1/ 🚀 Introducing AIDO.StructureDiffusion: A generative model for structural protein design—enabling high-quality, controllable generation of monomers, complexes, and antibodies. 🧵

2/ What it does: → Residue-wise CAT class conditioning → Precision CDR and light chain control → scFv generation → Multi-domain single-chain designs → Immunoglobulin-specific tuning

3/AIDO.StructureDiffusion enables end-to-end antibody generation, not just loop design or masked editing. You can design antibodies from scratch, guided by function, structure, and developability.

4/ It learns from real-world diversity. We trained the base model on AFDB and RCSB structures, weighted by structural motifs. Fine-tuned on SAbDab and interacting chains from RCSB, the model excels at producing viable backbones for nanobodies and fragments.

5/ Why it matters: Controllability is key to molecular design. → You can guide the structure via the CAT hierarchy → Annotate CDRs, species, and chain types → Tune for loop length and developability → Build entire scFvs, not just fragments

6/ This marks a step forward in fully integrated AI-guided protein design, where the design is no longer isolated but embedded within a broader biological context. Read the blog: 🔗

Open source??

Hey keep going

impressive

protein folding in a diffusive way? cool.

This is next-level biotech! Excited to see the breakthroughs ahead!

Amazing!

Thanks for sharing, interesting innovation, future shape of DNA modeling will came to us.

That's amazing 👌

This makes me want to learn how to use blender so much!! Beautiful stuff

Wowee

Well shit. Ill read more on this.

i write about genetics on substack, i want to ask you something, how can i connect with you?

这技术太酷了！期待更多应用！

Very good chemistry

High quality food is protein.

This sounds like a major breakthrough in protein design! Excited to see how AIDO.StructureDiffusion will accelerate drug discovery and synthetic biology. The control over monomers and complexes could open up so many new possibilities.

Wow da protein is literally shakin

AIDO.StructureDiffusion shows how generative AI is transforming protein design. At Trakintel, we’re always inspired by innovations that push the boundaries of data-driven discovery.

@grok 有什么用？

AI is the new DNA — it learns, adapts, and replicates ideas like genes. 🤖.

Gm

Can you explain in one sentence what it does?

Impressive leap in generative biology excited to see its impact on antibody and complex design !

wow

This would be good with Blockchain.

👏

Amazing !

How does it compare to Alphafold?

Okay, controllable generation of proteins? So you guys are basically building the biological LEGO factory now. That is seriously cool work, this feels like a massive step forward.