Sabrina Halper
@SabrinaHalper • 12,689 subscribers
Exploring the mind, machine, and meaning of it all 🎙️🔮 | @stanford
Videos
Bowhead whales can live for over 200 years. Greenland sharks can live for up to 400. There’s even an immortal jellyfish that can reset its own life cycle. Nature has already solved longevity in dozens of different ways. What can we learn from these species in our own quest to live longer, healthier lives? Jacob Kimmel of NewLimit shares his take.
Sabrina Halper38,906 Aufrufe • vor 2 Tagen
Founder of Signal, Moxie Marlinspike Marlinspike on Telegram: "Telegrams not a private messenger. There's nothing private about it. It's the opposite. It's a cloud messenger where every message you've ever sent or received is in plain text in a database that telegram the organization controls and has access to it" "It's like 'Russian oligarch starts unencrypted version of WhatsApp', a pixel for pixel clone of WhatsApp. That should be kind of a difficult brand to operate. And somehow, they've done a really amazing job of convincing the whole world that this is an encrypted messaging app and that the founder is some kind of Russian dissident, even though he goes there once a month, the whole team lives there, and their families are there." " What happened in France is they just chose not to respond to the subpoena. And so that's in violation of the law. And, he gets arrested in France, right? And everyone's like, oh, France, but I think the key point is they have the data, like they can respond to the subpoenas where as Signal, for instance, doesn't have access to the data and couldn't respond to that same request. To me it's very obvious that Russia would've had a much less polite version of that conversation with Pavel Durov and the telegram team before this moment. "
Sabrina Halper880,467 Aufrufe • vor 5 Monaten
"We have this long term vision of turning biology from something which is trial and error and experimental and make it something that looks more like an engineering discipline in the next century." New Episode with Jack Dent ! 0:00 Intro 02:28 Inside Stripe w/ Patrick Collison, at <100 People 08:45 Sam Altman role in Chai Discovery origin 16:20 Chai-2 Antibody Breakthrough 19:24 Approaching biology as an engineering problem 24:45 Using AI models to treat people on an individual scale 26:52 Robotics in labs 27:22 Pharma industry today 29:49 The clinical trial bottleneck 32:53 Personalized biology models & cancer vaccines 36:24 Longevity, peptides, and trillion-dollar drugs 39:02 Does it matter that the government cut exploratory science grants? 41:00 What next-gen Chai models will do 42:08 Can frontier AI labs build this themselves? 43:26 Biology is hard
Sabrina Halper38,838 Aufrufe • vor 1 Monat
.Dwarkesh Patel's episode with Eric Jang is awesome. Eric has a rare gift for making complicated ideas feel simple, which is exactly what struck me when I first met him at a dinner and immediately peppered him with questions. If you are looking to hear more from him, listen to our conversation from a couple years ago! "The history of neural networks and actually many things in AI have been inspired a lot by biology, like genetic algorithms, evolutionary algorithms, processes in both neuroscience and psychology and biology and so forth. I think drawing from nature is a great way to get inspiration... And this is going to get me a lot of flack from the scientific community, but I feel like in the last decade and a half-ish of deep learning progress, the vast majority of major contributions have come from people who did not really adhere to that way of thinking, but more like, how do I push as much data as fast as possible onto my GPU? It just empirically seems to me that people who are very attached to the idea of replicating a particular nature inspired architecture at the expense of enabling brute force compute... do not make the best algorithms. There's this essay by Sara Hooker called the the hardware lottery where it's arguing that people who focused on maximizing and designing their algorithms to suit the hardware so that it could run the brute force thing as fast as possible tended to win. "
Sabrina Halper39,759 Aufrufe • vor 2 Monaten
Jack Dent story time - his path from high school in the UK to founding Chai is pretty amazing: - Cold-emailed Stripe as a teenager - Daniela Amodei was running Stripe’s careers inbox and forwarded his email to Patrick Collison - Interned on Stripe’s payments API and eventually became the only engineer working on it - Greg Brockman walked around the office with no shoes - Met Joshua Meier while at Harvard. Years later, Sam Altman Facebook-messaged him about Josh when he was leaving OAI - asked if he could be convinced to stay or start a company ... All of it became part of the path to co-founding Chai Discovery a few years later. Early Stripe was a talent epicenter Daniela Amodei Patrick Collison Greg Brockman Sam Altman
Sabrina Halper33,476 Aufrufe • vor 1 Monat
Who do you think will be the most powerful human in 20 years? "It might just be the person who has the most coherent picture of what they want the future to look like." Richard Ngo It seems valuable to spend more time thinking and developing a strong pov of what you want things to look like. Easier than ever to execute on it.
Sabrina Halper22,541 Aufrufe • vor 1 Monat
Ken Liu Ken Liu on how modern explanations to questions like "why do we dream?", "why do I love this person?", "why are we here?" explain everything while explaining nothing at all. Science can explain mechanism. It can't explain meaning. Stories create meaning. Modern states ask citizens to die for them all the time - for the sake of a story. Humans will die for a story. It's the only thing humans have ever willingly died for.
Sabrina Halper62,310 Aufrufe • vor 6 Monaten
Isabelle Boemeke isabelle 🪐 on the pre-Hiroshima moment we’re in with AI. "The United States rushes to build the bomb, and up until that point there was a mix of excitement and fear about nuclear. I think it's similar to what we feel about AI at this moment. We are in that moment with AI where we can see both scenarios in our minds, right? It could be incredible. We could cure all these diseases, we could solve all these complex problems, but we can also all die. And it was a very similar thing, until the bombs were dropped in Hiroshima and Nagasaki and all of that potential was cemented in one image, which was of a mushroom cloud."
Sabrina Halper41,314 Aufrufe • vor 5 Monaten
"The day that article came out was the absolute bottom. The number of people who didn't respond, who I never heard from again. People you thought would be lifelong friends. You realize how many people are there for the good times and how many run." In 2021, Peter Thiel wrote his largest check ever, outside Founders Fund, into Keri Findley’s first fund. Keri joined Wall Street at 21. Made partner at Third Point building their structured credit business from scratch. Shortly after leaving and moving to SF, everything hit at once: an article claiming she was under SEC investigation, a divorce where her partner tried to take 100% of her assets, and a period of real pain that ultimately shaped her grit and perspective today. She went on to found her own firm, Tacora Capital, which provides structured credit and financing to high-growth companies, and now oversees billions - quietly becoming one of the largest, most under-the-radar investors in the US. One of the most personal conversations I've ever had on this podcast and grateful to Keri for giving us a rare glimpse behind the curtain.
Sabrina Halper16,672 Aufrufe • vor 3 Monaten
New Episode with the one & only Moxie Marlinspike Marlinspike, founder of Signal. Recorded in the ocean, on a floating sauna, that he built alone. TIMESTAMPS - 00:00 Intro 01:09 Building Physical World Projects Centered on Experiences 07:43 Tales from Hitchhiking 15:04 The Birth of Signal 22:23 Privacy 31:21 Introducing Confer: Private AI Chat 37:17 What is Developer Responsibility w/ AI 38:21 Historical Perspective on Encryption 39:15 Skepticism Towards Crypto 41:24 The Impact of Self-Publishing and Cancel Culture 44:01 Imagining MoxieLand 49:41 Why Do Conspiracy Theories Exist 58:00 Signal Gate 1:02:30 Limits of Solo Ambitions 1:05:09 Solving Aging 1:09:00 Moxie’s Next Physical World Project
Sabrina Halper24,498 Aufrufe • vor 5 Monaten
.Richard Ngo on why birth rates will probably keep falling: - Birth rates are falling because marriage rates are falling. - AI could either distract us from relationships or help mediate them. - If the future economy is dominated by social + emotional labor, it may skew female - dating gets harder when women outpace men in status.
Sabrina Halper29,434 Aufrufe • vor 8 Monaten
We need more access to energy. The best path to increasing nuclear energy production in the US in next 5 years is just making the current large plants more efficient. Isabelle Boemeke isabelle 🪐 breaks down current landscape so well. Companies raising billions but no working prototypes yet, and new large plant projects are too expensive for most utility companies to take on.
Sabrina Halper19,932 Aufrufe • vor 5 Monaten
Congratulations to Ben Lamm and Colossal Biosciences® on announcing the successful de-extinction of the dire wolf. Wild. Two years ago, I interviewed Ben—he pushed founders to go bigger, and challenged investors to back the moonshots. It feels like the future is arriving.
Sabrina Halper30,167 Aufrufe • vor 1 Jahr
EPISODE 2! with Isa Fulford! Isa Fulford We talk: -Early life, classical music, math, & discipline -Building Deep Research & creating datasets from zero -Building ChatGPT’s agent -Future of internet & agent communication -Personal AI -Talent wars -Lessons from Sam Altman
Sabrina Halper14,741 Aufrufe • vor 8 Monaten
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