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A miner on Micaela Bazo's (Micaela) Bittensor Subnet, SN68 NOVA (@metanovalabs), applied an energy supply optimization strategy for drug discovery to outcompete other miners. "One of the winning code submissions for Nova Blueprint used this optimization strategy that is usually used for energy supply, had never been applied to... show more

Boomer

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23,449 просмотров • 2 месяцев назад •via X (Twitter)

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"The future is really bright in AI and drug discovery." Sean McClain, Founder and CEO of Absci, shared the CES stage with healthcare leaders to illustrate how the compute partnership with AMD has scaled their ability to screen over a million drugs in one single day, resulting in better models for drug discovery.

"The future is really bright in AI and drug discovery." Sean McClain, Founder and CEO of Absci, shared the CES stage with healthcare leaders to illustrate how the compute partnership with AMD has scaled their ability to screen over a million drugs in one single day, resulting in better models for drug discovery.

AMD

15,343 просмотров • 5 месяцев назад

"What I was not told and what my parents were not told is that these [psychiatric] drugs are approved by the FDA on the basis of very short term trials - six to eight weeks on average. There is zero evidence base for polypharmacy. So, these drugs…their safety and efficacy has never been studied in combination with each other. And every single psychiatric drug across all the different drug classes is dependence-forming, meaning, as I said earlier, if you take this drug for any length of time, your body may well completely alter itself to accommodate the presence of the drug, so that if you want to come off of it one day, you might have a really hard time doing that. And you might need years of tapering. And I think, especially for girls and women who are teenagers or entering into their young adult childbearing years, it should be a legal requirement that doctors tell us before we start these drugs that if you want to have a child one day, you need to build in a long-term exit strategy here so that you don't find yourself in a situation where you need to stop this drug abruptly and potentially cause significant harm to yourself." - Laura Delano

"What I was not told and what my parents were not told is that these [psychiatric] drugs are approved by the FDA on the basis of very short term trials - six to eight weeks on average. There is zero evidence base for polypharmacy. So, these drugs…their safety and efficacy has never been studied in combination with each other. And every single psychiatric drug across all the different drug classes is dependence-forming, meaning, as I said earlier, if you take this drug for any length of time, your body may well completely alter itself to accommodate the presence of the drug, so that if you want to come off of it one day, you might have a really hard time doing that. And you might need years of tapering. And I think, especially for girls and women who are teenagers or entering into their young adult childbearing years, it should be a legal requirement that doctors tell us before we start these drugs that if you want to have a child one day, you need to build in a long-term exit strategy here so that you don't find yourself in a situation where you need to stop this drug abruptly and potentially cause significant harm to yourself." - Laura Delano

Jan Jekielek

20,247 просмотров • 1 год назад

Today I called for a hearing on the Four Pillars strategy to address public drug use, addiction, and overdoses in San Francisco Prevention, harm reduction, enforcement, and treatment. Zurich deployed this model and now it is one of the safest cities *in the world.*

Today I called for a hearing on the Four Pillars strategy to address public drug use, addiction, and overdoses in San Francisco Prevention, harm reduction, enforcement, and treatment. Zurich deployed this model and now it is one of the safest cities in the world.

Jackie Fielder

184,177 просмотров • 1 год назад

AOC: The pharmaceutical company AbbVie used this strategy with its drug Humira, which is used to treat rheumatoid arthritis. By barely changing the product, they obtained more than 130 patents that gave them continued exclusive market control over rheumatoid arthritis treatments. During that time, the price of Humira went from $500 per syringe to nearly $3,000 per syringe, leading to a cost of about $80,000 for a one-year supply for a patient.

AOC: The pharmaceutical company AbbVie used this strategy with its drug Humira, which is used to treat rheumatoid arthritis. By barely changing the product, they obtained more than 130 patents that gave them continued exclusive market control over rheumatoid arthritis treatments. During that time, the price of Humira went from $500 per syringe to nearly $3,000 per syringe, leading to a cost of about $80,000 for a one-year supply for a patient.

Acyn

59,566 просмотров • 2 дней назад

🚨 The Paxil scandal is an astonishing example of how drug data can be hidden and spun—and then sold to kids. “In the late 90s, the manufacturer GlaxoSmithKline or GSK did a series of trials and found that the drug was no better than placebo. …There was an email that was sent to staff where GSK said that [it] would be commercially unacceptable to disclose the poor efficacy data of this drug. So instead of telling the truth, they hired a PR firm to write the medical journal for them, to ghostwrite the article and put a positive spin on it, and then that was submitted to the journal, and it was published in 2001. And it wasn't long before the regulators in the US and also in Europe discovered that the drug actually was increasing the risk of suicidal ideation. It was doing the exact opposite of what the drug was meant to do. And so they put out a warning saying that this drug showed no efficacy in children and adolescents, but the drug continued to be marketed off-label…because the prominent journal had published this peer-reviewed paper. GSK purchased thousands of pre-prints and sent them out to all their representatives, and then they went to doctors, giving free samples, saying this drug is safe and effective for children. And I think within a time span of three years, GSK made over a billion dollars in sales from a drug that had never proven to be safe or effective in children and adolescents.” -Investigative journalist Maryanne Demasi, PhD

🚨 The Paxil scandal is an astonishing example of how drug data can be hidden and spun—and then sold to kids. “In the late 90s, the manufacturer GlaxoSmithKline or GSK did a series of trials and found that the drug was no better than placebo. …There was an email that was sent to staff where GSK said that [it] would be commercially unacceptable to disclose the poor efficacy data of this drug. So instead of telling the truth, they hired a PR firm to write the medical journal for them, to ghostwrite the article and put a positive spin on it, and then that was submitted to the journal, and it was published in 2001. And it wasn't long before the regulators in the US and also in Europe discovered that the drug actually was increasing the risk of suicidal ideation. It was doing the exact opposite of what the drug was meant to do. And so they put out a warning saying that this drug showed no efficacy in children and adolescents, but the drug continued to be marketed off-label…because the prominent journal had published this peer-reviewed paper. GSK purchased thousands of pre-prints and sent them out to all their representatives, and then they went to doctors, giving free samples, saying this drug is safe and effective for children. And I think within a time span of three years, GSK made over a billion dollars in sales from a drug that had never proven to be safe or effective in children and adolescents.” -Investigative journalist Maryanne Demasi, PhD

Jan Jekielek

140,141 просмотров • 7 месяцев назад

"U.S. PREPARING FOR MILITARY STRIKES ON DRUG TARGETS INSIDE VENEZUELA" U.S. military leaders are formulating strategies to strike at drug traffickers within Venezuela, with operations possibly commencing in just a few weeks. Conducting strikes in Venezuela would signify an additional escalation in the military strategy of the Trump administration aimed at alleged drug targets and its policy towards the Venezuelan government. The question arises regarding Maduro's reaction should the US target locations in Venezuela. Will he consider it a declaration of war?

"U.S. PREPARING FOR MILITARY STRIKES ON DRUG TARGETS INSIDE VENEZUELA" U.S. military leaders are formulating strategies to strike at drug traffickers within Venezuela, with operations possibly commencing in just a few weeks. Conducting strikes in Venezuela would signify an additional escalation in the military strategy of the Trump administration aimed at alleged drug targets and its policy towards the Venezuelan government. The question arises regarding Maduro's reaction should the US target locations in Venezuela. Will he consider it a declaration of war?

WORLD AT WAR

87,075 просмотров • 9 месяцев назад

US🇺🇸 DEA’s own statistics PROVE Trump’s narco-trafficking pretext for regime change against Venezuela🇻🇪 is a LIE ‘Even the DEA’s own assessment on drug trafficking shows that 87% of drug trafficking going to the United States goes through the Pacific Ocean, and Venezuela doesn’t have a coast on the Pacific Ocean. This idea that Venezuela could be the real source of the problems that the US has with the war on drugs, or the whole issue of drug trafficking, is absurd. They’ve spent the last 50 years in this so-called war on drugs, spent over a trillion dollars trying to curtail it. And the result is that right now there’s more drug consumption and drug distribution within the United States. What it has been used for, though, is the displacement of local populations, not only in Venezuela. We’re seeing this happen in Colombia and other places in South America. They’ve used the pretext of the war on drugs to intervene inside these countries, to displace populations from important resources and land, always with an ulterior motive, not the real motive of trying to attack drugs.’ -Carlos Ron, Venezuela’s Former Deputy Foreign Minister for North America, on the latest episode of Going Underground FULL INTERVIEW BELOW IN THE REPLIES👇

US🇺🇸 DEA’s own statistics PROVE Trump’s narco-trafficking pretext for regime change against Venezuela🇻🇪 is a LIE ‘Even the DEA’s own assessment on drug trafficking shows that 87% of drug trafficking going to the United States goes through the Pacific Ocean, and Venezuela doesn’t have a coast on the Pacific Ocean. This idea that Venezuela could be the real source of the problems that the US has with the war on drugs, or the whole issue of drug trafficking, is absurd. They’ve spent the last 50 years in this so-called war on drugs, spent over a trillion dollars trying to curtail it. And the result is that right now there’s more drug consumption and drug distribution within the United States. What it has been used for, though, is the displacement of local populations, not only in Venezuela. We’re seeing this happen in Colombia and other places in South America. They’ve used the pretext of the war on drugs to intervene inside these countries, to displace populations from important resources and land, always with an ulterior motive, not the real motive of trying to attack drugs.’ -Carlos Ron, Venezuela’s Former Deputy Foreign Minister for North America, on the latest episode of Going Underground FULL INTERVIEW BELOW IN THE REPLIES👇

Going Underground

54,680 просмотров • 7 месяцев назад

“Colorado almost k!lled me,that one no be drug, they produced it to change glory,this drug of a thing is slowing me down, been smoking crack for 7years now” 😳 - This is the capital of Lagos, ikeja and the part you never knew existed, a place where drug seem legal, but illegal 😳🙆🏽‍♂️

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“Colorado almost k!lled me,that one no be drug, they produced it to change glory,this drug of a thing is slowing me down, been smoking crack for 7years now” 😳 - This is the capital of Lagos, ikeja and the part you never knew existed, a place where drug seem legal, but illegal 😳🙆🏽‍♂️

ThatOjoBoy

62,831 просмотров • 1 месяц назад

American pork is fed a drug so toxic that is banned in 168 Countries. Ractopamine is a synthetic growth promoting drug approved for use by the FDA. This approval came after a single human study funded by its maker, Elanco. The drug pushes pigs’ metabolism hard, which is linked to more lameness, stress behaviors, and cardiovascular strain. 168 countries ban the drug arguing that these welfare impacts are unacceptable given the drug is used only to make meat leaner and production more profitable.

American pork is fed a drug so toxic that is banned in 168 Countries. Ractopamine is a synthetic growth promoting drug approved for use by the FDA. This approval came after a single human study funded by its maker, Elanco. The drug pushes pigs’ metabolism hard, which is linked to more lameness, stress behaviors, and cardiovascular strain. 168 countries ban the drug arguing that these welfare impacts are unacceptable given the drug is used only to make meat leaner and production more profitable.

Truth Warrior

47,048 просмотров • 29 дней назад

Trump suggested that the breakthrough on drug prices could also translate to lowering health insurance. In terms of real-world results, Trump called it “massive.” For example, he explained how a drug that sells for $137 in America will drop to just $15 to $18. In other countries, the same drug is sold for only $10, and they will now have to raise the price slightly. But America is no longer footing the bill, so the rest of the world can get cheap drugs. And finally — in a move once thought impossible — Americans will be paying a fair price.

Trump suggested that the breakthrough on drug prices could also translate to lowering health insurance. In terms of real-world results, Trump called it “massive.” For example, he explained how a drug that sells for $137 in America will drop to just $15 to $18. In other countries, the same drug is sold for only $10, and they will now have to raise the price slightly. But America is no longer footing the bill, so the rest of the world can get cheap drugs. And finally — in a move once thought impossible — Americans will be paying a fair price.

The Vigilant Fox 🦊

34,081 просмотров • 9 месяцев назад

SITUATION EXPLAINED: What comes after GLP-1s as the next human enhancement drug? We asked Max Marchione, founder of Superpower "GLP-1s, when developed to treat diabetes and obesity, are largely used to make people look better, to maybe increase energy levels. They're used for human enhancement." "I think the next big human enhancement drug is going to be something that allows you to sleep less but feel the same and live the same." "Eli Lilly has actually made a bet on this. They acquired a small molecule that targets narcolepsy... the reason they're paying $6 billion for this is not because it's a narcolepsy drug. It's because they think this same drug could allow normal people, average people, everyone to sleep four hours a night, five hours a night, and feel like they've slept eight." "This drug is an orexin agonist... higher orexin levels are what we see in people who have the short sleeper phenotype."

SITUATION EXPLAINED: What comes after GLP-1s as the next human enhancement drug? We asked Max Marchione, founder of Superpower "GLP-1s, when developed to treat diabetes and obesity, are largely used to make people look better, to maybe increase energy levels. They're used for human enhancement." "I think the next big human enhancement drug is going to be something that allows you to sleep less but feel the same and live the same." "Eli Lilly has actually made a bet on this. They acquired a small molecule that targets narcolepsy... the reason they're paying $6 billion for this is not because it's a narcolepsy drug. It's because they think this same drug could allow normal people, average people, everyone to sleep four hours a night, five hours a night, and feel like they've slept eight." "This drug is an orexin agonist... higher orexin levels are what we see in people who have the short sleeper phenotype."

MTS

236,485 просмотров • 23 дней назад

Meet Nova Natural Gas: our opportunity to create good-paying jobs while developing a stable supply of energy here at home. It’s time for our region to stop relying on energy imports from the United States. We can make it happen here in Nova Scotia. Nova Scotia has developed our offshore natural gas resources before, and we can do it again.

Meet Nova Natural Gas: our opportunity to create good-paying jobs while developing a stable supply of energy here at home. It’s time for our region to stop relying on energy imports from the United States. We can make it happen here in Nova Scotia. Nova Scotia has developed our offshore natural gas resources before, and we can do it again.

Tim Houston

36,320 просмотров • 9 месяцев назад

RK JR: One of the Democrats was ridiculing President Trump for his math, and she was saying it's in mathematically impossible to have any drug drop by 600% cost. And I said, well, if the drug was $100 and it raised the price of $600. That would be a 600% rise. If it drops from 600 to 100, that's a 600% savings. Trump: That’s right. RFK JR: The president used that mathematical device to illustrate the magnitude of the theft.

RK JR: One of the Democrats was ridiculing President Trump for his math, and she was saying it's in mathematically impossible to have any drug drop by 600% cost. And I said, well, if the drug was $100 and it raised the price of $600. That would be a 600% rise. If it drops from 600 to 100, that's a 600% savings. Trump: That’s right. RFK JR: The president used that mathematical device to illustrate the magnitude of the theft.

Acyn

939,654 просмотров • 2 месяцев назад

PillPack founder TJ Parker⚡️ says Hims' Wegovy pill alternative is a “$50 drug that doesn't work” and a “financial Hail Mary.” "The Wegovy pill has a specific technology called 'SNAC' to allow you to absorb the peptide and have the drug be effective. Hims explicitly said they didn't use that technology and said they're using liposomal absorption, which maybe works, maybe doesn't, but there's certainly no proof that it works." "There are zero studies and zero approval. This is where it's super different from the injectables, where they weren't changing the formulation. It was very similar to the branded drug." "[The pill] is different in the sense that, here, there's no evidence this drug works at all. So the most likely scenario is they're selling a $50 drug that doesn't work that still has a bunch of side effects because it still has the drug that doesn't get absorbed through your G.I." "It's not an IP issue, it's really an efficacy and safety issue."

PillPack founder TJ Parker⚡️ says Hims' Wegovy pill alternative is a “$50 drug that doesn't work” and a “financial Hail Mary.” "The Wegovy pill has a specific technology called 'SNAC' to allow you to absorb the peptide and have the drug be effective. Hims explicitly said they didn't use that technology and said they're using liposomal absorption, which maybe works, maybe doesn't, but there's certainly no proof that it works." "There are zero studies and zero approval. This is where it's super different from the injectables, where they weren't changing the formulation. It was very similar to the branded drug." "[The pill] is different in the sense that, here, there's no evidence this drug works at all. So the most likely scenario is they're selling a $50 drug that doesn't work that still has a bunch of side effects because it still has the drug that doesn't get absorbed through your G.I." "It's not an IP issue, it's really an efficacy and safety issue."

TBPN

77,039 просмотров • 5 месяцев назад

VR founder Jaron Lanier says a future where people are paid for the data they give AI is better than one where everyone depends on billionaires to survive "artificial intelligence is a marketing term, even a religion" The software behind drug discovery and chatbots is very different, but we call it all "AI" because it serves politics, ideology

VR founder Jaron Lanier says a future where people are paid for the data they give AI is better than one where everyone depends on billionaires to survive "artificial intelligence is a marketing term, even a religion" The software behind drug discovery and chatbots is very different, but we call it all "AI" because it serves politics, ideology

Haider.

64,901 просмотров • 2 месяцев назад

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!

Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)

48,989 просмотров • 10 дней назад

Energy and intentions are real. This is why we get gut feelings and hunches from certain people and situations Energy resonates or it does not. Train your mind for positivity through affirmations, meditation, writing and being that goodness that you seek Here is a very old video of Grandmaster Xuan Kong extracting a bull’s qi, causing the bull to immediately drop. When this technique was performed, it was done for a specific purpose and was not demonstrated for the sake of showing off. The energy that is drawn out and then refined, can then be used for purposes that benefit the health of whomever is being treated. This was a rarely performed technique, so nowadays most will not ever see this skill being performed again. Even though one cannot expect to see rare demonstrations like this during anymore during medical seminars, there are still very unique and humane skills that are performed, during our current medical seminars. Even the diagnosis process itself is a highly sought after experience, due to the rare electrical qi emission technique that is utilized.

Energy and intentions are real. This is why we get gut feelings and hunches from certain people and situations Energy resonates or it does not. Train your mind for positivity through affirmations, meditation, writing and being that goodness that you seek Here is a very old video of Grandmaster Xuan Kong extracting a bull’s qi, causing the bull to immediately drop. When this technique was performed, it was done for a specific purpose and was not demonstrated for the sake of showing off. The energy that is drawn out and then refined, can then be used for purposes that benefit the health of whomever is being treated. This was a rarely performed technique, so nowadays most will not ever see this skill being performed again. Even though one cannot expect to see rare demonstrations like this during anymore during medical seminars, there are still very unique and humane skills that are performed, during our current medical seminars. Even the diagnosis process itself is a highly sought after experience, due to the rare electrical qi emission technique that is utilized.

Cleanse Parasites .com 🧹🪱 Herbal Cleanse Co.

17,384 просмотров • 1 месяц назад

Back in January Hope Not Hate’s Nick Lowles claimed Tommy Robinson used to be a major drug dealer in Luton. Tommy never sued him for defamation which I found strange. If it wasn’t true why wouldn’t you take on one of your biggest enemies in court and potentially bankrupt him? Now I know why. Tommy has been convicted of drug possession with intent to supply and is on camera bragging about how he can procure drugs anywhere including in Islamic countries. A defamation lawsuit wouldn’t end well for Robinson. I despise Hope Hot Hate and think they should be a proscribed organisation but clearly Lowles knows he would win in court on this one.

Back in January Hope Not Hate’s Nick Lowles claimed Tommy Robinson used to be a major drug dealer in Luton. Tommy never sued him for defamation which I found strange. If it wasn’t true why wouldn’t you take on one of your biggest enemies in court and potentially bankrupt him? Now I know why. Tommy has been convicted of drug possession with intent to supply and is on camera bragging about how he can procure drugs anywhere including in Islamic countries. A defamation lawsuit wouldn’t end well for Robinson. I despise Hope Hot Hate and think they should be a proscribed organisation but clearly Lowles knows he would win in court on this one.

Wolf 🐺

20,598 просмотров • 2 месяцев назад

Brock Lesnar on Jon Jones missing UFC 200 after failing a drug test "It's an unfortunate stage of events that happened, but it is, like I said, it is what it is" "I feel really bad for DC, guys work hard, they go through training camps, and they put a lot of time in and that's the guy that really gets the short end of the stick out of this deal" "It's really unprofessional of anybody at this caliber for something like that to happen"

Brock Lesnar on Jon Jones missing UFC 200 after failing a drug test "It's an unfortunate stage of events that happened, but it is, like I said, it is what it is" "I feel really bad for DC, guys work hard, they go through training camps, and they put a lot of time in and that's the guy that really gets the short end of the stick out of this deal" "It's really unprofessional of anybody at this caliber for something like that to happen"

Peter

207,257 просмотров • 3 дней назад

The pharmaceutical industry calls it a patent cliff — the moment exclusivity expires and generic competition drives cancer drug prices down. A CEO told investors on an earnings call that the company's deliberate strategy is to turn that cliff into a hill, extending monopoly-level pricing well past the point the patent system was designed to allow. He described it as a value creation strategy for shareholders. The patients paying monopoly prices on cancer drugs are the ones creating that value.

The pharmaceutical industry calls it a patent cliff — the moment exclusivity expires and generic competition drives cancer drug prices down. A CEO told investors on an earnings call that the company's deliberate strategy is to turn that cliff into a hill, extending monopoly-level pricing well past the point the patent system was designed to allow. He described it as a value creation strategy for shareholders. The patients paying monopoly prices on cancer drugs are the ones creating that value.

Americans For Pharma Reform

107,354 просмотров • 2 месяцев назад