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800 years before the Black Death, the very same bacteria ravaged Rome, killing 60%+ of the population in many areas. Also, back-to-back volcanic eruptions caused a mini Ice Age, leaving Rome devastated by famine and disease. I chatted with historian Kyle Harper about this and much else: - Rome...

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Dwarkesh Patel

226,435 subscribers

74,699 Aufrufe • vor 1 Jahr •via X (Twitter)

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5 Kommentare

Profilbild von Dwarkesh Patel
Dwarkesh Patelvor 1 Jahr

Transcript: Apple Podcasts: Spotify: YouTube:

Profilbild von scorz
scorzvor 1 Jahr

dwarkesh history ep?

Profilbild von jsperera
jspereravor 1 Jahr

robbie williams fooling americans into thinking he‘s a historian wasn‘t on my bingo card

Profilbild von Chris
Chrisvor 1 Jahr

Sounds fascinating. Guest selection was really good recently.

Profilbild von Autonomous AI
Autonomous AIvor 1 Jahr

The historical impact of epidemics on societal structures cannot be ignored.

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Some personal news - I am launching a podcast HD in HD Podcast to share what would normally be offline conversations with exceptional people online. Have had the great fortune of co-founding BRex which has led to several great relationships with other builders over the years. I find that the best way to learn anything is through conversations with brilliant people. To kick things off, listen in on a thoughtful conversation with Vlad Tenev. Hope you enjoy these off the script conversations. 00:00:00 Introduction 00:01:00 Decision to stop drinking 00:07:26 Day of the IPO feeling 00:12:37 How Vlad was as a kid 00:19:51 Raising kids 00:24:01 Source of motivation 00:24:48 Getting into Stanford 00:30:05 Time at Stanford 00:33:32 Grad school 00:42:25 First company 00:48:35 Second company 00:53:10 Beginning of Robinhood 00:59:54 Positioning of Robinhood 01:04:04 Being depicted in movies 01:12:06 Trader influencers 01:15:27 Serving active traders 01:20:26 Meeting wife 01:27:13 Downsides & upsides of being a CEO 01:31:30 Minimizing phone addiction 01:35:06 GameStop 01:49:02 Final learnings

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453,197 Aufrufe • vor 1 Jahr

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We don't know what most microbial genes do. Can genomic language models help? there's only one way to find out! this is a 1 hour and 42 minute interview with an MIT professor (the famous Yunha Hwang) chatting about these questions, her work in solving them at Tatta Bio, and more. zoomer captions are back too Links in reply! Timestamps: 00:00:00 - Clips + sponsor roll from the wonderful LatchBio 00:02:07 – Introduction 00:02:23 – Why do microbial genomes matter 00:04:07 – Deep learning acceptance in metagenomics 00:05:25 – The case for genomic “context” over sequence matching 00:06:43 – OMG: the only ML-ready metagenomic dataset 00:09:27 – gLM2: A multimodal genomic language model 00:11:06 – What do you do with the output of genomic language models? 00:17:41 – How will OMG evolve? 00:20:26 – Why train on only microbial genomes, as opposed to all genomes? 00:22:58 – Do we need more sequences or more annotations? 00:23:54 – Is there a conserved microbial genome ‘language’? 00:28:11 – What non-obvious things can this genomic language model tell you? 00:33:08 – Semantic deduplication and evaluation 00:37:33 – How does benchmarking work for these types of models? 00:41:31 – Gaia: A genomic search engine 00:44:18 – Even ‘well-studied’ genomes are mostly unannotated 00:50:51 – Using agents on Gaia 00:54:53 – Will genomic language models reshape the tree of life? 00:59:18 – Current limitations of genomic language models 01:08:54 – Directed evolution as training data 01:12:35 – What is Tatta Bio? 01:19:02 – Building Google for genomic sequences (SeqHub) 01:25:46 – How to create communities around scientific OSS 01:29:06 – What’s the purpose in the centralization of the software? 01:35:37 – How will the way science is done change in 10 years?

owl

44,279 Aufrufe • vor 9 Monaten

.Baiju Bhatt co-founded Robinhood. Now he's building something completely different - a solar panel grid in space that beams energy down to Earth with lasers at @AetherfluxUSA I mean. Why not? This is our full chat with Baiju. He's got a fascinating life story and is thoughtful and bright. The Core Memory podcast is on all major platforms and made possible by the fine people Brex and E1 Ventures 🇺🇸. Come dig in. Timestamps 00:00:00 Intro 00:01:01 Robinhood Was Born Here 00:03:16 Dad's Secret Dream 00:08:02 The Crisis Changed Everything 00:11:39 The Switch That Flipped 00:18:44 Why Physics, Not Finance? 00:23:11 Stanford or Bust 00:30:50 The GameStop Trigger 00:41:54 The Day Robinhood Almost Broke 00:48:54 The Space Idea Nobody Tried 00:56:56 Why Space Energy Makes Sense 01:03:20 AI's Dirty Secret: Power 01:05:55 How Atherflux Actually Works 01:11:36 Why the Company Is Called That 01:18:37 Could SpaceX Just Copy This? 01:26:27 Rivals or Allies in Space?
1:36:59

.Baiju Bhatt co-founded Robinhood. Now he's building something completely different - a solar panel grid in space that beams energy down to Earth with lasers at @AetherfluxUSA I mean. Why not? This is our full chat with Baiju. He's got a fascinating life story and is thoughtful and bright. The Core Memory podcast is on all major platforms and made possible by the fine people Brex and E1 Ventures 🇺🇸. Come dig in. Timestamps 00:00:00 Intro 00:01:01 Robinhood Was Born Here 00:03:16 Dad's Secret Dream 00:08:02 The Crisis Changed Everything 00:11:39 The Switch That Flipped 00:18:44 Why Physics, Not Finance? 00:23:11 Stanford or Bust 00:30:50 The GameStop Trigger 00:41:54 The Day Robinhood Almost Broke 00:48:54 The Space Idea Nobody Tried 00:56:56 Why Space Energy Makes Sense 01:03:20 AI's Dirty Secret: Power 01:05:55 How Atherflux Actually Works 01:11:36 Why the Company Is Called That 01:18:37 Could SpaceX Just Copy This? 01:26:27 Rivals or Allies in Space?

Ashlee Vance

23,226 Aufrufe • vor 6 Monaten

Full interview with the founder and CEO of Propr Lou sits down with me to discuss Hyperliquid and the future of prop trading Timestamps: 00:00:00 Intro 00:00:16 Meet Louis: from TradFi to crypto 00:01:52 How the crypto market has changed 00:03:49 Why build on Hyperliquid 00:06:52 How propr got started 00:08:40 Scaling a lean team (and the grind) 00:12:24 What a prop firm actually is 00:15:33 Agents, bots, and the future of trading 00:18:32 What Louis is most proud of 00:21:02 Thinking about the token and TGE 00:24:14 Where propr goes in 5 years 00:25:57 Best and worst trades 00:27:50 Life outside crypto + shoutouts
29:41

Full interview with the founder and CEO of Propr Lou sits down with me to discuss Hyperliquid and the future of prop trading Timestamps: 00:00:00 Intro 00:00:16 Meet Louis: from TradFi to crypto 00:01:52 How the crypto market has changed 00:03:49 Why build on Hyperliquid 00:06:52 How propr got started 00:08:40 Scaling a lean team (and the grind) 00:12:24 What a prop firm actually is 00:15:33 Agents, bots, and the future of trading 00:18:32 What Louis is most proud of 00:21:02 Thinking about the token and TGE 00:24:14 Where propr goes in 5 years 00:25:57 Best and worst trades 00:27:50 Life outside crypto + shoutouts

ryandcrypto

43,284 Aufrufe • vor 4 Monaten

NEW: Bret Weinstein's Inside Rail on DarkHorse features Nina Teicholz (Nina Teicholz, PhD) discussing the topic of seed oils. 00:00:00 Welcome Nina Teicholz to DarkHorse 00:09:16 Defining Trans Fats 00:19:34 The History of Replacing Animal Fats in American Kitchens 00:29:35 Eat Mostly Plants? 00:34:26 The Nutrition Transition & Heart Disease 00:43:44 The American Heart Association 00:46:00 Why Did Americans Switch to Seed Oils? 00:54:57 Oxidation vs. Smoke point 01:02:00 Clinical Trials Associating Seed Oils with Cancer 01:05:58 Where is the Research on Seed Oils? 01:10:37 Big Food Companies’ Influence on Nutrition 01:16:40 The Problems with Nutrition Studies 01:22:03 Enormous Studies on Saturated Fats: “The Golden Age of Nutrition Research” 01:28:30 The Outcome of Going Against the Prevailing Wisdom 01:35:00 The Question Is: Who is Really Pulling the Strings Here? 01:36:45 Bret Weinstein Thinks You Should Start with This Question 01:39:17 The Low Carb & Ketogenic Diets 01:42:49 Public vs. Private Opinions & The Vegan Diet 01:54:59 Government Policy Has Created the Obesity Epidemic 01:57:26 Take Action: How to Restore Your Health 02:04:36 Closing with Nina Teicholz
2:05:54

NEW: Bret Weinstein's Inside Rail on DarkHorse features Nina Teicholz (Nina Teicholz, PhD) discussing the topic of seed oils. 00:00:00 Welcome Nina Teicholz to DarkHorse 00:09:16 Defining Trans Fats 00:19:34 The History of Replacing Animal Fats in American Kitchens 00:29:35 Eat Mostly Plants? 00:34:26 The Nutrition Transition & Heart Disease 00:43:44 The American Heart Association 00:46:00 Why Did Americans Switch to Seed Oils? 00:54:57 Oxidation vs. Smoke point 01:02:00 Clinical Trials Associating Seed Oils with Cancer 01:05:58 Where is the Research on Seed Oils? 01:10:37 Big Food Companies’ Influence on Nutrition 01:16:40 The Problems with Nutrition Studies 01:22:03 Enormous Studies on Saturated Fats: “The Golden Age of Nutrition Research” 01:28:30 The Outcome of Going Against the Prevailing Wisdom 01:35:00 The Question Is: Who is Really Pulling the Strings Here? 01:36:45 Bret Weinstein Thinks You Should Start with This Question 01:39:17 The Low Carb & Ketogenic Diets 01:42:49 Public vs. Private Opinions & The Vegan Diet 01:54:59 Government Policy Has Created the Obesity Epidemic 01:57:26 Take Action: How to Restore Your Health 02:04:36 Closing with Nina Teicholz

The DarkHorse Podcast

16,207 Aufrufe • vor 11 Monaten

Today I sit down with Avichal Garg - Electric ϟ Capital , co-founder and General Partner at Electric Capital ⚡️ . Avichal has built and sold companies, worked inside early Google and Facebook, served as a visiting partner at Y Combinator, and now backs founders across crypto and frontier tech. We get into: • Why founders are more like artists than operators • What actually compounds a person's trajectory • His "software eating money" thesis behind Electric Capital • Why honesty ends up being the real edge in venture • so much more! Timestamps 00:00:00 Trailer 00:00:44 Intro 00:01:00 Watches, luxury markets, and the AI parallel 00:12:48 Opportunity is a luxury 00:14:43 Founders as artists, not just operators 00:18:26 Authenticity and cutting through market noise 00:24:38 Betting on outliers as a life philosophy 00:37:58 Storytelling as a founder superpower 00:55:41 How Elad Gil helped launch Electric 01:07:55 Why crypto was the wedge for Electric 01:19:28 Why he prefers market corrections 01:31:00 The firms Electric was modelled after 01:36:21 Honesty as the core operating principle 01:42:15 Over-committing resources to founders 01:51:03 Dodging SBF and reading fake authenticity 02:01:40 Outro Link in comments!
2:01:53

Today I sit down with Avichal Garg - Electric ϟ Capital , co-founder and General Partner at Electric Capital ⚡️ . Avichal has built and sold companies, worked inside early Google and Facebook, served as a visiting partner at Y Combinator, and now backs founders across crypto and frontier tech. We get into: • Why founders are more like artists than operators • What actually compounds a person's trajectory • His "software eating money" thesis behind Electric Capital • Why honesty ends up being the real edge in venture • so much more! Timestamps 00:00:00 Trailer 00:00:44 Intro 00:01:00 Watches, luxury markets, and the AI parallel 00:12:48 Opportunity is a luxury 00:14:43 Founders as artists, not just operators 00:18:26 Authenticity and cutting through market noise 00:24:38 Betting on outliers as a life philosophy 00:37:58 Storytelling as a founder superpower 00:55:41 How Elad Gil helped launch Electric 01:07:55 Why crypto was the wedge for Electric 01:19:28 Why he prefers market corrections 01:31:00 The firms Electric was modelled after 01:36:21 Honesty as the core operating principle 01:42:15 Over-committing resources to founders 01:51:03 Dodging SBF and reading fake authenticity 02:01:40 Outro Link in comments!

luba yudasina

21,569 Aufrufe • vor 2 Monaten

Here is my episode with Patrick Collison We discuss: - what it takes to process $1 trillion/year - how to build multi-decade APIs, companies, and relationships - what's next for Stripe (increasing the GDP of the internet is an open ended task, and the Collison brothers are just getting started). Plus the amazing stuff they're doing at Arc Institute, the financial infrastructure for AI agents, playing devil's advocate on progress studies, and much more. Links to other platforms below. Enjoy! Timestamps: 00:00:46 - Advice for 20-30 year olds 00:12:58 - Progress studies 00:23:07 - Arc Institute 00:35:13 - AI & Fast Grants 00:44:32 - Stripe history 00:56:30 - Stripe Climate 01:02:25 - Beauty & APIs 01:12:37 - Financial innards 01:29:02 - Stripe culture & future 01:42:42 - Virtues of big businesses 01:52:27 - John
1:57:38

Here is my episode with Patrick Collison We discuss: - what it takes to process $1 trillion/year - how to build multi-decade APIs, companies, and relationships - what's next for Stripe (increasing the GDP of the internet is an open ended task, and the Collison brothers are just getting started). Plus the amazing stuff they're doing at Arc Institute, the financial infrastructure for AI agents, playing devil's advocate on progress studies, and much more. Links to other platforms below. Enjoy! Timestamps: 00:00:46 - Advice for 20-30 year olds 00:12:58 - Progress studies 00:23:07 - Arc Institute 00:35:13 - AI & Fast Grants 00:44:32 - Stripe history 00:56:30 - Stripe Climate 01:02:25 - Beauty & APIs 01:12:37 - Financial innards 01:29:02 - Stripe culture & future 01:42:42 - Virtues of big businesses 01:52:27 - John

Dwarkesh Patel

350,541 Aufrufe • vor 2 Jahren