“If their DNA could be retrained, maybe microbes could... deliver nitrogen directly to wheat, corn, and other crops when it’s most needed.” Chris Voigt is helping turn that idea into reality by engineering microbes to work harder and smarter. Read his story:show more

Dug is sending puppy love to young patients and... their families! Spot him on screens at select children's hospitals, part of Disney’s commitment to help reimagine the hospital experience. Thank you, Dug, for helping deliver joy when it’s needed most! 🐶❤️show more

🔴 Russia is using interceptors armed with metallic rods... to “joust” Ukrainian drones in the sky ⁠ 🖇️ Read the story to understand how the FPV drones work and if they could be instrumental for Russia on the battlefield:show more

Englishman: “You could clear this up right now. Would... it be better if England was governed by English people or non-English people?” Jew: “Hmmmmmmmmm” (after a long pause and stroking his chin) It’s getting harder and harder to justify exempting Jews from remigration.show more

Getting away from Coors could boost Angel Chivilli's FB... movement, but the slider is the pitch I'm most fascinated by. If they can get that pitch to have more drop and be more of that deathball-like shape, he could be gross. This sequence to Teoscar Hernandez is fun.show more

I see a lot of skepticism around Crimson Desert,... and I get it, it’s extremely ambitious! BUT, if this game is able to deliver on the sheer scale, content and level of interactivity their promising, this could be a generation defining experience 😳show more

This is on the Ohio River in Cincinnati near... Route 8 You see the color of this water being dumped into the Ohio River? It’s pink…. It’s coming out of the Newport Pumping Station The City sometimes injects colored dye into drains and sewer to watch where it emerges to map flows and or study river dispersion This could be that, or this could be something else being dumps directly into the Ohio River…. The EPA should be checking this out to verifyshow more

🚨 BREAKING: Scientists have demonstrated “metajets” light-propelled metasurfaces with... full 3D maneuverability. That means laser-driven propulsion is moving from concept toward controllable engineering. If scalable, this could strengthen the case for Starshot-style missions to Alpha Centauri in ~20 years. What fascinates me most: Light isn’t just carrying information here it’s becoming steering, force, and propulsion. Could engineered photonic structures turn light itself into a practical engine? Follow me for more frontier physics.show more

it’s very clear that Phoebe and Simone would be... back on the Bridgerton set if someone was to give them a call and put their characters in the scripts… There’s no excuse the show could ever make about Daphne or Kate’s absence when we have these queens confirming their commitmentshow more

Some microbes carry a protein, called SNIPE, that "chops... up" phage DNA as it's being injected into the cell. This is a new mechanism for phage defense! CRISPR–Cas and restriction enzymes also evolved to fight against phages, but they work by recognizing sequences. SNIPE works, instead, by sensing "touch." SNIPE is a protein with about 500 amino acids. After it's made by the ribosome, it latches onto ManYZ, two proteins which sit on the cell's inner membrane. (ManYZ is an importer; it brings mannose and other sugars into the cell.) Once attached to ManYZ, SNIPE sits and waits for an invading phage. Some phages, including lambda, actually infect cells by pushing their DNA through this ManYZ channel. Lambda uses its "tail" to reach inside the protein channel, basically, and inject its DNA. When this physical touch happens, though, SNIPE is waiting. As soon as the phage DNA starts entering the cell, and passes through ManYZ and SNIPE, it gets immediately destroyed. This means that SNIPE is the first phage defense system discovered, so far, that uses spatial positioning at the injection site to destroy invaders. But there are caveats, of course. If you untether SNIPE from ManYZ, such that it can freely diffuse through the cell, it will chew up the bacterium's genome. It is not a highly discerning nuclease! Also, SNIPE is not found in most bacteria. A prior pangenome study, which sequenced lots of different microbes, found that roughly a third of well-studied bacterial lineages had at least one member with a SNIPE-like protein. (For this paper, they just ported one of those homologs into an E. coli laboratory strain.) And finally, because SNIPE's mechanism is tightly tied to ManYZ, it cannot be used to defend against phages that enter the cell through different routes. T4 phages, for example, inject their DNA straight through the cell membrane and into the cytoplasm, without interacting with ManYZ. This is a nice basic science paper. Applications TBD. (Just remember that scientists figured out that bacteria had a phage defense system, called CRISPR-Cas, many years before it was repurposed into a gene-editing tool.) P.S. The video below shows how cells with the SNIPE gene (middle row) kill invading phages, and thus continue growing and dividing. Empty vector (top row) refers to bacteria carrying a plasmid with no SNIPE gene; this is a control group. And SNIPE E414A refers to cells which received a mutated SNIPE gene, where the glutamate at position 414 has been changed to an alanine, thus destroying the protein's nuclease activity. These cells also die when they get infected with a phage.show more

Today was my hardest workout before the Javelina 100—an... uphill treadmill supercompensation session accumulating 60 minutes of intervals at 10% grade, starting at threshold and ending harder. I think uphill treadmill threshold sessions can be magical for some athletes. Threshold work is classically defined as LT2 or easier, around what you could sustain for 1 hour. In practice, that feels relatively relaxed at first, and it only starts to get harder after you accumulate a substantial amount of volume. The rationale of threshold work is that it improves lactate shuttling, helping mitochondria be more efficient at processing and transporting lactate, preventing fatigue cascades even at harder efforts on other days (or at easier efforts in marathons or ultras). In other words, it’s primarily an aerobic stress. Faster is not better. The real-world obstacles with threshold work are twofold. First, for most of us, it’s pretty slow when done right, or way too hard when done wrong. A study on the training of elite athletes found that long intervals had the lowest correlation with long-term growth, and this conundrum is probably why—athletes do their long intervals too hard, breaking themselves down without the mechanical or aerobic stimulus to justify it. Second, outdoor threshold work can be an injury risk. If I tried this workout outdoors, it would wreck my calves and high hamstrings for days. The uphill treadmill can help athletes get around these hurdles. It’s slower by design, putting the emphasis squarely on the aerobic system. That helps athletes develop a much more precise understanding of threshold. But perhaps most significantly, the uphill treadmill reduces impact forces immensely. When I finish one of these—even a supercompensation session—I feel fine the next day, allowing me to absorb way more work (and more specific work to my goals). Particularly with age, I find that running training is about managing the efforts that are high impact to be limited and focused. While most of the uphill treadmill work I do is very controlled, it’s also ok to occasionally dig deeper. Today was about supercompensation. It’s not called The Pain Cave for nothing 🔥show more

🇺🇸🇮🇷 Donald Trump stated that the war with Iran... could continue for another two or three weeks: “We have already done most of what needed to be done. There are probably two more weeks left — two weeks, maybe three. And time is not a decisive factor for us,” the U.S. President said. Video is generated by grok AIshow more

What if a network could deliver AI results closer... to where data is created, instead of sending it to far‑off data centers? In collaboration with NVIDIA and Decart, we’re making that a reality by bringing GPU‑powered computing to the network edge — closer to homes and businesses — so AI applications respond in real-time. This is how we're laying the foundation for the next generation of AI‑driven services:show more

Blueface was PLEASED when his new babe India told... him to keep Neveah and his other baby mama IN PLACE so they could avoid any future issues. 😳👀 India made it clear that everyone needs to know their role, reminding him that “NO ONE IS BIGGER THAN THE PROGRAM.” 🔥show more

I heard today one of the most transphobic and... bizarre speeches with an MP saying that changing gender can endanger children. The idea that a predator has an advantage to work in a school or nursery if they have a Scottish GRC is dog whistle bigotry I could not let stand.show more

Krypton moon (Wegthor) broken by Doomsday 🌖 The original... Doomsday managed to destroy Krypton's moon under a red sun, imagine what he could do under a yellow sun. In addition, “Steppenwolf barely managed to survive the encounter“ ” against him. Compared to that, Zod's Doomsday was a baby, yes...and fortunately! At a later stage, the latter could have been much more lethal. Unlike Superman and other Kryptonians who gradually lose their strength by harnessing their abilities at night and need to recharge while sleeping, Doomsday's strength is literally infinite day and night, with only the age of the nearby sun determining his strength level. #ZackSnydersJusticeLeague 2 "Story Lesson"show more

A year later, it still feels like Charlie Kirk... is watching over the country he loved. He believed America could turn the corner. That courage could beat fear, truth could beat propaganda, faith could outlast chaos, and a new generation could still be reminded what this country is supposed to stand for. That mission didn’t end with him. Every time someone speaks up, refuses to surrender their values, defends freedom, or chooses to fight for the future of this country, a piece of that mission keeps moving forward. Maybe that’s the best way to honor him now. Keep going. Keep believing. Keep fighting for the America he believed was still possible. Rest easy, Charlie. We’re not done yet.show more

A Kanchipuram Sari is not mere fabric. It is... a language with grammar, a financial instrument you can wear, a biological object dyed with chemistry, & a cultural archive woven by history & hand. For over a millennium, it functioned as liquid wealth. In desperate times, the silk could be burned away, leaving behind real silver & gold. A garment that protected its wearer, even in fire. Today, that loom meets AI, microbes, & cryptography — systems trying to relearn lost grammar, grow colour without poisoning land, & turn trust from promise into proof. What happens when a thousand-year-old loom meets 21st century’s thinking machines? Issue 3: Kanchipuram Saris & Thinking Machines, written by Nivedita, designed & built by Alt Carbonshow more