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Siqi Chen

@blader • 416,214 subscribers

🏗️ Love to build (@arithecfo @sandboxvr @zynga) people love 💸 Investor @mercury @owner @elevenlabs @gammaapp @sfcompute @turingcom @recallai @eightsleep ++

Shorts

two days ago, sam altman casually mentions that openai recently made a huge breakthrough that pushes “the frontier of discovery forward - the 4th such breakthrough in its 8 year history. yesterday, the decel faction suddenly ousts him. no coincidence.

two days ago, sam altman casually mentions that openai recently made a huge breakthrough that pushes “the frontier of discovery forward - the 4th such breakthrough in its 8 year history. yesterday, the decel faction suddenly ousts him. no coincidence.

1,154,106 次观看

over the weekend, i built an app that i sincerely hope you will never have a need for, but if you do happen to need a friendly, free, private mri viewer designed to make it easy for you to track tumor progression, you can try it here: here's the story: as some of you may know, last last september, my six year old daughter mira was diagnosed with an extremely rare brain tumor called an adamatinomatous craniopharyngioma, and since then our family has been doing everything we can possibly do to find a cure for her. we tortured chatgpt deep research, put together our own private research team, raised $1.4M and donated it all to Hankinson-Mitra Lab research thanks to $MIRA, explored every remotely applicable drug whether on the market or not, and even began working with md anderson to develop a personalized vaccine that we hope can lead to a more permanent cure unfortunately, we received the devastating news last march that the tumor has continued to grow since her initial surgery, and we had to start to consider more drastic options which would have seriously impacted mira’s quality of life. thankfully, with the help of dr. sabine mueller UCSF Benioff SF and the Hankinson-Mitra Lab at the university of colorado, in april, we started her on an alternative but extremely experimental treatment for this disease. to our unimaginable relief, her tumor has responded extraordinarily well to this treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibhits VEGF proteins). we know this, because mira gets an MRI scan of her brain every few months. and every time we get a new scan, the first thing we do is compare it against her last scan. so we have to find the matching weight of the scan, and then find the same plane, and then carefully find the slices of the scan where the tumor is visible, and then find the closest match to last month’s scan, then adjust the zoom, rotation, and brightness / contrast so they all look the same. we got pretty good at this. but it shouldn't be this hard. so i built last weekend using gemini 3 with some gpt 5.2 xhigh. you just import your DICOM MRI files (either zip, files or a folder), and you can align all of your scans across multiple dates instantly, just click and drag a rectangle around the tumor on any image, and it will use some very clever algorithms to automatically align up and find the closest matching slice from all your other scans, match the brightness / contrast, rotation, pan, zoom, and even shear to make sure the registration is as close as possible, and make it as easy to possible to compare tumor progression. it has a grid view so you can see all your scans for the same location all at once, and an overlay view so you can quickly compare two scans visually (by holding down the space bar to toggle quickly between two scans), along with tools to animate your scans both within the same sequence as well as over multiple scans to show progression. there is no server, it runs entirely locally on your browser - nothing ever gets uploaded and it's all open source: if you've found this useful, please consider a donation to the UCSF Benioff SF hospital foundation, who has given us extraordinary care over the past year or so:

over the weekend, i built an app that i sincerely hope you will never have a need for, but if you do happen to need a friendly, free, private mri viewer designed to make it easy for you to track tumor progression, you can try it here: here's the story: as some of you may know, last last september, my six year old daughter mira was diagnosed with an extremely rare brain tumor called an adamatinomatous craniopharyngioma, and since then our family has been doing everything we can possibly do to find a cure for her. we tortured chatgpt deep research, put together our own private research team, raised $1.4M and donated it all to Hankinson-Mitra Lab research thanks to $MIRA, explored every remotely applicable drug whether on the market or not, and even began working with md anderson to develop a personalized vaccine that we hope can lead to a more permanent cure unfortunately, we received the devastating news last march that the tumor has continued to grow since her initial surgery, and we had to start to consider more drastic options which would have seriously impacted mira’s quality of life. thankfully, with the help of dr. sabine mueller UCSF Benioff SF and the Hankinson-Mitra Lab at the university of colorado, in april, we started her on an alternative but extremely experimental treatment for this disease. to our unimaginable relief, her tumor has responded extraordinarily well to this treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibhits VEGF proteins). we know this, because mira gets an MRI scan of her brain every few months. and every time we get a new scan, the first thing we do is compare it against her last scan. so we have to find the matching weight of the scan, and then find the same plane, and then carefully find the slices of the scan where the tumor is visible, and then find the closest match to last month’s scan, then adjust the zoom, rotation, and brightness / contrast so they all look the same. we got pretty good at this. but it shouldn't be this hard. so i built last weekend using gemini 3 with some gpt 5.2 xhigh. you just import your DICOM MRI files (either zip, files or a folder), and you can align all of your scans across multiple dates instantly, just click and drag a rectangle around the tumor on any image, and it will use some very clever algorithms to automatically align up and find the closest matching slice from all your other scans, match the brightness / contrast, rotation, pan, zoom, and even shear to make sure the registration is as close as possible, and make it as easy to possible to compare tumor progression. it has a grid view so you can see all your scans for the same location all at once, and an overlay view so you can quickly compare two scans visually (by holding down the space bar to toggle quickly between two scans), along with tools to animate your scans both within the same sequence as well as over multiple scans to show progression. there is no server, it runs entirely locally on your browser - nothing ever gets uploaded and it's all open source: if you've found this useful, please consider a donation to the UCSF Benioff SF hospital foundation, who has given us extraordinary care over the past year or so:

209,414 次观看

"Are you fucking kidding me?" ^ how damianjesparza.eth, CEO of SmartProperty reacted when cfo.ai found $400K left on table for him, in real time.

"Are you fucking kidding me?" ^ how damianjesparza.eth, CEO of SmartProperty reacted when cfo.ai found $400K left on table for him, in real time.

12,783 次观看

"I am so in love with I can't get enough of it, I need it to be in my eyes at all times." i thought Waseem was kidding about wanting in his eyes at all times, but turns out he meant it literally:

"I am so in love with I can't get enough of it, I need it to be in my eyes at all times." i thought Waseem was kidding about wanting in his eyes at all times, but turns out he meant it literally:

13,119 次观看

founder led marketing

founder led marketing

81,119 次观看

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wait what how does the first lady of china speak better american than the first lady of america

wait what how does the first lady of china speak better american than the first lady of america

7,175,420 次观看 • 1 个月前

update less than a week in, is growing faster than runway has ever grown in any month in our entire history anyway 1. here's your obligatory launch video 2. you can now just sign up and try instantly. for free. no waitlist. 3. tag cfo.ai with your most unhinged financial modeling requests. she's back on duty and feeling spicy. (and so is Geri but people won't stop asking him about his memecoin 🤷)

update less than a week in, is growing faster than runway has ever grown in any month in our entire history anyway 1. here's your obligatory launch video 2. you can now just sign up and try instantly. for free. no waitlist. 3. tag cfo.ai with your most unhinged financial modeling requests. she's back on duty and feeling spicy. (and so is Geri but people won't stop asking him about his memecoin 🤷)

363,290 次观看 • 1 个月前

i showed my wife this video of muhammad ali's boxing gloves and she was like: "uh yeah it's a pair of boxing gloves, so what." then i told her the gloves weren't actually there and it's an AR rendering and she went 🤯

i showed my wife this video of muhammad ali's boxing gloves and she was like: "uh yeah it's a pair of boxing gloves, so what." then i told her the gloves weren't actually there and it's an AR rendering and she went 🤯

4,338,158 次观看 • 2 年前

so we raised a new round, but haven't told anyone yet our investors are like, hey put our money to use how come burn isn't going up i gotchu fam introducing burn rate by runway an award winning, blind taste-tested (by me!) hot sauce, wrapped in a genuine $100 bill for $13.99

so we raised a new round, but haven't told anyone yet our investors are like, hey put our money to use how come burn isn't going up i gotchu fam introducing burn rate by runway an award winning, blind taste-tested (by me!) hot sauce, wrapped in a genuine $100 bill for $13.99

1,403,517 次观看 • 1 年前

we spent the last four years reimagining what finance can be, unburdened by what has been. runway makes clear the significance of the passage of time in the context of all in which your business lives and what came before you. this is the result 👇

we spent the last four years reimagining what finance can be, unburdened by what has been. runway makes clear the significance of the passage of time in the context of all in which your business lives and what came before you. this is the result 👇

2,259,615 次观看 • 2 年前

$"Within an hour of setting up Ari, I was floored…" "I'm not usually so impressed by something that I want to jump on a call immediately. I imagine you guys have been hearing similar feedback. It's impressive." - Jake Petoskey, CEO Lighthouse Partners (a fractional CFO group)$

"Within an hour of setting up Ari, I was floored…" "I'm not usually so impressed by something that I want to jump on a call immediately. I imagine you guys have been hearing similar feedback. It's impressive." - Jake Petoskey, CEO Lighthouse Partners (a fractional CFO group)

55,074 次观看 • 25 天前

gpt-4 can turn your napkin sketch into a web app, instantly. we are deep into uncharted territory here.

gpt-4 can turn your napkin sketch into a web app, instantly. we are deep into uncharted territory here.

2,094,722 次观看 • 3 年前

“I've done more for the environment than any single human on earth. What I care about is the reality of goodness, not the perception of it - and what I see all over the place is people who care about looking good while doing evil.” “Fuck them."

“I've done more for the environment than any single human on earth. What I care about is the reality of goodness, not the perception of it - and what I see all over the place is people who care about looking good while doing evil.” “Fuck them."

591,324 次观看 • 2 年前

leaked footage from openai's sora 2. i thought this kind of quality was maybe a year away but here we are. coming next week.

leaked footage from openai's sora 2. i thought this kind of quality was maybe a year away but here we are. coming next week.

303,791 次观看 • 1 年前

hey you watch this video about runway it's like 47 seconds and it's fire

hey you watch this video about runway it's like 47 seconds and it's fire

117,959 次观看 • 2 年前

this is an absolutely wild unpaid ad for @sandboxvr on rogan’s podcast with zuck, it’s so enthusiastic i almost thought it was ai generated but no it’s actually real

this is an absolutely wild unpaid ad for @sandboxvr on rogan’s podcast with zuck, it’s so enthusiastic i almost thought it was ai generated but no it’s actually real

31,313 次观看 • 1 年前

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