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Martin Picard

@MitoPsychoBio • 27,184 subscribers

Mitochondrial Psychobiology. Bridging the science of energy and the human experience. Upcoming book: ENERGY (2027).

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Today on The Science and Experience of Energy, we describe mysterious mitochondria-like particles that we found in blood and saliva using high-resolution electron microscopy. These particles had double membranes, and some had folds in the internal membrane—a feature that is unique to mitochondria. We don’t yet know what exactly these particles are or their purpose, but we're excited to learn more about them. The massive image database is the first of its kind—have a look if you want to see what circulates in the human blood. Thanks to NIH and Baszucki Group who've supported our work, this resource is freely available to everyone.

Today on The Science and Experience of Energy, we describe mysterious mitochondria-like particles that we found in blood and saliva using high-resolution electron microscopy. These particles had double membranes, and some had folds in the internal membrane—a feature that is unique to mitochondria. We don’t yet know what exactly these particles are or their purpose, but we're excited to learn more about them. The massive image database is the first of its kind—have a look if you want to see what circulates in the human blood. Thanks to NIH and Baszucki Group who've supported our work, this resource is freely available to everyone.

12,972 views

The cycle of life, every instant, in your mitochondria. The major electron carrier in mitochondria is NAD+. When it collects an electron from the food you eat, NAD+ is converted into NADH. NADH then feeds the electron to the electron transport chain so the electron can flow to oxygen - the ultimate electron acceptor. How easily electrons make their way to oxygen determines energy resistance (éR) following the energy resistance principle (ERP) Mitochondrial matrix and cell cytoplasm are two different "sealed" compartments, but there is a special system that connects the NAD+/NADH pools between mito and cytoplasm: the Malate-Aspartate shuttle The Malate-Aspartate shuttle shown below is how NADH from the cytoplasm (made by glycolysis) is carried into mitochondria. The electron transport chain can then regenerate NAD+ by respiring the flowing electron. Everywhere in biology: energy transfer. Sometimes without molecular carriers. Here with a number of enzymatic intermediates, creating an integrated electrical circuit. The circuit is in service of the flowing electron looking for a place to rest. Getting back onto oxygen to become H2O (water) again, as it was initially before getting ripped off by light energy and stuck onto a carbon backbone in a green leaf. Animation by Janet Iwasa lab

The cycle of life, every instant, in your mitochondria. The major electron carrier in mitochondria is NAD+. When it collects an electron from the food you eat, NAD+ is converted into NADH. NADH then feeds the electron to the electron transport chain so the electron can flow to oxygen - the ultimate electron acceptor. How easily electrons make their way to oxygen determines energy resistance (éR) following the energy resistance principle (ERP) Mitochondrial matrix and cell cytoplasm are two different "sealed" compartments, but there is a special system that connects the NAD+/NADH pools between mito and cytoplasm: the Malate-Aspartate shuttle The Malate-Aspartate shuttle shown below is how NADH from the cytoplasm (made by glycolysis) is carried into mitochondria. The electron transport chain can then regenerate NAD+ by respiring the flowing electron. Everywhere in biology: energy transfer. Sometimes without molecular carriers. Here with a number of enzymatic intermediates, creating an integrated electrical circuit. The circuit is in service of the flowing electron looking for a place to rest. Getting back onto oxygen to become H2O (water) again, as it was initially before getting ripped off by light energy and stuck onto a carbon backbone in a green leaf. Animation by Janet Iwasa lab

121,890 views

Seeing this mitochondrial reconstruction for the first time with MJ McManus was one of the most exciting sight ever! It changed my life. What do you see? The story behind cristae alignment here:

Seeing this mitochondrial reconstruction for the first time with MJ McManus was one of the most exciting sight ever! It changed my life. What do you see? The story behind cristae alignment here:

55,758 views

In our bodies, a whole universe of energy

In our bodies, a whole universe of energy

26,779 views

During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA! We now find that mito-nuclear DNA transfer happens in the human brain along the lifespan and every few days in cultured cells.

During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA! We now find that mito-nuclear DNA transfer happens in the human brain along the lifespan and every few days in cultured cells.

20,454 views

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Nobody is the average. You are not the average, I am not the average... yet most of our scientific approach to health/disease is a science of averages that says little about you as a person. I understand people's frustration. We need a new way of doing science that serves each of us. We are all agents in building a healthier, more compassionate, sustainable future. I feel inspired to help build that future. Exciting times ahead! More about current initiatives in partnership with @msahsorin and our growing team here:
2:07
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Nobody is the average. You are not the average, I am not the average... yet most of our scientific approach to health/disease is a science of averages that says little about you as a person. I understand people's frustration. We need a new way of doing science that serves each of us. We are all agents in building a healthier, more compassionate, sustainable future. I feel inspired to help build that future. Exciting times ahead! More about current initiatives in partnership with @msahsorin and our growing team here:

Martin Picard

253,603 views • 8 months ago

Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By Janet Iwasa
0:40
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Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By Janet Iwasa

Martin Picard

266,099 views • 1 year ago

Cells feel each other
0:20
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Cells feel each other

Martin Picard

91,170 views • 6 months ago

Understanding the brain and mental health from an energetic perspective ushers psychiatry into its next phase of evolution. Exciting times!
1:36
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Understanding the brain and mental health from an energetic perspective ushers psychiatry into its next phase of evolution. Exciting times!

Martin Picard

33,512 views • 3 months ago

Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!
3:15
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Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!

Martin Picard

12,796 views • 1 month ago

Every second, trillions of flowing cells transporting oxygen to your respiring mitochondria The blood is the bridge between breath and flowing electrons in your mitochondria So beautiful !
1:06
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Every second, trillions of flowing cells transporting oxygen to your respiring mitochondria The blood is the bridge between breath and flowing electrons in your mitochondria So beautiful !

Martin Picard

87,539 views • 1 year ago

When we look at life up close, like chromosome separation, it's always so jiggly! 😯 This is the stuff our energy flows through. No wonder that human lives and experiences also are jiggly, unstable, and beautifully unpredictable.
0:22
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When we look at life up close, like chromosome separation, it's always so jiggly! 😯 This is the stuff our energy flows through. No wonder that human lives and experiences also are jiggly, unstable, and beautifully unpredictable.

Martin Picard

48,244 views • 10 months ago

How much energy does it cost to grow a new spinal cord during development?
0:22
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How much energy does it cost to grow a new spinal cord during development?

Martin Picard

70,525 views • 1 year ago

Walking along a single hair strand shows the sudden greying (over a few days), and subsequent full regain of pigmentation The white segment corresponded to "the most stressful two months of my life" for this participant The first *quantitative* evidence of a link between stress and hair greying in humans There also was a change in the proteome of that hair between the "youthful" dark and "aged" white segments: MORE mitochondrial proteins in the white segment, suggesting metabolic recalibrations linked to the high stress period
0:27
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Walking along a single hair strand shows the sudden greying (over a few days), and subsequent full regain of pigmentation The white segment corresponded to "the most stressful two months of my life" for this participant The first *quantitative* evidence of a link between stress and hair greying in humans There also was a change in the proteome of that hair between the "youthful" dark and "aged" white segments: MORE mitochondrial proteins in the white segment, suggesting metabolic recalibrations linked to the high stress period

Martin Picard

55,574 views • 1 year ago

Look at those beautiful mitochondria (red) surrounding a lipid droplet in a liver cell!
0:28
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Look at those beautiful mitochondria (red) surrounding a lipid droplet in a liver cell!

Martin Picard

23,018 views • 7 months ago

Energy metabolism is really quite remarkable Little bits of energy we call metabolites flow continuously, converging in our mitochondria (TCA or Krebs cycle) where they are re-routed and directed where needed The basis of life and health is the flow of energy Great animation showing the fate, trajectory, and possible routes that glucose (top) and glutamine (bottom right) take within most of our cells Video by Janet Iwasa
0:40
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Energy metabolism is really quite remarkable Little bits of energy we call metabolites flow continuously, converging in our mitochondria (TCA or Krebs cycle) where they are re-routed and directed where needed The basis of life and health is the flow of energy Great animation showing the fate, trajectory, and possible routes that glucose (top) and glutamine (bottom right) take within most of our cells Video by Janet Iwasa

Martin Picard

35,655 views • 1 year ago

Deep thoughts on quantum biology: "Every single thing is connected through a string of vibration"
2:19
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Deep thoughts on quantum biology: "Every single thing is connected through a string of vibration"

Martin Picard

37,159 views • 1 year ago

Exercise triggers mitochondrial biogenesis, increasing the number and size of the mitochondrial collective in various cell types What else do we know increases mitochondrial content? What else should we test?
0:33
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Exercise triggers mitochondrial biogenesis, increasing the number and size of the mitochondrial collective in various cell types What else do we know increases mitochondrial content? What else should we test?

Martin Picard

26,874 views • 1 year ago

Neurons are amazing Energetically expensive to power but magnificent integrative units each with a mitochondrial information processing system (MIPS)
0:45
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Neurons are amazing Energetically expensive to power but magnificent integrative units each with a mitochondrial information processing system (MIPS)

Martin Picard

27,899 views • 1 year ago

Our states of mind are connected to our mitochondria.
3:28
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Our states of mind are connected to our mitochondria.

Martin Picard

15,644 views • 8 months ago

You are an energetic process We enter an energetic paradigm allowing us to understand how feeding mitochondria what they need may help address physical and mental health disorders Metabolic Mind Thank you Lauren Kennedy West for sharing your story
1:37
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You are an energetic process We enter an energetic paradigm allowing us to understand how feeding mitochondria what they need may help address physical and mental health disorders Metabolic Mind Thank you Lauren Kennedy West for sharing your story

Martin Picard

14,970 views • 1 year ago

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