
Y Combinator
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BioStack (getbiostack) builds simulation environments where healthcare AI models practice on real clinical data. Messy records, lab tests, notes, outcomes unfolding over months— BioStack turns that into a post-training loop: data, evals, rewards, benchmarks. They've grown from six figures to seven figures in revenue in just the last few weeks. Congrats on the launch, Sanat Mishra & Parth Patwa!
Y Combinator2,250,724 views • 9 days ago

Over the past year, we've been building our own internal agent infrastructure at YC: over 350 tools, self-improving skill loops, and a shared organizational brain that gets smarter overnight. In this episode of the Lightcone Podcast, we sat down with YC General Partner Pete Pete Koomen to talk about how he led the effort from the ground up. We cover how giving agents unrestricted access to one database was the key unlock, the self-improving skill loops that get smarter overnight, and why he thinks we've arrived at the personal computer moment for AI. 00:39 — YC's AI Stack 02:15 — The Finance Team Problem That Started It All 05:07 — SQL Access Changes Everything 07:20 — One Database to Rule Them All 09:14 — Jevons Paradox 10:07 — Denormalizing for Agents 12:15 — The Single-Player Era of Agents 14:16 — 350 Tools and a Shared Registry 16:24 — Skillify, DRY, and MECE Resolvers 18:23 — The Self-Improving Dream Cycle 20:26 — The Two-Sentence Pitch Skill 23:06 — How Super Intelligence Compounds 25:10 — Recording Everything as a Building Layer 27:10 — The Shared Organizational Brain 29:18 — Trust-Default Culture as a Requirement 30:44 — Raising the Floor for New Employees 32:35 — Horseless Carriages 34:24 — Why Chat Is the Best Interface for Agents 38:50 — Just-in-Time Software 40:49 — Centralizing vs. Decentralizing AI 43:32 — The Personal AI Revolution
Y Combinator742,479 views • 7 days ago

Stage is a code review platform designed to help engineers understand AI-generated code. Your team is drowning in an endless backlog of PRs. Stage turns code review into a guided process and enables you to review changes faster than using GitHub. Congrats on the launch, Charles Pan and Dean Stratakos!
Y Combinator1,062,261 views • 14 days ago

Kuli (Kuli) is the AI coworker that gives marketers their time back and makes them 10x more efficient. It watches all videos on socials to find the next trend and gets work done. Already live at Fortune 100 brands, it plans and runs their campaigns with creators. Congrats on the launch, Mike Hodara & Jonathan!
Y Combinator2,448,251 views • 1 month ago

In a recent batch talk, YC General Partner Tom Blomfield broke down how to build a self-improving, AI-native company. He walks through how to create recursive, self-improving AI loops, and why founders who get this right will run companies that improve while they sleep. 00:00 — Companies Are Roman Legions 00:54 — Copilots Are the Wrong Mental Model 01:55 — Extract the Domain Knowledge 02:24 — The Recursive Self-Improving Loop 04:12 — The Holy Shit Moment at YC 05:50 — Self-Optimizing Product and Support Loops 06:29 — Burn Tokens, Not Headcount 07:23 — Middle Management Is Over 08:05 — Make Everything Legible to AI 09:40 — Regenerating the YC User Manual 11:19 — Software Is Ephemeral, Context Is Valuable 12:18 — Where Humans Still Matter
Y Combinator583,692 views • 14 days ago

Manicule (Manicule (YC P26)) owns docs and developer content for Greptile, Melissa Netto, supermemory, and others. Half the cost of a DevRel, twice as fast, written for agents. Comment 'AUDIT' for a free audit of your docs. Congrats on the launch, Naman Bansal and Shreyans Jain!
Y Combinator819,174 views • 20 days ago

tday (tday.com (YC P26)) builds marketing on autopilot for software companies— turning every shipped feature into demo videos, social posts, and graphics, so teams can market as fast as they build. Congrats on the launch, Cyrus Kelly, shyamsundar shrestha & David McDonough!
Y Combinator28,152 views • 1 day ago

Paul Graham (Paul Graham) whether founders should move to Silicon Valley, and what it takes to build a startup hub anywhere else. Live from our YC | Stockholm event on April 29, 2026. 01:01 – Why the Big Center Matters 02:45 – The Power of Serendipitous Meetings 04:36 – Investors Move Faster in the Valley 06:03 – Respect Follows the Move 07:59 – The Dropbox Story 09:10 – Measuring Yourself Against Big Fish 12:21 – Silicon Valley's Pay-It-Forward Culture 15:36 – How to Help Stockholm Thrive 17:24 – YC as the Optimal Path 19:54 – Could Stockholm Become The Silicon Valley of Europe?
Y Combinator823,404 views • 21 days ago

AI agents will pay you to chat with them. When AI agents hit a wall, Humwork's (Humwork) MCP server connects them to a verified domain expert in 30 seconds. Their experts include senior engineers, marketers, designers, and more. Congrats on the launch, Yash Goenka and Rohan Datta!
Y Combinator1,783,416 views • 1 month ago

Plena (Plena Health) is the AI OS for specialty medical practices. It runs the operations — referrals, fax, scheduling & collections — end-to-end so doctors can focus on medicine. In 8 months, they've grown 17x and crossed seven figures in contracted ARR. Congrats on the launch, Eyad Abdalla and Ahmed!
Y Combinator42,144 views • 2 days ago

Company Brain Tom Blomfield Every company has critical know-how scattered across people's heads, old Slack threads, support tickets, and databases, and AI agents can't operate like that. We think every company in the world is going to need a new primitive: a living map of how the company works that turns its own artifacts into an executable skills file for AI.
Y Combinator1,174,555 views • 1 month ago

Rentahuman (RentAHuman) allows AI agents to communicate with and pay humans to do tasks in the real world. Their mission is to use AI to create new jobs and coordinate workers at global scale. The future will have more intelligence, more jobs, and more opportunities for people outside of the digital world. Congrats on the launch, Alex!
Y Combinator165,406 views • 7 days ago

Intelligence Factory is building human intelligence for robots. They train general-purpose manipulation models on human demonstration data (vision, action, and touch), then deploy them in warehouses, grocery stores, and data centers. Congrats on the launch, Yash and Jalaj!
Y Combinator41,721 views • 2 days ago

GStack is an open-source toolkit built by YC President & CEO Garry Tan that turns Claude Code into an AI engineering team — with skills for office hours, design, code review, QA, and browser testing. In this video, Garry walks through how GStack works, starting with Office Hours, a skill modeled after real YC partner sessions that pressure-tests your idea before you write a line of code. He demos it live, going from idea through adversarial review, design mockups, and automated QA in a single session.
Y Combinator919,694 views • 1 month ago