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Dear Colleagues at #ASCO25 Honored to introduce Dr. Matthias Preusser🇦🇹 of the Medical University of Vienna who just Presented Results from the TUXEDO-3 Trials with a concomitant publication in Nature Medicine Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial Leptomeningeal metastatic disease (LMD) is a devastating complication of solid tumors with limited treatment options. In cohort 3 of the phase 2 TUXEDO-3 trial, the antibody–drug conjugate patritumab deruxtecan (HER3-DXd) was evaluated for safety and efficacy in 20 patients with LMD from solid cancers, primarily #BreastCancer (60%) and🫁 #LungCancer (30%). Patients received HER3-DXd every three weeks, and after a median follow-up of 5.4 months, 65% were alive at 3 months, meeting the primary endpoint. The 3- and 6-month overall survival rates were 69.6% and 58.9%, respectively, with intracranial and extracranial clinical benefit rates of 50.0% and 38.5%. Neurological symptoms and quality of life remained stable or improved, with no new neurological toxicities. The most common adverse events were generally manageable, supporting HER3-DXd as a promising therapeutic option for patients with LMD. Lung Christian Rolfo gilberto lopes Narjust Florez, MD, FASCO Stephen V Liu, MD H. Jack West, MD, FASCO Bartomeu Massuti Dr. Antonio Calles 🫁🚭 Solange Peters Umberto Malapelle Christine Lovly, MD, PhD, FASCO Jill Feldman Ben Solomon Sanjay Popat Jordi Remon Jarushka Naidoo Dr. Estela Rodriguez Julien Mazieres Breast Matteo Lambertini, MD PhD Philippe Aftimos, MD  Evandro de Azambuja, MD, PhD 𝙅𝙚𝙨𝙪𝙨 𝘼𝙣𝙖𝙢𝙥𝙖 𝙈.𝘿, 𝙈.𝙎🧬🔬 Erika Hamilton, MD Dr. Kelly Shanahan Stacey Tinianov (she/her) MPH, BCPA Julia Maués Maryam Lustberg MD, MPH, FASCO IBC Research Fdn Roberta A Albany Hope Rugo Sara Tolaney Sherene Loi, MD Javier Cortes MD PhD Janice Cowden #OncoAlertAF Dra. María Natalia Gandur Quiroga Biagio Ricciuti, MD, PhD Emre Yekedüz Hidehito HORINOUCHI Fadi Haddad, MD Al-Ola A Abdallah MD (USMIRC) Jose Fernando Moura, PhD Elisa Agostinetto Elisabetta Bonzano MD, PhD Bárbara Melão, MD, PhD Dr Joseph McCollom DO Erman Akkus Luca Arecco, MD Gaia Griguolo Kristina Jankovic, MD MEDSIR

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