PolyBio
@polybioRF • 14,226 subscribers
501(c)3 transforming how LongCovid, ME/CFS, Lyme+ and Alzheimer’s are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.
Videos
![Dr. Tim Henrich presented new findings surrounding long term persistence of SARS-CoV-2 proteins & RNA in Long COVID gut tissue at PolyBio’s recent Spring symposium. “We actually see [gut viral persistence] in both areas, the epithelium—which turns over every several days to week—to the lamina propria where you have long-lived myeloid immune cells… suggesting there may even be replication in some individuals,” said Henrich. Using a highly sensitive method of detecting viral RNA, “around 20-25% of the time, we see detection… all the way up until 3-4 years after initial infection” in Long COVID patients.](https://image.24vids.com/tw-2064372060395106805/amplify_video_thumb/2064371846837886976/img/jSEOYf8uWFu88ob7.jpg)
Dr. Tim Henrich presented new findings surrounding long term persistence of SARS-CoV-2 proteins & RNA in Long COVID gut tissue at PolyBio’s recent Spring symposium. “We actually see [gut viral persistence] in both areas, the epithelium—which turns over every several days to week—to the lamina propria where you have long-lived myeloid immune cells… suggesting there may even be replication in some individuals,” said Henrich. Using a highly sensitive method of detecting viral RNA, “around 20-25% of the time, we see detection… all the way up until 3-4 years after initial infection” in Long COVID patients.
PolyBio33,545 Aufrufe • vor 7 Tagen
Said Dr. Mark Painter in a recent episode of PolyBio’s Lab Visits: “What we’re seeing in a third of people with Long COVID, maybe more, is evidence that T cells recognizing either SARS-CoV-2—or in some different people, herpesviruses—are persistently activated. Which is suggestive that those viruses are present somewhere in the body.” Listen to the full interview here:
PolyBio17,544 Aufrufe • vor 13 Tagen
UCSF researcher Dr. Tim Henrich describes how the PolyBio-supported PASC tissue program is changing the game: “What we’ve really been finding is that SARS-CoV-2 is able to persist for a long period of time in various tissues across the body… the gut, the bone marrow, the brain, and other deeper tissues that are actually very difficult to sample. We’ve also been finding that there is profound changes in immune responses and inflammation in these tissues as well.”
PolyBio127,052 Aufrufe • vor 7 Monaten
“We found evidence of SARS-CoV-2 infected cells both in the gut and female reproductive tract… more than 4 years after the initial infection,” said Dr. Marta Mirabent, who is part of the Roan lab team investigating SCV2 persistence in these sites as driver of Long Covid. Their initial findings suggested SCV2 RNA and proteins can persist in the endometrium, endo-cervix and ecto-cervix; with more patient biopsies currently underway.
PolyBio55,928 Aufrufe • vor 5 Monaten
![Dr. David Izquierdo and his team developed the novel radiotracer [64Cu]-FBP8 that can identify fibrin accumulation in the lung, brain and heart tissue of Long COVID patients when visualized with PET. “Now the question is; can we [use this technology] with patients that have symptoms, but don’t have any clinical evidence,” said Izquierdo. “What we’re trying to do here is determine if Long COVID has a signal that we can measure, quantify and detect in vivo, noninvasively.”](https://image.24vids.com/tw-2043809303262277853/amplify_video_thumb/2043809081106878464/img/GO-ixEdO3MgdWndZ.jpg)
Dr. David Izquierdo and his team developed the novel radiotracer [64Cu]-FBP8 that can identify fibrin accumulation in the lung, brain and heart tissue of Long COVID patients when visualized with PET. “Now the question is; can we [use this technology] with patients that have symptoms, but don’t have any clinical evidence,” said Izquierdo. “What we’re trying to do here is determine if Long COVID has a signal that we can measure, quantify and detect in vivo, noninvasively.”
PolyBio25,416 Aufrufe • vor 2 Monaten
Now recruiting: Long COVID patients in NYC—consider joining the CoRE at Mount Sinai clinical trial of repurposed antivirals Truvada & Maraviroc. These repurposed HIV antivirals may have activity against SARS-CoV-2 reservoirs and reactivated EBV. Email [email protected] to apply!
PolyBio69,747 Aufrufe • vor 10 Monaten
“To get rid of HIV, we need to go after the virus, we need to go after the inflammation, we need the immune system to work better,” says Dr. Steve Deeks. “Over the last 20 years we have built up all these collaborations with industry, funders, and other academic groups trying to target those pathways. And those are the exact same pathways that we’re now targeting with Long COVID.”
PolyBio51,099 Aufrufe • vor 7 Monaten
Dr. Amy Proal on the Tick Bootcamp podcast last week: “If you’re a pathogen and you’re going to infect someone, and persist in their body, the blood is not a smart place to be... A lot of pathogens over time will hide in a person’s tissue… Where they’re somewhat able to evade immune recognition.”
PolyBio21,590 Aufrufe • vor 2 Monaten
Dr. Shannon Stott is leading a team using a novel microfluidics approach to identify SARS-CoV-2. A ‘Herringbone’ chip is coated with ACE-2, to pull out SARS-CoV-2 from blood: in acute COVID, “when we looked at basic plasma testing, we saw that no virus was found… but those same samples when used with our microfluidic capture, we saw 30,000 copies of SARS-CoV-2.”
PolyBio54,174 Aufrufe • vor 11 Monaten
“Chronic pathogens are the closest thing there are to hackers of the human body,” said Dr. Amy Proal at her TedX Talk on the infectious drivers of human aging. “As they live in us, they can create proteins & products that actively distort the signalling of our own human genes.”
PolyBio31,799 Aufrufe • vor 6 Monaten
![Dr. Amy Proal last week: “When people get an infection, there’s a huge assumption that it just clears after their symptoms go away… Little amounts of the pathogen [can persist] in parts of your tissue, parts of your nerves—where they can still drive inflammation and directly hijack the functioning of your mitochondria.”](https://image.24vids.com/tw-1943067810701414809/amplify_video_thumb/1943067588843458560/img/vMrQjbSUikPgTmO9.jpg)
Dr. Amy Proal last week: “When people get an infection, there’s a huge assumption that it just clears after their symptoms go away… Little amounts of the pathogen [can persist] in parts of your tissue, parts of your nerves—where they can still drive inflammation and directly hijack the functioning of your mitochondria.”
PolyBio44,412 Aufrufe • vor 11 Monaten
Long Covid, ME/CFS and Post-Treatment Lyme patients living in NYC: Mount Sinai’s CoRE clinic is actively recruiting for a clinical trial of Lumbrokinase. This enzyme breaks down fibrin, a coagulation factor linked to chronic symptoms, which may build up in patients’ bodies as a result of SARS-CoV-2 or Borrelia burgdorferi. If you’re interested in participating in this trial, email [email protected].
PolyBio18,349 Aufrufe • vor 4 Monaten
![1/ “When you have persistent pathogens & chronic inflammation associated with that, you have a lot of reactive oxygen species. The mitochondria are trying to create energy in a hostile environment…the more that you do, the harder it is to [function].” -Dr. Putrino of CoRE at Mount Sinai](https://image.24vids.com/tw-1869815059607892262/amplify_video_thumb/1869814829034110976/img/JsugzMx5-ZTae6pb.jpg)
1/ “When you have persistent pathogens & chronic inflammation associated with that, you have a lot of reactive oxygen species. The mitochondria are trying to create energy in a hostile environment…the more that you do, the harder it is to [function].” -Dr. Putrino of CoRE at Mount Sinai
PolyBio54,251 Aufrufe • vor 1 Jahr
In Long Covid and ME/CFS patients, Dr. VanElzakker and his team are using PET-MRI scans to determine areas of neuroinflammation. Analysis of blood from Long Covid patients undergoing the scans “found several mediators associated with vascular problems that correlated with the neuroinflammation signal.” These included elevated L-selectin, responsible for leukocyte extravasion into tissues; and fibrinogen, a main blood clotting component.
PolyBio13,009 Aufrufe • vor 3 Monaten
“Our results have now clearly documented that Bartonella, Babesia, and the relapsing fever Borrelias… can certainly persist in human blood for long periods of time,” said Dr. Ed Breitschwerdt, an expert on tick-borne disease. “If you’re infected with one of these 3 genera, and COVID comes along, you might have a very aberrant immune response that persists.”
PolyBio22,863 Aufrufe • vor 9 Monaten
Dr. Amy Proal on the Foresight Institute Existential Hope podcast highlights NK & T-cell activating therapy, Anktiva: “there are a growing number of companies… that are working on therapies that do not suppress the immune system, but support the immune system.”
PolyBio17,609 Aufrufe • vor 6 Monaten
![Dr. Morgane Bomsel is studying SARS-CoV-2 persistence in Long Covid patients’ platelets and megakaryocytes. Thus far, their early data shows that spike protein and viral RNA “can be found in at least 2/3 of the Long Covid patients’ [megakaryocytes]… this research suggests MKs may form SARS-CoV-2 reservoirs in Long Covid patients, which may produce platelets sheltering infectious SCV2.”](https://image.24vids.com/tw-1975710059351953657/amplify_video_thumb/1975709816367493120/img/D0uQn3kWGF95DcLd.jpg)
Dr. Morgane Bomsel is studying SARS-CoV-2 persistence in Long Covid patients’ platelets and megakaryocytes. Thus far, their early data shows that spike protein and viral RNA “can be found in at least 2/3 of the Long Covid patients’ [megakaryocytes]… this research suggests MKs may form SARS-CoV-2 reservoirs in Long Covid patients, which may produce platelets sheltering infectious SCV2.”
PolyBio15,951 Aufrufe • vor 8 Monaten
Want first access to antiviral therapies for Long Covid? We’re looking for participants for a clinical trial of Truvada & Maraviroc. The trial is using cutting-edge biological markers including deep immune profiling & EndoPAT to determine efficacy of these medications in LC. If you have been diagnosed with Long Covid & live in NYC, consider joining this first-of-a-kind trial. Email [email protected] to see if you’re eligible.
PolyBio10,492 Aufrufe • vor 4 Monaten
![Dr. Marcelo Freire is investigating potential Long Covid oral cavity biomarkers: “We’re trying to ask the question: ‘We find all this immune dysfunction [in saliva samples] that is persistent, could we look into how the microbiome actually impacts the salivary immune function?’… We were able to find that the microbiome in saliva… was the highest predictive factor for health vs. disease [post-COVID].”](https://image.24vids.com/tw-1960806393100792020/amplify_video_thumb/1960806214540972032/img/3Q5S3Ja8Etn8a7e6.jpg)
Dr. Marcelo Freire is investigating potential Long Covid oral cavity biomarkers: “We’re trying to ask the question: ‘We find all this immune dysfunction [in saliva samples] that is persistent, could we look into how the microbiome actually impacts the salivary immune function?’… We were able to find that the microbiome in saliva… was the highest predictive factor for health vs. disease [post-COVID].”
PolyBio17,108 Aufrufe • vor 9 Monaten