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Julian Issa

@juliankissa • 1,681 subscribers

Host @ The Beyond Tomorrow Podcast | Longevity & AI | Creating a world where anyone can flourish

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I interviewed a longevity scientist from one of the world's top genetics labs. Derya Unutmaz shared 8 surprising insights everyone needs to hear to live healthier, sharper and maybe even forever: 1) Only 1 in 5-10 statin users actually benefit

I interviewed a longevity scientist from one of the world's top genetics labs. Derya Unutmaz shared 8 surprising insights everyone needs to hear to live healthier, sharper and maybe even forever: 1) Only 1 in 5-10 statin users actually benefit

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I interviewed a board-certified physician specialized in women's hormones and longevity. Dr. Amy Killen shared 10 surprising insights every woman needs to hear to live healthier, more youthful and longer: 1) Women can lose up to 30% of brain energy at 35 years old

I interviewed a board-certified physician specialized in women's hormones and longevity. Dr. Amy Killen shared 10 surprising insights every woman needs to hear to live healthier, more youthful and longer: 1) Women can lose up to 30% of brain energy at 35 years old

372,725 views • 6 months ago

Four longevity legends just revealed when they think we’ll beat aging. More precisely, when will science repair the damage of aging faster than our bodies create it? Their answers couldn’t be more different: 1) Aubrey de Grey: a 50/50 chance within 12–15 years He coined the term “longevity escape velocity,” so he went first. His estimate is based on how fast each area of damage repair is moving, and how far we need to get to delay age-related decline by the first 20 years. Aubrey de Grey

Four longevity legends just revealed when they think we’ll beat aging. More precisely, when will science repair the damage of aging faster than our bodies create it? Their answers couldn’t be more different: 1) Aubrey de Grey: a 50/50 chance within 12–15 years He coined the term “longevity escape velocity,” so he went first. His estimate is based on how fast each area of damage repair is moving, and how far we need to get to delay age-related decline by the first 20 years. Aubrey de Grey

21,295 views • 12 days ago

Demis Hassabis is a Nobel laureate, and is widely seen as one of the ‘good guys’ in AI. But Dr. Roman Yampolskiy has a rule: anyone building superintelligence will be complicit if an AI-led doomsday arrives. I asked him if Demis Hassabis might just be the one person to prove him wrong.

Demis Hassabis is a Nobel laureate, and is widely seen as one of the ‘good guys’ in AI. But Dr. Roman Yampolskiy has a rule: anyone building superintelligence will be complicit if an AI-led doomsday arrives. I asked him if Demis Hassabis might just be the one person to prove him wrong.

56,610 views • 1 month ago

I put four longevity titans in one room for an hour, and they gave me four very different answers on when we’ll beat aging. They challenged each other on timelines, the FDA, AI, and the hype problem in longevity science. Watch Aubrey de Grey, Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs), george church, and Michael Ringel, JD PhD battle it out, live now on The Beyond Tomorrow Podcast!

I put four longevity titans in one room for an hour, and they gave me four very different answers on when we’ll beat aging. They challenged each other on timelines, the FDA, AI, and the hype problem in longevity science. Watch Aubrey de Grey, Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs), george church, and Michael Ringel, JD PhD battle it out, live now on The Beyond Tomorrow Podcast!

21,872 views • 13 days ago

I spent two hours with top sports scientist Dr. Mike Israetel. Nothing was off the table. He thinks most adults should be on a GLP-1, 60-year-olds will look 22 by the late 2030s, and his P(doom) is close to zero. Our conversation went everywhere, from steroids to superintelligence. 8 moments I had to share: 1) The vast majority of American adults should be on a GLP-1 His pick is tirzepatide. He says the weight loss alone makes the case, but the bigger benefits are lower inflammation, better glucose control, and new cancer data. There are exceptions: having a sensitive GI tract, very low body weight, or bone density issues.

I spent two hours with top sports scientist Dr. Mike Israetel. Nothing was off the table. He thinks most adults should be on a GLP-1, 60-year-olds will look 22 by the late 2030s, and his P(doom) is close to zero. Our conversation went everywhere, from steroids to superintelligence. 8 moments I had to share: 1) The vast majority of American adults should be on a GLP-1 His pick is tirzepatide. He says the weight loss alone makes the case, but the bigger benefits are lower inflammation, better glucose control, and new cancer data. There are exceptions: having a sensitive GI tract, very low body weight, or bone density issues.

43,132 views • 1 month ago

8) His parting words: listen to Elon Musk and Jeff Bezos I asked what he'd say if tomorrow were his last day on Earth. "To the stars. Humanity can make it to the stars. And listen to folks like Elon Musk more and Jeff Bezos more. They're not evil. They're just ahead of the curve."

8) His parting words: listen to Elon Musk and Jeff Bezos I asked what he'd say if tomorrow were his last day on Earth. "To the stars. Humanity can make it to the stars. And listen to folks like Elon Musk more and Jeff Bezos more. They're not evil. They're just ahead of the curve."

42,017 views • 1 month ago

Ben Goertzel believes an 82-year-old could take a daily pill and get back the body they had at 30. He says this'll happen in 2-4 years. He says getting old is just our body's cells slowly wearing out, not a fixed rule of nature. Scientists have already discovered old cells can turn young again in a lab. The missing piece is only a mind smart enough to plan the repair for all 37 trillion cells in the human body. Goertzel believes a super-smart AI will do exactly that. He even said it about his own parents, who are 82 and healthy: "If we get super-intelligence in the next 5 years, they will probably not die." — Ben Goertzel (.Ben Goertzel), founder of SingularityNET (.SingularityNET)

Ben Goertzel believes an 82-year-old could take a daily pill and get back the body they had at 30. He says this'll happen in 2-4 years. He says getting old is just our body's cells slowly wearing out, not a fixed rule of nature. Scientists have already discovered old cells can turn young again in a lab. The missing piece is only a mind smart enough to plan the repair for all 37 trillion cells in the human body. Goertzel believes a super-smart AI will do exactly that. He even said it about his own parents, who are 82 and healthy: "If we get super-intelligence in the next 5 years, they will probably not die." — Ben Goertzel (.Ben Goertzel), founder of SingularityNET (.SingularityNET)

108,793 views • 3 months ago

Neuroscientist David Eagleman thinks an AI president is inevitable, and that it could happen within a decade. We talked about why AI could make better moral decisions than humans, how it could give us real democracy, and why we might end up as “the squirrels” to superintelligence. Full episode below! ⏱️ Timestamps: 00:00 Intro 00:05 Are We in the Middle of AGI? 03:26 AI’s Greatest Advantage 04:25 The Case for a Utilitarian AI President 07:16 Who Defines AI’s Parameters? 09:06 The Danger of Politically Biased AI 11:49 Behind the Scenes 12:33 Are We Ready for an AI President? 14:41 What Should an AI Government Optimize For? 18:31 How Soon Could We Have an AI President? 22:24 The Trolley Problem and AI Morality 27:54 What Happens When Humans Have Too Much Free Time? 29:07 The Neuroscience of Tribalism 30:13 The Neural Basis of Empathy 31:24 Why We’re Wired for Us vs. Them 32:43 Can AI Become Conscious? 33:51 Could AI Eradicate Humanity? 35:51 Artificial Wisdom and AI Guardrails 38:57 AGI Is Already Happening 41:22 An AI President in Our Lifetime 43:26 The Biggest Fear About AI

Neuroscientist David Eagleman thinks an AI president is inevitable, and that it could happen within a decade. We talked about why AI could make better moral decisions than humans, how it could give us real democracy, and why we might end up as “the squirrels” to superintelligence. Full episode below! ⏱️ Timestamps: 00:00 Intro 00:05 Are We in the Middle of AGI? 03:26 AI’s Greatest Advantage 04:25 The Case for a Utilitarian AI President 07:16 Who Defines AI’s Parameters? 09:06 The Danger of Politically Biased AI 11:49 Behind the Scenes 12:33 Are We Ready for an AI President? 14:41 What Should an AI Government Optimize For? 18:31 How Soon Could We Have an AI President? 22:24 The Trolley Problem and AI Morality 27:54 What Happens When Humans Have Too Much Free Time? 29:07 The Neuroscience of Tribalism 30:13 The Neural Basis of Empathy 31:24 Why We’re Wired for Us vs. Them 32:43 Can AI Become Conscious? 33:51 Could AI Eradicate Humanity? 35:51 Artificial Wisdom and AI Guardrails 38:57 AGI Is Already Happening 41:22 An AI President in Our Lifetime 43:26 The Biggest Fear About AI

10,704 views • 10 days ago

“Psychopath is a more appropriate word for someone planning to kill 8 billion people with 10% probability." This was AI safety expert Roman Yampolskiy’s reaction to the "10% p(doom), let's build it anyway" crowd when I sat down with him on the podcast this week. Dr. Roman Yampolskiy

“Psychopath is a more appropriate word for someone planning to kill 8 billion people with 10% probability." This was AI safety expert Roman Yampolskiy’s reaction to the "10% p(doom), let's build it anyway" crowd when I sat down with him on the podcast this week. Dr. Roman Yampolskiy

31,463 views • 1 month ago

"Every country will be run by AI within 30 years, 40 at most." Emad Mostaque (.Emad), founder of Stability AI, believes NO ONE is ready for what's coming. His 8 predictions on how the world changes in the next few decades: 1) AI will cure most diseases within 10 years

"Every country will be run by AI within 30 years, 40 at most." Emad Mostaque (.Emad), founder of Stability AI, believes NO ONE is ready for what's coming. His 8 predictions on how the world changes in the next few decades: 1) AI will cure most diseases within 10 years

38,440 views • 3 months ago

I asked 4 longevity experts; "Over the next 5 years, which therapeutic wins?" Kaeberlein ranked them in this order: 1) Rapamycin 2) Plasma dilution 3) Senolytics 4) Partial reprogramming 5) NAD boosters Rapamycin tops it because it has the best, most reproducible data by far. He also says reprogramming has the highest ceiling of all. — Matt Kaeberlein (.Matt Kaeberlein)

I asked 4 longevity experts; "Over the next 5 years, which therapeutic wins?" Kaeberlein ranked them in this order: 1) Rapamycin 2) Plasma dilution 3) Senolytics 4) Partial reprogramming 5) NAD boosters Rapamycin tops it because it has the best, most reproducible data by far. He also says reprogramming has the highest ceiling of all. — Matt Kaeberlein (.Matt Kaeberlein)

36,503 views • 3 months ago

Mike Israetel is out now and it's the most unfiltered conversation I've ever had on the show. We spoke GLP-1s, his full stack (steroids included), the biggest scam in longevity, and age reversal by the late 2030s. He also told me why his P(doom) is basically zero, a week after Dr. Roman Yampolskiy told me his was 99.9%. Which got me thinking: I need these two in a room together. Dr. Mike Israetel

Mike Israetel is out now and it's the most unfiltered conversation I've ever had on the show. We spoke GLP-1s, his full stack (steroids included), the biggest scam in longevity, and age reversal by the late 2030s. He also told me why his P(doom) is basically zero, a week after Dr. Roman Yampolskiy told me his was 99.9%. Which got me thinking: I need these two in a room together. Dr. Mike Israetel

10,146 views • 1 month ago

Is biological aging actually reversible? De Grey believes it will eventually be possible. Kaeberlein is the complete opposite: "I think it's almost impossible, if not impossible, to completely reverse biological aging." His reason is simple. "You can't reverse entropy." However, does believe you can improve health and parts of biological aging. — Matt Kaeberlein (.Matt Kaeberlein) and Aubrey de Grey (.Aubrey de Grey)

Is biological aging actually reversible? De Grey believes it will eventually be possible. Kaeberlein is the complete opposite: "I think it's almost impossible, if not impossible, to completely reverse biological aging." His reason is simple. "You can't reverse entropy." However, does believe you can improve health and parts of biological aging. — Matt Kaeberlein (.Matt Kaeberlein) and Aubrey de Grey (.Aubrey de Grey)

24,223 views • 3 months ago

Our vitalist / longevity special with Nathan S. Cheng thinks you should work on aging. and Adam Gries is out now on The Beyond Tomorrow Podcast

Our vitalist / longevity special with Nathan S. Cheng thinks you should work on aging. and Adam Gries is out now on The Beyond Tomorrow Podcast

13,839 views • 4 months ago

When I asked Derya Unutmaz "What's the best piece of advice you've ever received", he gave me two answers. The first was what his father told him: "Be careful about one thing in life. How comfortable you are. If you are too comfortable, then you should really worry." When you're comfortable, you become complacent. When you're complacent, you stop evolving. The second came from watching Steve Job's Stanford speech, and is actually related to the first: "Stay hungry, stay foolish." Stay foolish so you never stop wondering, no matter how much you think you know. Stay hungry so you never lose the drive to solve the next big problem, and there's always one. — Derya Unutmaz (.Derya Unutmaz, MD)

When I asked Derya Unutmaz "What's the best piece of advice you've ever received", he gave me two answers. The first was what his father told him: "Be careful about one thing in life. How comfortable you are. If you are too comfortable, then you should really worry." When you're comfortable, you become complacent. When you're complacent, you stop evolving. The second came from watching Steve Job's Stanford speech, and is actually related to the first: "Stay hungry, stay foolish." Stay foolish so you never stop wondering, no matter how much you think you know. Stay hungry so you never lose the drive to solve the next big problem, and there's always one. — Derya Unutmaz (.Derya Unutmaz, MD)

11,584 views • 4 months ago

Here's the full conversation with Dr. Gordan Lauc (Co-founder at GlycanAge), Dr. Matt Kaeberlein (CEO at Optispan) and Dr. Aubrey de Grey (President and CSO of Longevity Escape Velocity Foundation) (00:00) Introduction (00:39) How do you measure biological age? (04:41) The role of advanced biomarkers in health (06:28) Understanding the glycan age test (10:19) Raising awareness on glycan age and inflammation (14:26) The science behind measuring biological age (18:48) How high error rates can mislead results (22:07) Should you test your biological age? (23:21) The hidden risks of sample mix-ups (26:46) Do we really need biological age tests? (27:09) The problem with epigenetic tests and misinterpreted data (30:40) What counts as a reliable health measure (34:51) The power of comprehensive health metrics (38:20) Building evidence-based longevity medicine (40:05) Why modern medicine is failing us (41:24) The risk of oversimplifying longevity science (46:50) Why the culture of medicine must change (51:17) The future of longevity and aging research (54:04) The unknown frontiers of longevity (58:10) How bad science misuses resources (01:01:16) When influencers take longevity too far (01:03:00) Tools that actually help us live longer (01:06:33) Taking ownership of your health (01:10:20) What the future holds for healthy aging Subscribe to newsletter below for written breakdowns.

Here's the full conversation with Dr. Gordan Lauc (Co-founder at GlycanAge), Dr. Matt Kaeberlein (CEO at Optispan) and Dr. Aubrey de Grey (President and CSO of Longevity Escape Velocity Foundation) (00:00) Introduction (00:39) How do you measure biological age? (04:41) The role of advanced biomarkers in health (06:28) Understanding the glycan age test (10:19) Raising awareness on glycan age and inflammation (14:26) The science behind measuring biological age (18:48) How high error rates can mislead results (22:07) Should you test your biological age? (23:21) The hidden risks of sample mix-ups (26:46) Do we really need biological age tests? (27:09) The problem with epigenetic tests and misinterpreted data (30:40) What counts as a reliable health measure (34:51) The power of comprehensive health metrics (38:20) Building evidence-based longevity medicine (40:05) Why modern medicine is failing us (41:24) The risk of oversimplifying longevity science (46:50) Why the culture of medicine must change (51:17) The future of longevity and aging research (54:04) The unknown frontiers of longevity (58:10) How bad science misuses resources (01:01:16) When influencers take longevity too far (01:03:00) Tools that actually help us live longer (01:06:33) Taking ownership of your health (01:10:20) What the future holds for healthy aging Subscribe to newsletter below for written breakdowns.

14,573 views • 7 months ago

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