Reid Hoffman

@reidhoffman • 1,032,693 subscribers

Co-Founder, LinkedIn. Investor. MSFT Board Member. Building an LLM to discover cures for cancer: @manas_co. Most importantly: Proud American.

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Reid Hoffman

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.Replit ⠕ CEO Amjad Masad on why product managers are the best vibe coders:

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Today, I launched Manas AI –– a full stack AI company setting out to shift drug discovery from a decade-long process to one that takes a few years; bringing life-saving treatments to patients faster than ever.

Wanted to resurface Satya Nadella's recommendation of "Two Paths to Prosperity." The book traces how China and Europe developed different social organizations and how those structures shaped economic and political trajectories across a millennium. Very relevant today.

The Epstein Files must be released, in full. Tonight, I supported World Without Exploitation to run this ad on Monday Night Football, calling for exactly that.

Why did I deepfake myself? To see if conversing with an AI-generated version of myself can lead to self-reflection, new insights into my thought patterns, and deep truths.

My message for American voters and Russian bots: don't vote for the guy too busy selling you a scamcoin. Vote for Vice President Harris, who knows how to put business—and the American people—first.

Excited to sit down with my friend Satya Nadella to talk about AI, the future of humanity, and going back into founder mode to cure cancer.

Satya Nadella on how to build infrastructure that could enable 20,000,000 agents to work alongside employees at Microsoft:

This election isn't about minor policy disagreements. It's about truth vs. fiction, the rule of law vs. chaos, and democracy vs. fascism. That's why I've backed Kamala Harris—and you should, too.

I came across this video of Justin Bieber using a full orchestra to turn the rhythms in his mind into music. Soon, anyone will be able to hum a tune, describe the vibe you’re aiming for, and have an AI-powered producer turn your ideas into reality.

"I don't think when you're diagnosed with cancer, it's time for a statistics lesson." Mathematician Hannah Fry on why humans struggle to see the world in probabilities, and how it changes decision-making.

"We are entering a new era of coding." Nobel Prize Winner and Google DeepMind CEO Demis Hassabis on coding with natural language.

" Everyone has domain knowledge in their head that is not monetized yet." Amjad Masad of Replit ⠕ on the explosion of niche, decentralized entrepreneurs:

Anthropic just filed for IPO. People continue to ask: Is all this AI revenue durable? My answer: yes. Enterprise revenue is durable, code revenue is durable, and both will keep compounding. There will be major new streams beyond them, too.

Respiratory illnesses may cost the economy $500B - $1T per year. Nan Ransohoff on Stripe's effort to cure stop respiratory infections:

To most people, $100M for one employee feels like Silicon Valley finally lost it. Those people don't understand the bet hyperscalers are making. When you’re aiming for a TRILLION in value, $100M is just table stakes. More on this week's episode of Possible:

" I think maybe in the next 10, 15 years we can actually have a real crack at solving all disease." Nobel Prize Winner and DeepMind CEO Demis Hassabis on how AI can revolutionize drug discovery doing "science at digital speed."

.Notion's Founder, Ivan Zhao: Stop trying to save costs when you're implementing AI. It's the easiest way to lose the race. More on how Ivan thinks about staying ahead of the AI curve:

AI gives humanity our best shot at curing cancer.

Had a great time with John Lilly on The General Podcast (The General Partnership ("TheGP"))!

With AI, "we did 1,000,000,000 years of PHD time in one year." Nobel Prize Winner and Google DeepMind CEO Demis Hassabis on AlphaFold, the groundbreaking AI system developed to solve one of biology’s most complex problems: protein folding.