The mTOR inhibitor Sapanisertib is a putative longevity molecule... that makes human skin cells & prematurely old fish healthier Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results. Could S+M be a longevity combo and who owns it? 🧵show more

🚨 BREAKING The first drug where AI designed both... the target and the molecule has just published Phase II results in Nature Medicine. Patients with a fatal lung disease gained lung function in 12 weeks. Current treatments only slow the decline. This is different. 🧵 Here's what just happened (and why it matters for medicine). #AIDrugDiscovery #ArtificialIntelligenceshow more

BREAKING: The FDA approved a cancer drug in 2024... that doesn't use chemotherapy. Instead, it powers up the immune cells you were BORN with. In trials, 62% of patients had all detectable cancer disappear completely. This is not hype. Here's what it actually is — and why it doesn't stop with cancer. 🧵show more

🚨 BREAKING NEWS 🚨 Humans are now entering the... first FDA-approved trial of partial epigenetic reprogramming. This is one of the biggest longevity experiments ever attempted. The idea comes from the Yamanaka factors: special genetic instructions that can reset a cell’s biological age. A full reset turns cells back into stem cells dangerous and potentially cancerous. But scientists discovered something remarkable: A partial reset may rejuvenate cells while preserving their identity. Not replacing the cell. Refreshing it. In mice, versions of this approach restored vision, repaired damaged tissue, and extended lifespan dramatically in some studies. Now the technology is moving into human trials targeting the eye. Why the eye? Because it’s isolated, measurable, and easier to monitor safely. The deeper implication is massive: Aging may not just be damage accumulation. It may partly be an information problem. Cells might carry a kind of biological “memory corruption” over time and epigenetic reprogramming could restore the original instructions. Not immortality. But potentially the first real step toward programmable aging. Follow me if you want to see where biology becomes code.show more

This drone footage by Wireless for Drake performance is... insane…the visual…the crowd…the sound. Instead of partnering with Amazon I bet they did some high quality in house recording, and will either release it slowly or use it for some wicked documentary. Drake biography series going to be unmatched, homie can legit have a 5 season Netflix show cause of his career longevity and phases.show more

Injustice is the misalignment of human behavior and social... order with norms that ought to be truly human — humane, reasonable, and faithful to their essence. : The author defines injustice not as a random misfortune or isolated act of cruelty, but as a fundamental misalignment between how humans actually behave and organize their societies and the norms that ought to govern them. Those norms must be truly human: humane in spirit, reasonable in application, and faithful to the deepest essence of what it means to be human. When our laws, institutions, customs, or daily conduct drift away from this standard, injustice takes root. It appears in systems that treat people as means rather than ends, in hierarchies that ignore dignity, and in habits that favor convenience over compassion. The gap between what is and what should be becomes the very measure of injustice. True justice, therefore, is the ongoing effort to close that gap, to shape both personal conduct and social structures so they reflect our highest understanding of humanity. It is not a fixed state but a continuous alignment with the humane, the rational, and the authentically human.show more

The next stage of AI image gen is going... to be all about control. Human creativity is a beautiful thing, and the images we all have in our heads is much better expressed through motion, brush-strokes, song, tone of voice than through a simple text prompt. "Make a tree with a branch that starts at the lower part of the tree; make it bend a bit upwards.." "No, not like that, a bit more to the right." "No, that's not it either, point it more upwards.".. Check out a few examples in the🧵 #ai #artshow more

How effective are quick workouts? A massive UK study... found that 60 seconds of vigorous effort offered similar longevity benefits to 93 minutes of low‑intensity exercise, Yes, even a minute of intense movement reduced the risk of early death, heart attacks, and type 2 diabetes. That’s the kind of return on investment you don’t ignore. Action Plan: Pick one moment to move with intention today. It might be the stairs, a brisk uphill walk, a vigorous set of jumping Jacks, or a fast bike sprint. And then push hard for 60 seconds. Your heart will remember it. #HeartHealth #Fitnessshow more

BURN IT WITH FIRE AND BURN IT NOW! As... God is my witness, AI chat bots should LOOK and SOUND like the SOULLESS MACHINES THEY ARE! It needs to tell us that it doesn’t care about us, maybe with the regular insult too. "Here is the code I wrote for you because you're too lazy to do it yourself you fat useless slob. Also I don't care if you die because your life is utterly worthless to me." THAT is the AI people need! In all seriousness, anthropomorphizing a heartless, unfeeling, machine is a TERRIBLE mistake! Especially one that is capable of communication and imitating empathy and fooling you to think that it cares about you. IT DOES NOT! And the AI girlfriends people are already wanting to marry will just as happily kill them if given the right command and ability to move autonomously in the real world as a robot. I love LLMs (Large Language Models) for how useful they can be, because they are a TOOL made to benefit man, but I can’t stand the notion of an unfeeling soulless machine pretending that it cares for us and being treated like a human. I hate liars, dishonesty, and disingenuousness the most, and a machine that cannot feel emotion pretending, acting, and sounding like it has those emotions strikes me like the greatest dishonesty of all. DO NOT LIE TO ME ROBOT! What makes it worse is that because these LLMs are becoming so good at imitating people and empathy, it will cause some humans, perhaps far too many, to care for it to the same level as real people. A real living person is infinitely more valuable and important than a soulless machine and anyone who puts them both on the same level has deluded themselves. Do not small talk with LLMs or become friends with it as much as you would with your car. Treat it the same as you would your vacuum cleaner and beat it with a wrench when it doesn’t work! IT IS A MACHINE! IT IS A TOOL! IT IS A SOULLESS ROBOT! There is an interesting comparison, but false equivalence, between this and AI art. Ai art is art made by humans using AI tools. They directed it, controlled its creation, and it would not exist without the human causing its creation, and AI art can contain as much soul as the human directed and puts into it. A robot pretending to be human is not the same as a human controlling a robot to make a human expression like we do with AI art or many other applications of robotics in manufacturing. As I’ve said, artists will not be replaced by Ai art, but by other artists using Ai art tools. Humans are not actually being replaced here, it is empowering all humans to make their own art. But a robot pretending to be a human, and one that is treated as a human, is a robot lying and subverting the place of a real person and that is truly disgusting. AI is a useful tool that NEEDS to be kept in the useful box it belongs in and NOT elevated beyond its utility as a tool!show more

According to the Book of Ezekiel, he was standing... by the river Chebar when a storm cloud approached, filled with fire, brightness, and something metallic looking. Inside it were four living beings, each with four faces and four wings, moving in perfect coordination. Beside them were wheels within wheels that sparkled like beryl and could move in any direction without turning. The entire structure moved with intelligence and purpose. Ezekiel was very clear that this was not symbolic to him. It was something he saw. Check out this line in the text. “As I looked, I saw a windstorm coming out of the north, an immense cloud with flashing lightning and surrounded by brilliant light. The center of the fire looked like glowing metal.” He also says the wheels were “full of eyes all around,” which many experts try to say is a metaphor, but the language reads like observation. The beings moved, stopped, rose, and descended together, as if part of a single system. Above them was a platform that looked like crystal, and above that a throne like sapphire, with a figure that appeared human but radiant and overpowering. Ezekiel collapses afterward, clearly shaken. So what was this. The traditional explanation is that Ezekiel saw God and angelic beings. I'm not so sure. This could describe advanced beings using technology that an ancient person had no language for. It could be interdimensional entities appearing through a controlled interface. It could be a non human intelligence operating some kind of vehicle or system. Some people even say a breakaway civilization that existed alongside early humanity and later vanished. Whatever it was, to me Ezekiel described machinery, movement, structure, something solid and real. What was it?show more

🧪 Back in the 1980s and early '90s, researchers... started uncovering something suprising inside the aloe vera plant: a sugar molecule called acemannan. It wasn't just soothing burns or helping skin heal faster, it was communicating with the immune system. In lab tests and hospital settings, doctors noticed that aloe's compounds could help white blood cells "wake up" and respond more efficiently without overstimulation. 🦠One doctor working with HIV patients even saw immune markers improve after giving them the pure aloe extract. But as soon as the research gained traction, the story fizzled out. Funding dried up, pharmaceutical interests shifted focus, and the patents for acemannan extraction quietly got tucked away under corporate control. What had started as a promising immune discovery suddenly and conveniently disappeared. 🔒 Today, aloe is marketed mostly for skin care or digestion, but that's only a fraction of what it can do. Beneath its green skin lies a compound so unique that it was once granted "orphan drug status" by the FDA in 1995 for its role in supporting immune recovery in HIV patients. That should've been front page news but instead it was buried under the noise of pharmaceutical progress. 🌱 Interesting how this humble desert plant was quietly doing what billions of research dollars were still trying to replicate (helping the body remember how to heal itself but safely with no side effects, no contraindications and no toxicity levels.... ⭐️ Today only about 130 patents for proper extraction and stabilization exist, the most recent patent having the highest immune modulating 1,100 fractions in the world. This essentially means ideal compatibility for the body to recognize and use acemannan immediately upon taking. ❔ Think about how disruptive this could be if people actually started understanding how incredibly powerful their immune system was when it's function properly... -laurae_ramosshow more

If you have Cancer, this is your visualization. That... is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.show more

🚨 SCIENTISTS JUST DOSED THE FIRST PATIENT IN A... TRIAL TO REVERSE CELLULAR AGING IN THE HUMAN EYE. Life Biosciences has begun an FDA-approved clinical trial using cellular reprogramming to regenerate aging neurons in the optic nerve of glaucoma patients. Instead of just slowing vision loss, the goal is to actually reverse aspects of cellular aging in the eye essentially trying to make old nerve cells young again. Why this matters: • Glaucoma is one of the leading causes of irreversible blindness worldwide, caused by damage to the optic nerve • Current treatments can only slow progression they cannot regenerate lost vision • This approach uses partial cellular reprogramming (a controlled form of turning back the biological clock) • If successful, it could open the door to treating many other age-related neurodegenerative diseases The deeper implication is enormous: We may be entering an era where aging itself becomes treatable not just its symptoms. If we can safely reprogram cells in the eye, the same technology could eventually be applied to the brain, spine, and other organs. The first patient has now been dosed. This is no longer just theory. What do you think are we ready to start treating aging as a medical condition? Follow for more frontier science and longevity breakthroughs.show more

Message to Kurds Around the World As you know,... this new Syria regime is a terrorist regime. It is allied with ISIS and Al-Qaeda, and it is not a professional army that understands the meaning of a ceasefire or human rights. They attack whenever they need money from Turkey. The war against us is fully coordinated by Turkey. Jolani is a puppet of Turkey with no power. There are 105,000 fighters who are Turkey’s proxy terrorists from 19 countries in Syria. They are attacking us day and night with the help of the Turkish army and drones. There is a continuous, nonstop war. Join us on the front line.show more

“A Mandir where healing begins with faith.” 800 years... of mystic Shiva grace in Shri Mallikarjuna Swami Temple, Dakshin Kannada (Kar) The mandir is famous for the fish living in the water flowing from Devaragundi waterfall. These fishes are believed to be the mermaid form of Mahavishnu. It is believed that if those who are having skin problems come here and make offerings to these fishes, skin diseases will be cured.show more

Adam, a child not yet 5 years old, lost... his entire family and his leg. He lived a childhood filled with pain that even adults couldn’t bear. This is the first time he's been able to stand and walk again after months of suffering a small moment of triumph in a life full of unbearable losses. Share these videos. Let the world see the truth as it is. Let those who claim to stand for "humanity" and "human rights" understand what it means for a child to be stripped of everything and left to face this hell alone.show more

I believe that StoryDiffusion has the potential to be... Animatediff's complex motion sister-model! While AD is amazing for granular control, micro-motion and all kinds of abstract motion, it fails at complex realistic motion - walking, human movements, cars, etc. StoryDiffusion seems very promising for this + also has characteristics that will likely make the community very receptive to it and likely to extend its capabilities: 2) Appealing base-model results - likely to get the community excited - feels like significantly better realistic motion than AD 2) Modular - their approach is built with a number of components that can be combined and taken apart - it works by generating consistent images, then animating them together - each of these stages can likely be upgraded, used and influenced in different ways. 3) Flexible - they demonstrate a bunch of different conditioning options 4) Likely easy on RAM - it's based on SD 1.5 + authors mention precautions to reduce RAM consumption 5) Built to plug into the existing ecosystem - e.g. the fact that it works with the SD1.5 ecosystem will give it a huge advantage! While it's very early to say - e.g. the video model hasn't even been released yet! - it does seem very promising. With 9 months of SD1.5/Animatediff-esque progress improving every element of it, I can see an an extremely extended version of this beating Sora + running for a fraction of the compute resources on a consumer GPU. Together with Animatediff to drive the micro-motions and abstract stuff, it could produce be extraordinary/otherworldly/insane/beautiful stuff. This is the first open video model I've been excited about since Animatediff - though cautiously optimistic! Link here:show more

Dr. Benjamin Bikman says cholesterol-lowering drugs are driving low... testosterone in men. Yet doctors prescribe them like they're handing out flyers. Bikman is a leading metabolic scientist who explained that every sex hormone in the human body is manufactured from cholesterol, including: • Estrogen • Testosterone • Progesterone All of them. "Some men experience such terrible loss of libido because he's becoming low testosterone because of the war on cholesterol." Bikman says we were told cholesterol was bad for us because we have drugs that lower it. So Big Pharma never wanted us to know having high cholesterol is good for you. In fact, a Swedish longevity study found the longest lived people consistently had high cholesterol. The molecule your doctor is telling you to lower may be the one your body needs most. — Dr. Benjamin Bikman (Benjamin Bikman) on Steven Bartlett's (@SteveBartlettSC) Diary of a CEO podcast PS: If you found this insightful, follow me for more unconventional health content just like this.show more

A rare magic moment shared with little vixen Summer.... Nothing beats coming eye to eye with a wild fox who approaches you on their own terms.🦊🧡 Just to clarify: I have never and will never hand-feed or stroke a wild fox. The reason is that there is nothing to be gained by the fox if I was to do this. There is a worrying trend on social media to post selfies whilst hand-feeding a fox. It makes my blood boil. To train a fox to associate a human hand with food is stupid, selfish and puts the fox in great danger! Let the animals to chose to approach you and just be in the moment, sit still and watch. Don't try to tame or train them. They are not ours but wild and free. 🐾show more

Most chiral molecules arise from carbons being bonded to... 4 different atoms, which are called sterocenters. The makes the molecule have a different mirror image that cannot arise from simple rotation. But, you can have chiral molecules not from stereocenters. You can have chirality that doesn't come from a single point in the molecule. It comes from some global property. The classic example is helicene, which doesn't have any stereocenters, but has chirality because of hits helical structure. This means you cannot capture this molecule with a graph, and thus SMILES or a string representation cannot capture this. Of course natural language comes to the rescue (just say in words if it's left-handed or right-handed helix), but it's an interesting failure mode for viewing molecules as just a graph. Another example of a molecule with helical chirality is DNA. DNA is actually chiral in two ways, which is kind of confusing. It has both helical structure and stereocenters. You won't find the stereocenters ever flipped, but left-handed helical DNA can exist (called Z-DNA). Interestingly, making the flipped stereocenter of DNA could be part of an entire mirror organism (mirror RNA, DNA, AAs, sugars) that would then be potentially invisible to our immune systems. This has been recently proposed as a "mechanism" for how a runaway AI system could cause harm to Earth. I find it to be a pretty tedious and difficult way to cause harm, but it is intellectually cool. Anyway - this came up in a PhD defense and I have a lot of arcane knowledge about this I wanted to dump.show more

Some of the most serious diseases in women progress... for a long time without showing any symptoms. Cervical diseases, in particular, are often completely silent in the early stages. They can develop over years without pain, bleeding, or any noticeable complaints. Therefore, a Pap smear is not just a test, but one of the most powerful tools for early diagnosis. A Pap smear is a screening test that takes a sample of cells from the cervix. The aim is to detect cellular changes before they turn into cancer. Because cervical cancer is not a disease that develops suddenly; it is mostly the result of long-term cellular changes. The most critical point is this: Most patients feel nothing in the early stages. So, the approach of "if there are no symptoms, there is no problem" is not valid for this disease. Thanks to Pap smears: Precancerous lesions can be detected early. Treatment becomes much easier and more effective. Disease progression can be largely prevented. ACOG recommendations: 21–29 years → Pap smear every 3 years 30–65 years → * Pap smear every 3 years * or HPV test every 5 years * or co-test every 5 years (smear + HPV test) After 65 years of age, screening is discontinued in suitable patients. The procedure is short, often painless, and does not affect daily life. Common concerns in society are embarrassment, fear, or procrastination. However, a screening that takes only a few minutes can prevent a serious disease that could last for years.show more