Freely access electrophysiological, morphological, and transcriptomic data measured from... thousands of individual mouse & human brain cells via the Allen Cell Types Database: #openscience #SfN23show more

Researchers can freely access the Allen Mouse Brain Common... Coordinate Framework (v3), a complete and high-resolution 3D atlas of the mouse brain. Learn more about it at #SfN23show more

Brain cell communication seen in action. Scientists have captured... the millisecond fast process of brain cell communication using advanced imaging. Teams in Berlin and the US used rapid freezing techniques on mouse and human neurons to observe neurotransmitter release and vesicle recycling, revealing key steps and proteins involved. This could help understand brain diseases.show more

Beautiful new paper: methods for getting stem-cell derived retinal... ganglion cells to integrate into the retina (mouse). Cells were capable of migrating & surviving. #NEIfunded Baranov Lab Levi Todd Mass Eye and Ear Harvard Ophthalmology PNASNews paper:show more

🚨: A petri dish of human brain cells just... learned to play DOOMshow more

Cells located in the midline of the embryo play... crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been challenging. Today, we introduce human midline #assembloids—3D self-organizing cellular clusters derived from stem cells by the functional integration of floor plate #organoids and spinal cord #organoids. We demonstrate that midline assembloids enable cell specification and axon guidance in human neurons. Additionally, we use these assembloids to screen and identify human-enriched factors that control these processes. Work led by the incredible Massimo Onesto & Neal Amin!! More details in the preprint 👇show more

Scientists have successfully trained a petri dish of human... brain cells to play DOOM.show more

He's hiding from the brain cell

Researchers HALT human brain tissue experiment over fears that... MICE could become CONSCIOUS Human brain tissue took over almost the entire mouse cortex in a new Stanford experiment Oxygen deprivation made them react like a human infant's brainshow more

This is only 1 Niagara emitter to handle thousands... of decals as particles using Data Channels! Significantly lower overhead on the GameThread and only a single component per grid cell. This also adds instancing to the decals which is normally not supported for individual decal components. Working on this as part of data-oriented projectiles that run without Actors, asynchronous collision and supporting multiplayer (incl. client side prediction). Removes a huge amount of overhead from the CPU, more on that soon!show more

New Cell paper from Bergles lab at Johns Hopkins... just built the most comprehensive map of brain myelin ever made — every oligodendrocyte, across the entire mouse brain, across the lifespan. The scale: >10 million cells per brain, terabyte-scale 3D lightsheet volumes, registered to the Allen Brain Atlas across 417 regions from 2 months to 2+ years of age. The technical stack: Custom tissue clearing (CUBIC-L + SHIELD + uRIMS with 40% urea) to preserve endogenous fluorescence. 3D Mask R-CNN for instance segmentation — not just semantic, instance — so it can distinguish individual cells within dense clusters at scale via overlapping sliding windows. Vision Transformer to classify newly-formed vs. mature oligodendrocytes using soma morphology. All cross-referenced against Allen ISH transcriptomics and MICrONS serial EM. What they found: Oligodendrocyte density varies 10,000-fold across brain regions. Left-right hemispheres: r=0.99. Sex: no significant difference. Strain: matters. The brain never stops myelinating. New oligodendrocytes are still being generated in 2-year-old mice. Prefrontal cortex L6 shows the fastest rates of new myelination into old age — the circuits for executive function keep rewiring throughout life. After demyelination, L4 sensory cortex is the most resilient — oligodendrocytes survive at higher rates. The hippocampus loses nearly everything and barely recovers. Degree of injury doesn't predict rate of recovery. These are independent axes. The Alzheimer's result is the most surprising: Dense-core plaques dominate in cortex and hippocampus. Diffuse/small-core plaques dominate in white matter fiber tracts. Old assumption: diffuse plaques are "less toxic." The data says the opposite — small plaques in fiber tracts cause more myelin loss per plaque than dense-core plaques in gray matter. Plaque load and oligodendrocyte loss are essentially uncorrelated (ρ=0.22). The damage is plaque-type and location specific, not load-dependent. For MS and AD research: you can't read off white matter injury from gray matter plaque burden. The pathology in fiber tracts is running on different rules. Data: Paper:show more

The most detailed 3D reconstruction of a cell ever... created. Blows my mind every time. But what exactly are we looking at here? The average human cell contains: ~ 15-20 total distinct organelle types, totalling between ~1-10 million working together per cell. All these nano-machines in the cell are made up of proteins. ~ 8,000-10,000 distinct types of unique proteins, adding up to between 40 million - 10 trillion total proteins making up all those cellular systems. ~ 10,000 - 15,000 distinct types of RNA shuttling information around the cell, totalling up to ~10 million RNA molecules moving around the cell simultaneously. ~ Billions of Lipid molecules packed together into the cell membrane, which is also packed tightly with millions more protein-based nano-machines. And let's not forget billions of lines of DNA information to build and run it all. That's TRILLIONS of of individual molecular pieces working together to make a single cell function. That means there is more complexity in a single cell than humanity's largest cities. And people still believe this wasn't Divinely Designed. This is God's Glory on Display. But to make the point. A cell couldn't have evolved from some nebulous simpler "protocell" because even the simplest cells still require massive complexity. The "simplest" cell ever created was engineered by scientists knocking out pieces of a functional cell until it stopped functioning. Here is what they found is the absolute necessary minimal requirements of a cell to function: - Over ~531,000 lines of coded DNA information - 473 total genes to create hundreds of unique protein products (they later added 19 genes back in because the cell was so weak) - Hundreds of thousands of total proteins all working together - Extensive regulatory networks guiding all these interactions If the cell doesn't have all these systems in place, from the start... it doesn't live. Cell rely on an intricate network of complex systems, which are themselves built from complex interconnected pieces woven together into an incomprehensibly complex web of functionilty. Only intelligence has ever been observed creation vast interconnected systems like this. Life was clearly Created. It couldn't happen any other way.show more

Scientists have mapped the vision centers of a mouse... brain, the largest and most detailed such rendering of neural circuits in a mammalian brain:show more

Real footage of cell division at kidney cells

Qorvex from Warframe 🤝 Titans from Destiny 2 sharing... the same brain cellshow more

Very excited to share our new preprint on visual... processing in the octopus! Led by Judit Pungor judit, together with Mea (josc) 🐙 and Angelique Allen, we measured the functional organization of visual responses in the octopus brain. 🐙👁️ 1/nshow more

Watch killer T cells swarm a tumor and destroy... cancer cells! These T cells don't naturally recognize the cancer. But a drug called a T-cell engager redirects them to attack. We captured 6 hours of cancer-cell killing in my lab, compressed into just 12 seconds. 🔬show more

I captured this video in my lab to show... the power of medicines called T-cell engagers. Left: T cells move in and out of a cancer tumoroid, largely ignoring it. Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.show more