A wick below 3000 for $ETH is where I’d... start wanting to snipe some entries.show more

ETH STAKING ENTRIES OUTPACE EXITS BY 8X There is... now some 3,484,960 $ETH waiting to be staked on the Ethereum network, compared with only 441,450 waiting to be unstaked. The 3,484,960 figure equates to roughly $8 billion worth of demand, based on current prices. For context, ETH staking entries have outpaced exits since as far back as December 2025, signalling real demand.show more

CB x CHELLY GIVEAWAY 🏒🎁 Our boy Chelly is... boots on ground at MSG for puck drop. Drop your username & NHL slips below for a chance to win some free entries! 💸show more

⚡ Fleek.xyz Thread Contest Reminder ⚡ One week left... to go, many great entries rolling in 🤙 Read Fleek Network's new whitepaper, write a thread, and tag fleekie for a chance to win up to $2.5k in ETH ($5K in total prizes)! Deadline: August 14th, rules below 👇show more

Forehand is coming together nicely 🤙 Curious where you... start to gain distance? I’d be pretty happy with a 300ft forehand Any tips would be appreciated!show more

I’m heading to 7-11 for a slurpee. But I’d... rather slurp…- you know where this is going, right? 😜show more

it gets to a point where you start to... question how some things relate to Deltaruneshow more

UniProt is where most researchers start when they want... to understand a protein. As of today, prokaryotic entries there will show something new: genomic context, powered by SeqHub, right in the Sequence section of the page.show more

The DeFi Renaissance enters its next phase with Epoch... 6 of DRIP! Main focus for this phase is ETH Explore new ways to put your ETH to work across Arbitrum’s top lending platforms belowshow more

Some microbes carry a protein, called SNIPE, that "chops... up" phage DNA as it's being injected into the cell. This is a new mechanism for phage defense! CRISPR–Cas and restriction enzymes also evolved to fight against phages, but they work by recognizing sequences. SNIPE works, instead, by sensing "touch." SNIPE is a protein with about 500 amino acids. After it's made by the ribosome, it latches onto ManYZ, two proteins which sit on the cell's inner membrane. (ManYZ is an importer; it brings mannose and other sugars into the cell.) Once attached to ManYZ, SNIPE sits and waits for an invading phage. Some phages, including lambda, actually infect cells by pushing their DNA through this ManYZ channel. Lambda uses its "tail" to reach inside the protein channel, basically, and inject its DNA. When this physical touch happens, though, SNIPE is waiting. As soon as the phage DNA starts entering the cell, and passes through ManYZ and SNIPE, it gets immediately destroyed. This means that SNIPE is the first phage defense system discovered, so far, that uses spatial positioning at the injection site to destroy invaders. But there are caveats, of course. If you untether SNIPE from ManYZ, such that it can freely diffuse through the cell, it will chew up the bacterium's genome. It is not a highly discerning nuclease! Also, SNIPE is not found in most bacteria. A prior pangenome study, which sequenced lots of different microbes, found that roughly a third of well-studied bacterial lineages had at least one member with a SNIPE-like protein. (For this paper, they just ported one of those homologs into an E. coli laboratory strain.) And finally, because SNIPE's mechanism is tightly tied to ManYZ, it cannot be used to defend against phages that enter the cell through different routes. T4 phages, for example, inject their DNA straight through the cell membrane and into the cytoplasm, without interacting with ManYZ. This is a nice basic science paper. Applications TBD. (Just remember that scientists figured out that bacteria had a phage defense system, called CRISPR-Cas, many years before it was repurposed into a gene-editing tool.) P.S. The video below shows how cells with the SNIPE gene (middle row) kill invading phages, and thus continue growing and dividing. Empty vector (top row) refers to bacteria carrying a plasmid with no SNIPE gene; this is a control group. And SNIPE E414A refers to cells which received a mutated SNIPE gene, where the glutamate at position 414 has been changed to an alanine, thus destroying the protein's nuclease activity. These cells also die when they get infected with a phage.show more

Update: Creator Wire x Outcome Badge Is Guuuddddd campaign... We've changed the qualification criteria: ➤ Night Editor: 5K total impressions across all your posts ➤ Herald: 15K impressions minimum across all your approved entries ➤ Oracle: awarded to the top 10 entries We will start to issue the first weeks badges on Monday, join the campaign below.show more

BREAKING: A John Wick game is coming to PS5!... Saber is working with Keanu Reeves, John Wick director Chad Stahelski, and Lionsgate to produce an adrenaline-fueled experience that fits into the John Wick timeline.show more

'RBKS by SHAKKA' is Live on manifold.xyz 🧊 .003... ETH each Open for 24 hours TEN editions to a random person who retweets 🔁 🔗 PLEASE READ THE THREAD BELOW ↓↓↓show more

Welcome to Super Seabird Sunday where we ask you... to share photos, videos & artwork of seabirds to brighten up timelines. Here is a start, some ‘billing’ Puffins #SuperSeabirdSundayshow more

An outrageous $7.7 billion worth of $ETH is currently... waiting to be staked on the network. At time of writing, some 3,631,455 $ETH is queuing to be staked on Ethereum, worth a little under $7.7 billion based on current prices. More impressive, however, is the fact that just 4,128 $ETH is waiting to be unstaked... ... a difference of nearly 880x.show more

Let's have some fun. Got your hands on a... Phone (2)? We want to see that moment come to life. Share your unboxing journey with us below. Our favourite 5 entries will receive Ear (2) black.show more

wanting a bitch to stay below my feet and... be crushed for hours smelling and licking everything DM on, it’s time to serve your master.show more

As you could already see from my previous videos,... the drop to $75,500 was expected at the same time as in 2023. In 2023, when Bitcoin experienced its first strong sell-off, a wick formed below the blue TEM zone. Measured from that point, it took roughly 5 days until Bitcoin fell 0.8% below the last TEM wick. I expected Bitcoin to once again drop 0.8% below the last wick outside the blue TEM area, which pointed to a price region of $75,500. The only change on the 4-hour timeframe is that a wick has formed below the blue zone once again. Looking at the timing and the day intervals, I conclude that Bitcoin has to see a pump within the next 3 days. If I compare the patterns one-to-one in percentage terms, $73,500 could be the exact target! If the $75k area is lost, $73,000–$73,900 are the next targets where I’ll add more to my long. Check out the picture! NFA Since this is a high-timeframe (1W) pattern, delays or deviations may occur on lower timeframes than 1W. It doesn't necessarily mean it has to happen again! bitcoin:nativeshow more

Someone is sitting on a $100M + $ETH long... right now That’s not a small bet anymore Bro is basically telling the market he expects ETH much higher Either the conviction is crazy or we’re about to witness some serious liquidation porn I don’t know what he knows but i’m definitely watching ETH a little closer nowshow more