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David Sinclair

@davidasinclair • 608,123 subscribers

Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan

Shorts

Broke a rule by eating a snack bar before bed. It completely messed up my glucose & I woke up feeling ill. Won’t do that again ❌

Broke a rule by eating a snack bar before bed. It completely messed up my glucose & I woke up feeling ill. Won’t do that again ❌

1,154,099 views

In my experience, ideas that take seconds to conceive take years to confirm in the lab and 1–2 years to get published in a top journal. This is biology’s Achilles heel Let’s see if AI can fix that

In my experience, ideas that take seconds to conceive take years to confirm in the lab and 1–2 years to get published in a top journal. This is biology’s Achilles heel Let’s see if AI can fix that

95,586 views

When our lab’s first baby jellyfish started moving

When our lab’s first baby jellyfish started moving

32,901 views

Naked mole rats are cool: Almost blind, highly social, with hierarchies like bees. The queen develops a long hump on her back & gives birth to all the offspring Mole rats evolved to maintain their bodies for a long time because they have no predators, unlike regular rats 🐀

Naked mole rats are cool: Almost blind, highly social, with hierarchies like bees. The queen develops a long hump on her back & gives birth to all the offspring Mole rats evolved to maintain their bodies for a long time because they have no predators, unlike regular rats 🐀

88,194 views

The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results. Could S+M be a longevity combo and who owns it? 🧵

The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results. Could S+M be a longevity combo and who owns it? 🧵

94,184 views

We live in an age of scientific misinformation. Fake journals churn out unreliable & fraudulent papers, which are then hyped on social media & disseminated for profit by deepfake channels allowed to persist on YouTube and TikTok US. How does the public know the truth anymore?

We live in an age of scientific misinformation. Fake journals churn out unreliable & fraudulent papers, which are then hyped on social media & disseminated for profit by deepfake channels allowed to persist on YouTube and TikTok US. How does the public know the truth anymore?

23,189 views

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Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/
4:32
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Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

David Sinclair

1,522,922 views • 3 years ago

Aortic aneurysms are known as the “silent killer”. Rupture of a bulging vessel can kill you in minutes. New study links low NAD+ to the formation of aneurysms. So, How do you prevent them? Can you detect them? Might taking NAD boosters help? A personal thread... 🧵
1:10
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Aortic aneurysms are known as the “silent killer”. Rupture of a bulging vessel can kill you in minutes. New study links low NAD+ to the formation of aneurysms. So, How do you prevent them? Can you detect them? Might taking NAD boosters help? A personal thread... 🧵

David Sinclair

242,576 views • 1 year ago

Landmark speech in UK’s House of Lords yesterday: “By becoming the first country to treat ageing as a medical condition, we can chart a course for more effective interventions and improved health outcomes.” Transcript below Evgeny Lebedev
4:02
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Landmark speech in UK’s House of Lords yesterday: “By becoming the first country to treat ageing as a medical condition, we can chart a course for more effective interventions and improved health outcomes.” Transcript below Evgeny Lebedev

David Sinclair

163,646 views • 1 year ago

Medicines that cause glucose expulsion in urine called SGLT2 inhibitors are putative longevity drugs. They also prevent aortic stenosis, but how? New pre-print says it's SIRT1 in the valve cells, pointing to SIRT1 activators & NAD precursors as therapeutics 🧵
0:31
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Medicines that cause glucose expulsion in urine called SGLT2 inhibitors are putative longevity drugs. They also prevent aortic stenosis, but how? New pre-print says it's SIRT1 in the valve cells, pointing to SIRT1 activators & NAD precursors as therapeutics 🧵

David Sinclair

67,712 views • 1 year ago

Terminating our funding to do what the government deemed high-priority medical research punishes America
0:42
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Terminating our funding to do what the government deemed high-priority medical research punishes America

David Sinclair

38,252 views • 1 year ago

Had fun helping lower the biological age of comedian-author David Walliams HQ on Brave New World with Evgeny Lebedev
0:27
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Had fun helping lower the biological age of comedian-author David Walliams HQ on Brave New World with Evgeny Lebedev

David Sinclair

44,317 views • 2 years ago

This is the chat we postponed because Serena’s doggie Jezebel 🐶 was passing away. Thankfully, Serena is back!
0:20
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This is the chat we postponed because Serena’s doggie Jezebel 🐶 was passing away. Thankfully, Serena is back!

David Sinclair

33,665 views • 2 years ago

Announcing "mPhenoAge," the first composite biological age measure for mice. Perfect for anyone who needs to know how old their mouse really is 🐭🧵 bioRxiv ISB @volofoundation
4:50
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Announcing "mPhenoAge," the first composite biological age measure for mice. Perfect for anyone who needs to know how old their mouse really is 🐭🧵 bioRxiv ISB @volofoundation

David Sinclair

16,608 views • 1 year ago

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