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Parmita Mishra

@parmita • 40,117 subscribers

founder CEO @precigenetics Scuba diver, engineer, biologist. interested in things that lie deep. // prev. Penn comp bio, research Penn Med (cells n epigenomics)

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the most relatable thing I have ever seen in my entire life:

the most relatable thing I have ever seen in my entire life:

479,711 views

AI is not accelerating nearly fast enough to cure cancer. That is the problem. And it literally cannot without actually seeing what’s happening inside the cell. There’s this new project claiming their models will “solve” cancer by predicting drug responses at scale. Cool story. Except their entire approach still treats the cell like a black box. They’re optimizing for binding affinity while having zero idea what the drug actually does once it’s inside a real, living cell. Meanwhile we’re over here building the tools to watch the cell in real time. No staining or sequencing. Just direct observation of mechanism. You can simulate all you want. But if you can’t see the actual cellular response, you’re just making very confident guesses about something you’ve never actually looked at. We’ve spent two years proving this. The data is there. The difference is night and day. AI is a tool. It’s not the microscope. If your model can’t tell you why a drug is killing the wrong cells or why resistance is forming in real time… it’s not ready to cure cancer. It’s ready to waste another billion dollars. We’re not competing with AI. We’re giving it eyes. Goodbye.

AI is not accelerating nearly fast enough to cure cancer. That is the problem. And it literally cannot without actually seeing what’s happening inside the cell. There’s this new project claiming their models will “solve” cancer by predicting drug responses at scale. Cool story. Except their entire approach still treats the cell like a black box. They’re optimizing for binding affinity while having zero idea what the drug actually does once it’s inside a real, living cell. Meanwhile we’re over here building the tools to watch the cell in real time. No staining or sequencing. Just direct observation of mechanism. You can simulate all you want. But if you can’t see the actual cellular response, you’re just making very confident guesses about something you’ve never actually looked at. We’ve spent two years proving this. The data is there. The difference is night and day. AI is a tool. It’s not the microscope. If your model can’t tell you why a drug is killing the wrong cells or why resistance is forming in real time… it’s not ready to cure cancer. It’s ready to waste another billion dollars. We’re not competing with AI. We’re giving it eyes. Goodbye.

48,203 views

when a cell dies

when a cell dies

16,157 views

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For too long we’ve asked the wrong question about AI: “Will it write my emails?” “Will it take my job?” The real question was always: Can AI help us finally end disease? The answer is yes. But only if we give it something worth seeing. 🧵

For too long we’ve asked the wrong question about AI: “Will it write my emails?” “Will it take my job?” The real question was always: Can AI help us finally end disease? The answer is yes. But only if we give it something worth seeing. 🧵

26,965 views • 7 days ago

This is an essential point people seem to misrepresent.

This is an essential point people seem to misrepresent.

1,851,662 views • 2 years ago

I’m done hiding what I’ve been going through. Since im cleared now, I will be taking in person meetings. But here’s the truth. Lost an EYEBROW to thyroid issues due to working nonstop in the lab with endocrine disruptors around. Something women uniquely have to go through. I haven’t taken one day off and I will not. But: I’m done hiding it. It’s reversible (non scarring alopecia) and my energy and my eyebrow are both going to get better soon. As a woman you have to face more than other people. But it’s my fault that I put in too much work without caring for my health. I take accountability.

I’m done hiding what I’ve been going through. Since im cleared now, I will be taking in person meetings. But here’s the truth. Lost an EYEBROW to thyroid issues due to working nonstop in the lab with endocrine disruptors around. Something women uniquely have to go through. I haven’t taken one day off and I will not. But: I’m done hiding it. It’s reversible (non scarring alopecia) and my energy and my eyebrow are both going to get better soon. As a woman you have to face more than other people. But it’s my fault that I put in too much work without caring for my health. I take accountability.

21,669 views • 8 days ago

I was recently asked “You’re doing all this drug testing. But where are the mice?” Our answer will never ever change They’re probably in a trash can in New York City In our lab, we don’t cure or torture mice. We make drugs that work in human beings.

I was recently asked “You’re doing all this drug testing. But where are the mice?” Our answer will never ever change They’re probably in a trash can in New York City In our lab, we don’t cure or torture mice. We make drugs that work in human beings.

67,281 views • 2 months ago

"People do not realize that there is only one bridge remaining." To solve disease + accelerate, we need to make disease solvable using compute. Data is the limiting reagent. This is why Precigenetics is essential for the future of biological superintelligence.

"People do not realize that there is only one bridge remaining." To solve disease + accelerate, we need to make disease solvable using compute. Data is the limiting reagent. This is why Precigenetics is essential for the future of biological superintelligence.

89,821 views • 4 months ago

Will Google solve disease in 10 years? Not without data. We can commoditize drug design, and STILL not solve most diseases. You need Precigenetics.

Will Google solve disease in 10 years? Not without data. We can commoditize drug design, and STILL not solve most diseases. You need Precigenetics.

72,548 views • 3 months ago

From my talk at MIT: our aim is to make an intelligent engine that can predict unseen, unmade human molecules in their response to human biology. Way better than the 97% failure rate today for cancer, and 90% failure rates across all diseases.

From my talk at MIT: our aim is to make an intelligent engine that can predict unseen, unmade human molecules in their response to human biology. Way better than the 97% failure rate today for cancer, and 90% failure rates across all diseases.

124,957 views • 8 months ago

The one engineer who secretly runs the entire company

The one engineer who secretly runs the entire company

158,310 views • 1 year ago

We are sending our public comments to the FDA today, for the MOST IMPORTANT FDA GUIDANCE in modern drug development. We have prepared the following comments as an overview. We will also be sharing our official comment documents on our website, link will be posted TODAY!

We are sending our public comments to the FDA today, for the MOST IMPORTANT FDA GUIDANCE in modern drug development. We have prepared the following comments as an overview. We will also be sharing our official comment documents on our website, link will be posted TODAY!

19,477 views • 2 months ago

This is my favorite video on the internet 16 hours of development, timelapsed Zebrafish embryo growing its elaborate sensory nervous system Dr. Haynes lab

This is my favorite video on the internet 16 hours of development, timelapsed Zebrafish embryo growing its elaborate sensory nervous system Dr. Haynes lab

100,623 views • 2 years ago

Ok so Mark Manson absolutely CRUSHED IT in this video. People ask: how do you win in a Machiavellian room of psychopath CEOs? THIS is how you win without losing your soul. I carry #1 with me wherever I go. Whoever knows me knows this! You’re welcome for the gold. 😇

Ok so Mark Manson absolutely CRUSHED IT in this video. People ask: how do you win in a Machiavellian room of psychopath CEOs? THIS is how you win without losing your soul. I carry #1 with me wherever I go. Whoever knows me knows this! You’re welcome for the gold. 😇

14,974 views • 4 months ago

at the speed of light (no pun intended) My talk for Deep Tech Week: optics, cancer, diagnostics, and Precigenetics

at the speed of light (no pun intended) My talk for Deep Tech Week: optics, cancer, diagnostics, and Precigenetics

33,942 views • 1 year ago

No, there is no one skin color that someone has. It is biologically impossible to losslessly replace a person’s skin color with one value. And it’s more informational than you’d believe If you have 18 minutes or can play in 2x, grab a drink. And watch my rant

No, there is no one skin color that someone has. It is biologically impossible to losslessly replace a person’s skin color with one value. And it’s more informational than you’d believe If you have 18 minutes or can play in 2x, grab a drink. And watch my rant

14,420 views • 6 months ago

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