NEJM

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The New England Journal of Medicine is the world’s leading medical journal and website.

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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

650,892 görüntüleme

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

18,016 görüntüleme

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

17,580 görüntüleme

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,201 görüntüleme

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A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

0:25

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

NEJM

90,490 görüntüleme • 9 gün önce

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

0:33

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A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

NEJM

77,042 görüntüleme • 16 gün önce

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

1:13

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

NEJM

32,725 görüntüleme • 8 gün önce

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

0:40

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

NEJM

28,531 görüntüleme • 12 gün önce

Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics

1:17

Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics

NEJM

41,761 görüntüleme • 22 gün önce

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

1:05

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

NEJM

103,809 görüntüleme • 2 ay önce

0:42

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

NEJM

155,245 görüntüleme • 4 ay önce

1:16

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

NEJM

185,502 görüntüleme • 7 ay önce

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

1:23

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

NEJM

17,950 görüntüleme • 16 gün önce

1:34

Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology

NEJM

49,527 görüntüleme • 2 ay önce

1:45

GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock

NEJM

27,012 görüntüleme • 1 ay önce

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

0:29

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

NEJM

40,524 görüntüleme • 1 ay önce

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

1:14

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

NEJM

12,637 görüntüleme • 15 gün önce

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

1:11

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

NEJM

17,386 görüntüleme • 25 gün önce

0:30

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

NEJM

62,428 görüntüleme • 3 ay önce

1:27

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

NEJM

89,790 görüntüleme • 5 ay önce

A 42-year-old man on prolonged immunosuppressive therapy for chronic graft-versus-host disease after stem-cell transplantation for acute lymphoblastic leukemia presented to clinic with a 2-week history of urinary frequency and weak stream. Physical examination was notable for several small papules on the penile shaft. Urinalysis showed 9 white cells per high-power field, and a urine culture was negative. Testing for human immunodeficiency virus was also negative. Resected urethral tissue showed papillomatous squamous proliferation with koilocytic atypia. What causes this condition? Submit your answer:

0:40

A 42-year-old man on prolonged immunosuppressive therapy for chronic graft-versus-host disease after stem-cell transplantation for acute lymphoblastic leukemia presented to clinic with a 2-week history of urinary frequency and weak stream. Physical examination was notable for several small papules on the penile shaft. Urinalysis showed 9 white cells per high-power field, and a urine culture was negative. Testing for human immunodeficiency virus was also negative. Resected urethral tissue showed papillomatous squamous proliferation with koilocytic atypia. What causes this condition? Submit your answer:

NEJM

17,063 görüntüleme • 26 gün önce

$Are PPIs Linked to COPD Flares? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a retrospective study investigating if proton pump inhibitor (PPI) use is associated with exacerbations of chronic obstructive airway diseases. Read the full summary by Molly S. Brett, MD: Visit for more Insights to Break Your Routine, including: 💊 Early Transition to Oral Antibiotics after Hospitalization for Serious Infection 🩸 Breaking the Unfractionated Heparin Habit in Acute VTE 🫘 Ablation for Small Localized Renal Cell Carcinomas 📈 How Helpful Are Continuous Glucose Monitors for Type 2 Diabetes?$

1:44

Are PPIs Linked to COPD Flares? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a retrospective study investigating if proton pump inhibitor (PPI) use is associated with exacerbations of chronic obstructive airway diseases. Read the full summary by Molly S. Brett, MD: Visit for more Insights to Break Your Routine, including: 💊 Early Transition to Oral Antibiotics after Hospitalization for Serious Infection 🩸 Breaking the Unfractionated Heparin Habit in Acute VTE 🫘 Ablation for Small Localized Renal Cell Carcinomas 📈 How Helpful Are Continuous Glucose Monitors for Type 2 Diabetes?

NEJM

28,904 görüntüleme • 1 ay önce

1:40

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉

NEJM

137,388 görüntüleme • 10 ay önce

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NEJM

Shorts

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

Videos

Watch Anya Live

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

Sensitive content

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉