualize life-saving drugs or genetic therapies being delivered to the target cells without causing harmful side effects? Another amazing study from Ali Max Erturk at Nature Biotechnology 🤩

Imagine being able to visualize life-saving drugs or genetic therapies being delivered to the target cells without causing harmful side effects? Another amazing study from Ali Max Erturk at Nature Biotechnology 🤩

Danielle Beckman

41,559 次观看 • 1 年前

My friends are dying. People are dying of #LongCovid and #MECFS while society keeps ignoring their existence. Rest in peace, Faraz. Sorry we failed you.

My friends are dying. People are dying of #LongCovid and #MECFS while society keeps ignoring their existence. Rest in peace, Faraz. Sorry we failed you.

Danielle Beckman

39,088 次观看 • 1 年前

*The uninvited guest* (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

The uninvited guest (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

Danielle Beckman

24,162 次观看 • 8 个月前

Armond has #LongCovid. This is his experience. #CountLongCovid

Armond has #LongCovid. This is his experience. #CountLongCovid

Danielle Beckman

28,922 次观看 • 11 个月前