NEJM

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The New England Journal of Medicine is the world’s leading medical journal and website.

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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

1,135,707 次观看

A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. When the patient’s hands were clenched into fists or pressed against the table, the joint deformities largely resolved. Read the full case details:

A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. When the patient’s hands were clenched into fists or pressed against the table, the joint deformities largely resolved. Read the full case details:

38,464 次观看

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

18,062 次观看

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,206 次观看

Videos

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A video shows a patient with progressive multiple sclerosis attempting to walk before and after treatment with JY231, an off-the-shelf lentiviral vector designed for the direct in vivo engineering of CD19-targeted CAR T cells. Learn more in the preliminary results of a phase 1 trial:

A video shows a patient with progressive multiple sclerosis attempting to walk before and after treatment with JY231, an off-the-shelf lentiviral vector designed for the direct in vivo engineering of CD19-targeted CAR T cells. Learn more in the preliminary results of a phase 1 trial:

112,470 次观看 • 9 天前

A 54-year-old woman presented with a 4-month history of progressively worsening asthenia and falls and 5 days of dyspnea. On exam, there was also head drop and mild symmetric weakness of the proximal upper and lower limbs. The creatine kinase level was 373 U per liter (reference range, 24 to 173). Magnetic resonance imaging of the head and cervical spine was notable for fatty infiltration of the tongue and paravertebral muscles. What is the most likely disease category? Submit your answer and see how others responded:

A 54-year-old woman presented with a 4-month history of progressively worsening asthenia and falls and 5 days of dyspnea. On exam, there was also head drop and mild symmetric weakness of the proximal upper and lower limbs. The creatine kinase level was 373 U per liter (reference range, 24 to 173). Magnetic resonance imaging of the head and cervical spine was notable for fatty infiltration of the tongue and paravertebral muscles. What is the most likely disease category? Submit your answer and see how others responded:

28,235 次观看 • 4 天前

As the director of an internal medicine residency program, would you recommend a 2-year “fast-track” option for residents or maintain the current 3-year program? Read more and cast your vote:

As the director of an internal medicine residency program, would you recommend a 2-year “fast-track” option for residents or maintain the current 3-year program? Read more and cast your vote:

84,605 次观看 • 1 个月前

A new Video in Clinical Medicine demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources. Watch the full video:

A new Video in Clinical Medicine demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources. Watch the full video:

35,258 次观看 • 20 天前

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

91,121 次观看 • 1 个月前

Well, it depends... who do you want to yell at you? Cardiology or Nephrology? Our latest video in partnership with Dr. Glaucomflecken summarizes the ARISE FLUIDS trial that examined whether hemodynamic resuscitation with early vasopressors versus more liberal fluids could affect outcomes in patients with septic shock. Read the full study for free: #emergencymedicine

Well, it depends... who do you want to yell at you? Cardiology or Nephrology? Our latest video in partnership with Dr. Glaucomflecken summarizes the ARISE FLUIDS trial that examined whether hemodynamic resuscitation with early vasopressors versus more liberal fluids could affect outcomes in patients with septic shock. Read the full study for free: #emergencymedicine

38,851 次观看 • 28 天前

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

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A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

77,147 次观看 • 2 个月前

Among adults with endocarditis caused by 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴, 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse. Full POET II trial results: #ESCCongress | European Society of Cardiology

Among adults with endocarditis caused by 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴, 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse. Full POET II trial results: #ESCCongress | European Society of Cardiology

20,654 次观看 • 16 天前

What do you counsel patients with #AFib who are candidates for long-term anticoagulation? NEJM Editorial Fellow Katerina Lin, MD, provides an overview of the recently published CHAMPION-AF trial. Read the full trial results:

What do you counsel patients with #AFib who are candidates for long-term anticoagulation? NEJM Editorial Fellow Katerina Lin, MD, provides an overview of the recently published CHAMPION-AF trial. Read the full trial results:

34,919 次观看 • 1 个月前

A 46-year-old man with chronic kidney disease presented with a 2-year history of painless shortening and rounding of the fingertips. Ten years earlier, he had received a diagnosis of chronic kidney disease due to obstructive nephropathy from nephrolithiasis. Since then, he had been intermittently lost to follow-up. On physical examination, all the fingertips were short, broad, and bulbous, with a pseudoclubbing appearance. The toes had similar but less severe changes. What do the findings on the exam and imaging represent? Submit your answer and see how others responded:

A 46-year-old man with chronic kidney disease presented with a 2-year history of painless shortening and rounding of the fingertips. Ten years earlier, he had received a diagnosis of chronic kidney disease due to obstructive nephropathy from nephrolithiasis. Since then, he had been intermittently lost to follow-up. On physical examination, all the fingertips were short, broad, and bulbous, with a pseudoclubbing appearance. The toes had similar but less severe changes. What do the findings on the exam and imaging represent? Submit your answer and see how others responded:

28,743 次观看 • 25 天前

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

155,245 次观看 • 6 个月前

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

104,553 次观看 • 4 个月前

NEJM Editorial Fellow Minali Nigam, MD, describes the case of a 22-year-old man who presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms. Read the case details and diagnosis:

NEJM Editorial Fellow Minali Nigam, MD, describes the case of a 22-year-old man who presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms. Read the case details and diagnosis:

36,141 次观看 • 1 个月前

Dr. Ken Wu, a pediatric doctor and NEJM editorial fellow from 2019 to 2020, reflects on his decision to apply for an NEJM editorial fellowship, some of the highlights of the fellowship, and the impact it has had on his career. Sound interesting? NEJM is looking for physicians at any career stage to apply for a one-year, full-time, paid editorial fellowship beginning in July 2027. Several fellows will be selected for the 2027–28 year; applications are due Saturday, August 15, 2026. To learn more and to apply, visit For more reflections from prior NEJM fellows and for more information, visit

Dr. Ken Wu, a pediatric doctor and NEJM editorial fellow from 2019 to 2020, reflects on his decision to apply for an NEJM editorial fellowship, some of the highlights of the fellowship, and the impact it has had on his career. Sound interesting? NEJM is looking for physicians at any career stage to apply for a one-year, full-time, paid editorial fellowship beginning in July 2027. Several fellows will be selected for the 2027–28 year; applications are due Saturday, August 15, 2026. To learn more and to apply, visit For more reflections from prior NEJM fellows and for more information, visit

34,145 次观看 • 1 个月前

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

185,718 次观看 • 9 个月前

A 61-year-old man with prolonged neutropenia as a result of salvage chemotherapy for acute myeloid leukemia was evaluated on hospital day 37 for persistent neutropenic fever despite treatment with broad-spectrum antimicrobial agents. Physical exam was notable for a lesion with central necrosis on the chest and a similar lesion on the left palm. A serum 1,3-β-D-glucan level was elevated, and a galactomannan was negative. Computed tomography of the chest, abdomen, and pelvis was performed. Gram’s staining of blood culture revealed septate, hyaline hyphae. What is the most likely causative organism? Submit your answer or see how others responded:

A 61-year-old man with prolonged neutropenia as a result of salvage chemotherapy for acute myeloid leukemia was evaluated on hospital day 37 for persistent neutropenic fever despite treatment with broad-spectrum antimicrobial agents. Physical exam was notable for a lesion with central necrosis on the chest and a similar lesion on the left palm. A serum 1,3-β-D-glucan level was elevated, and a galactomannan was negative. Computed tomography of the chest, abdomen, and pelvis was performed. Gram’s staining of blood culture revealed septate, hyaline hyphae. What is the most likely causative organism? Submit your answer or see how others responded:

33,857 次观看 • 1 个月前

An article by Rose Anne Kenny, MD, DSc, summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients. Read “Syncope”:

An article by Rose Anne Kenny, MD, DSc, summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients. Read “Syncope”:

24,581 次观看 • 27 天前

In patients with atrial fibrillation and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results: #ESCCongress | European Society of Cardiology

In patients with atrial fibrillation and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results: #ESCCongress | European Society of Cardiology

16,284 次观看 • 17 天前

This video in our partnership with Dr. Glaucomflecken explains a head-to-head trial comparing rituximab versus ocrelizumab in newly diagnosed relapsing multiple sclerosis. Access the full results of the OVERLORD-MS trial for free: #neurology

This video in our partnership with Dr. Glaucomflecken explains a head-to-head trial comparing rituximab versus ocrelizumab in newly diagnosed relapsing multiple sclerosis. Access the full results of the OVERLORD-MS trial for free: #neurology

35,502 次观看 • 1 个月前