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Danielle Beckman

@DaniBeckman • 39,409 subscribers

PharmD, MSc in Biophysics, PhD in Biochemistry 🇧🇷 🇺🇸 🇩🇪 International Society of Long COVID & Post-Acute Infection Syndromes: https://t.co/L7rdQ9mOPm

Shorts

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend Harsharan Bhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys.

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend Harsharan Bhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys.

31,923 views

Charging $42,250 for an HIV drug that can be sold for $40 a year and still make 30% profit is criminal. This drug has outstanding results in preventing #HIV transmission. People at the #AIDS2024 conference protesting today.

Charging $42,250 for an HIV drug that can be sold for $40 a year and still make 30% profit is criminal. This drug has outstanding results in preventing #HIV transmission. People at the #AIDS2024 conference protesting today.

171,612 views

Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid

Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid

107,291 views

Happy #3DThursday! I'm quantifying some microglia morphology and trying to figure out why sometimes these cells start eliminating neuronal synapses🧐 Markers: IBA1 for microglia, PSD95 for synaptic protein. Z-stack image acquired with ZEISS Microscopy, analysis with Imaris 3D/4D Imaging

Happy #3DThursday! I'm quantifying some microglia morphology and trying to figure out why sometimes these cells start eliminating neuronal synapses🧐 Markers: IBA1 for microglia, PSD95 for synaptic protein. Z-stack image acquired with ZEISS Microscopy, analysis with Imaris 3D/4D Imaging

32,020 views

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Had fun putting this video together 😎 Whole-body imaging is opening new possibilities for biology. Two new preprints from Deep Piction showcase what's possible when whole-body imaging meets molecular biology: 🔬 DISCO-seq: anatomically guided single-cell transcriptomics. 🚀 LipiGo: next-generation targeted lipid nanoparticles. Seeing the whole picture changes the questions we can ask. Happy #FluorescenceFriday!

Had fun putting this video together 😎 Whole-body imaging is opening new possibilities for biology. Two new preprints from Deep Piction showcase what's possible when whole-body imaging meets molecular biology: 🔬 DISCO-seq: anatomically guided single-cell transcriptomics. 🚀 LipiGo: next-generation targeted lipid nanoparticles. Seeing the whole picture changes the questions we can ask. Happy #FluorescenceFriday!

Danielle Beckman

49,819 views • 2 months ago

We are not talking enough about this? An Idaho health department isn’t allowed to give #COVID19 vaccines anymore. The first in the nation.

We are not talking enough about this? An Idaho health department isn’t allowed to give #COVID19 vaccines anymore. The first in the nation.

Danielle Beckman

277,627 views • 1 year ago

My last post about being sick with #COVID19 attracted much attention, good and bad. For those who wished me well, thank you very much! I have already recovered my sense of smell and taste and am improving from Covid symptoms every day. For the denialists who took precious time of their lives to come to my post and say that the virus does not exist or that it is just a common cold, just a message: I directly see the virus in the brain using microscopy, and you can see it as well in the video I made below. Viral protein (red, viral nucleocapsid) is found mainly inside neurons (blue, neun) in the olfactory cortex. Glial cells such as astrocytes (white, gfap) and microglia (green, iba1( are attacking these infected neurons, trying to slow down the viral spreading across the brain. Although beneficial, this mechanism also generates more neuroinflammatory propagation, with additional collateral damage to the circuits besides the death of infected neurons. You can deny as much as you want that this is happening, but science is here clearly proving what is going on. Our first study was published last year: We are currently also looking at how vaccines can modulate this type of neuronal damage. So far, it seems that, although not able to prevent neuronal infection, vaccination reduces the neuroinflammatory response generated by the immune system in the brain. More to come soon! #FluorescenceFriday

My last post about being sick with #COVID19 attracted much attention, good and bad. For those who wished me well, thank you very much! I have already recovered my sense of smell and taste and am improving from Covid symptoms every day. For the denialists who took precious time of their lives to come to my post and say that the virus does not exist or that it is just a common cold, just a message: I directly see the virus in the brain using microscopy, and you can see it as well in the video I made below. Viral protein (red, viral nucleocapsid) is found mainly inside neurons (blue, neun) in the olfactory cortex. Glial cells such as astrocytes (white, gfap) and microglia (green, iba1( are attacking these infected neurons, trying to slow down the viral spreading across the brain. Although beneficial, this mechanism also generates more neuroinflammatory propagation, with additional collateral damage to the circuits besides the death of infected neurons. You can deny as much as you want that this is happening, but science is here clearly proving what is going on. Our first study was published last year: We are currently also looking at how vaccines can modulate this type of neuronal damage. So far, it seems that, although not able to prevent neuronal infection, vaccination reduces the neuroinflammatory response generated by the immune system in the brain. More to come soon! #FluorescenceFriday

Danielle Beckman

387,794 views • 2 years ago

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at Deep Piction🤩🔬

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at Deep Piction🤩🔬

Danielle Beckman

40,725 views • 2 months ago

This video that covers our work showing how SARS-CoV-2 spreads in the brain and can cause #LongCovid is from almost 2 years ago. Unbelievable to see so little progress was made in this area... #CovidIsNotOver

This video that covers our work showing how SARS-CoV-2 spreads in the brain and can cause #LongCovid is from almost 2 years ago. Unbelievable to see so little progress was made in this area... #CovidIsNotOver

Danielle Beckman

392,494 views • 3 years ago

People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.

People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.

Danielle Beckman

48,849 views • 3 months ago

Dianna Dianna Cowern keeps showing us that there is hope for the millions of people suffering out there after infections. To everyone affected by #LongCovid and #MECFS, recovery can be slow, but it is possible! Don't give up! ❤️‍🩹

Dianna Dianna Cowern keeps showing us that there is hope for the millions of people suffering out there after infections. To everyone affected by #LongCovid and #MECFS, recovery can be slow, but it is possible! Don't give up! ❤️‍🩹

Danielle Beckman

185,731 views • 1 year ago

Can we please put this on street video boards all over and air it as a commercial on every channel?? #AIRBORNE #COVID

Can we please put this on street video boards all over and air it as a commercial on every channel?? #AIRBORNE #COVID

Danielle Beckman

173,689 views • 1 year ago

It shouldn't surprise anyone that infections can trigger cancers. It also shouldn't be a surprise that repetitive infections with a very contagious airborne virus can trigger high cancer rates in young people. #LongCovid

It shouldn't surprise anyone that infections can trigger cancers. It also shouldn't be a surprise that repetitive infections with a very contagious airborne virus can trigger high cancer rates in young people. #LongCovid

Danielle Beckman

147,484 views • 1 year ago

If you have to watch one single video in your life about Myalgic Encephalomyelitis (#MECFS), please watch the one below by Jennifer Brea🦒. Since the pandemic started, the number of people suffering like this has skyrocketed. The time to inform ourselves is now. #LongCovid

If you have to watch one single video in your life about Myalgic Encephalomyelitis (#MECFS), please watch the one below by Jennifer Brea🦒. Since the pandemic started, the number of people suffering like this has skyrocketed. The time to inform ourselves is now. #LongCovid

Danielle Beckman

163,021 views • 2 years ago

This is what Jay Bhattacharya, the new head of NIH, has to say about vaccinating kids for #COVID. This interview was conducted 3 months ago. He doesn't see a benefit because the kids are not dying, completely dismissing the millions getting impaired with #LongCovid.

This is what Jay Bhattacharya, the new head of NIH, has to say about vaccinating kids for #COVID. This interview was conducted 3 months ago. He doesn't see a benefit because the kids are not dying, completely dismissing the millions getting impaired with #LongCovid.

Danielle Beckman

92,178 views • 1 year ago

An intact human heart, rendered transparent. Because disease doesn't happen in 2D. Whole-organ tissue clearing + microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ. More at: 🫀🔬#FluorescenceFriday!

An intact human heart, rendered transparent. Because disease doesn't happen in 2D. Whole-organ tissue clearing + microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ. More at: 🫀🔬#FluorescenceFriday!

Danielle Beckman

13,064 views • 1 month ago

The denialists can keep trying, but the science will keep coming. I know it is scary, but we won't stop talking about it. As Ali Max Erturk said, this is not just an individual health issue – it is a societal challenge. #NeuroCovid #LongCovid

The denialists can keep trying, but the science will keep coming. I know it is scary, but we won't stop talking about it. As Ali Max Erturk said, this is not just an individual health issue – it is a societal challenge. #NeuroCovid #LongCovid

Danielle Beckman

78,818 views • 1 year ago

I am just a microscopist with social anxiety. But seeing #Covid impact on the brain through the lenses of the microscope has affected me. It’s hard not to feel for the millions sick everywhere. Below is a 2021 video about our research. Can we please keep talking about #LongCovid

I am just a microscopist with social anxiety. But seeing #Covid impact on the brain through the lenses of the microscope has affected me. It’s hard not to feel for the millions sick everywhere. Below is a 2021 video about our research. Can we please keep talking about #LongCovid

Danielle Beckman

54,776 views • 1 year ago

What We Know About Covid’s Impact on Your Brain? By Jason Gale for Bloomberg A clip of the video for those behind the paywall. Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition. #NeuroCovid

What We Know About Covid’s Impact on Your Brain? By Jason Gale for Bloomberg A clip of the video for those behind the paywall. Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition. #NeuroCovid

Danielle Beckman

61,940 views • 1 year ago

Imagine being able to visualize life-saving drugs or genetic therapies being delivered to the target cells without causing harmful side effects? Another amazing study from Ali Max Erturk at Nature Biotechnology 🤩

Imagine being able to visualize life-saving drugs or genetic therapies being delivered to the target cells without causing harmful side effects? Another amazing study from Ali Max Erturk at Nature Biotechnology 🤩

Danielle Beckman

41,559 views • 1 year ago

My friends are dying. People are dying of #LongCovid and #MECFS while society keeps ignoring their existence. Rest in peace, Faraz. Sorry we failed you.

My friends are dying. People are dying of #LongCovid and #MECFS while society keeps ignoring their existence. Rest in peace, Faraz. Sorry we failed you.

Danielle Beckman

39,094 views • 1 year ago

*The uninvited guest* (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

The uninvited guest (sound on) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

Danielle Beckman

24,201 views • 10 months ago