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Karl Mehta

@karlmehta144,217 subscribers

3x Exited Founder/ CEO of tech cos, Chairman Emeritus- QUIN(Quad), former VC@Menlo Ventures, Author of 2 books, fmr White House fellow. All tweets personal.

Shorts

Scientists tracked 25,315 women for 25 years. Those who followed one eating pattern had 23% lower risk of dying from anything. Not a fad. Not restriction. A 4,000-year-old diet backed by the largest nutrition trial ever run. Here's exactly what I'd eat (and avoid): 🧵

Scientists tracked 25,315 women for 25 years. Those who followed one eating pattern had 23% lower risk of dying from anything. Not a fad. Not restriction. A 4,000-year-old diet backed by the largest nutrition trial ever run. Here's exactly what I'd eat (and avoid): 🧵

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9/ The Constitutional Restoration Trump's framing: • Brings back the Constitution • Restores separation of powers • Opposite of power concentration • Stops judicial branch from stealing executive authority

9/ The Constitutional Restoration Trump's framing: • Brings back the Constitution • Restores separation of powers • Opposite of power concentration • Stops judicial branch from stealing executive authority

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The numbers are staggering. Household income growth hit 7-8% in April alone. Real wages for hourly workers rose almost 2% in just 5 months. Bessent dropped this bombshell: "No president has done that before." But here's where it gets interesting...

The numbers are staggering. Household income growth hit 7-8% in April alone. Real wages for hourly workers rose almost 2% in just 5 months. Bessent dropped this bombshell: "No president has done that before." But here's where it gets interesting...

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Mark Zuckerberg reveals the fourth business address: an AI agent inside your customer's inbox "Just like every business today has an email address" "And a website and a social media presence" "In the future every business is gonna have an AI agent" "That lives in the different messaging platform" The first three addresses made a company reachable. The fourth makes it conversational. The next distribution layer is not another page. It is a persistent agent living where customers already message. - Mark Zuckerberg (Mark Zuckerberg), CEO of Meta, at Stripe Sessions (Stripe)

Mark Zuckerberg reveals the fourth business address: an AI agent inside your customer's inbox "Just like every business today has an email address" "And a website and a social media presence" "In the future every business is gonna have an AI agent" "That lives in the different messaging platform" The first three addresses made a company reachable. The fourth makes it conversational. The next distribution layer is not another page. It is a persistent agent living where customers already message. - Mark Zuckerberg (Mark Zuckerberg), CEO of Meta, at Stripe Sessions (Stripe)

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Sam Altman explains biology's intelligence bottleneck: understanding a discovery is far easier than making one "We are not that smart and biology is enormously complex." "We can imagine kind of anything." "We can have someone explain enormously complex things to us and then we can get it." "But to discover these things requires a lot of brain power." That is the hidden health AI bet. The breakthrough is not another chatbot that can summarize known medicine. It is enough machine intelligence to search biology's enormous possibility space for discoveries humans have not made. Medicine has no shortage of explanations. It has a discovery bottleneck. If models can supply the missing brain power, the highest-value output will not be answers. It will be new biological knowledge. - Sam Altman (Sam Altman), CEO of OpenAI, on CNN

Sam Altman explains biology's intelligence bottleneck: understanding a discovery is far easier than making one "We are not that smart and biology is enormously complex." "We can imagine kind of anything." "We can have someone explain enormously complex things to us and then we can get it." "But to discover these things requires a lot of brain power." That is the hidden health AI bet. The breakthrough is not another chatbot that can summarize known medicine. It is enough machine intelligence to search biology's enormous possibility space for discoveries humans have not made. Medicine has no shortage of explanations. It has a discovery bottleneck. If models can supply the missing brain power, the highest-value output will not be answers. It will be new biological knowledge. - Sam Altman (Sam Altman), CEO of OpenAI, on CNN

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Polyphenols are one of the most underrated anti-aging compounds on Earth. Used right, they extend cellular lifespan & activate your body's youth genes. Yet no one talks about them. So I researched the science. What I found will blow your mind: 🧵

Polyphenols are one of the most underrated anti-aging compounds on Earth. Used right, they extend cellular lifespan & activate your body's youth genes. Yet no one talks about them. So I researched the science. What I found will blow your mind: 🧵

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Satya Nadella says LinkedIn merged four job titles, product manager, designer, front-end engineer and back-end engineer, into one: "I'll give you at LinkedIn, we used to have product managers, we had designers, we had front-end engineers, and then we had back-end engineers and so on." "So what we did is we sort of took those first four roles and combined them. In fact, increased scope and said, they're all full-stack builders." "So at the same time, as you can imagine, if we're to build an AI product today, there's a complete new workflow, right? It starts with evals, right?" "So basically, there's this eval to science, to infrastructure." "And so evals are done by these full-stack builders and what have you and product managers in the new form, the infrastructure is built by the systems engineers at the back-end because they support the science that supports the product." "So in some sense, there's a new loop and you have to structurally change." LinkedIn has already put this into hiring. Its Associate Product Manager program is finished, and the replacement, the Associate Product Builder track, teaches code, design and product management at the same time. Evals sit at the front of that workflow rather than the end, so writing them is now part of building the product instead of a check before shipping. - Satya Nadella (Satya Nadella), Chairman and CEO of Microsoft (Microsoft), with the All-In Podcast (The All-In Podcast) at USA House, Davos 2026.

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Geoffrey Hinton says a big language model runs on about 1% of your brain's connections and still ends up knowing more than you: "So in your brain, you have a hundred trillion connections, roughly speaking. Okay. That's a lot. And you only live for about two billion seconds. That's not much." "If you compare how many seconds you live for, with how many connections you've got, you have a whole lot more connections than experiences." "Now with these neural nets, it's sort of the other way round. They only have of the order of a trillion connections. So like 1% of your connections, even in a big language model, many of them fewer, but they get thousands of times more experience than you." "So the big language models are solving the problem with not many connections, only a trillion. How do I make use of a huge amount of experience?" "And back propagation is really, really good at packing huge amounts of knowledge into not many connections." "But that's not the problem we're solving. We've got huge numbers of connections, not much experience. We need to sort of extract the most we can from each experience." Two to three billion seconds is the whole budget. Everything you know, you learned inside it. So evolution built you to squeeze a lot out of very little. Hinton's point is that a language model has the opposite problem and the opposite fix, and backprop turned out to be extremely good at that fix. Worth noticing what this predicts about failure. A system running on 1% of your wiring and thousands of times your experience is not going to fail the way you do. You fail from having seen too few examples. It fails from compressing too many into too little, and the compression is where the errors get made. That is a strange thing to be deploying into hospitals and courts with no way to inspect it. We test these systems by asking them questions, which tells you what came out. Nobody can yet look at a trillion connections and say what got packed in. - Geoffrey Hinton, Nobel laureate and Turing Award winner, on StarTalk (StarTalk) with Neil deGrasse Tyson.

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Warren Buffett says he could collect 20 to 40 billion dollars a year from government bonds without taking any risk, and that is the number he holds AI spending against: "AI companies, you're putting out huge amounts of money. And I can put huge amounts of money into government bonds and get, you know, 20 or 30 or 40 billion dollars a year in terms of payments from them." "So a good business is one that earns a lot more than, and has prospects of continuing to earn a lot more than the returns on essentially riskless investments, which you could define as Treasuries." "But if you take something like American Express, you know, most of the banks earn 13, 14% on capital." "But it's so different that it earns 30% plus on capital, and it does not incur more risk in doing so than the banks that earn 13 or 14%." "And the trick in life is to find, I mean in investing, is to find businesses that are going to earn high returns on capital for an extended period of time." "A long period of time gets to be very important because those doubles later on are very big numbers." That is a hurdle rate, and you can hold the next AI capex announcement against it the same day you read it. His second condition is the harder one. Earning high returns for an extended period means somebody has to show the returns will hold, and almost every number that would show it for AI is published by the company doing the spending. When the entity being measured also runs the measurement, what you are reading is marketing. Buffett has been able to check American Express against decades of audited filings. There is no equivalent for an AI model yet, and building it is the whole job. - Warren Buffett, chairman of Berkshire Hathaway, on CNBC (CNBC).

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