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A 42-year-old man on prolonged immunosuppressive therapy for chronic graft-versus-host disease after stem-cell transplantation for acute lymphoblastic leukemia presented to clinic with a 2-week history of urinary frequency and weak stream. Physical examination was notable for several small papules on the penile shaft. Urinalysis showed 9 white cells per...

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17,063 次观看 • 26 天前 •via X (Twitter)

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A 55-year-old man with acute myeloid leukemia presented with dyspnea, cough, and hypoxemia 17 days after undergoing myeloablative allogeneic stem-cell transplantation. Videos show the results of chest CT imaging. Read the full case:
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A 55-year-old man with acute myeloid leukemia presented with dyspnea, cough, and hypoxemia 17 days after undergoing myeloablative allogeneic stem-cell transplantation. Videos show the results of chest CT imaging. Read the full case:

NEJM

53,718 次观看 • 2 年前

A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. A punch biopsy showed dermal infiltration by small, round, blue cells arranged in nests, with scant cytoplasm and frequent mitoses. Immunohistochemical testing for perinuclear CK20 and synaptophysin was positive. What is the most likely diagnosis?
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A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. A punch biopsy showed dermal infiltration by small, round, blue cells arranged in nests, with scant cytoplasm and frequent mitoses. Immunohistochemical testing for perinuclear CK20 and synaptophysin was positive. What is the most likely diagnosis?

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A 63-year-old woman with psoriatic arthritis involving her knees presented for evaluation of 9-months of pain in the left knee. Physical examination was notable for a nontender, palpable mass in the left popliteal fossa. Point-of-care musculoskeletal ultrasonography is shown. What is the most likely diagnosis?
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A 63-year-old woman with psoriatic arthritis involving her knees presented for evaluation of 9-months of pain in the left knee. Physical examination was notable for a nontender, palpable mass in the left popliteal fossa. Point-of-care musculoskeletal ultrasonography is shown. What is the most likely diagnosis?

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12,441 次观看 • 6 个月前

A 74-year-old man presented to the hospital for the third time in three weeks with recurrent fever, muscle aches, and vomiting. In the prior two hospitalizations, symptoms had self-resolved and broad work-up was unremarkable. He had traveled to Yosemite National Park one week prior to symptom onset. Physical examination was notable for rigors and diaphoresis. Peripheral blood smears are shown. What is the most likely diagnosis?
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A 74-year-old man presented to the hospital for the third time in three weeks with recurrent fever, muscle aches, and vomiting. In the prior two hospitalizations, symptoms had self-resolved and broad work-up was unremarkable. He had traveled to Yosemite National Park one week prior to symptom onset. Physical examination was notable for rigors and diaphoresis. Peripheral blood smears are shown. What is the most likely diagnosis?

NEJM

14,125 次观看 • 4 个月前

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:
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A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

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28,531 次观看 • 12 天前

A 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. The rash had first appeared on the scalp and then spread across the body within 24 hours. What is the most likely diagnosis?
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A 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. The rash had first appeared on the scalp and then spread across the body within 24 hours. What is the most likely diagnosis?

NEJM

44,325 次观看 • 10 个月前

Dr. Suzanne Humphries: What if the very method of vaccine creation was its greatest flaw? We're told vaccines are a miracle of modern science. But how are they actually made? It starts by extracting a virus from a sick human or animal. This live, virulent virus then must be "attenuated" – weakened. How? By serial passage. They incubate it through a series of foreign cell lines to force it to mutate. Think: human amniotic cells, chicken embryo cells, and most notoriously... monkey kidney cells. But then, they need to mass-produce it. This is where it gets even more concerning. To multiply the virus for millions of doses, they grow it on rapidly dividing cell cultures. Some of these are: ➡️ Madin-Darby Canine Kidney (MDCK) cells (from a cocker spaniel, made tumorigenic so they multiply forever). ➡️ WI-38 & MRC-5 cells (fibroblasts from human fetal lung tissue, originating from elective abortions in the 1960s). These aren't conspiracy theories. They are listed right on the package inserts. You are not just being injected with a "weakened virus." You are being injected with a biological soup of foreign animal DNA, cell debris, and growth medium residuals. The obvious question: What unknown pathogens hitch a ride? History gives us the answer. For 30 years, a cancer-causing monkey virus—SV40—was injected into millions via the polio vaccine before it was "discovered" and acknowledged. It is now heavily associated with human tumors. And SV40 is not alone. Third-party researchers have repeatedly found stray viruses, retroviruses, and other contaminants that were not tested for. Why? Because you can't test for something you don't know exists. The entire process is built on a foundation of biological cross-contamination. We are playing a complex game of genetic roulette, trusting that no new unknown virus is silently passed along. This isn't anti-science. This is PRO-transparency and real safety. It's time to ask the hard questions they don't want to answer. What are we really injecting? What long-term effects are we ignoring?
1:55

Dr. Suzanne Humphries: What if the very method of vaccine creation was its greatest flaw? We're told vaccines are a miracle of modern science. But how are they actually made? It starts by extracting a virus from a sick human or animal. This live, virulent virus then must be "attenuated" – weakened. How? By serial passage. They incubate it through a series of foreign cell lines to force it to mutate. Think: human amniotic cells, chicken embryo cells, and most notoriously... monkey kidney cells. But then, they need to mass-produce it. This is where it gets even more concerning. To multiply the virus for millions of doses, they grow it on rapidly dividing cell cultures. Some of these are: ➡️ Madin-Darby Canine Kidney (MDCK) cells (from a cocker spaniel, made tumorigenic so they multiply forever). ➡️ WI-38 & MRC-5 cells (fibroblasts from human fetal lung tissue, originating from elective abortions in the 1960s). These aren't conspiracy theories. They are listed right on the package inserts. You are not just being injected with a "weakened virus." You are being injected with a biological soup of foreign animal DNA, cell debris, and growth medium residuals. The obvious question: What unknown pathogens hitch a ride? History gives us the answer. For 30 years, a cancer-causing monkey virus—SV40—was injected into millions via the polio vaccine before it was "discovered" and acknowledged. It is now heavily associated with human tumors. And SV40 is not alone. Third-party researchers have repeatedly found stray viruses, retroviruses, and other contaminants that were not tested for. Why? Because you can't test for something you don't know exists. The entire process is built on a foundation of biological cross-contamination. We are playing a complex game of genetic roulette, trusting that no new unknown virus is silently passed along. This isn't anti-science. This is PRO-transparency and real safety. It's time to ask the hard questions they don't want to answer. What are we really injecting? What long-term effects are we ignoring?

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Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology
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Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

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Police have arrested a 22-year-old man who was behind the wheel of a Land Rover involved in a five-vehicle collision on the New Klang Valley Expressway (NKVE), which went viral on social media. In a statement, Petaling Jaya district police chief ACP Shamsudin Mamat said investigations showed the crash, which occurred around 5.17pm on October 18, involved two lorries and three cars after the vehicle driven by the suspect lost control and rammed into several vehicles ahead. He said the suspect, a local man with no previous criminal record, was detained for investigation under Section 42 of the Road Transport Act 1987 for dangerous driving.
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Police have arrested a 22-year-old man who was behind the wheel of a Land Rover involved in a five-vehicle collision on the New Klang Valley Expressway (NKVE), which went viral on social media. In a statement, Petaling Jaya district police chief ACP Shamsudin Mamat said investigations showed the crash, which occurred around 5.17pm on October 18, involved two lorries and three cars after the vehicle driven by the suspect lost control and rammed into several vehicles ahead. He said the suspect, a local man with no previous criminal record, was detained for investigation under Section 42 of the Road Transport Act 1987 for dangerous driving.

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In low-risk patients with MI and early complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy was noninferior to dual antiplatelet therapy for ischemic outcomes and led to reduced bleeding at 1 year. Read the full TARGET-FIRST trial results in the Original Article “Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction”:
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In low-risk patients with MI and early complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy was noninferior to dual antiplatelet therapy for ischemic outcomes and led to reduced bleeding at 1 year. Read the full TARGET-FIRST trial results in the Original Article “Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction”:

NEJM

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Weight Regain after Stopping Obesity Medications: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a recent meta-analysis that showed projected return to baseline weight within 2 years. Full context and comment by Sarah E. Post, MD: Visit for more Insights You’ll Love This Week, including: 🩺 A Streamlined Approach to Blood Pressure Measurement 🎗️ Risk-Based Breast Cancer Screening vs. Annual Mammograms 🧬 Predicting Acute Chest Syndrome in Sickle Cell Disease 💉 Ketamine vs. Etomidate for Emergent Intubation #MedTwitter
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Weight Regain after Stopping Obesity Medications: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a recent meta-analysis that showed projected return to baseline weight within 2 years. Full context and comment by Sarah E. Post, MD: Visit for more Insights You’ll Love This Week, including: 🩺 A Streamlined Approach to Blood Pressure Measurement 🎗️ Risk-Based Breast Cancer Screening vs. Annual Mammograms 🧬 Predicting Acute Chest Syndrome in Sickle Cell Disease 💉 Ketamine vs. Etomidate for Emergent Intubation #MedTwitter

NEJM

20,543 次观看 • 5 个月前

Retired U.S. Sergeant and Marshal Arrested for Sending Illicit Messages to a 13-Year-Old Decoy. A retired sergeant who also served as a U.S. Marshal was arrested after exchanging sexually explicit messages with someone he believed was a 13-year-old girl. The encounter was part of a sting operation by a predator poaching group (Decoy Twinkle / Falcon Pursuit Coalition in Illinois). The man showed up expecting to meet the minor, leading to his arrest on related charges. Reports from the sting noted his wife appeared indifferent when informed.
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Sensitive content

Retired U.S. Sergeant and Marshal Arrested for Sending Illicit Messages to a 13-Year-Old Decoy. A retired sergeant who also served as a U.S. Marshal was arrested after exchanging sexually explicit messages with someone he believed was a 13-year-old girl. The encounter was part of a sting operation by a predator poaching group (Decoy Twinkle / Falcon Pursuit Coalition in Illinois). The man showed up expecting to meet the minor, leading to his arrest on related charges. Reports from the sting noted his wife appeared indifferent when informed.

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263,285 次观看 • 2 个月前

World-renowned physician Dr. William Li explains how cacao can stimulate stem cells to migrate to various sites of repair and regeneration throughout the body. Cacao is the core ingredient in chocolate and is produced from the beans of cacao tree through a process of fermentation, drying and roasting. Clinical studies have shown that men in their sixties with heart disease, who drank 2 cups of dark hot cocoa per day for a month, doubled their stem cells and significantly improved their circulation. The COSMOS (COcoa Supplement and Multivitamin Outcomes Study) is a large-scale clinical trial that recently showed that consuming high flavanol cocoa decreases the risk of cardiovascular death. What are your thoughts on this?
1:15

World-renowned physician Dr. William Li explains how cacao can stimulate stem cells to migrate to various sites of repair and regeneration throughout the body. Cacao is the core ingredient in chocolate and is produced from the beans of cacao tree through a process of fermentation, drying and roasting. Clinical studies have shown that men in their sixties with heart disease, who drank 2 cups of dark hot cocoa per day for a month, doubled their stem cells and significantly improved their circulation. The COSMOS (COcoa Supplement and Multivitamin Outcomes Study) is a large-scale clinical trial that recently showed that consuming high flavanol cocoa decreases the risk of cardiovascular death. What are your thoughts on this?

Barbara Oneill

449,949 次观看 • 2 年前

An interim analysis of a phase 1–2 study of gene therapy for Artemis-deficient severe combined immunodeficiency suggests that this treatment is safe and effective. New research findings are summarized in a short video.
2:19

An interim analysis of a phase 1–2 study of gene therapy for Artemis-deficient severe combined immunodeficiency suggests that this treatment is safe and effective. New research findings are summarized in a short video.

NEJM

45,461 次观看 • 3 年前

🚨BREAKING UPDATE: Man accused of st*bbing an elderly couple and setting their bodies on fire is a level 3 s*x offender with a 30-year violent criminal history and was out on parole for first-degree robbery 42-year-old Jamel McGriff is armed and dangerous Investigators believe he st*bbed an elderly couple and set their bodies on fire to cover the m*rders He has a 30-year violent criminal history McGriff is a Level 3 registered s*x offender, the highest risk for reoffending He is out on parole for a 2006 first-degree robbery after serving 16 years He is also wanted for two robberies in Manhattan in July and an attempted Midtown robbery on August 31 Police say he was last seen in the Bronx earlier today pawning two cell phones
0:30

🚨BREAKING UPDATE: Man accused of st*bbing an elderly couple and setting their bodies on fire is a level 3 s*x offender with a 30-year violent criminal history and was out on parole for first-degree robbery 42-year-old Jamel McGriff is armed and dangerous Investigators believe he st*bbed an elderly couple and set their bodies on fire to cover the m*rders He has a 30-year violent criminal history McGriff is a Level 3 registered s*x offender, the highest risk for reoffending He is out on parole for a 2006 first-degree robbery after serving 16 years He is also wanted for two robberies in Manhattan in July and an attempted Midtown robbery on August 31 Police say he was last seen in the Bronx earlier today pawning two cell phones

Unlimited L's

3,109,244 次观看 • 10 个月前

NEW: Man killed by transgender driver who plowed into him, backed over him and stabbed him 9 times before kissing him and prancing over his body. Absolutely horrific. 20-year-old suspect Karon Fisher is a man according to court papers. After trying to flee the scene in a car, Fisher jumped over the body of 64-year-old Steven Anderson. The Houston man was going to check the mail when he was attacked. Fisher was charged for the murder and is being held on a $2 million bond. He was also charged with assaulting a hospital staff member on the same day.
0:36

Sensitive content

NEW: Man killed by transgender driver who plowed into him, backed over him and stabbed him 9 times before kissing him and prancing over his body. Absolutely horrific. 20-year-old suspect Karon Fisher is a man according to court papers. After trying to flee the scene in a car, Fisher jumped over the body of 64-year-old Steven Anderson. The Houston man was going to check the mail when he was attacked. Fisher was charged for the murder and is being held on a $2 million bond. He was also charged with assaulting a hospital staff member on the same day.

Collin Rugg

3,970,780 次观看 • 2 年前

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:
0:25

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

NEJM

90,490 次观看 • 9 天前

In patients with atrial fibrillation and a drug-eluting stent placed at least 1 year earlier, monotherapy with a non–vitamin K antagonist oral anticoagulant was noninferior to combination therapy with clopidogrel for net adverse clinical events. Full ADAPT AF-DES trial results and Research Summary:
1:29

In patients with atrial fibrillation and a drug-eluting stent placed at least 1 year earlier, monotherapy with a non–vitamin K antagonist oral anticoagulant was noninferior to combination therapy with clopidogrel for net adverse clinical events. Full ADAPT AF-DES trial results and Research Summary:

NEJM

12,252 次观看 • 5 个月前

Videos show pronuclear transfer, which was performed in a series of women with pathogenic mtDNA variants to reduce the transmission of these variants to their children. Read the full study about this method in the Original Article “Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease” by L.A. Hyslop et al.:
1:43

Videos show pronuclear transfer, which was performed in a series of women with pathogenic mtDNA variants to reduce the transmission of these variants to their children. Read the full study about this method in the Original Article “Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease” by L.A. Hyslop et al.:

NEJM

13,014 次观看 • 1 年前

NEW: Florida man caught with a d*ldo and a fake bladder in what police are calling a "jerry-rigged Whizzinator" to fake a urine sample. "I would know if there was a peebag and a godd*amn d*ldo in my car," the police officer was heard saying. 52-year-old James Shepard showed up to a court-ordered drug test driving on a suspended license. Investigators say he came with a fake bladder full of fake urine connected to a heating pad with a fake weiner. While in handcuffs for driving on a suspended license, Shepard was seen on camera pulling out the "jerry-rigged Whizzinator" before throwing it to the side. He is now facing charges of driving without a valid license, violating his probation, defrauding a drug test, and tampering with evidence.
1:32

Sensitive content

NEW: Florida man caught with a d*ldo and a fake bladder in what police are calling a "jerry-rigged Whizzinator" to fake a urine sample. "I would know if there was a peebag and a godd*amn d*ldo in my car," the police officer was heard saying. 52-year-old James Shepard showed up to a court-ordered drug test driving on a suspended license. Investigators say he came with a fake bladder full of fake urine connected to a heating pad with a fake weiner. While in handcuffs for driving on a suspended license, Shepard was seen on camera pulling out the "jerry-rigged Whizzinator" before throwing it to the side. He is now facing charges of driving without a valid license, violating his probation, defrauding a drug test, and tampering with evidence.

Collin Rugg

634,856 次观看 • 13 天前